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Gemfibrozil is a lipid regulating drug And was approved in Sept 1993.It helps cut back cholesterol and triglycerides (fatty acids) in the blood. High levels of those kinds of fat in the blood are related to an exaggerated risk of atherosclerosis (clogged arteries).It lowers very high levels of “bad cholesterol” (low-density lipoprotein, or LDL) and fatty acids (triglycerides) in the blood.It is employed to treat very high cholesterol and triglyceride levels in individuals with pancreatitis.Gemfibrozil is additionally used to lower the chance of stroke, heart attack, or different heart complications in individuals with high cholesterol and triglycerides who haven’t been helped by different treatment strategies. It will increase the activity of lipoprotein lipase enzyme, causing a raised formation of free fatty acids and glycerine from the triglycerides of VLDL, thus, decreasing the concentration of VLDL in the blood. It probably also decreases the formation of VLDL in the liver. The more common side effects that may occur with use of gemfibrozil include stomach pain, nausea, constipation, dizziness, changes in the way things taste, indigestion, diarrhea, vomiting, rash, headache, muscle pain while Serious side effects and their symptoms will include; Gallstones, Rhabdomyolysis (muscle toxicity). Avoid gemfibrozil if you’re allergic to that if you have: severe renal disorder, severe liver disease, gallbladder disease; or if you’re additionally taking repaglinide or simvastatin (Zocor, Vytorin, Juvisync, Simcor).Also Avoid intense foods that are high in fat or cholesterol whereas taking gemfibrozil, or the medication won’t be as effective at lowering cholesterol. The result of this drug in pregnant women has not been well-studied. gemfibrozil ought to be used during pregnancy only if the potential profit justifies the unknown but potential risk to the fetus.It is not best-known whether or not gemfibrozil is excreted in human milk. The suggested dose for adults is 1200 mg administered in 2 divided doses half-hour before the morning and evening meal. Related Article: IMPORTANT INFORMATION ABOUT DULOXETINE

Metoclopramide is an antiemetic as well as a stimulant to the motility of the upper git.it is also used for Preventing nausea and vomiting caused by radiotherapy,anti-cancer chemotherapy, surgery, Relieving nausea and vomiting, and helping painkillers to be absorbed in a migraine.Treating nausea, vomiting, and hiccups in palliative care. Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, so increasing the cholinergic response of the gi smooth muscle. It accelerates intestinal transit and gastric evacuation by preventing relaxation of gastric body and increasing the phasic activity of antrum. at the same time, this action is in the middle of relaxation of the upper small intestine, leading to an improved coordination between the body and antrum of the stomach and therefore the upper small intestine. This drug additionally decreases reflux into the esophagus by increasing the resting pressure of the lower passage anatomical sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramide’s dopamine antagonist action raises the threshold of activity within the receptor trigger zone and reduces the input from afferent visceral nerves. Studies have additionally shown that high doses of metoclopramide will antagonize 5-hydroxytryptamine (5-HT) receptors within the peripheral nervous system in animals. The more common side effects of metoclopramide will include: sleepiness, confusion, dizziness, headache, trouble sleeping, restlessness, exhaustion while Serious side effects and their symptoms will include the following: hypersensitivity, neuroleptic malignant syndrome (nervous system disorder), parkinsonism (symptoms kind of like those caused by Parkinson’s disease), Depression and suicide, dyskinesia, a movement disorder that may be permanent and Hyperprolactinemia (increased levels of the secretion prolactin). The usual dose of metoclopramide for treating GERD is 10-15 mg four times daily, half-hour before every meal.Gastroparesis is treated with 10 mg administered orally four times daily, half-hour before every meal and at bedtime. Related article : important information about Rabeprazole

Rabeprazole belongs to a group of drugs known as Proton Pump Inhibitors and  are prescribed for the treatment of Active benign gastric ulcer,Gastro-oesophageal reflux disease long management (GORD maintenance), Zollinger-Ellison syndrome, Active duodenal ulcer, Symptomatic erosive or ulcerative gastro-oesophageal reflux disease (GORD), Symptomatic treatment of moderate to terribly severe gastro-oesophageal reflux disease (symptomatic GORD), together with appropriate antibacterial therapeutic regimens for the destruction of Helicobacter pylori in patients with peptic ulceration disease. Side effect The more common side effects of rabeprazole will include pain within the abdomen (stomach area), gas, constipation, headache, pharyngitis, infection, diarrhoea whereas Serious side effects and their symptoms will include the following: Systemic lupus erythematosus (SLE), Severe diarrhoea (caused by infection with C. difficile), Low levels of magnesium (a mineral), cutaneous lupus erythematosus (CLE). Mechanism Of Action It inhibits the enzyme H+K+ Atipase irreversibly in the cell membrane of the parietal cells. this will completely inhibit the formation of gastric acid.Because this enzyme is considered the acid (proton) pump among the parietal cell, rabeprazole has been characterised as a gastric proton-pump inhibitor. Rabeprazole blocks the ultimate step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to a vigorous sulfenamide. once studied in vitro, rabeprazole is chemically activated at ph 1.2 with a half-life of 78 seconds. Dose It is used orally in a dose of 20 mg daily in the morning for 6 weeks in a gastric ulcer and for four to eight weeks in duodenal ulcer. Precautions Do not take this drugs if you’ve got an allergy to rabeprazole.Tell your doctor if you’ve got osteoporosis or low bone mineral density (osteopenia), low levels of magnesium in your blood, liver disease, lupus (an autoimmune disorder). Pregnancy This drug mustn’t be used throughout pregnancy unless the advantages outweigh the risks. If you become pregnant while taking this medication, contact your doctor at once.while It isn’t best-known if rabeprazole passes into breast milk. If you are a breast-feeding mother and are taking this medication, it’s going to have an effect on your baby. Related article: Important information About Esomeprazole

Verapamil is in a group of Drugs called calcium-channel blocker. it’s prescribed to treat a variety of heart and blood vessel-related conditions. These are abnormal heart rhythms (arrhythmias), high pressure (hypertension), and angina chest pain. Verapamil inhibits voltage-dependent calcium channels. Specifically, its impact on L-type calcium channels within the heart causes a reduction in ionotropy and chronotropy, so reducing heart rate and blood pressure. Verapamil’s mechanism of effect during a cluster headache is believed to be coupled to its calcium-channel blocker effect, however that channel subtypes are involved is presently not best-known. Avoid verapamil if you’ve got a significant heart condition such as “sick sinus syndrome” or “AV block” (unless you’ve got a pacemaker), slow heartbeats that have caused you to faint, or certain cardiac rhythm disorders of the atrium (the higher chambers of the heart that enable blood to flow into the heart) And severe cardiopathy. Tell your doctor if you are allergic (hypersensitive) to verapamil hydrochloride or any of the other ingredients in calcium blocker. If you’re pregnant, making an attempt for a baby or breastfeeding or you’ve got low blood pressure (hypotension), And If you’ve got any issues with the way your liver works. The most common side effects that occur with verapamil include: nausea and vomiting, face flushing, weakness or fatigue, constipation, sexual issues, like male erecticle dysfunction, headache while Serious side effects include; dizziness or light headedness, quick heartbeat, palpitations, irregular heartbeat, or chest pain, swelling of your legs or ankles, slow heartbeat, problem breathing, fainting, skin rash. The dose for migraine is 160-320 mg three to four times daily.For Hypertension (immediate release): 80-320 mg twice daily.Hypertension (extended release): 120-480 mg once or twice daily depending on the brand.While For Angina (immediate release formulations): 80-160 mg 3 times daily. Angina (extended release formulations): 180-540 mg at bedtime. verapamil is taken with food. Related Article : Abortion Pills Side Effects

Duloxetine is a selective serotonin-norepinephrine reuptake inhibitor and is employed to treat depression and anxiety. It is additionally used to help relieve nerve pain (peripheral neuropathy) in individuals with diabetes or current pain because of medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine could be a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors. The antidepressant drug and pain inhibitory actions of duloxetine are believed to be associated with its potentiation of serotonergic and noradrenergic activity within the central nervous system. The mechanism of action of duloxetine in SUI has not been determined, however, is believed to be related to the potentiation of serotonin and norepinephrine activity within the spinal cord, that will increase urethral closure forces and thereby reduces involuntary urine loss. The most common side effects of duloxetine in adults include: dry mouth, fatigue, loss of appetence, dizziness, nausea, sleepiness, constipation, raised sweating and in children: decreased weight, diarrhea, nausea, dizziness, stomach pain. While Serious side effects include: problems with urination, changes in blood pressure, abnormal hemorrhage. Duloxetine might increase your risk of bleeding or bruising, particularly if you’re taking warfarin or NSAID medication, manic episodes in individuals with depression or bipolar disorder, seizures or convulsions, liver damage, serotonin syndrome, severe skin reactions, vision issues, low salt (sodium) levels in your blood. Toxicity in animal studies.Use as long as potential advantages, outweighs risk; Risk of neonatal withdrawal symptoms if used close to term. The suggested dose for treating depression is 20 or 30 mg twice daily or 60 mg once daily. Patients are also started with 30 mg once daily for one week before the dose is advanced to 60 mg daily.The suggested dose for anxiety disorder, pain associated with diabetic neuropathy, fibromyalgia, or chronic musculoskeletal pain is 60 mg daily. starting at 30 mg daily for one week before increasing to sixty mg daily might facilitate patients comply with the drug. there’s no proof that doses larger than 60 mg/day provide further advantages. However, the maximum dose for depression or anxiety disorder is 120 mg/day.

Diphenhydramine is an over-the-counter medication that reduces the consequences of natural chemical histamine in the body. histamine will produce symptoms of itching, sneezing, watery eyes, and runny nose.  Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the results of histamine on HA-receptors, resulting in a reduction of the negative symptoms brought on by histamine HA-receptor binding.  Common side effects may include: Dry mouth, Dizziness, Headache, Tightness within the chest, Constipation, Drowsiness, Dry nose and throat, Nausea, Feeling edgy (especially in children), Weakness, Loss of appetency while antihistamine will have some serious side effects like Trouble passing pee, change in vision, trouble breathing. Diphenhydramine causes dizziness and drowsiness. don’t drive, use machinery, or do something that wants mental alertness till you recognize how this drug affects you. don’t stand or sit up quickly, particularly if you’re an older patient. This reduces the danger of dizzy or fainting spells. Alcohol could interfere with the effect of this medication. Avoid alcoholic drinks.  Before taking diphenhydramine, tell your doctor or pharmacist if you’re allergic to it, or to dimenhydrinate; or if you have got any other allergies. additionally Before using this medication, tell your doctor or health care provider your medical history, particularly of: breathing problems (such as asthma, emphysema),heart problems,high pressure in the eye(glaucoma), high blood pressure, seizures, stomach/intestine issues (such as ulcers, blockage),liver disease, overactive thyroid(hyperthyroidism), issue urinating (for example, due to enlarged prostate).  A common regimen for treating adult allergic reaction is 25-50 mg each 4-6 hours to not exceed 300 mg daily.When used to treat insomnia, it’s prescribed at bedtime. people over the age of 60 years are particularly sensitive to the sedating and anticholinergic effects of diphenhydramine, and therefore the dose ought to be reduced.Insomnia is treated with fifty mg taken a half-hour before bedtime.  It is a US FDA category B Drug. Diphenhydramine isn’t expected to cause damage to mothers or babies throughout pregnancy – however, this is often not best-known obviously. like any drug, until any studies are done, use diphenhydramine throughout pregnancy given that it is necessary and you have got no alternatives.  Related Article: IMPORTANT INFORMATION ABOUT METOCLOPRAMIDE

Paroxetine belongs to a group of medication referred to as selective serotonin reuptake inhibitors (SSRIs) and is employed as an antidepressant. Paroxetine affects chemicals within the brain that may be unbalanced in individuals with depression, anxiety, or alternative disorders.Paroxetine and different antidepressants are required to hold a black-box warning due to an increased risk of suicide.  Paroxetine is a potent and extremely selective inhibitor of neuronal serotonin re-uptake. Paroxetine probably inhibits the uptake of serotonin at the neuronic membrane, enhances serotonergic neurotransmission by reducing turnover of the neurotransmitter, so it prolongs its activity at junction receptor sites and potentiates 5-HT within the CNS; paroxetine is more potent than other selective-serotonin reuptake inhibitors|SSRI} and fluoxetine in its ability to inhibit 5-HT reuptake. Compared to the tricyclic antidepressants, SSRIs have dramatically minimized binding to histamine, acetylcholine, and noradrenaline receptors. The mechanism of action for the treatment of vasomotor symptoms is unknown.  Pregnant women shouldn’t take Paroxetine, significantly in early pregnancy and through the last few months of pregnancy. The drug could cause heart defects in unborn babies and has been connected to other health issues in newborns.    The more common side effects of paroxetine oral pill, oral extended-release pill, and oral solution will include:sleepiness, dizziness, weakness, reduced sexual desire, delayed ejaculation, impotence, shaking, dry mouth, infection, headache, nausea, anxiousness or wakefulness, sweating, reduced appetite, constipation, yawning, fatigue whereas Serious side effects and their symptoms will include the following: serotonin syndrome or neuroleptic malignant syndrome-like reactions, Severe hypersensitive reactions, Seizures or convulsions, Changes in appetency or weight, Bone fracture, Changes in mood, anxiety or behavior, Eye issues, Abnormal hemorrhage, manic episodes And Low Na levels.  it is prescribed as a once-daily dose, to be taken within the morning. There are many strengths of paroxetine tablets – 10 mg, 20 mg, and 30 mg. Your doctor can tell you which ones strength is right for you.For major Depression in adults, 20 mg daily raised after 3-4 weeks if necessary.Maximum dose per day is 60mg and for child age 8-18 years 10 mg daily increased after 1-2 weeks if necessary, and maximum dose just in case of a toddler is 20 mg daily.  The dose for obsessive-compulsive disorder in adult over 18 years is 20 mg daily and a maximum dose is 60 mg daily .while in case of the older individuals maximum dose is 40 mg daily however 60 mg are often used.   Related article: Important information About Cefixime