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Rabeprazole: Uses, Side Effects, Dosage

  • Rabeprazole belongs to a group of drugs known as Proton Pump Inhibitors and  are prescribed for the treatment of Active benign gastric ulcer,Gastro-oesophageal reflux disease long management (GORD maintenance), Zollinger-Ellison syndrome, Active duodenal ulcer, Symptomatic erosive or ulcerative gastro-oesophageal reflux disease (GORD), Symptomatic treatment of moderate to terribly severe gastro-oesophageal reflux disease (symptomatic GORD), together with appropriate antibacterial therapeutic regimens for the destruction of Helicobacter pylori in patients with peptic ulceration disease.

Side effect

  • The more common side effects of rabeprazole will include pain within the abdomen (stomach area), gas, constipation, headache, pharyngitis, infection, diarrhoea whereas Serious side effects and their symptoms will include the following: Systemic lupus erythematosus (SLE), Severe diarrhoea (caused by infection with C. difficile), Low levels of magnesium (a mineral), cutaneous lupus erythematosus (CLE).

Mechanism Of Action

  • It inhibits the enzyme H+K+ Atipase irreversibly in the cell membrane of the parietal cells. this will completely inhibit the formation of gastric acid.Because this enzyme is considered the acid (proton) pump among the parietal cell, rabeprazole has been characterised as a gastric proton-pump inhibitor. Rabeprazole blocks the ultimate step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to a vigorous sulfenamide. once studied in vitro, rabeprazole is chemically activated at ph 1.2 with a half-life of 78 seconds.

Dose

  • It is used orally in a dose of 20 mg daily in the morning for 6 weeks in a gastric ulcer and for four to eight weeks in duodenal ulcer.

Precautions

  • Do not take this drugs if you’ve got an allergy to rabeprazole.Tell your doctor if you’ve got osteoporosis or low bone mineral density (osteopenia), low levels of magnesium in your blood, liver disease, lupus (an autoimmune disorder).

Pregnancy

  • This drug mustn’t be used throughout pregnancy unless the advantages outweigh the risks. If you become pregnant while taking this medication, contact your doctor at once.while It isn’t best-known if rabeprazole passes into breast milk. If you are a breast-feeding mother and are taking this medication, it’s going to have an effect on your baby.

Related article: Important information About Esomeprazole

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