Zolpidem: Uses, Side Effects, Dosage

Zolpidem is a non-benzodiazepine and belongs to a class of medicines known as sedative-hypnotics. It works by slowing activity in the brain to allow sleep.It affects chemicals within the brain that may be unbalanced in individuals with sleep issues (insomnia). 

  • It modulates the alpha-subunit, called the benzodiazepine receptor, inside the GABAAreceptor chloride channel macromolecular complex. not like the benzodiazepines, that non-selectively interact with all 3 alpha-receptor subtypes, Zolpidem preferentially binds to the alpha-1 receptor. 
  • The more common side effects will include; drowsiness, headache, dizziness, dry mouth, diarrhea, grogginess, chest pain, palpitations (fast, strong, or irregular pulse, or feeling like your heart is skipping a beat), muscle pain, lightheadedness while Serious side effects and their symptoms will include the following: hypersensitivity, Abnormal thoughts or behaviors, trouble breathing, Hallucinations, New or worsening symptoms of depression, Doing activities whereas you’re asleep and having no memory of the event, amnesia (memory loss).


  • Zolpidem (Tartrate) is contraindicated in conditions like Sleep apnea syndrome, myasthenia, Psychosis, respiratory depression, pulmonary insufficiency. 
  • Zolpidem should be used throughout pregnancy or lactation as long as clearly required. It ought to be used with caution in patients with any pre-existing kidney disease, liver disease, lungs disease, history of drug dependence or depression, breathing issues or if have any hypersensitivity reaction. 
  • The usual recommended adult dose of zolpidem typical tablets or spray is 5 mg for females, the elderly, or fragile people, and 5 to 10 mg for males.The maximum dose is 10 mg daily.For females and also the elderly, give 6.25 mg of extended-release tablets; and males ought to receive 6.25 to 12.5 mg.The maximum dose of extended-release tablets is 12.5 mg daily.Elderly patients have reduced the ability to eliminate zolpidem from the body, and accumulating zolpidem might cause side effects. 


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