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Dovato: Uses, Side Effects, Precautions, Dosage & FAQs

Dovato is a recently approved HIV/AIDS medicine. It is the brand name for the two antiretroviral medications (Dolutegravir and Lamivudine) to treat Human Immunodeficiency Virus-1 (HIV-1)/AIDs in adults and in children aged above 12 years.  Dovato is the first once-daily, two-drugs, single tablet, and complete regime approved by the US Food and Drugs Administration (FDA) [01] for treating HIV infection. It is used to help reduce the amount of HIV in your body so your immune system can function properly. This reduces the likelihood of complications of HIV (for example, new infections and cancer) and improves the quality of life. The drug Dovato is marketed by GlaxoSmithKline (GSK) [02] and has been reported as a complete regimen for treating HIV-1 infection in adult patients with no history of antiretroviral treatment known or suspected substitutions associated with resistance to either dolutegravir or lamivudine. Dovato Composition 1. Dolutegravir 50mg 2. Lamivudine 300mg Dolutegravir Dolutegravir is a prescription drug approved by the US Food and Drug Administration (FDA) to treat HIV infection in combination with other drugs. Dolutegravir is an HIV-1 interferon inhibitor that blocks the filament transfer phase of the viral genome integration into the host cell. Integrase inhibitors block an HIV enzyme called integrase. Blocking the integrase enzyme prevents the proliferation of HIV and reduces the amount of HIV in the body. The effect of this drug has no similarity in human host cells, giving it excellent tolerance and minimal toxicity. Lamivudine Lamivudine is another prescription drug for treating HIV infection and hepatitis B (HBV). Lamivudine belongs to a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs). Although lamivudine does not cure HIV, it can reduce the chances of developing Acquired Immune Deficiency Syndrome (AIDS) and HIV-related diseases such as serious infections or cancer. Dovato Uses The drug is approved for the following conditions. Please note that this drug comes with a black box warning of the risk of hepatitis B virus (HBV) that’s lamivudine-resistant and worsening hepatitis B. It is the first once-daily, single-tablet for HIV1 Patients. It is a complete 2-drug regimen for treating HIV infection in adults with no history of antiretroviral therapy (ART). Dovato Mechanism Dolutegravir is an antiretroviral agent for HIV-1. It inhibits the integrase of HIV by binding to the active site and blocking the step of transferring the retroviral DNA integration filament into the host cell. The filament transfer phase is essential in the HIV replication cycle and inhibits virus activity. Lamivudine is a synthetic nucleoside analog and is intracellular phosphorylated to its active metabolite, lamivudine triphosphate (L-TP), 5′-triphosphate. This nucleoside analog is incorporated into the viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in the termination of the DNA chain. Dovato Side Effects The most common side effects with Dovato were Headache, Diarrhea, Nausea, Weakness Belly Pain, Loss of appetite, Fatigue. Less common side effects (Occurred in less than 2% of People) of Dovato include; Hepatitis Anemia Thrombocytopenia Fever Abdominal Discomfort Flatulence Hypersensitivity Pruritus and Rash Renal impairment. Insomnia Anxiety Myositis Immune reconstitution syndrome. Suicidal Thoughts Note: This is not a complete list of side effects. You may experience other side effects; consult your doctor. Although the chances of developing severe allergic reactions are low, it may, in rare cases, causes swelling under the skin, tongue, lips, hands, and eyelids. Talk to your doctor if you experience these symptoms. To avoid liver-related issues, your GP may recommend some tests from time to time to check your enzyme level. Precautions Before taking this medicine, tell your health care provider if you; Are allergic to dolutegravir or any other medicines. Have any other medical conditions? Have you ever had liver problems, including hepatitis B virus infection (HBV) or hepatitis C virus infection (HCV)? Are you pregnant or plan to become pregnant? Are you breastfeeding or plan to breastfeed? Have diabetes; you should know that 3 grams of sucrose are in each tablespoon (15 mL) of lamivudine solution. Lactic acidosis and severe hepatomegaly have been reported with the use of lamivudine. Are using hormone-based birth control.’ Avoid it if you take other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products. Also, the concomitant administration of Dovato with another antiretroviral drug for HUV1 is not recommended. Their doctor should closely monitor HIV-positive and hepatitis B-infected patients who stop using this medicine. Dovato Contraindications It is contraindicated in the following conditions. Hypersensitivity to the ingredients used in Dovato.  It is also contraindicated in combination with dofetilide. Avoid Dovato in pregnancy and breastfeeding women.  Dovato in Pregnancy & Breastfeeding As there is a known risk for neural tube defects with dolutegravir, patients are advised to avoid using Dovato from conception through the first trimester of pregnancy. Also, It is not recommended for use in breastfeeding women. Interactions Talk to your pharmacist or doctor whether you’re taking any other medications, including those you obtain without a prescription from your pharmacist or health food store. Dovato should not be used with the following drugs and conditions. These drugs may increase or decrease the concentration of Dovato, which may lead to side effects. Dofetilide Carbamazepine Fosamprenavir Magnesium citrate Magnesium Aspartate Phenobarbital Fosphenytoin Oxcarbazepine Sorbitol Phenytoin Tafenoquine Rifampin St John’s wort Tipranavir Sucralfate Metformin Acid reducers are used for treating indigestion and heartburn, and iron and calcium supplements can stop Dovato absorption in the body and make it less effective. So, it’s better not to use this medication with antacid, iron, and calcium.  This is not a complete list of drugs. You can consult your doctor before using Dovato along with other drugs. Dovato Dosage It is a single tablet containing two drugs, dolutegravir 50 mg and lamivudine 300 mg. It is a once-daily regime. You can take it with or without food. Clinical Results Dovato is effective in clinical trials when the treatment has maintained low levels of HIV RNA (less than 50 copies/ml) in the blood for at least 48 weeks. The approval was based on Gemini I and II involving more than 1,400 HIV-1 infected patients. This shows

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Femara 2.5mg Tablet (Letrozole): Uses, Side Effects, Dosage & FAQs

Femara (Generic: Letrozole) belongs to a group of drugs known as an aromatase inhibitor. It is used in the treatment of specific types of breast cancer in postmenopausal women. Although it is approved by the FDA for breast cancer, it may also be used to stimulate ovulation in women with polycystic ovary syndrome (PCOS) and unexplained infertility. Many fertility specialists recommend Femara over Clomiphene citrate because it has fewer side effects than Clomid, and there is a lower chance of multiple pregnancies. The second reason is, it is used in people with Clomid resistance. Originally manufactured by Novartis, Femara was approved in 1997 by the Food and Drug Administration (FDA). Femara Tablet Uses Letrozole has been used in Estrogen receptor-positive early breast cancer in postmenopausal women. It is also used in early invasive breast cancer in postmenopausal ladies when five years of tamoxifen therapy have failed to work. It is used in advanced breast cancer in postmenopausal women. It is additionally employed in pre-operative treatment in postmenopausal women with localized hormone receptor-positive breast cancer. Femara is most commonly used in unexplained infertility. (off-label use) It is used to stimulate ovulation in women with polycystic ovary syndrome (PCOS). Note: Your doctor may have suggested this medication for conditions other than those listed in this medication guide. Contraindications It is contraindicated by the following conditions: Premenopausal women Liver disease (especially cirrhosis) It is contraindicated in people allergic to the active ingredient present or any of the excipients. Osteoporosis, Osteopenia (low bone mineral density), High cholesterol; or If you also take tamoxifen. The use of Femara might cause decreases in the density of your bones and increase bone fractures and osteoporosis. Avoid if you are under 18 years of age. Precautions Before taking this drug, Tell your doctor or pharmacist if you are allergic to Femara or any other ingredients in this medication. Tell your GP if you have high cholesterol, liver disease, and osteoporosis. Tell your doctor about your current as well as past medical history. Tell him your other prescriptions, and non-prescription drugs, nutritional supplements you are taking. Tell Your Doctor if you are pregnant or planning to become pregnant before starting Femara. Don’t take Femara if you still have periods. This drug is only used in women who are no longer having periods. Always check the expiry date and Don’t take it after the Expiry date printed on the packing. Mechanism Of Action Letrozole is a selective nonsteroidal inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult nontumor- and tumor-bearing females, Letrozole is as effective as ovariectomy in reducing uterine weight. It also causes elevating blood serum luteinizing hormone and inflicts the regression of estrogen-dependent tumors. In distinction to ovariectomy, treatment with Letrozole doesn’t cause a rise in serum follicle-stimulating hormone. Letrozole selectively inhibits gonadal steroidogenesis but has no important effect on adrenal mineralocorticoid or glucocorticoid synthesis. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme. This inhibition leads to a reduction of estrogen synthesis in all tissues. Treatment of women with Letrozole significantly lowers blood serum estrone, estradiol, and estrone sulfate. However, it has not been shown to affect adrenal corticosteroid synthesis, aldosterone synthesis, or the synthesis of thyroid hormones. Pharmacokinetics Letrozole (Femara Tablet) is quickly absorbed with 100% bioavailability. However, it has a slow metabolism, a large volume of Distribution, and a Time half (t½) of approximately 40 hours. Drug Interactions If you take other medicines or over-the-counter medicines simultaneously, the effects of Femara Tablet may change. This may increase the risk of side effects or make your medications not work correctly. Tell your doctor about all the medicines, supplements, herbal remedies, and vitamins you use. Femara can interact with the following medications: Don’t Take Letrozole if you are already taking tamoxifen. While interaction with warfarin showed no clinical effect of Letrozole on warfarin pharmacokinetics. Cimetidine showed no clinically significant effect on letrozole pharmacokinetics. Femara may also interact with Estrogens (Conjugated estrogens and Ethinyl estradiol). Avoid eating grapefruit and drinking grapefruit juice while taking Letrozole because it slows down the breakdown of Letrozole. This could cause letrozole levels in the blood to rise dangerously high. Alcohol or marijuana can make you dizzier. Limit alcohol while taking Femara. It may also interact with Citalopram, Thalidomide, and Clopidogrel. It may also interact with Birth Control pills. According to a study published in the Journal, of Cell Chemical Biology suggests that exposure to the Estrogen mimicking compound could significantly reduce the effectiveness of anti-estrogen therapies like the Letrozole and palbociclib combination. Foods to avoid while taking Letrozole for fertility While taking letrozole for fertility, there are no specific foods to avoid, as food doesn’t interact with letrozole directly. However, it’s advisable to limit consumption of foods high in estrogen, as they may counteract the medication’s effects and potentially increase side effects. Additionally, it’s a good idea to reduce intake of alcohol, high-sugar foods, refined carbohydrates, excessive caffeine, saturated fats, and processed foods during this time. Femara Tablet Side Effects Like any other medicine, Femara can cause some side effects along with its beneficial effects. Therefore, it is essential to know the side effects before taking it. Most people do not feel all the side effects of Femara. Side effects are often predictable in terms of appearance and duration. In addition, the side effects of Femara are almost always reversible and disappear once treatment is complete. The following is a list of possible side effects that may occur from using this medicine; Most common Femara Side effects The most common side effects from this medication include: Nausea, Vomiting, Hot flushes, Dyspepsia, Dizziness, Headache, Diarrhea, Constipation, Anorexia, Depression, Hypercholesteremia, Raised sweating, Alopecia, Increased craving, Peripheral edema, Skin rashes, Bone fracture, Osteoporosis etc. Less Common Side Effects Less common side effects from Femara Tablet include Tachycardia, High blood pressure, Palpitation, Cough, Dyspnea, Anxiety, Insomnia, Memory impairment, Taste disturbance, Urticaria, Pruritis, Dry skin, Urinary frequency, Abdominal pain, Thrombophlebitis, Urinary tract infection, Viginal discharge,

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Celestamine Tablet: Uses, Side Effects, Dosage

What Is Celestamine Tablet? Celestamine is a medicine that helps with a variety of allergies and inflammations in the body. It’s particularly useful for people who have severe allergic reactions that affect their breathing or eyes. But that’s not all – Celestamine can also help with itchy skin, rashes, and even some types of arthritis. This medicine is made by a well-known company called Merck, which has been creating medicines for many years. They’re based in the United States but sell their products all over the world. What makes Celestamine special is that it contains two different ingredients that work together. One part helps to reduce swelling and inflammation in your body, while the other part fights against allergy symptoms like sneezing or itching. By combining these two ingredients, Celestamine can provide relief for several problems at once. It’s important to remember that even though Celestamine can help with many conditions, you should always talk to your doctor before taking it. They can tell you if it’s the right medicine for you and how to use it safely. Like all medicines, Celestamine should be taken exactly as your doctor recommends. Celestamine Tablet Composition  The composition of these two components in each tablet is below: Betamethasone—250 mcg Dexchlorpheniramine Maleate – 2 mg This product also comes in syrup form. Here is its composition; Each 5 mL of syrup contains Betamethasone 0.25 mg and Dexchlorpheniramine maleate 2 mg. Celestamine Tablet Uses Celestamine is a prescription medication that doctors prescribe to treat, control, prevent, and improve the following diseases, conditions, and symptoms. Here’s a simple breakdown of what it can help with: Allergies and Breathing Problems: If you’re struggling with allergies that affect your breathing or cause constant sneezing, Celestamine might offer relief. Skin Issues: It can help with itchy skin, rashes, and other types of skin inflammation. Even stubborn conditions like scalp psoriasis may improve with Celestamine. Inflammatory Conditions: Celestamine tablet is useful for reducing inflammation in various parts of the body. This makes it helpful for conditions like arthritis and ulcerative colitis (a type of bowel inflammation). Neurological Disorders: In some cases, doctors might prescribe Celestamine tablets for neurological conditions like ataxia (problems with movement and coordination) or to reduce swelling in the brain (cerebral edema). Blood Disorders: Celestamine can be part of the treatment plan for certain blood-related problems. These include some types of anemia and conditions where the body’s immune system mistakenly attacks blood cells. It can be used in hematologic disorders such as Acquired(autoimmune) hemolytic anemia, Diamond-Blackfan anemia, and idiopathic thrombocytopenic purpura in adults. Other Uses: It may also be prescribed for less common conditions like phimosis (a foreskin problem in males). Remember, Celestamine is a prescription medicine. This means you should only take it under a doctor’s guidance. They will decide if it’s right for you based on your specific health needs and medical history. Always follow your doctor’s instructions on how to take this medicine safely and effectively. Celestamine: Mechanism of Action Celestamine is a combination medication with anti-inflammatory and antiallergic properties. It contains two active ingredients: betamethasone and dexchlorpheniramine maleate. Betamethasone:Betamethasone is a synthetic glucocorticoid with metabolic, immunosuppressive, and anti-inflammatory effects. As a member of the 21-hydroxysteroid class, it reduces the production of inflammatory chemicals in the body. Mechanism: Binds to glucocorticoid receptors Interacts with DNA to modify gene expression Enhances synthesis of certain anti-inflammatory proteins Suppresses production of inflammatory mediators Results in overall reduction of autoimmune reactions and inflammation Lowers the body’s natural immune response Dexchlorpheniramine Maleate Dexchlorpheniramine maleate is a first-generation antihistamine with antiallergic properties. Mechanism: Competes with histamine for H1 receptor binding sites Inhibits histamine effects on: Bronchial smooth muscle Capillaries Gastric smooth muscle Blocks actions of endogenous histamines, including: Histamine-induced bronchoconstriction Vasodilation Increased capillary permeability Effects on gastrointestinal smooth muscle and skin Due to these actions, dexchlorpheniramine maleate effectively treats allergic conditions such as hay fever and urticaria. Celestamine Side Effects While Celestamine is generally considered safe, it’s crucial to be aware of its potential side effects. These can range from mild inconveniences to serious health concerns. Let’s explore them through a categorized approach: Visual and Neurological Effects 👁️ Vision problems (due to increased intraocular pressure) 🧠 Severe depression or unusual thoughts/behavior 🌀 Vertigo and headaches 😵 Seizures (convulsions) Cardiovascular & Respiratory Issues ❤️ Congestive heart failure (in susceptible patients) 🫁 Shortness of breath 🩸 Coughing up blood Gastrointestinal (GI) Concerns 🦠 Peptic ulcers 🚽 Irregular bowels, nausea, vomiting 🎈 Abdominal distention Musculoskeletal Effects 💪 Muscle weakness and loss of muscle mass 🦴 Osteoporosis and pathological fractures 🎗️ Tendon rupture Skin and Healing Issues 🔵 Skin discoloration (bluish tint) 🩹 Impaired wound healing 💧 Increased sweating, urticaria 📜 Thin and fragile skin Metabolic and Hormonal Changes ⚖️ Rapid weight gain 💧 Fluid and electrolyte imbalances 🌺 Menstrual irregularities General Systemic Effects 💤 Sedation and drowsiness 😊 Euphoria, mood swings 🦠 Increased susceptibility to infections (watch for cough, fever, chills) Severe Reactions 😰 Swelling of face, lips, tongue, or throat 🩸 Bloody or tarry stools Seek immediate medical attention in case of serious reactions. Remember: This list isn’t complete, and individual experiences may vary. Always consult your healthcare provider about any side effects you experience. They can help determine if the benefits of Celestamine outweigh the risks in your specific case. Precautions 🚦 Before You Begin: Allergy Alert 🚨 Disclose any allergies to: • Betamethasone • Other components in betamethasone preparations • Similar medications • Foods or other substances Describe your allergy symptoms: □ Rash or hives □ Itching □ Breathing difficulties (shortness of breath, wheezing, cough) □ Facial swelling (lips, tongue, throat) □ Other reactions Medical History Matters 📋 Inform your doctor or pharmacist if you have: □ Fungal infections □ Malaria □ Herpes infections □ Neurological issues Full Disclosure 🔍 Provide a complete list of: • Prescription medications • Non prescription (Over-the-counter drugs) • Natural products and supplements • Vitamins Discuss all current health conditions Compatibility Check ✅ Ensure Celestamine is safe to use with: Your current medication regimen

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Ketoprofen (Profenid Tablet): Uses, Side Effects, Dosage etc

Profenid tablet contain an active ingredient known as Ketoprofen. It belong to a group of drugs called Non Steroidal Anti-inflammatory Drugs (NSAIDs). It is used for rheumatoid arthritis, osteoarthritis, tooth extraction pain, Acute gout, Inflammation in backbone and spinal, painful menstruation, inflammation after soft tissue injuries, swollen joints,and other conditions. Profenid Tablet is manufactured by Sanofi Aventis. Mechanism Of Action Ketoprofen (Profenid tablet) is used for its antipyretic, analgesic and anti-inflammatory properties by cyclooxygenase-1 and -2 (COX-1 and COX-2) Enzymes reversibly inhibits, which reduces the production of pro-inflammatory prostaglandin precursors. This results in a decrease in prostaglandin levels that mediates pain, fever and inflammation. Profenid Tablet Uses Ketoprofen is used in the Treatment, Prevention and Control of the following symptoms and diseases. Profenid tablet is used to relieve pain from various conditions. It also reduces pain, swelling, and joint stiffness from arthritis. This medication is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body’s production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever. Tooth extraction pain. Acute gout. Inflammation in backbone. Rheumatoid arthritis. Osteoarthritis. Inflammation in spinal. Painful menstruation. Used in musculoskeletal disorder such as low back pain, sciatica, bursitis, synovitis, tendinitis and fibrositis. Note: Ketoprofen (Profenid)  may also be used for purposes not listed in this medication guide. Profenid tablet (Ketoprofen) Side Effects The more common side effects that can occur with ketoprofen include: Nausea Diarrhea Stomach upset Drowsiness Headache Dizziness Serious side effects and their symptoms can include the following: Heart attack or stroke. Kidney damage Heart failure. Stomach problems, such as ulcers or bleeding. Liver problems. Skin reactions. Allergic reactions. Contraindications Profenid Tablet is a contraindicated in case of Hypersensitivity. In addition, Profenid Tablet should not be used if you have the following conditions: Gastrointestinal bleeding Active peptic ulcer Alcohol Breastfeeding. Interaction With Other Drugs Profenid Tablet may interact with the following drugs and products: Antacids Aspirin Diuretics Digoxin Warfarin Probencid Lithium Methotrexate This can increase the risk of side effects or can make your medication not work properly. Tell your doctor about all the medicines, vitamins, and herbal supplements you use to help your doctor prevent or control drug interactions. Profenid tablet in pregnancy Taking ketoprofen (Profenid) during the last 3 months of pregnancy can harm the unborn baby. Do not use this medicine without medical advice if you are pregnant. Profenid in Breastfeeding  It is not known if ketoprofen passes into breast milk or if it could harm a baby. Do not use this medicine without medical advice if you are breast-feeding a baby. Profenid Tablet Dosage The recommended initial dose is 100 to 200 mg per day, which is taken regularly throughout the day in unit doses of 50 mg with food. It is important that you use the lowest dose that relieves pain. Ketoprofen should not be taken longer than necessary to control the symptoms. Frequently Asked Questions 1. What are the uses of Profenid?  Profenid contain ketoprofen which is NSAID and is used for Rheumatoid arthritis, Osteoarthritis, tooth extraction pain, Acute gout, Inflammation in backbone, Inflammation in spinal, Painful menstruation, Inflammation after soft tissue injuries,Swollen joints,and other conditions. 2. What are the side effects of Profenid?  Side effects associated with the use of this medicine are Nausea, Diarrhea, Stomach upset, Drowsiness, Headache, Dizziness. For more check above. 3. Is Profenid safe in Pregnancy?  Consult your doctor before using this medicine as it can harm your baby. It is contraindicated especially in the third trimester of pregnancy. 4. Is Profenid safe while Breastfeeding?  It is unknown if ketoprofen passes into breast milk or if it could harm a baby. Do not use this medicine without medical advice if you are breast-feeding a baby. 5. How long does it take for profenid to work? It takes 30 minutes to show it’s effect while last for up to 6 hours after taking a ketoprofen dose. However, if your condition has not improved after taking ketoprofen, you should call your doctor. 6. Can you overdose on profenid? A slight overdose of ketoprofen usually does not cause serious problems. The person may have abdominal pain and vomiting. A large overdose can cause serious harm to children and adults. In case of an emergency or overdose, call local emergency services or go to the nearest emergency department. 7. What should I do if I miss a dose? If you miss a dose of Profenid, take it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and take your usual dose as planned. Do not take a double dose. 8. How should I take profenid? Take it orally. It can be taken with food because of the stomach upset. If you have persistent abdominal pain, talk to your doctor or pharmacist. 9. How do I store Profenid? Profenid is best kept at room temperature in relation to direct light and humidity. To avoid damaging drugs. Do not store it in the bathroom or in the freezer. For your safety, keep all medicines out of the reach of children and pets. You should not throw it in the toilet or pour it into a sewer unless you are asked to do so. It is important to dispose of this product properly when it is out of date or no longer needed. Contact your pharmacist for more information on safely disposing of the product. 10. Does the food or alcohol work with Profenid? It may interact with food or alcohol by altering the mode of action of the drug or increasing the risk of serious side effects. Talk to your doctor or pharmacist about possible interactions with food or alcohol before using this medication. 11. What is the dose of Profenid for a child? The dosage has not been established in children under 15 years of age. This can be dangerous for your child. It is always important to understand the safety of the drug before using it. Contact your doctor or pharmacist for more information.

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Depo Provera: Uses, Side Effects, Dosage & FAQs

Depo Provera is a brand name for a type of birth control medication that contains medroxyprogesterone acetate. It is given as an injection, usually in the arm or buttock, once every three months to prevent pregnancy. The progestin in Depo Provera thickens cervical mucus, making it harder for sperm to reach an egg. It also prevents ovulation, which is the release of an egg from the ovaries. Depo Provera is a highly effective form of birth control and is often used by people who cannot or do not want to use other forms of contraceptive methods, such as condoms or birth control pills. Depo-Provera generally inhibits ovulation and prevents the ovaries from releasing an egg. Depo-Provera also thickens cervical mucus to prevent sperm from entering the egg. It’s also called Depo-Shot. It’s an injection that a doctor makes in your arm or buttocks. Each injection will work for 12 to 14 weeks, but you should receive the injection every 12 weeks. Depo Provera is a safe, convenient, and private contraception method that works very well if you always get it on time. Mechanism of Depo Provera A progestin prevents you from becoming pregnant by preventing ovulation. If there is no egg in the tube, pregnancy is not possible. It also works by making the cervical mucus thicker. If cervical mucus is thicker, sperm can no longer occur. And if the sperm and the egg can not meet, the pregnancy can not take place. Contraindications Depo Provera is contraindicated for those who have: Liver disease Blood clots Unexplained vaginal bleeding Breast cancer osteoporosis Pregnancy Pros And Cons Of Depo Provera Pros It’s very Convenient The depo shot is 97-98% Effective it doesn’t interrupt sex No daily contraceptives pill-taking like I Pill and unwanted 72. it’s not affected by other medicines Each shot lasts for either 8 or 13 weeks it’s safe to use while you’re breastfeeding it’s an option if you can’t use estrogen-based contraception. it may reduce heavy, painful periods and help with premenstrual symptoms for some women you don’t have to remember to take a pill every day. Cons It does not protect against sexually transmitted infections. You may have spots between periods. Periods can become irregular. Remember to schedule an injection every three months. It is not generally recommended for long-term use. Depo Provera Side Effects Common Side effects of depo provera can include Nausea, Weight gain, Headaches Stomach cramping or pain, Dizziness, Bloating, Mood swings, Irritability, Drowsiness, Breast tenderness and Hair loss Acne Your periods may become more irregular, heavier, shorter, lighter, or stop altogether. Serious Side effects of Depo Provera include; Worsening depression, Bone pain, Changes in sexual interest or ability, Swelling of the ankles or feet, Persistent nausea or vomiting, dark urine, unusual changes in vaginal bleeding severe abdominal pain, Seizures Unusual weakness or tiredness, Yellowing eyes or skin. Dosage Depo Provera is administered by injection and injected into the muscle every 3 months. One injection of 150 mg intramuscularly. It must be administered within the first five days of a normal menstrual cycle. Frequently Asked Questions 1. What is Depo Provera? Depo Provera is a contraceptive injection for women containing the progestin hormone. This is the brand name for medroxyprogesterone acetate. Depo-Provera is given by injection every three months. 2. How fast does it work? Depo-Provera starts acting as a contraceptive method immediately after the first injection if you receive it within your period’s first 5 days. 3. How should I take Depo-Provera? Your doctor will give you Depo-Provera as an injection into your muscle (intramuscular injection). The injection takes place every 3 months in the buttocks or the arm. After 3 months, you should consult your doctor for the next injection to continue to protect you from pregnancy. 4. How well does it work? Depo Provera is an extremely effective contraceptive method when administered every three months (99.8% effectiveness). Approximately one in twenty (six percent) women become pregnant with Depo Provera. 5. What did I notice after taking Depo Provera? Some women have irregular or persistent bleeding, especially in the first three to six months. This is safe for your body, and there are pills to stop this when it happens. 6. Can I get pregnant after dropping the Depo provera injection? You can get pregnant 3 to 4 months after your last injection. However, some women need at least one or two years to get pregnant after having stopped this contraception type. This delay does not seem to be related to the useful life of the plan. 7. How does Depo Provera work? It prevents pregnancy by preventing the ovaries from releasing an egg every month. There are also changes in the lining of the uterus. 8. What is the level of security when shooting with Depo Provera? It is safe for most people, but all medications have risks and side effects. Your doctor or nurse will help you determine if the vaccine is right for you. 9. Is it safe to use Depo Provera during breastfeeding? Yes, it is safe to use contraceptives during breastfeeding. This should not affect the amount of milk it produces and will not harm your baby. In fact, the vaccine is an excellent method if you are breastfeeding and do not want to get pregnant. 10. What if I forget to have my depo shot on time? It depends on your delay. You can receive your follow-up vaccinations as soon as 10 weeks after your last injection or up to 15 weeks after your last injection. However, if you have been vaccinated for more than 15 weeks after the last injection, you must use a contraceptive backup method, such as a condom, during the first week of filming. Learn more about Medicine Brands

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Faslodex (Fulvestrant): Uses, Side Effects, Dosage, FAQs

Faslodex is the brand name for Fulvestrant. Faslodex belongs to a class of hormone therapy drugs. It fights cancer as an “estrogen receptor Antagonist.” Faslodex is a liquid given once a month as an injection into a muscle, usually at your doctor’s office. AstraZeneca manufactures Faslodex for the treatment of metastatic hormone receptor-positive breast cancer. Faslodex Uses Faslodex injection is used to treat breast cancer spread to other parts of the body in postmenopausal women. It is used in the treatment and prevention of the following conditions. It is used in Hormone receptor (HR)-positive advanced breast cancer, women who have gone through menopause and whose disease has progressed after antiestrogen therapy. It is also used in Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer, who have gone through menopause and have not been previously treated with endocrine therapy. It is used in combination with palbociclib (Ibrance)  or abemaciclib in treating HR-positive, HER2-negative advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic). Faslodex does not work on hormone-receptor-negative breast cancer. Mechanism Of Action The female sex hormones estrogen and progesterone stimulate the growth of certain breast cancers. These breast cancers are called hormone-sensitive or hormone receptor-positive. Drugs that block these hormones’ actions can slow down or stop the growth of breast cancer cells. Faslodex prevents estrogen from reaching cancer cells by blocking estrogen receptors and reducing the number of cancer cell receptors. It binds, blocks, and increases the degradation of the estrogen receptor. Faslodex Side Effects The most common side effects of Faslodex are: Nausea Vomiting Diarrhea Hot flashes constipation Stomach/abdominal pain injection site pain sore throat back pain headache Some women may have other side effects while taking Faslodex: Dizziness Bone/joint pain Swelling loss of appetite Dry skin. Sweating Sleeping problems Nervousness/anxiety Precautions Before using this injection, tell your doctor or pharmacist if you are/have Allergic to it; or if you have any other allergies. Faslodex may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you can safely perform such activities. Liver disease, bleeding problems, and low platelet counts (thrombocytopenia). Pregnant or plan to become pregnant. It would help if you did not become pregnant while using fulvestrant. Fulvestrant may harm an unborn baby. Do not breastfeed while taking this medication. Contraindications Faslodex Injection is contraindicated in patients with known hypersensitivity to the drug or any of its components. Hypersensitivity reactions, including Angioedema Urticaria and Redness of the face, Other symptoms include Dizziness, A headache, shortness of breath and Anxiety. Dosage The recommended dose is 500 mg by intramuscular route in the buttocks. Inject it slowly for 1 to 2 minutes. There are two injections of 5 ml each, one in each buttock on days 1, 15, and 29, then once a month. When used in combination with palbociclib (Ibrance), the recommended dose is 500 mg intramuscularly slowly in the buttocks. Inject it slowly for 1 to 2 minutes. There are 2 injections of 5 ml on days 1, 15, and 29, and once a month since then. The recommended dose of palbociclib is a 125 mg capsule once a day for 21 consecutive days, followed by a rest period of 7 days, including a full cycle of 28 days. Palbociclib should be taken with a meal. Frequently Asked Questions (FAQS) 1. What is the Faslodex Injection? It is the Brand/Trade name for Fulvestrant. It belongs to a class of hormone therapy drugs.  It fights cancer as an “estrogen receptor down-regulator.” 2. What Faslodex is used for? Faslodex Injection treats certain types of breast cancer in post-menopausal women that have spread to other areas of the body. 3. How to Use it? This medicine is slowly injected into the gluteal muscle as directed by your doctor. It is usually given every 2 weeks for the first 3 doses and then monthly. You will be asked if you want to give your dose in one or two injections. 4. What happens if I overdose on Faslodex? Since a healthcare professional administers this drug in a medical setting, it is unlikely to overdose. If an overdose is suspected, contact a poison control center or the emergency room immediately. 5. What other drugs will affect Faslodex? Tell your doctor about all your other prescriptions and over-the-counter medications, especially: warfarin, Coumadin, Jantoven. According to a study published in the Journal “Of British Pharmacological Society,” the addition of fulvestrant to anastrozole treatment decreased the trough anastrozole concentration. This is not a complete list of drug interactions. Consult your doctor before using other medications with Faslodex. 6. What are the side effects of Faslodex Injection? Common side effects associated with the use of this medicine include;  nausea, vomiting, diarrhea, hot flashes, constipation, stomach/abdominal pain, sore throat, back pain, headache, and injection site pain. Check more above. 7. Is Faslodex a form of Chemotherapy? Faslodex is a targeted therapy that keeps estrogen from forming more cancer cells. 8. Is Faslodex Safe to use during Pregnancy? You should not receive fulvestrant if you are pregnant. Avoid becoming pregnant for at least one year after stopping this medication. The use of fulvestrant during pregnancy can harm the fetus. Use effective contraception to prevent pregnancy using this medication and at least one year after the treatment. 9. Is Faslodex safe while breastfeeding? It is not known if Fulvestrant enters breast milk or could harm the baby. You should not receive fulvestrant while breastfeeding. Avoid breastfeeding for at least one year after stopping this medication. Ask your doctor. 10. Can I drive or use machines after taking Faslodex? This medicine may make you feel dizzy. Do not drive, operate machinery, or perform activities requiring alertness until you can safely perform them. 11. How is it stored? Supplied in two 5 ml clear glass containers (type 1), each containing 250 mg / 5 ml Intramuscular solution, with a tamper-evident cap. 12. Who can not take this medicine? Do not use this medicine if you are allergic to fulvestrant or any of the other

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Ibrance (Palbociclib): Uses, Side Effects, Dosage & FAQs

Ibrance is the brand name for the generic drug Palbociclib [1]. This medicine belongs to a group of second-generation cyclin-dependent kinase inhibitors (CDK) 4/6 inhibitors. Palbociclib is used in combination with letrozole (Femara) as initial endocrine therapy for the treatment of human epidermal growth factor receptor 2 (HER2) and hormone receptor (HR) positive breast tumors in adult cancer patients. Palbociclib is developed by Pfizer for the treatment of cancer and there is no other generic medicine available on this drug. It is also approved in combination with fulvestrant in patients with progressive disease receiving prior endocrine therapy. You will need to take it with or without food and can be used concurrently with proton pump inhibitors to avoid GI distress. Don’t crush or chew the tablet before administration. swallowed it as a whole with a glass of water. The Ibrance cost depends on the pharmacy you are getting but generally, it is around 13007$ for 21 capsules. Ibrance is not covered by insurance and the price is for regular customers. Ibrance Uses It is used in combination with other drugs to treat the following conditions. Ibrance alone is used to treat advanced (metastatic) breast cancer. In combination with other medications used to treat HR-positive breast cancer. Also used to treat HER2-negative advanced or metastatic breast cancer. How Effective is Ibrance? The product’s effectiveness was evaluated by 2 clinical trials. According to the results of those clinical trials, Ibrance appeared to significantly slow the movement of advanced, HR-positive, HER2-negative breast cancer. Progression implies the spreading or deterioration of cancer growth. The first study looks at ladies whose cancer had returned or spread after hormone treatment. These women were given fulvestrant. They took fulvestrant either with Ibrance or with a placebo. Women who took Ibrance with fulvestrant had a 54% lower danger of their cancer progression contrasted with ladies who took fulvestrant with a placebo. Ibrance was twice as effective as a placebo treatment at postponing disease movement in this study. The subsequent looks at postmenopausal ladies who hadn’t just had hormone treatment for their breast cancer. A portion of these women took Ibrance with letrozole. Other ladies took letrozole with a placebo treatment. Women who took Ibrance with Femara (letrozole) had a 42% lower danger of their cancer progressing contrasted with women who took letrozole with a placebo treatment. Ibrance Mechanism Cancer cells grow uncontrollably. Ibrance is an inhibitor of the cyclo-dependent kinase (CDK) 4/6. A kinase is a type of protein in the body that helps control cell division. CDK 4/6 inhibitors work by disrupting the kinase and preventing cancer cells from dividing and developing. Ibrance in Pregnancy and Breastfeeding It is approved only for menopausal women. However, it is important to know that pregnant women or those planning pregnancies should not take this medicine.  You mustn’t become pregnant while taking Palbociclib. You must use an effective contraceptive method while taking it and at least two weeks after the last dose. Women who are breastfeeding or who intend to breastfeed should not take Palbociclib. Together, you and your doctor will decide if you want to take it or breastfeed. Ibrance Side Effects The most common and serious side effects of Ibrance are: Upper respiratory infection Low blood counts. Fatigue Frequent infection These less common Ibrance side effects are Nausea Vomiting Diarrhea Mouth sores Hair loss/thinning Weakness Decreased appetite Peripheral neuropathy Nosebleeds Precautions Tell your doctor and pharmacist if you are Allergy to palbociclib, another medicine,, or any of the ingredients in palbociclib capsules. Tell your doctor and pharmacist what herbal products you are taking, especially St. John’s wort. Tell your doctor if you have an infection or if you have or have liver or kidney disease. Do not eat grapefruit or drink grapefruit juice while you are taking this medicine. Talk to your doctor about your medical history, especially about neutropenia. Contraindications It is contraindicated in the following conditions. Hypersensitivity reactions to this drug or any other ingredients. Pregnancy Breastfeeding It is contraindicated in fungal infections. Ibrance Dosage Take this medication with a meal prescribed by your doctor. Usually once a day for 21 days. Then take medicine for 7 days. This is a treatment cycle. Continue taking this medication as directed by your doctor. Swallow the capsules whole. Do not crush, chew, or open the capsules. Do not carry any broken or damaged capsules with you. If you vomit after taking it, do not take another dose of the medication that day. Take the next dose at the usual time of the next day. The recommended initial dose of Ibrance is 125 mg once a day with food for 21 consecutive days, followed by 7 days without treatment. IBRANCE should be taken with food. When used concomitantly with Ibrance, the recommended dose of fulvestrant is 500 mg taken on Days 1, 15, 29, and once monthly thereafter. Please consult the complete dosing information of fulvestrant. The dose depends on your health status, laboratory tests, response to treatment,, and other medications you take. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, over-the-counter medications, and herbal products). If you notice any side effects, your doctor may stop your treatment for a while or reduce your dose. Talk to your doctor to get more information. It is available in 3 different dosage forms and strengths. 125 mg capsules 100 mg capsules 75 mg capsules Ibrance is also available in tablet form with the same strengths. Use this medication regularly to make the most of it. At the same time, take it simultaneously when you take medicine to remember it. Do not increase your dose, and do not use this medication more often or for longer than expected. Your condition will not improve faster and will increase the risk of serious side effects. Interactions You should not take a type of medicine called a CYP3A inhibitor because it increases this drug’s effects. CYP3A includes antifungal medicines such as Itraconazole Clarithromycin, Antiretroviral drugs used

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Anastrozole (Arimidex): Uses, Side Effects, Dosage

Anastrozole (Brand name: Arimidex) belongs to a group of drugs called aromatase inhibitors. Anastrozole reduces estrogen levels in postmenopausal women, which might impede the development of specific kinds of breast tumors that need estrogen to grow in the human body. It is a type of hormone treatment (also called hormone treatment) and belongs to a group of medications known as aromatase inhibitors. Anastrozole (Arimidex) is the generic (non-branded) name of this medication. All brands include exactly the exact same dose of this medication. Consequently, the quantity of estrogen that the tumor is exposed to is reduced, limiting the development of the tumor. Men with breast cancer might also be given anastrozole, though tamoxifen is much more commonly utilized. Arimidex Uses Anastrozole is used in the treatment of the following conditions For adjuvant treatment of hormone receptor-positive breast cancer, Hormonal treatment of breast cancer in postmenopausal women. Used to treat pubertal gynecomastia. McCune-Albright syndrome. Arimidex Mechanism of Action Anastrozole is a nonsteroidal aromatase inhibitor. It works by blocking aromatase, an enzyme that causes increased levels of estrogen in postmenopausal women. Consequently, estrogen levels in the body are diminished, as well as the increase of cancer cells that rely on estrogen can be stopped or slowed. Aromatase inhibition Contributes to a decrease in tumor and serum concentration of estrogen, resulting in a decreased tumor mass or delayed progression of tumor growth in certain women Arimidex Side effects Like most hormonal treatment drugs, anastrozole may cause unwanted side effects. A number of Arimidex side effects may be serious so it’s important to see the comprehensive information below. How hormonal treatment impacts individuals changes from person to person. Your physician or nurse can speak with you about this and provide you suggestions for the best way best to handle Arimidex side effects. Arimidex side effects are different in different people. Following are some of the side effects related to this drug. Some common Arimidex Side effects are; Pain, Arthritis, Hot flashes, Headache, Depression, Nausea, Vomiting, Bone pain, Sleeplessness, and Rash Serious Arimidex side effects are: Low red blood cell count Weak or broken bones Blood clots Stroke, heart attack Cancer of the lining of the uterus Low white blood cell count Increased blood pressure Stevens-Johnson syndrome Liver inflammation Cataracts. Anastrozole in Pregnancy & Breastfeeding Anastrozole isn’t advisable for pregnant moms under any conditions. Anastrozole can cause fetal damage and terminate maternity. It Shouldn’t Be administered to nursing moms to avoid any injury to the newborn. Precautions In case you haven’t gone through menopause you shouldn’t take anastrozole. Avoid if you’ve got osteoporosis (a condition that causes your bones to become thinner and weaker than normal) Avoid if you have issues with your kidneys or liver. If you are currently taking any other medicines, including medicines you may buy without a prescription, like herbal and complementary medicines Interaction with other medications Anastrozole (Arimidex) shouldn’t be used with tamoxifen since tamoxifen can decrease anastrozole amounts within the body and lessen its curative outcomes. Estrogens reduce the impact of anastrozole by raising estrogen levels in the human body. Foods To Avoid When Taking Anastrozole While taking Anastrozole, most individuals can maintain a regular diet. However, if you experience diarrhea, it’s advisable to avoid raw fruits, vegetables, whole-grain foods, cereals, and seeds. Instead, opt for soluble fiber-rich foods to alleviate diarrhea. Additionally, consider reducing your intake of spicy foods, caffeine, alcohol, and refrain from smoking for overall well-being during Anastrozole treatment. Always consult your healthcare provider for personalized dietary guidance. Arimidex Dosage Anastrozole is generally taken once every day. Follow all instructions on your prescription label. Don’t take this medication in smaller or larger quantities or for longer than advised. The suggested Arimidex dosage for adults such as the elderly is just one 1 mg tablet once each day. For postmenopausal women using hormone receptor-positive early invasive breast cancer, the recommended length of adjuvant hormone therapy is 5 years. You might take anastrozole with or without meals. You might want to continue taking this medicine for as many as five decades. Follow your physician’s directions. But if it’s almost time for the next dose, skip the missed dose and return to your regular dosing schedule. Don’t double doses. Store at room temperature away from heat and moisture. Related article: More Medicine Brands

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Nasacort Nasal Spray (Triamcinolone acetonide): Uses, Side Effects, Dosage

Nasacort Nasal Spray contain Triamcinolone acetonide and can be used to treat itching, coughing, and runny nose brought on by seasonal allergies or hay fever. Uses Nasacort Nasal Spray can be used in the treatment and prevention of the following conditions: Seasonal Allergies like itching, coughing, Runny nose Nasacort Nasal Spray prevents the release of compounds from the body that cause inflammation. It’s a steroid spray which may help improve nasal congestion and might be helpful to decrease snoring and as an adjunctive treatment for obstructive sleep apnea when allergic rhinitis is current. Triamcinolone nasal may also be utilized for different functions not listed in this medication guide. Precautions Nasacort shouldn’t be used if you have an open wound or ulcer inside your nose. The use of this medication in pregnancy shows adverse effects in animals and use in lactation is unknown. If you’re nursing or pregnant, you need to go over the security and risks versus rewards with your doctor. If you’ve had recent therapy with other corticosteroid drugs, you might not wish to utilize Nasacort. Certain eye conditions like increased intraocular pressure, glaucoma, or cataracts might be a contraindication. In case you have an untreated disease, particularly with tuberculosis, herpes simplex impacting the eye, or exposure to measles or varicella (chickenpox), Nasacort ought to be used with care. It might not be a good idea to use it in case you suffer from recurrent nosebleeds (epistaxis). Children must be followed closely if long-term usage happens. Contraindications Nasacort is contraindicated in patients with a history of hypersensitivity to triamcinolone acetonide or to any of the other ingredients of this preparation. Mechanism Nasacort nasal spray includes the active ingredient triamcinolone acetonide, which is a form of medication called a corticosteroid (or steroid). Corticosteroids are hormones produced naturally by the adrenal glands which have many important functions, including control of inflammatory responses. When administered to the nose, then triamcinolone is absorbed into the tissues of the nasal lining. It works by preventing those cells by releasing substances which trigger inflammatory and allergic responses. Additionally, it may help alleviate associated eye symptoms such as itchy, red and watery eyes. Side effects The most Frequent side effects after nasal inhalation of Nasacort (triamcinolone acetonide) are: Increased cough, Nausea or vomiting, Sore throat, Nasal itching and soreness, Nasal congestion, Sneezing, Nasal burning, Bloody nasal discharge, Depression, Acne, Increased hair growth Irregular menstrual cycles, Nasal dryness. Other adverse effects reported with intranasal triamcinolone acetonide contain: Headache , Nausea , and watery eyes. Nasacort Spray in Pregnancy & Lactation Significant complications (like cleft palateand births) have been reported if oral corticosteroids were administered during maternity . It’s not known if the tiny amounts of corticosteroids which show up in the blood after intranasal use take the identical risk. Triamcinolone acetonide use during pregnancy ought to be avoided unless your doctor feels that the possible therapeutic benefit outweighs the possible risk to the embryo. It’s unknown if triamcinolone acetonide collects in breast milk. But, it’s understood that other corticosteroids are excreted in breast milk. The consequences on the child, if any, are still unknown. Nasacort Spray Interactions Inform your doctor about all the medications you take, including non-prescription and prescription medications, vitamins, minerals, and herbal nutritional supplements. Especially tell your Physician if you take: Antibiotics Amphotericin B Anticholinesterase agents like donepezil, rivastigmine, and galantamine. Aminoglutethimide Anticoagulants like warfarin Non-steroidal anti inflammatory agents like aspirin, Naproxen, and celecoxib. Antidiabetic agents Isoniazid Digoxin Phenytoin Ketoconazole Cholestyramine Cyclosporine Estrogens, Carbamazepine Rifampin This isn’t a comprehensive list of all Nasacort drug interactions. Consult your physician or pharmacist to learn more. Dosage Use exactly as prescribed by your physician. Don’t use in smaller or larger quantities or for longer than advised. Follow the instructions on your prescription label. Adult: 2 sprays in each nostril once daily. Reduce dose as symptoms improve. Children: Age less than 2yrs: not suggested. Age 2-6yrs: 1 spray in each nostril once daily. Age 6-12yrs: 1 spray in each nostril once daily; max 2 sprays in each nostril once daily. Note: If you forget to use your Nasacort nasal spray utilize it as soon as you remember, unless it’s almost time for your next dose. In this scenario just leave out the forgotten dose and take the next dose as normal. Do not use a double dose to make up for a missed dose.

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Isotretinoin (Zenatane): Uses, Side Effects, Dosage

Isotretinoin (Zenatane) is an effective systemic medication used in the treatment of severe inflammatory acne. Isotretinoin is categorized as a retinoid created from a synthetic form of vitamin A. This medication can have severe side effects, but it has to be treated and supervised by a healthcare provider. Isotretinoin is a medicine used for treating severe acne. It’s occasionally utilized in the avoidance of certain skin cancers. Isotretinoin is an oral medication used for the prevention and treatment of acute acne. Acne results from inflammation of the skin. The we Food and Drugs Administration approved Isotretinoin in May 1982. Precautions (Zenatane) Before taking isotretinoin, tell your Physician if you or Anybody in your family has any of the conditions like Diabetes, asthma, liver disease, heart disorder and depression. You should also tell your doctor if you are allergic to any medications, particularly parabens (compounds used in cosmetics, moisturizers, and isotretinoin). Do not take isotretinoin if you have hypervitaminosis A. Be sure to tell your doctor if you are taking any other medicines, even over-the-counter medicines. Do not take isotretinoin if you have severe liver disease. Do not take isotretinoin if you have very high-fat levels (cholesterol, triglycerides) in your blood. Mechanism Isotretinoin (Zenatane) reduces the size and activity of the sebaceous glands within the skin, which lowers the total amount of sebum that’s generated. This prevents the glands from getting obstructed, and germs are not as likely to flourish. Additionally, it lessens the redness of the skin. Side effects Serious side effects are rare and occur in less than 1 in 1,000 individuals. Stop taking isotretinoin Zenatane capsules and inform a doctor straight away in the Event That You get: Stress, Suicidal ideas – these may be indications of mental health issues Acute pain in your stomach without diarrhea, Violence and aggression, Feeling ill, and Nausea Trouble moving your arms or thighs, and painful, swollen or bruised parts of the body. A Severe skin rash that soothes or has blisters Even darkened urine Yellowish eyes or skin, Difficulty swallowing or feeling quite tired A lousy headache which does not go off and cause you to feel sick or vomit Abrupt changes in vision It is infrequent; however, isotretinoin capsules can occasionally result in sadness or make it worse and also make people feel dizzy. In rare situations, it is likely to have a severe allergic reaction to isotretinoin capsules. Zenatane in Pregnancy Isotretinoin is damaging to the fetus and so shouldn’t be used through pregnancy. Women of childbearing age should have two negative pregnancy evaluation results before treatment is initiated, and a pregnancy test must be run during every month of treatment. Two powerful kinds of birth control have to be utilized throughout treatment. Pregnancy ought to be avoided a month prior to, during, and at least one month after stopping isotretinoin. It’s not known whether isotretinoin is secreted in breast milk, but because of its potentially serious side effects, it Shouldn’t Be utilized by breastfeeding moms. Isotretinoin Interactions Inform your doctor of all of the medications you are taking. This also has over-the-counter and prescription drugs, vitamins and other nutritional supplements (nutritional shakes, protein powders, etc.), herbal remedies and some other recreational and illegal drugs. Speak with Your doctor about the risks and benefits of taking isotretinoin (Zenatane) if you are using Phenytoin, carbamazepine, Corticosteroids, such as prednisone, prednisolone, or triamcinolone and herbal treatments. Do not take isotretinoin (Zenatane) if you are taking tetracycline antibiotics, such as demeclocycline, doxycycline or vitamin A. You need to limit or avoid drinking while taking isotretinoin. Dose for isotretinoin The suggested dose of isotretinoin (Zenatane) is 0.5 to 2 mg per kg of body weight every day. The daily dose generally is administered in 2 divided doses for 15-20 weeks. Isotretinoin should be taken with meals so as to increase its absorption. Explore More Medicine 

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