Duspatalin (Mebeverine): Uses, Side Effects, Dosage & FAQs

Mebeverine (Duspatalin) belongs to the group of medicines called antispasmodics. It helps relax the intestinal muscles, which in turn reduces pain and irritability.

Duspatalin Uses

Mebeverine is used to treat the following conditions.

  • Symptoms of irritable bowel syndrome, a common intestinal disease that causes spasms and intestinal pain, as well as stomach pain, persistent diarrhea (sometimes alternating with periods of constipation) and wind (flatulence).
  • It is used to relax the muscles of the intestine and to treat the symptoms of irritable bowel syndrome and related conditions.
  • It is a direct relaxant of the intestinal muscle and is sometimes referred to as an anticonvulsant.
  • The chronic irritable large bowel, spastic constipation, mucosal colitis, and spastic colitis.
  • Inflammation of the digestive tract
  • Bile duct disease,
  • Inflammation of the digestive system,
  • Gall bladder disease.

Mechanism of action

Mebeverine hydrochloride is a type of medicine called an antispasmodic. Relax the muscles in the intestinal walls. This relieves painful muscle spasms in the intestine and reduces associated symptoms such as cramping, pain and abdominal cramps, flatulence, winds (flatulence) and diarrhea with constipation.

Duspatalin Side effects

Duspatalin can cause such side effects:

  • Allergic reactions (angioedema, urticaria, rash and swelling of the face)
  • Diarrhea
  • Constipation.
  • Dizziness (very rare)
  • Breathing and swelling of the hands and face.

Duspatalin in pregnancy

It is a category B medicine, that is, it has not been used safely during pregnancy due to possible adverse effects on fetal development. Therefore, Duspatalin is not recommended during the first trimester of pregnancy and, otherwise, a risk-benefit approach should be considered in pregnant women. While mebeverine is excreted in breast milk (<10 micrograms/ml after an oral dose of 100 mg of mebeverine hydrochloride).

Duspatalin is contraindicated in patients with hypersensitivity to mebeverine or other excipients.


  • Duspatalin with omeprazole/lansoprazole: There are no known serious interactions between mebeverine and omeprazole/lansoprazole.
  • Duspatalin with Imodium/Loperamide: There are no known serious drug interactions between mebeverine and Imodium / loperamide.
  • Mebeverine with Buscopan contains butylscopolamine, which, like mebeverine, is also anticonvulsant. The concomitant use of Mebeverine and Buscopan leads to an additional effect but may cause additional side effects.
  • Mebeverine with paracetamolThere are no known serious drug interactions between mebeverine and paracetamol and preparations containing codeine with paracetamol.
  • Mebeverine with antibioticsThere are no known serious interactions between mebeverine and antibiotics.

Ask your doctor about all medications taken before and during the course of taking mebeverine

Dosage of Duspatalin

  • It is taken orally 20 minutes before a meal without chewing or drinking water.
  • Another dose is a tablet three times a day.
  • Children over 12 years old should use the medication twice a day (200 mg). The capsule should be swallowed without chewing and should be drunk with water. The duration of the cure is determined individually by the doctor.
  • Duspatalin should not be used in children 3 years old or younger as there is no clinical data available.

How to store?

  • Store in a cool, dry place, away from heat and direct light.
  • Keep all medications out of the sight and reach of children.

Frequently Asked Questions

1. What is Mebeverine used to treat?

Duspatalin is used to treat symptoms of irritable bowel syndrome (IBS) and similar problems such as spastic constipation, spastic colitis, chronic irritable colon, and mucous colitis.

2. Can Mebeverine be taken after food?

Intestinal spasms are often strongest shortly after eating; Therefore, it is usually best to take Mebeverine about 20 minutes before a meal.

3. What are the side effects of Duspatalin?

Common side effects associated with the use of this drug include indigestion, heartburn, tiredness, constipation, loss of appetite, diarrhea, general malaise, insomnia, headache, dizziness,  and decreased pulse rate.

4. Is it safe to use Duspatalin Tablet if you are pregnant?

Duspatalin contains a pregnancy Category B drug which is not recommended during the first trimester of pregnancy and, otherwise, a risk-benefit approach should be considered in pregnant women.

5. Is Duspatalin Tablet Safe During Breastfeeding?

It is excreted in breast milk, therefore, it is not recommended for use while breastfeeding especially in the first trimester. Please always consult with your doctor to weigh the potential benefits and risks before taking This drug.

6. What is the dose of Duspatalin for adults?

The usual Adults and Elderly dose are 1 tablet three times a day. The number of pills you take can be reduced as your symptoms improve. Do not take more than 3 tablets a day.

7. What is the dose of Duspatalin in children?

Do not give Duspatalin® 135 mg tablets to children and adolescents under 18 years of age.

8. What should I do in case of an emergency or overdose?

In case of emergency or overdose, consult with local emergency services or go to the nearest emergency room.

9. What should I do if I miss a dose of duspatalin?

If you forget a tablet, take it as soon as you remember. However, if it is almost time to take the next dose, skip the missed dose. Do not take a double dose if you forget to take the previous dose.

10. Is Duspatalin Addictive a product?


11. Can I drive while taking Duspatalin?

Yes, duspatalin should not affect your ability to drive.

12. Can I drink alcohol while taking mebeverine?

Yes, within recommended amounts alcohol does not affect this medicine. Although it’s better to limit the amount of alcohol.

13. Can Duspatalin be used for constipation?

Yes, it is used to treat the symptoms of irritable bowel syndrome and related intestinal disorders such as constipation, chronic irritable colon, spastic, mucous colitis, and spastic colitis.

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