Celestamine (Betamethasone): Uses, Side Effects, Dosage & 14 FAQs

Celestamine (Generic: Betamethasone) belongs to a group of drugs known as corticosteroids. It is manufactured and marketed by Schering Plough Limited (Under – Merck Sharp and Dohme LLC).

Celestamine tablets contain a medicinal mixture of two components, Betamethasone, and dexchlorpheniramine. The composition of these two components in each tablet is below:

  • Betamethasone: 250 mcg per tablet
  • Dexchlorpheniramine Maleate – 2 mg per tablet

It is used for allergic disorders, itching or rash, dermatitis, ataxia telangiectasia, psoriasis of the scalp, ulcerative colitis, arthritis, phimosis, and other such conditions.

Celestamine Uses

Celestamine Tablet is used to treat, control, prevent, and improve the following diseases, conditions, and symptoms:

  • Breathing disorders
  • Itch or rash
  • Allergic disorders
  • Skin inflammation
  • Ataxia telangiectasia
  • Cerebral edema
  • Scalp psoriasis
  • Arthritis
  • Ulcerative colitis
  • Phimosis
  • It can be used in hematologic disorders such as Acquired(autoimmune) hemolytic anemia, Diamond-Blackfan anemia, idiopathic thrombocytopenic purpura in adults.
  • Blood disorders.

Celestamine Mechanism

Celestamine is a combination of anti-inflammatory and anti-allergic medications.

Betamethasone is a synthetic glucocorticoid drug with metabolic, immunosuppressive, and anti-inflammatory activities. It belongs to a group of drugs known as 21-hydroxysteroids that are used to reduce the number of inflammatory chemicals your body produces. 

⇒ Betamethasone binds to glucocorticoid receptors and then binds to DNA to modify gene expression, which leads to the synthesis of some inflammatory proteins while reducing the synthesis of some inflammatory mediators. This way this drug causes an overall reduction in autoimmune reactions and inflammation, thus lowering the body’s natural immune response.

⇒ While the dexchlorpheniramine maleate has antihistamine properties. This is a first-generation antihistamine and antiallergic drug. It competes with H1 receptors, thus inhibiting histamine on H1 histamine receptors on bronchial smooth muscle, capillaries, and gastric smooth muscle. Dexchlorpheniramine’s aggressive action inhibits the action of endogenous histamines, such as histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle and skin, that’s why it treats allergic conditions such as hay fever or urticaria.

Celestamine Side Effects

The more common side effects that can occur with Celestamine include:

  • Problems with your vision as it increases intraocular pressure. 
  • Swelling, rapid weight gain,
  • Feeling short of breath;
  • Severe depression, unusual thoughts or behavior,
  • Seizure (convulsions);
  • Bloody or tarry stools,
  • Coughing up blood;
  • Sedation and drowsiness
  • Fluid and electrolyte disturbance in the body
  • Muscle weakness, loss of muscle mass, tendon rupture.
  • Congestive heart failure in susceptible patients
  • Osteoporosis, pathological fractures
  • Peptic ulcers, irregular bowels, nausea, vomiting
  • Skin discoloration (Blue skin color).
  • Impaired healing of wounds
  • Swelling of your face, lips, tongue, or throat.
  • Seizure
  • Abdominal distention.
  • Thin and fragile skin.
  • Increased sweating, urticaria.
  • Vertigo, headaches.
  • Euphoria, mood swings, depression.
  • Menstrual irregularities
  • Infection. Signs may include cough, fever, chills.

Precautions

  • Before you taking Celestamine tell your doctor If you have an allergy to betamethasone or any other part of betamethasone preparations.
  • Tell you, doctor, If you are allergic to any drugs like this one, any other drugs, foods, or other substances.
  • Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • Please keep in mind that Celestamine is not suitable for infants.
  • Before taking Celestamine, Tell Your Doctor If you have any of these health problems: A fungal infection or malaria infection, herpes infection.
  • If you have nerve problems.
  • Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems.
  • You must check to ensure that it is safe for you to take Betamethasone oral solution with all of your drugs and health problems.
  • Do not start, stop, or change the dose of any drug without checking with your doctor.
  • Should not use celestamine for a prolonged time.

Celestamine In Pregnancy & Breastfeeding

The FDA has assigned pregnancy category C to betamethasone. Studies in animals have shown teratogenicity when oral corticosteroids are administered, or potent steroids are administered topically. There are no controlled data on human pregnancy. Betamethasone has been shown to cross the placenta. Betamethasone is recommended only during pregnancy when there are no alternatives, and the benefits outweigh the risks.

Celestamine is not safe to take if you are breastfeeding or intending to start breastfeeding. The corticosteroid can damage the fetus or a baby. This can also disrupt the average growth of a newborn baby. Always consult a health care professional before using Celestamine if you are breastfeeding a baby.

Celestamine interactions

If you use other medications or over the counter products at precisely the same time, the effects of Celestamine Tablet can alter. This might increase your chance for side-effects or trigger your medication not to operate correctly. Inform your doctor about all of the medications, vitamins, minerals, and herbal supplements you’re using, so your physician can help you prevent or handle drug interactions. Celestamine Tablet may interact with these drugs and products:

  • Estrogen
  • Phenobarbital, Phenytoin, rifampicin, or ephedrine
  • Potassium-depleting diuretics can increase the chances of hypokalemia.
  • Cardiac glycosides can improve the chance of arrhythmias or digitalis toxicity associated with hypokalemia.
  • Coumarin-type anticoagulants can increase or reduce the anticoagulant effects.
  • Corticosteroids may improve the potassium depletion brought on by amphotericin B. In most patients taking at least one of these drug treatment mixes, serum electrolyte determinations must be tracked carefully, especially potassium levels.
  • Dosage adjustments of antidiabetic medication may be mandatory if corticosteroids are given to people with diabetes. Antihistamines could inhibit the activity of oral anticoagulants
  • Corticosteroids may reduce blood salicylate concentrations. Acetylsalicylic acid ought to be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.
  • Celestamine can also interact with digoxin and cyclosporine etc.

Celestamine Dosage

The usual recommended dose of Celestamine for adults is 2 to 6 tablets per day. As the patient improves, the dosage should be gradually reduced to the minimum required. The drug should stop whenever possible.

The usual recommended dose of Celestamine for children age 6-12 years is 1/2 tablets or 1/2 teaspoonful of celestamine syrup 3 times a day.

The usual recommended dose for children age 2-6 years is 1/4 teaspoonful 3-4 times a day. The dose should be adjusted as per the patient’s condition.

Your doctor will determine the right dose for you based on your individual needs. Your overall health can affect your dose. Tell your doctor about all the health conditions you have before your doctor or nurse gives you the medicine.


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Frequently Asked Questions

1. Should I use Celestamine Tablet on an empty stomach before or after meals?

Answer: Celestamine should be used daily as directed by your healthcare practitioner. Generally, it is used after meals and at bedtime.

2. What is Celestamine used to treat?

Answer: Celestamine Tablet is used to treat, control, prevent inflammation, allergic reactions, skin rashes, and many other conditions. Check Uses above.

3. Is it safe to use Celestamine Tablet if you are pregnant?

Answer: It is a Category C drug. There are no controlled data on human pregnancy. Betamethasone has been shown to cross the placenta. Betamethasone is recommended only during pregnancy when there are no alternatives, and the benefits outweigh the risks. Consult your doctor for specific recommendations for each case.

4. Is Celestamine Tablet Safe During Breastfeeding?

Answer: It is not safe to take if you are breastfeeding or intending to start breastfeeding. The corticosteroid can damage the fetus or a baby. This can also disrupt the average growth of a newborn baby. Consult your physician.

5. Can Celestamine Tablet be used for itching or rashes and allergies?

Answer: Yes, itching or rash and allergy are among the most commonly used applications reported for Celestamine Tablet. Always ask your GP before using it for any condition.

6. Is it safe to handle or operate heavy machinery when using this product?

Answer: You should not drive if you use the medicine; make you drowsy, dizzy, or your blood pressure goes down. Always ask your doctor about recommendations for your body and your health conditions.

7. Can I stop using Celestamine immediately, or should I stop using it slowly?

Answer: Some medications can not be stopped immediately due to rebound effects. Consult your doctor for recommendations on your body, health, and other medicines you may use

8. Is this substance or addictive product, or is it a habit?

Answer: No, it is not addictive.

9. Is this steroid?

Answer: Yes, It contains Betamethasone, which belongs to a group of drugs known as a corticosteroid.

10. What to do if I missed a dose of Celestamine? 

Answer: If you miss a dose of celestamine, take it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and take your usual dose as planned. Do not take a double dose.

11What should I do in an emergency or overdose of Celestamine?

Answer: In case of an emergency or overdose, consult your local ambulance or go to the nearest emergency room. The estimated lethal dose of Celestamine is 2.5-5mg/Kg. 

12. How should I take Celestamine? 

Answer: The usual dose for adults is 2 to 6 tablets per day. As the patient improves, the dosage should be gradually reduced to the minimum required. Always consult your physician before taking the drug.

13. Is Celestamine an antihistamine?

Answer: No, It contains Betamethasone as an active ingredient, which belongs to a group of drugs known as corticosteroids.

14. What are the side effects of Celestamine?

Answer: The most common side effects of this drug include headache, nausea, sleep disturbances, Gastric ulcer, poor appetite, Diarrhea, and others. This is not a complete list of side effects; for more, check above.

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8 thoughts on “Celestamine (Betamethasone): Uses, Side Effects, Dosage & 14 FAQs

  1. I have been using celestamine for almost a year..seems like i rely on it on my allergy..if i missed a tablet i will notice i have a swelling face on the morning..my skin also swells and has redness on every part…how can I stop using this tablet what will be the alternative medicine should i use for my allergy which became very dependant on celestamine

  2. Very informative article about this topic. Keep up the great work

  3. Great content. I am following this site and it great will visit this again. Keep up the great work

  4. I have been using celestamine for almost 2yrs now n it really relieves me from allergy. But I’m worried cus I’m sleepy always

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