Categories: ArticlesDrugs

Important Information About Rifampicin

Uses

Rifampicin is a semisynthetic derivative of rafmycin B obtained from streptomyces mediterranei.Rifampicin is clinically used in the treatment of following Condition:

  • For the Treatment of Tuberculosis in combination with other anti Tuberculosis drugs.
  • Treatment of leprosy and atypical mycobacterial infection.
  • Prevention of Meningococcal meningitis.
  • Prevention of meningitis caused by H.influenza in children.
  • In combination with co-trimxazole for the eradication of staphylococcal infections.
  • Along with Vancomycin,ceftriaxone or cefotoxime ,for the treatment of meningitis caused by highly penicillin resistant pneumococci.

Mechanism Of Action

Rifampicin is a bactericidal drug and inhibits the synthesis of RNA in the bacterium by inhibition of the enzyme referred to as DNA dependent RNA polymerase.It inhibits DNA dependent RNA synthesis.Probably the basis of selective toxicity is that mammalian RNA polymerase doesn’t avidly bind rafampicin.Resistance to Rifampicin could occur due to mutation in the gene of RNA polymerase of the mycobacteria.This will stop the binding of rifampicin with the RNA polymerase of bacterium.

Side Effects:

  • Headache, Diarrhea, and abdominal discomfort .
  • If Given in less than twice weekly doses,it can cause flu-like symptoms,such as fever,malaise,muscle pain,thrombocytopenia,neutropenia, anaemia and renal tubular necrosis may occur.
  • Hypersensitivity reactions like skin rashes and fever may occur.
  • Cholestatic jaundice and rarely hepatitis can occur.
  • It can cause your urine and sweat to have an orange or reddish colour but This is completely harmless.
  • Collapse and shock,acute renal failure, respiartory symtoms include shortness of breath.

Pregnancy

There are very limited knowledge regarding fetal risks following exposure to Rifampicin throughout pregnancy. No exaggerated risks of miscarriage, congenital malformation, preterm delivery or low birth weight are attributed to Rifampicin exposure, though the underlying maternal infections requiring Rifampicin treatment have known independent risks throughout pregnancy.Manufacturer advise very high doses teratogenic in animal studies in first trimester and risk of infant bleeding is also increased in third trimester.While quantity of Rifampicin in breast milk is simply too little to be harmful.

Doses

  • Dose For The Treatment of Tuberculosis is 10 mg/kg/day (600 mg daily) twice weekly.
  • Dose For The prevention of meningococcal meningitis is 600 mg twice daily for two days.
  • Dose for the prevention of meningitis caused by H.influenza in children is 20 mg/kg/day for four days.
  • Dose For Brucellosis,legionnaires disease,endocarditis in combination with other drugs is 0.6g-1.2g per day in 2-4 divided doses.

Related Article: Important Information About Isoniazid

View Comments

Share
Tags: Rifampicin

Recent Posts

Review Of Osaki OS 4000 CS massage chair

The Osaki Os 4000 CS massage chair is an upgraded version of the Osaki OS-4000 and 4000 T models. It is… Read More

3 days ago

10 Best Thermometer For Babies (2020 Helpful Buyer Guide)

Nothing can best observe a baby’s uneasiness but a mother’s lap. There is nothing as powerful as a mother’s love… Read More

5 days ago

10 Best Massage Chairs Under 2000 & 1000$ (2020 Helpful Buyer Guide)

Today you're going to learn some of the best massage chairs under 2000 $ and also some under 1000$.  Massaging… Read More

6 days ago

Best Thermometer For Nurses (2020 Helpful Buyer Guide)

A thermometer is a device that is used for the measurement of body temperature. It is mainly used to see… Read More

1 week ago

6 Best Pre Workout To Lose Weight & Gain Muscle

Pre-workout supplements are multi-ingredient nutritional formulas designed to improve energy, focus, endurance, and sports performance. It can be mixed with… Read More

2 weeks ago

Reviews Of Rainbow Light Vitamins

Here we will discuss some of the reviews of rainbow light vitamins. So if you are searching for this company… Read More

2 weeks ago