Rifampicin is a semisynthetic derivative of rafmycin B obtained from streptomyces mediterranei.Rifampicin is clinically used in the treatment of following Condition:
Rifampicin is a bactericidal drug and inhibits the synthesis of RNA in the bacterium by inhibition of the enzyme referred to as DNA dependent RNA polymerase.It inhibits DNA dependent RNA synthesis.Probably the basis of selective toxicity is that mammalian RNA polymerase doesn’t avidly bind rafampicin.Resistance to Rifampicin could occur due to mutation in the gene of RNA polymerase of the mycobacteria.This will stop the binding of rifampicin with the RNA polymerase of bacterium.
There are very limited knowledge regarding fetal risks following exposure to Rifampicin throughout pregnancy. No exaggerated risks of miscarriage, congenital malformation, preterm delivery or low birth weight are attributed to Rifampicin exposure, though the underlying maternal infections requiring Rifampicin treatment have known independent risks throughout pregnancy.Manufacturer advise very high doses teratogenic in animal studies in first trimester and risk of infant bleeding is also increased in third trimester.While quantity of Rifampicin in breast milk is simply too little to be harmful.
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