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9 Best Stretch Mark Prevention Creams During Pregnancy [Pharmacist Recommended]

Are you looking for the best stretch mark prevention cream during pregnancy? Read this review to find out more. American Academy of Dermatology defines stretch marks, also known as striae distensae or striae gravidarum—are the indented bands or colored lines on your skin [1]. It is more common in pregnancy because of the too much stretching of the skin in the last trimester. They can also appear in case of too much weight gain and loss. Stretch marks on your tummy are the most common things that occur when you get pregnant. As your tummy begins to stretch, preparing the growing baby, your skin begins to stretch to accommodate your growing baby. These Stretch marks are caused by small tears in the tissue under your skin as it’s pushed to its limit during pregnancy. Pregnancy is often rough on the skin, but a high-quality stretch mark cream can help ease some of these painful consequences. Consider ingredients and your specific needs when shopping for one that will work with you during pregnancy and after delivery! The good news? There’s more than one kind available; keep in mind what they are designed to do differently, such as preventing new ones from forming or reducing existing scarring left behind by them (or both). Furthermore, when shopping around during your next product, consider what ingredients will best suit you and how these products work together while keeping cost considerations at heart, so don’t forget about them. It’s important to know all of your options before choosing a product, but it can be difficult when there are too many. Luckily for you, we have compiled the best stretch mark cream for pregnancy on this page, so that will make things easier! Our Top Picks Best Overall: Skinception™—The best stretch mark removal cream This product is specially designed to visibly reduce the appearance of stretch marks from pregnancy, weight gain, growth spurts, surgery, or other causes. Best Massage Cream: Palmer’s Cocoa Butter Formula Massage Lotion for Stretch Marks  This lotion-type product is packed with cocoa butter and vitamin E to strengthen the skin and reduce the marks. You can read our full list below. How to Prevent These Stretch Marks? Please remember that these lines are common and normal (they can occur to anyone, especially pregnant women). The following are some home remedies and prevention techniques that will help while you’re expecting. The more you drink water and other juices, the more you will reduce the chances of stretch marks, So drink lots of water and stay hydrated. Moisturize your tummy. Do regular exercise (this one is the most recommended home remedy). Control your weight because you can also develop stretch lines if you are overweight. Include Protein, Vitamin C, D, E, and zinc in your diet. You can also try the best stretch mark removal cream, lotion, balm, butter, or oil. Studies suggest that pregnancy, early age and family history of stretch marks, weight gain before pregnancy and childbirth, and weight gain at birth were the main risk factors identified for stretch marks. Many different treatment options are available such as the use of retinoids, laser therapy, glycolic acid, and the use of stretch mark creams. In this article, we will only discuss stretch mark creams. So with a myriad of different skincare products on the market claiming to be best, we narrow down our list to the nine best stretch mark prevention creams during pregnancy. We rank products mostly based on research studies, adherence to quality, safety profile, verified customer feedback, and the time spent with the products. 09 Best Stretch Mark Prevention Creams During Pregnancy After hours of research, we have compiled a list of the best cream for pregnancy stretch marks. These creams are the best sellers, high quality, and made from clinically tested and well-researched ingredients. #1. Skinception™—The best stretch mark removal cream Skinception is the best cream for pregnancy stretch marks because it is loaded with a list of scientifically and clinically proven ingredients that combine to help remarkably vanish and even erase unsightly stretch marks from your belly, buttocks, breasts, and other parts of the body. Skinception is the best stretch mark prevention cream during pregnancy because of it’s ground-breaking list of ingredients, including Darutoside and Regestril—all of these can boost your natural production of collagen and elastin production. According to the manufacturer, the product will reduce the appearance of stretch marks by up to 72% after using it for two months. The best part is, they are offering a 67 days money-back guarantee and free shipping on selected packages. This type of guarantee makes it easy for customers to try it, and if it doesn’t work, return it and get your money back. You can get the best offers on the company’s official site before the stock runs out. Why do we recommend this? The cream is made from clinically proven ingredients. The product comes with 67 days money-back guarantee—return it if you are not satisfied and get back your money.  The more you buy, the more you will save. (Discounts on bulk purchases). #2. Palmer’s Cocoa Butter Formula Massage Lotion for Stretch Marks The formula tries to keep this better by hydrating it with a mixture of cocoa butter, sweet almond oil, and argan oil. It also includes collagen and elastin to maintain skin elasticity. Vitamin E is also added to this cream for beautiful texture and skin tone. The antioxidant is believed to stimulate cell growth and regeneration to reduce fine lines and imperfections. This is the best cream for old stretch marks and stretch marks during and after pregnancy or weight fluctuations. This concentrated cream formula is ideal for areas prone to stretch marks, such as the hips, thighs, tummy, and bust. The benefits of using coconut oil or other oils during workouts should be obvious: it helps reduce inflammation (which improves joint health). It promotes quicker muscle recovery after exertion because of increased blood flow locally. The product has got amazing customer feedback with an overall 4.7/5 star

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Natural Ways to Boost Testosterone

  Testosterone is a natural hormone produced by the testicle, and it affects a men appearance and sexual development. This hormone is responsible for building lean muscles and bone density. It also improves your sperm and sexual desire. Now that we are talking about the hormone, we can briefly highlight the phenomenon of testosterone. Testosterone hormones boost sexual drives. These hormones are substances that initiate or inhibit many processes in the body. A minimal amount of this hormone is already effective. Hormones are transported through the blood and broken down in the liver. They control, among other things, growth, metabolic behavior, and character. The hormone is produced in the gonads (sex glands) and adrenal glands. The same applies to testosterone for women, but this happens to a much lesser extent. Women depend on what they get from the adrenal glands. Testosterone causes pubic hair production in women during puberty. When the body produces too much testosterone, a woman may suffer from irregular or non-menstrual periods. Other effects are acne or more muscle mass. Testosterone is active in several areas of the body. First, it has various growth functions. There are various drugs to boost testosterone levels, such as andro 400 easily, It works rapidly to increase the testosterone level, and the andro 400 review gives positive results. There are more benefits of andro 400 for testosterone. You can get more ideas about the andro 400 T booster under the following. Increase your testosterone level by 42% in twelve days! There are a lot of good testosterone boosters on the market, some of which we highlight. These boosters speed up the process by which your body creates muscle mass. This is all made possible by testosterone! Which testosterone boosters can you use best? The trick is to find a booster that is incredibly effective but at the same time legal. We list several options: 1. Nugenix This supplement is a combination of different natural ingredients that can increase your testosterone hormone and improve your overall muscle building and bone density, according to the product’s manufacturer. Nugenix comes in two variants like Nugenix T and Nugenix T ultimate. The basic formula of these two is the same, but the ultimate formula has some added ingredients that work best for Muscle building and test boosting. 2. Andro 400 This booster is the best muscle-building product and a genius combination of the best natural ingredients ideal for serious athletes. You get a mega-dose of 1500 mg of pro-testosterone boosters and growth hormones that play an important role in muscle tissue production. The two added forms of Arginine increase the release of the growth hormone and have a protective effect on the immune system. 3. T-100 Hardcore This supplement is super effective and contains ingredients that increase testosterone levels in the body by 42% within twelve days. The ingredient Tribulus 90% saponins is a good supplement, resulting in muscle growth, endurance, muscle pump, and libido. The capsules of this perfect formula also contain Indole 3 carbinol: for maintaining a healthy hormonal balance. Also, the supplement contains a fatigue-fighting extract: Rhodiola. 4. BHAM Alpha Test No side effects with this 100% natural testosterone booster. It contains Tribulus Terrestris, Protodioscine, and natural testosterone. The first two enhance the effect and production of testosterone. Normally a supplement contains 1% of Protodioscine, but this supplement contains no less than 20%. And that means that the cells are optimally stimulated to increase testosterone levels. A super-powerful agent for the natural production of testosterone and muscle mass.

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10 Best Deep Tissue Massagers [Honest & Expert Opinion]

In this article, you will learn about the best deep tissue massagers available on the market. A deep tissue massage is a type of therapeutic massage that is more common in integrative and complementary medicine [1]. It is mainly used to treat sprains, plantar fasciitis, fibromyalgia, and sports injuries. They can also be used to promote faster healing by reducing inflammation. The use of deep tissue massager can have many advantages. It can relieve muscle pain and help to solve back problems. In this article, we present some Best deep tissue massagers. These models are the best in their price ranges and offer comfortable and entertaining massages. Check out these best deep tissue massagers. They can relieve muscle tension, reduce back pain, and even make your skin look better. 10 Best Deep Tissue Massagers #1. Purewave CM-05 Percussion Therapy Massager Pure Wave CM5 is one of the best deep tissue massagers on the market. The CM5 has a good design that allows you to reach every part of your back; that is why it is the best handheld back massager. The device’s grip is easy to grasp, and the massager is not too heavy to transport it comfortably. This model comes with a lithium battery that can last up to 3 hours, depending on the massage functions you use. An advantage of this model is that it is equipped with a powerful motor. The motor generates up to 3,700 pulses per minute, so if you want, you can enjoy a very intense massage. In general, it is one of the best deep tissue massager devices on the market. Positives Beautiful Design Lightweight It can generate up to 3700 pulses per minute. Lithium battery which can last up to 3 hours. Portable #2. Professional Deep Muscle Massager By KDRose The KDRose QUIETec Deep Tissue Massager machine is Designed to increase lymphatic flow and reduce lactic acid; you do not experience the intense pain and tension that, unfortunately, you will be used to. With four massage heads, you can easily change them and make sure to easily reach all the pain points of your body for instant relief. What really made the difference with this model is that it has 6 different speed settings. In fact, this is the first model offering 6 configurations. Therefore, if you are looking for versatility, it can not be better. Positives Adjustable Arm Can be used on sensitive parts of the body Four Heads 6 different speed settings #3. Wahl Deep Tissue Percussion Therapeutic Handheld Massager If you want to massage large areas of the body very efficiently and with different intensity, you can achieve a great deal by choosing the deep tissue massage device. Variable speeds are very impressive, with a range of 2000 pulses per minute to 4000. This way, you can choose the type of massage you want instead of sticking to a certain speed. The optional massager is not intended for travel. It does not work with batteries and must be connected to work. While the power cord is 8 feet long, it cannot be removed in any way. Since the dial cannot be used with batteries under any circumstances, it is not suitable for travel. This is also the best handheld back massager available on the market. Positives Can be used for a large part of the body Beautiful design Durable #4. TEC.BEAN Handheld Deep Percussion Massager Wit Heat This deep tissue massager is one of the best in its price range. This model features 6 interchangeable massage heads that allow you to perform a relaxing massage for any part of your body. A positive aspect of this portable massager is that it comes with 2 massage signs that can be used with massage oils and lotions. The use of oils and lotions can stimulate muscle relaxation and improve health. Overall, This is one of the best deep tissue massagers. Positives Uses heated massage function 6 interchangeable massage heads Variable speed Features Stylish and soft design Best handheld back massager #5 Deep Tissue Massager by TIMTAM It is probably one of the most well-known and best deep tissue massagers to date. The machine is powerful enough by aligning with its appearance: it can reach 2,000 rounds per minute. If you have tight knots in the muscles, this will defeat them in an instant. For this to work, squeeze the trigger. The good thing about this type of operation is that you do not have to use your own strength to pressure the place in question. TimTam will do all the work for you. Positives Most durable 90-degree articulating head aids Endorsed by world known athletes The only downside is its price, but this is the most durable model if you can afford it. #6. TheraRub Massager Percussion Double Head Electric Massager The TheraTub handheld massager for the back is specially designed to massage aching muscles and one of the best deep tissue massagers. This unit comes with three different sets of massage heads to offer a good massage experience. One of the advantages of using this model is that it comes with a very long power cord. The power cord is 14 feet long so that you won’t have a problem moving the massager from one side of your body to the other. Positives Interchangeable Heads Adjustable speed Long power wire #7.OHUHU Deep Tissue Massager The Ohuhu portable deep tissue massager is a beautiful device that has a good price. This model has a good design and comes with three pairs of massage head accessories to allow a full massage for aching muscles. The electric handheld massager for the back and other parts of the body is well designed and can easily adjust its position. Despite its relatively large dimensions, the grip of the device is comfortable. It is covered with a non-slip material, which allows you to maintain the device’s position for a long time. This portable massager is made of recyclable materials and, therefore, is respectful of the environment. This can be a significant benefit

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8 Best Gifts For Doctors (#3 is Our Top Pick)

We all cherish the idea of celebrating special occasions of our friends or loved ones with something extraordinary. At times, it gets so tricky to select a gift that is appealing and has considerable utility for recipients. If your friend is a health professional, a doctor, or a pharmacist, it often gets hard to come by something that suits their taste and need. Why not? These saviors are the ones who help us in our desperate times and deserve all the massive appreciation and gratitude. Luckily, we have piled up a list of the top 8 best gifts for doctors and pharmacists which they are absolutely going to love. 8 Best Gifts For Doctors Below, we’re sharing with you some really best gifts for doctors that every doctor will surely be happy to receive. Here they are, #1. Professional Lab Coat One of the striking aspects of any health professional outlook is white overall. It distinguishes doctors and pharmacists from all the other support staff and helps them carry out their duties with ease with minimal damage to their clothes. Any healthcare professional wouldn’t mind multiple sets of lab coats in his wardrobe. Dickies Lab Coats are favored by most doctors with their best quality and elegant designs. These cotton made coats are available in various style and sizes. You can always give it a personal touch by embroidering names or logos over. It is a must-have thing and one of the Best Gifts For Doctors. Positives Multiple Pockets to easily hold gadgets and other work accessories. Available in different size and shapes High cotton percentage Durability Back strip to adjust the size for customary use Tailored by skilled workers using the highest quality machinery #2. Fancy Pen It’s no secret that doctors and pharmacists use pens quite often to write down patients’ history and medications. Ask any doctor, and they will tell you they could use a pair of extra pens. And what if it’s as graceful as Ren Handcraft Pen set. The trio of pens is made with wood covering and packed inside a beautiful wooden case, which gives it a perfect presentation for a present. The color combination of golden and wooden brown is what makes it a lot more classy and aesthetic. While these pens can be used as one in the pocket, they also come with a desktop stand to place it over the table. It provides a variety of fountain and ballpoint pens which satisfy the likings of different individuals. Positives: Long-lasting use as refills is available. Fine and clear lines with 0.5 mm Already in aesthetic packaging Made up of eco-friendly material #3. Littmann Stethoscope Doctors diagnose patients for their pathologies, and they almost always use their trademark stethoscopes to go through the diagnostic process. It’s because of the very fact that doctors take pride in hanging these acoustic diagnostic tools around their neck. Hence, it won’t be a bad idea to surprise your Doctor’s friend with a high-quality stethoscope. Several brands are available in the market, but Littmann stethoscopes are time tested and the most reliable among them all. 3M Littmann classic III stethoscopes is a new design and high-performance stethoscopes with additional desirable features. It offers the best acoustic sensitivity any Doctor could ask for and could be used for both geriatric and pediatric patients equally. Simply put, this is one of the best gifts for doctors. Positives: Easy to use and clean High sensitivity Available in various colors and designs Stain resistible The tunable design makes it ideal for both old and young patients. Long lasting warranty #4. Coffee Mug Doctors and pharmacists’ profession demands to work around the clock, and at times, their duty gets relentless for hours with no real break. Lethargic bodies and tired minds need something to keep them active and going. What is better than a good cup of coffee to offer some relief in exhausting work hours. Thus, it makes a coffee mug so valuable for most doctors. This coffee mug is one of the Best Gifts For Doctors as it is easy to carry around in the hospital, which helps doctors move around during their duty. Positives: Can hold up to 30oz of coffee Available with cleaning brush to facilitate washing Hygienic stainless steel interior Portable Available with the lid to prevent spillage Insulation keeps the coffee hot for half a day. Provided with stainless steel multi-use straw #5. Leather Bag Like any other professional, humanity’s saviors need to carry their work accessories and other documents along with them almost always. AmeriLeather bags with their vintage and classic black look provide that spacious inner space that can easily hold everything that a doctor or a Pharmacist need. There are different compartments inside allows users to designate each one for different sorts of items. Also, it has room for electronic gadgets with its special zipped pocket. It’s made from cow leather and is available in black and brown color. Along with its usefulness, it brings style and grace to their personality. Positives. Compartmental and elegant design Best leather quality Pen, business card, and cellphone holder Can be used as hand carry or shoulder strap #6. Wireless headphones In the hospital’s chaotic workdays, doctors rarely have some time for themselves to relax and have a breather. Most doctors in their little in-between breaks like to hear soothing music or make calls to friends or family. It often seems difficult to make calls or enjoy music without headphones in the crowd of the hospital. Obviously, Presenting them with some quality headphones will bring more to their work life. They can listen to their favorite songs or answer calls on the go without holding their phones. LETSCOM Bluetooth headphones are silicone made which hold up so perfectly that it hardly displaces on its own. It can be used while working out in the gym or jogging in parks. They are available in various colors and designs with lightweight, which makes them suitable for extended use. This

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Ebola vaccine shows high efficacy rate in outbreak

An experimental vaccine against Ebola epidemics in the Democratic Republic of Congo (DRC) is delivering promising results, said a new World Health Organization (WHO) study on Friday. The vaccine showed an efficiency of 97.5%. In August last year, 93,965 people at risk were vaccinated. Only 71 of them developed Ebola. Of the 71 people, nearly 56 had symptoms within 10 days of receiving the vaccine. It takes about 10 days for the vaccine to develop immunity to the virus. The other 15 people contracted the virus ten days after vaccination. “No deaths were reported among vaccinees who developed Ebola with onset 10 or more days after vaccination. These early results confirm previous observations of high efficacy of (rVSV-ZEBOV-GP) Ebola vaccine against the disease,” the study said. Health officials are taking the ring vaccine strategy to vaccinate only the most frequently infected individuals to test the Ebola vaccine. The procedure was first adopted to prevent the spread of smallpox. “The ring vaccination strategy is a highly efficient delivery strategy for Ebola vaccines during outbreaks,” the WHO maintained. The frequent Ebola epidemics have created a major health problem worldwide. During the recent outbreak in the Democratic Republic of the Congo (DRC), approximately 1,206 confirmed and probable cases of Ebola infection have been reported. The virus killed dozens of people in the northern provinces of Kivu and Ituri. Fearing an Ebola outbreak, the European Union, Russia and China are developing vaccines against the Ebola virus. There are currently more than 15 vaccines in various stages of testing. According to the WHO statement issued last year, pharmaceutical companies have committed to increasing their production capacity once the vaccine has passed the required tests. “This could be the fastest vaccine in history.” Despite the growing number of Ebola cases in the Democratic Republic of the Congo, senior WHO officials refused on Friday to declare the epidemic a global health emergency. “It was the view of the Committee the ongoing Ebola outbreak in North Kivu, and Ituri provinces of the Democratic Republic of the Congo does not constitute a Public Health Emergency of International Concern (PHEIC),” said Robert Steffen, chair of the WHO committee convened in an emergency declaration.

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Breast cancer: Causes, Symptoms, Treatment

Breast cancer is a disease in which the breast cells grow out of control. There are different types of breast cancer. The type of breast cancer depends on the mammary cells that turn into cancer. After skin cancer, breast cancer is the most commonly diagnosed cancer among women in the United States. Breast cancer can occur in men and women, but is much more common in women. Breast Cancer Symptoms The signs and symptoms of breast cancer can be: A knot in the chest or a thickening that feels different than the surrounding tissue. Changes in the skin on the chest, such as. B. dimples Change the size, shape or appearance of a breast. The pigmented skin surrounding the nipple (areola) or breast skin Redness or tingling of the breasts, like the skin of an orange Causes The exact cause of breast cancer is not fully understood but we know that the risk of breast cancer increases with age. After puberty, a woman’s breast consists of fat, connective tissue and thousands of lobes, tiny glands that produce milk for lactation. Tiny tubes or tubes transport milk to the nipple. In cancer, the body cells multiply uncontrollably. It is an excessive cell growth that causes cancer. Breast cancer usually begins in the lining of the milk ducts or in the lobes that supply them with milk. From there it can spread to other parts of the body. Treatment Some treatments eliminate or destroy the disease in the breast and near tissues, such as lymph nodes. This includes: Surgery to remove the entire breast, called mastectomy, or just to remove the tumor and surrounding tissue, lumpectomy or surgery to maintain the breast. There are several types of mastectomies and lumpectomies. Radiotherapy that uses high energy waves to kill cancer cells. Hormone therapy uses drugs to prevent hormones, especially estrogen, from stimulating the growth of breast cancer cells. Drugs include tamoxifen, in pre- and post-menopausal women and aromatase inhibitors, including anastrozole (Arimidex), exemestane (Aromasin) and letrozole (Femara) in postmenopausal women. Side effects can include hot flashes and vaginal dryness. Some types of therapy work by preventing the ovaries from producing hormones, either through surgery or medication. Fulvestrant (Faslodex) is an injection that prevents the binding of estrogen to cancer cells. Chemotherapy uses drugs to kill cancer cells. Because these powerful medicines fight the disease, they can also cause side effects such as nausea, hair loss, early menopause, hot flashes and tiredness. Targeted therapies such as lapatinib (Tykerb), pertuzumab (Perjeta) and trastuzumab (Herceptin). These drugs stimulate the body’s immune system to destroy cancer. They target breast cancer cells that contain a high proportion of HER2. Palbociclib (Ibrance) and ribociclib (Kisqali) block a substance that promotes cancer growth. Palbociclib and ribociclib are indicated with an aromatase inhibitors for postmenopausal women with certain advanced cancers. Abemaciclib and palbociclib are sometimes used in combination with a hormonal treatment with fulvestrant (Faslodex).

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Leflox Tablet Uses, Side Effects, Dosage, & FAQs

Leflox is the brand name for Levofloxacin which belongs to a group of drugs known as Fluoroquinolones antibiotics. It is a broad spectrum antibiotic and is used in different bacterial infections such as sinuses, skin, lungs, ears, airways, bones, and joints infections. It is most commonly used antibiotic in urinary tract infections and other infections. This article will explore the Leflox tablet uses, side effects, dosage, and frequently asked questions. Quick Overview Product Name: Leflox Manufacturer: Getz Pharma Available Forms: Tablet, Infusion Uses: Respiratory tract infections, sinus infections and urinary tract infections etc. Strengths: Leflox 500mg tablet, Leflox 250mg tablet, Leflox 750mg infusion, Leflox 500mg infusion. Leflox Tablet Uses  Leflox tablets are prescribed for treating various bacterial infections in different body parts. It is effective against a wide range of bacteria and is often utilized for the following conditions: Respiratory Infections: Leflox is commonly used to treat respiratory tract infections, such as bronchitis and pneumonia. It helps in combating bacterial growth responsible for these infections. Urinary Tract Infections: The medication effectively treats urinary tract infections (UTIs) caused by susceptible bacteria. Skin and Soft Tissue Infections: Leflox can be prescribed to treat skin infections, including cellulitis and abscesses. Sinus Infections: It manages bacterial sinus infections that lead to sinusitis. Gastrointestinal Infections: Leflox may be recommended for certain gastrointestinal tract bacterial infections. Prostate Infections: In some cases, it is utilized to treat bacterial infections of the prostate gland. Dosage and Administration Leflox tablets are available in different strengths, with 500mg being a common dosage. The dosage and duration of treatment will depend on the specific infection and the severity of the condition. It’s important to follow the prescribed dosage instructions provided by your healthcare provider. The tablets are typically taken orally with a glass of water, with or without food. It’s essential to complete the full course of treatment even if you start feeling better before the prescribed duration is over. Skipping doses or stopping the medication prematurely may lead to incomplete eradication of bacteria, potentially causing the infection to return or become resistant to the antibiotic. Side Effects of Leflox Tablet  While Leflox can effectively treat bacterial infections, like any medication, it can also be associated with certain side effects. Common side effects may include: Nausea and Vomiting: Some individuals may experience stomach discomfort, nausea, and vomiting. Diarrhea: Leflox can disrupt the normal gut flora, leading to diarrhea in some cases. Headache: Headaches are a possible side effect, although generally mild. Dizziness: Some individuals may feel dizzy or lightheaded while taking Leflox. Photosensitivity: It’s important to note that fluoroquinolone antibiotics like Leflox can increase sensitivity to sunlight, potentially leading to sunburn more easily. Tendon Rupture: Although rare, fluoroquinolones have been associated with an increased risk of tendon rupture, particularly in the Achilles tendon. If you experience any severe or persistent side effects, it’s crucial to contact your healthcare provider immediately. Precautions Before taking levofloxacin, tell your doctor or pharmacist if you are Allergic to it; or other quinolone antibiotics (such as ciprofloxacin, moxifloxacin, ofloxacin); or if you have other allergies. Tell your doctor or pharmacist your medical history, especially: diabetes, joint / tendon problems (eg tendinitis, bursitis), kidney problems, mental disorders (eg depression), certain muscle disorders (myasthenia) severe), nervous problems (eg, peripheral neuropathy), epileptic disorder. Levofloxacin may cause a disease that affects the heart rhythm (prolongation of the QT interval). QT prolongation rarely results in fast / severe (rarely fatal) rapid heartbeats and other symptoms (such as severe dizziness or fainting) that require immediate medical attention. Levofloxacin Mechanism Levofloxacin, a fluoroquinolone antibiotic, operates by zeroing in on a vital bacterial enzyme called topoisomerase or DNA gyrase. These enzymes are central to bacterial DNA processes, including replication and repair. Levofloxacin disrupts their function, leading to twisted or broken bacterial DNA strands, halting their growth and multiplication. This precision targeting is a key feature, as levofloxacin’s mechanism focuses solely on bacterial cells, sparing human cells from harm. By thwarting bacterial DNA integrity, levofloxacin curtails the infection’s progression and provides an effective strategy against various bacterial infections, while its selectivity ensures minimal impact on the host. Drug Interactions with Levofloxacin (Leflox) Levofloxacin, commonly known as Leflox, is a potent antibiotic to treat bacterial infections. However, it’s important to know potential interactions with other medications that could affect their effectiveness and safety. Here’s a summary of key drug interactions to consider: NSAIDs: Combining levofloxacin with non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of seizures and tendon issues. Anticoagulants: Levofloxacin can enhance the effects of anticoagulants, leading to an increased risk of bleeding. Corticosteroids: Co-administering corticosteroids with levofloxacin may elevate the risk of tendonitis and tendon rupture. Antiarrhythmics: Levofloxacin can lead to potentially dangerous heart rhythm disturbances when combined with certain antiarrhythmic medications. Antidiabetic Medications: Levofloxacin might affect blood sugar levels and the efficacy of antidiabetic medications like Insulin, requiring careful monitoring. Iron, Zinc, Antacids, and Sucralfate can reduce levofloxacin’s absorption, so it’s advisable to separate their administration by a few hours. Theophylline and Caffeine: Levofloxacin can increase levels of theophylline and caffeine, leading to side effects like rapid heart rate and restlessness. Leflox Tablet Alternatives: Exploring Similar Medications While Leflox (levofloxacin) is a commonly prescribed antibiotic with a wide spectrum of bacterial coverage, several alternative medications offer similar therapeutic effects. Healthcare providers may consider these alternatives based on the patient’s medical history, specific infection, and individual response to treatment. Here are a few notable options for Leflox: Levoxin (Levofloxacin) by Searle Pharma PVT Ltd: Levoxin is a pharmaceutical product by Searle Pharma PVT Ltd that contains levofloxacin as its active ingredient, similar to Leflox. Like Leflox, Levoxin is a fluoroquinolone antibiotic used to treat various bacterial infections. It is available in multiple strengths and formulations, and its usage, dosage, and potential side effects are comparable to Leflox’s. Levo (Levofloxacin) by Ferozsons:  Levo, manufactured by Ferozsons Laboratories, also contains levofloxacin and is utilized to combat bacterial infections. Like Leflox, Levo is effective against various bacterial strains causing infections in different body parts. It is essential to note that

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Nuberol Forte Tablet 650mg/50mg: Uses, Side Effects, Dosage And FAQs

Nuberol Forte is the combination of Orphenadrine and Paracetamol. These two drugs’ combined effect provides relief from the pain associated with skeletal muscle and helps reduce fever. Searle Co Ltd manufactures it. Nuberol comes in 2 strengths; one is Nuberol standard that contains 450mg of Paracetamol and 35mg of Orphenadrine. While the Nuberol Forte contains 650mg of Paracetamol and 50mg of Orphenadrine. Orphenadrine is an anticholinergic and belongs to a class of ethanolamine antihistamines; It is closely related to diphenhydramine. Orphenadrine is commonly used to treat muscle pain and help motor control Parkinson’s disease but has mainly been replaced by new drugs.  While Paracetamol belongs to a class of drugs known as Analgesics, it is a common painkiller used to treat aches and pain. It can also be used to reduce fever. Composition Orphenadrine 50 mg Paracetamol 650 mg. Nuberol Forte Tablet Uses Nuberol Forte is used to treat, prevent or control the following conditions; Best for Muscle spasms, Pain and Fever, Sprains, Relief of painful skeletal muscle spasm, Chronic low back pain, The prolapsed intervertebral disc, Non-articular rheumatism, Tension headache, Muscle injury, Dysmenorrhea, Headache, Toothache, and Ear Pain, Cold and Flu. Note: This drug may also be used for other conditions. Contraindications Nuberol Forte is contraindicated in the following conditions Don’t use it If you are hypersensitive to Paracetamol or Orphenadrine Citrate. If you have Myasthenia gravis, Also, if you are suffering from glaucoma (High pressure in the eye), Don’t use in case of urinary retention, If you are a Lactating woman. Don’t take this medicine After expiry, if the packaging shows signs of tampering. In a child under the age of 12 years. Before you start to take Nuberol Forte, Tell your doctor or pharmacist if; If you are allergic to any other medicines, foods, preservatives, or dyes; Are cardiac patient (Heart Problem) you have any liver or kidney problems; you are taking other Paracetamol-containing products. You have alcohol abuse problems. How does Nuberol Forte work? In Nuberol Forte, Paracetamol’s combined analgesic effect and the relaxing muscle action of orphenadrine citrate provide profound relief of the pain associated with skeletal muscle spasm. Paracetamol has similar analgesic and antipyretic effects as salicylates. Analgesia is mediated at the peripheral and central levels. Orphenadrine citrate is an effective oral muscle relaxant. Muscle relaxation is not based on a direct effect on the muscle itself. The place of action of Orphenadrincitrat is relatively central. Nuberol Forte Interactions Following drugs can interact with Nuberol forte and may aggravate its side effects. Alcohol Ketoconazole Leflunomide Teriflunomide Prilocaine You should avoid these drugs simultaneously and consult your doctor before taking any medicine. Nuberol Forte Dosage The usual recommended dose of Nuberol forte for adults is 1-2 tablets twice daily. You will need to take it orally after food and with a glass of water. Don’t use on empty stomach to avoid stomach upset. This is the usual recommended dose but the actual dose depends on your condition and your pharmacist or doctor will adjust the dose as per your condition. Don’t use more than prescribed, it will do more harm than any good. It is not recommended for use in children. Nuberol Forte Alternatives Various options are available when seeking alternatives to Nuberol Forte tablets, each offering its unique composition and benefits. Here are a few notable options from different pharmaceutical companies: Ridal Forte by Stanley Pharma: Ridal Forte, formulated by Stanley Pharma, is a viable alternative to Nuberol Forte tablets. This medication encompasses a distinctive blend of active ingredients that work synergistically to relieve pain, reduce fever, and alleviate discomfort. Ridal Forte is commonly prescribed for conditions such as headaches, muscle aches, and menstrual cramps, making it a compelling choice for individuals exploring alternatives. Wilgesic by Wilson’s Pharma: Wilgesic, produced by Wilson’s Pharma, is another noteworthy alternative. Engineered to address various types of pain, Wilgesic boasts a carefully crafted formulation that targets pain relief effectively. Its unique ingredients and mode of action make it a suitable option for those seeking an alternative to Nuberol Forte. Provas N by Sami Pharma: Provas N, developed by Sami Pharma, offers a distinct pain management and relief approach. With its specialized formulation, Provas N targets pain at its source and relieves discomfort. This alternative may be particularly beneficial for individuals who require pain relief while considering options for Nuberol Forte tablets. Medigesic by Wilshire Laboratory: Medigesic, a product of Wilshire Laboratory, provides an alternative solution for pain management. This medication is designed to address a range of pain types and offers relief through its carefully chosen combination of active ingredients. Medigesic’s formulation makes it an intriguing option for those exploring alternatives to Nuberol Forte. Sinaxamol by AGP Pharmaceuticals, Pakistan: Sinaxamol, developed by AGP Pharmaceuticals in Pakistan, is another viable alternative to Nuberol Forte tablets. With its unique composition, Sinaxamol aims to provide effective pain relief and manage discomfort. Individuals seeking an alternative option for pain management may find Sinaxamol a suitable choice. Selecting the Right Alternative: The decision to switch to an alternative to Nuberol Forte tablets should be made in consultation with a healthcare professional. Factors such as medical history, existing conditions, and potential interactions with other medications are crucial in determining the most suitable option. Patients are advised to thoroughly discuss with their doctor to make an informed choice that aligns with their specific needs and circumstances. Frequently asked questions (FAQs) 1. Is Nuberol Tablet safe to use when pregnant? It is not recommended for use during pregnancy. Tell your doctor if you are pregnant or intend to become pregnant. 2. Is Nuberol Tablet safe while breastfeeding? It is not recommended for use during lactation. Tell your doctor if you are breastfeeding. 3. Should I use Nuberol Tablet empty stomach, before food or after food? Take this medicine after food with a glass of water. Take Nuberol forte tablets only as directed by your doctor or pharmacist. Do not change the dose unless your doctor tells you to do so. 4. Is Nuberol Forte a Pain Killer? Nuberol contains Paracetamol and Orphenadrine. Both of these

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This Male Birth Control Pill Passes Human safety Test

A Male Birth Control pill for men has passed the first tests of human safety, experts at a leading medical conference have heard. The Male Birth Control Pill once a day contains hormones designed to stop sperm production. It would be a welcome addition to condoms or vasectomy, the only options currently available to men. But the doctors attending the annual meeting of the Society of Endocrinology were informed that it would take another decade to bring them to the market. Study The results of the Phase 1 study were presented on March 24 at the annual meeting of the Endocrine Society in New Orleans. Stephanie Page, a professor of medicine at the University of Washington School of Medicine, co-directed the study with Christina Wang, professor of medicine at UCLA in Los Angeles. The results of the study indicate that the male experimental oral contraceptive reduces sperm production while preserving libido. The pill is called dodecylcarbonate of 11-beta-methyl-19-nortestosterone or 11-beta-MNTDC. It is a modified testosterone that combines the action of a male hormone (androgen) and a progesterone. The study involved 40 healthy men at two sites: the UW Medical Center in Seattle and the Biomedical Research Institute in Los Angeles, Torrance, California. Ten study participants randomly received one placebo capsule and another 30 received 11-beta-MNTDC in one of two doses. ; 14 men received 200 mg and 16 received the 400 mg dose. The subjects took the drug or placebo once a day for 28 days. The researchers reported that the levels of two hormones needed for sperm production had significantly decreased in the cohort studied compared with those who took the placebo. And among those who took the androgen-based drug, hormone levels needed for sperm production dropped significantly compared to placebo, returning to normal after the trial. In fertile men, new sperm are constantly produced in the testes, activated by hormones. The problem is the temporary blockage of this effect without decreasing hormone levels to the point of creating side effects. But the latest male pill, which is currently being tested by researchers at LA BioMed and the University of Washington, should achieve this goal, say the researchers. Side effects In contrast, the adverse effects of these male birth control pill were few and light. Erectile dysfunction Five men who took the pill reported a slight decrease in sexual desire. Two of them described mild erectile dysfunction, but the sexual activity did not decrease, no participant stopped taking it due to side effects and all passed the safety tests. The researcher behind the work, Professor Christina Wang and her colleagues, are enthusiastic but cautious about libido as a side effect. Other scientists have tried to administer long-acting contraceptive hormones in a vaccine administered every two months. But they stopped recruiting men for their Phase 2 study, examining the safety and effectiveness of the injection, after some volunteers reported side effects, including mood disorders or depression. For men who do not feel like taking hormones, the researchers looked for ways to block the flow of semen, preventing it from leaving the penis, effectively, a non-surgical vasectomy. Vasalgel, a polymeric material that is injected into the two channels that carry sperm from the left and right testes to the penis, is being developed as a reversible, long-lasting, non-hormonal male contraceptive. So far, it has only been tested on animals, but the researchers behind this project have recently received funds to start human trials.

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An evidence based approach to treat “Dyslipidemia”

Identification and treatment of dyslipidemia is necessary to reduce the rate of atherosclerosis and the subsequent cardiovascular events, including coronary artery disease (CAD), which may be pharmacologic or non pharmacologic. Patients with abnormal lipid profiles (dyslipidemia) shall be identified and treated on the basis of patients’ risk profiles. Important points regarding the diagnosis of dyslipidemia: From the age of 20 everyone shall be screened for dyslipidemia every 5 years including those who have a normal lipid profile. But those who are obese and having other risk factors including positive family history for dyslipidemia and those with CAD, should perform annual screening. Fasting serum lipid profile is normally preferred. Subject shall be screened for the metabolic causes of dyslipidemia, including diabetes mellitus (DM), liver diseases, hypothyroidism, and nephrotic syndrome. Patient medication history shall also be assessed, because medications containing progestins, corticosteroids, or anabolic steroids can lead to dyslipidemia. Risk Assessment? Patients with established coronary heart disease  (CHD) and those with a risk of developing CHD must be considered for lipid-lowering therapy CHD or equivalent patients (>20%) with a 10 – year risk of CHD, having DM or Peripheral Vascular Disease or abdominal aortic aneurysm, or CAD.  CHD risk factors Family history of developing CAD (age <55 for men, <65 for women), or low serum high density lipoprotein  HDL (age <45 for men, <55 for women), or hypertension, or smoking, or age( >45 for men, <55 for women). Initiation of therapy and the ideal goal for LDL and non-HDL levels: The ideal LDL goal for CAD or equivalent patients, shall be <100 (or <70) and the non-HDL goal shall be <130 while initiation of the therapy shall be regardless of LDL level in the body. Patients having 0-1 risk factors for developing CHD will have an ideal goal for LDL as ( <160), and non-HDL as (<190) while for initiation of the therapy the LDL level must be >190. Patients having 2+ risk factors for developing CHD will have an ideal goal for LDL as ( <130), and non-HDL as (<160) while for initiation of the therapy the patient must have a 10-year risk and 10-20% LDL as >130 or a 10year risk and <10%LDL as >160 Life style changes required for therapy: life style modifications, as described below, are advised to be followed, for at least 6 weeks, before initiating pharmacotheraphy. <7% of Calories shall be obtained from saturated fat on a daily maintenance basis Out of the total calories not more than 25-35% must be obtained from total fat Intake of monounsaturated fats and polyunsaturated fats must be increased. monounsaturated fats up to 10 % of the total caloric intake polyunsaturated fats up to 20 % of the total caloric intake total daily cholesterol shall not be consumed more than 200mg exercise and weight loss may be beneficial up to some extent health diet containing plant sterols, Omega-3 fatty acids, and a viscous fiber shall be consumed Pharmacotherapy: HMG-CoA reductase inhibitors (statins): can lower LDL by 18-55% and Triglycerides by 7-30% can increase HDL by 15% check baseline LFTs  three months after initiating therapy , discontinue therapy if LFTs>3 times the upper limit of normal keep in view the ADRs and efficacy of every agent BileAcid Sequestrants: decrease LDL by 15-30% increase HDL by 3-5% lower or no effect on TGs GI upset and decrease absorption of other medications are ADRs Nicotinic Acid: decrease LDL by 5-25% increase HDL by 15-35% decrease TGs by 20-50% contraindicated in gout, CLD, or diabetes relatively Fibrates: decrease LDL by 5-20% increase HDL by 10-35% decrease TGs by 20-50% dyspepsia, myopathy etc are the ADRs Ezatimibe: decrease LDL by 18-20% increase HDL by 1-5% decrease TGs by 5-11% contraindicated in liver diseases Omega-3 fatty acids: reduce hepatic production of TGs modestly reduce LDL and increase HDL associated with increased risk of bleeding and decrease in glucose control Approach to treatment: Therapy depends on the LDL goal as shown in the figure below once LDL goal is achieved then HDL and TGs levels can be considered. statins are the first line drugs, treatment shall be started with a low dose (10-20mg) to assess lipid-lowering effect and tolerability, then shall be titrated gradually. a second agent may be added if lipid goal is not achieved even with a maximum dose Complimentary and Alternative Therapies: Plant sterols/stenols reduce LDL but not TGs, HDL. Soluble fibers has modest lowering effect on Total Cholesterol (TC), LDL. Soy protein has modest effect on lowering of TC, LDL, TGs. Guggul has also been shown to reduce TC, LDL, TGs. Note: all of the above supplements can cause GI upsets Red yeast rice, both in capsules and extract form, reduce TC and LDL with no known significant adverse effects Clinical Pearls: LDL shall be treated first before considering secondary goals. Patients with CHD can take more benefit from statins Patients with acute MI shall early start statins regardless of the LDL levels Different statins shall be started before switching to or adding other agents Patient profile of creatinine phosphokinase shall only be obtained when muscles pain is experienced Pre-medication with aspirin and gradual titration of the dose is advised to improve the effects of Niacin  If TG>1000 hospitalize the patient and start fibrate urgently References: A Practical Approach to Cardiovascular Medicine, First Edition. Edited by Reza Ardehali, Marco Perez, Paul Wang. @2011Blafkwell Publishing Ltd. Published 2011by Blackwell Publishing Ltd.

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