Manzoor (Pharm D)

A Professional Pharmacist, a passionate blogger, and fountainhead of DrugsBank. You can learn more about Manzoor here

Livogen: Uses, Side Effects, Dose & FAQs

Livogen is the brand name of two active ingredients along with some non active ingredients. The active ingredients present in this formulation are Ferrous Fumarate and Folic Acid. Livogen Tablet is mainly used for the treatment of anemia and deficiency of folic acid. It is also used as a supplemental medication for diseases which cause a deficiency of iron and folic acid in the body. It is also used in other conditions. See below Uses. Composition The active present in this formulation are Elemental Iron (Ferrous Fumarate) – 152 mg Folic Acid (Vitamin B9) – 1.5 mg Other Variants Livogen -Z Captab Livogen Hemtonic Syrup Livogen-XT Tablet Livogen Injection Livogen Tablet Uses: This medicine is used in different conditions and symptoms: Anemia During pregnancy Megaloblastic anemias due to a deficiency of folic acid Anemias of nutritional origin, Folate deficiency Anemia in Pregnancy Anemia due to folic acid deficiency Malabsorption of food Celiac disease Mechanism Of Action It works by acting on the bone marrow to produce a normoblastic marrow and promotes the production of blood cells in the body. Other conditions for which livogeni are prescribed as an additional drug include low levels of red blood cells or hemoglobin, infantile anemia and megaloblastic anemia.  It Helps to supply sufficient Elemental Iron or Ferrous Fumarate, which helps in regulating the oxygen supply through RBC to various parts of the body. The Livogen tablet should only be taken with a doctor’s prescription. Your doctor may prescribe different options depending on your health, age and needs. Livogen Side Effects Following  are some of the common side effects associated with the use of Livogen tablet are Biliousness Nausea Constipation Flatulence Allergic reactions Dark or green stools Irritability Bloating Stomach cramps Darker coloured stool Gastric irritation Pain in leg Dark coloured urine Less common side effects include Depression Confusion Easily angered and annoyed Gas Itching Loss of appetite Swelling of the abdomen Not feeling well Over-excitement Rashes Taste problems Sleep disorder Precautions Avoid Livogen tablet and tell your doctor or pharmacist: If you are allergic to any of the ingredients. People with anemia due to vitamin B12 deficiency (pernicious anemia). Hereditary disease that causes too much iron accumulation in the tissue (hemochromatosis). People with anemia due to folic acid deficiency. People with a disorder that affects the iron in the body (hemosiderosis). People with a state of sudden loss of hemoglobin (oxygen that transports proteins in the blood) in the urine during the night (paroxysmal nocturnal hemoglobinuria). People with other diseases that affect hemoglobin, such as sickle cell disease or thalassemia. People with an active gastric ulcer People receive repeated blood transfusions. Inflammatory bowel disease such as ulcerative colitis or Crohn’s disease. Children. Avoid alcohol consumption, especially if having alcoholic cirrhosis Bowel problems Colitis Diverticulitis Crohn disease Type 2 Diabetes Ulcer in intestine Child younger than 4 months old Livogen In Pregnancy & Breastfeeding This medicine is safe during pregnancy. However, you should ask your doctor or midwife if you need to take iron and folic acid supplements during pregnancy. All pregnant women should not take supplements; Your diet may contain enough nutrients. No known harmful effects when this medication is used by nursing mothers. Interaction With other drugs The following medicine can interact with Livogen and may change the effect of this drug Levothyroxine Bisphosphonates, e.g. alendronate Entacapone Levodopa Penicillamine Methyldopa (iron tablets can also reduce the effect of lowering methyldopa blood pressure) ciprofloxacin, norfloxacin, ofloxacin, levofloxacin Zinc and calcium supplements reduce the absorption of iron supplements. Separate the drugs for at least two hours. Oxytetracycline, doxycycline, minocycline, tetracycline Trientene, used to treat Wilson’s disease, also reduces the absorption of iron supplements from the intestine, making them less effective unless the doses are separated by at least two hours. Magnesium carbonate, magnesium hydroxide, aluminum hydroxide and calcium carbonate, can reduce the absorption of iron by the intestine and make the less effective supplements. Separate the drugs for at least two hours. Folic acid can reduce the blood levels of the anti-epileptic drugs phenobarbital, phenytoin and primidone. If you take folic acid in combination with any of these anti-epileptic drugs, your doctor may need to increase the dose of this antiepileptic to keep the seizures under control. Milk, milk-based products, tea, coffee and eggs can reduce the absorption of iron from the intestine, while vitamin C (ascorbic acid) increases it. Dosage The dose of this drug depend on your medical condition. Your doctor will decide the amount of dose. However it is recommended to be taken empty stomach, at least one hour before or two hours after a meal. Along with the dosage recommended for this medicine.  it is very important to follow the diet plan recommended by the doctor or healthcare provider to facilitate better absorption of the medicine. Consume enough iron-rich foods in order to get maximum iron from natural food sources. Frequently Asked Questions 1. What is Livogen? Livogen is a multivitamin supplement composed of ferrous fumarate and and folic acid (Vitamin B9). It is used in different conditions. check it above in Uses Section. 2. What is the use of Livogen? Livogen is a supplemental product mainly used for anemia, pregnancy,  low RBC or hemoglobin count, lack of iron and vitamin B9 supply in diet, childhood anemia, Megaloblastic anemia. and other conditions. 3. What are the side effects of Livogen? The most common side effects associated with the use of this drug are nausea, constipation, allergic reactions, flatulence, Dark or green stools, and dark urine. There are other side effects check above “Side effects”. 4. Can I take Livogen on an empty stomach? Take with food if this medicine cause stomach upset. Ask your pharmacist before using. 5. What happens if i Overdose Livogen? Taking more than prescribed Livogen Tablet may cause harmful side effects. Consult your doctor if you suffer any kind of side effects. 6. What happens if i Miss a dose of Livogen? If missed certain regular dose, take as earliest possible, and if it is time for the next dosage,

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Pantocid (Pantoprazole): Uses, Side Effects, Dosage

Pantoprazole is in a class of medications known as proton-pump inhibitors (PPIs).It is marketed under the brand name Protonix, Pantocid and other. It is prescription drug used as a short-term treatment for gastroesophageal reflux disease (GERD), heart burn,  and acid reflux. Pantocid is manufactured by Sun Pharma Laboratories Ltd. Pantocid Uses It is used in the treatment and prevention of various medical conditions such Gastooesophageal Reflux disease. Gastric ulcers Gastrin secreting tumour Benign gastric ulcer Small intestine ulcer Gastric ulcerative Heart Burn Acid reflux. Zollinger-Ellison Syndrome H. Pylori infection. Your doctor may have prescribed it for another reason. Ask your GP if you have any questions about why Pantoprazole has been prescribed for you. Pantocid Side effects The more common side effects that can occur with pantoprazole (Pantocid)  include: Nausea or vomiting Diarrhea Stomach pain Headache Gas Joint pain Dizziness Serious side effects Serious side effects can include the following: Low magnesium levels. Using this drug for three months or longer can cause low magnesium levels. Vitamin B-12 deficiency from long term use. Severe diarrhea. Bone fractures Kidney damage. Cutaneous lupus erythematosus (CLE). Systemic lupus erythematosus (SLE). Fundic gland polyps (don’t usually cause symptoms) Other reported side effects include: Pancreatitis Liver damage Reduced levels of blood cells Muscle breakdown. Interaction with Medicine Severe interactions occur with Methotrexate Nelfinavir While moderate interaction with Warfarin Digoxin Reduce blood levels of atazanavir or nelfinavir, reducing their effect. Precautions Do not take it if you are allergic to any medicines containing pantoprazole or any of the ingredients in this formulation. Do not use it in combination with antibiotics or other medicines if you are allergic to any of the antibiotics. Do not use it if you have severe liver disease or cirrhosis. Do not use it in combination with atazanavir. It should not be given to children. Do not take this medicine after the expiry date stated on the carton (EXP), or if the packaging is torn or showing signs of tampering. Don’t take If you are pregnant or planning to become pregnant, talk to your doctor. Tell your doctor if you want to breastfeed or breastfeed. Tell your doctor if you have or have had other illnesses. Mechanism Pantoprazole, like other proton pump inhibitors, blocks the enzyme that produces acid in the stomach. Blocking the enzyme reduces acid production, healing the stomach and esophagus. Dose of Pantocid It is common to take pantoprazole 40 mg once a day, in the morning. If you are taking pantoprazole twice a day, take 1 dose in the morning and 1 dose in the evening. Usual adult recommended dose for GERD and healing erosive esophagitis is 40 mg daily for 4-8 weeks. The usual recommended dose for treating Zollinger-Ellison syndrome is 40 mg twice daily. It is generally recommended to take the tablets about 30 minutes before meals for maximum effectiveness. The tablets should be swallowed whole and not crushed, split or chewed. Frequently Asked Questions   1. What is Pantocid 40 mg used to treat? It is the brand name for Pantoprazole. It is used in the treatment and prevention of various medical conditions such as gastroesophageal reflux disease (GERD), heart burn,  and acid reflux. 2. What are the side effect of Pantocid? Common side effects may include: dizziness; stomach pain, headache, gas, nausea, joint pain; vomiting, diarrhea. For complete list of side effects check above uses. 3. What is the best time of day to take Pantocid? It generally is recommended that Pantocid tablets be taken approximately 30 minutes prior to meals for maximal effectiveness. 4. Can you take 2 Pantocid a day? It recommended to take pantoprazole once a day, in the morning. However your doctor will determine the right dose for you based on your medical condition. 5. How Pantocid Works? Pantocid contain pantoprazole which belongs to a group of drugs known as proton pump inhibitors. It blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal. 6. Can Pantocid be used as a painkiller? No it is a proton pump inhibitor and should not be used as a painkiller. 7. Can Pantocid Tablet used over a long period of time? No, This medicine cannot be taken over a long period of time unless prescribed by a doctor. Long term use can cause bone fractures and low magnesium levels. 8. Does Pantocid cause gas? Yes, some of the side effects of using Pantocid tablet include gas or flatulence, bloating, and abdominal distension. 9. Can Pantocid cause diarrhoea? Yes, the most common side effects associated with the use of this medicine is diarrhoea. consult your physician if these symptoms persist. 10. Does it have an expiry date? Like any other medication it has an expiry date. Always check the expiry date on the packet before purchasing it. 11. Is it Safe with alcohol? Interaction with alcohol is not known. It is recommended to consult your doctor before consumption. 12. Is Pantocid habit forming? No habit-forming tendencies were reported. 13. Is Pantocid safe to take if I’m pregnant ? It is not generally recommended during pregnancy. 14. Is it safe to take it while i am breastfeeding? Pantoprazole has not been studied in females who are nursing. 15. Can i take Pantocid for long term? Long-term use of pantoprazole may make it difficult for your body to absorb vitamin B-12, which could result in a B-12 deficiency. 16. What if i Missed a Dose of Pantocid? If you miss a dose of pantocid, take it as soon as you remember. You should skip the missed dose if it is almost time for your next scheduled dose. 17. What happens if i overdose Pantocid Tablet? Seek emergency medical treatment or contact your doctor in case of an overdose. But in case of suspicion of overdose, the doctor will start emergency treatment. 18. How long should Pantocid take? Your doctor will tell you how long the tablets should be taken. 19. How to store it?  Store the tablet at room temperature between 15 and 30 ° C and protected

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New Study Suggests A Cure for Brain Tumor

A study by the University of Michigan identifies why people with glioma, a type of tumor, tend to live much longer than others. The research was funded by the National Institutes of Health, which suggested that the combination of radiation therapy against cancer to block DNA repair could be an effective treatment. Some patients are less aggressive and can repair DNA better than others, but they are difficult to eliminate by radiation. The research article was published on February 13, 2019 in the journal Science Translation Magazine. Researchers have focused on low-grade gliomas. These gliomas are carriers of a disease that causes changes in a gene called isocitrate dehydrogenase 1 (IDH1). These changes are found in about 50% of cases with low levels of primary glioma. Findings According to the research, patients with glioma have changes in IDH1 are mostly of young age. In addition, they live longer than patients with normal genes. The experiment was performed by replicating the patient’s tumor by genetic programming of mice to increase cancer cells in the brain. These cells carry pathogenic mutations in IDH1 as well as mutations in TP53 (a tumor suppressor gene) and ATRX (a DNA-protein complex remodeling gene). In terms of patients, the results of the study showed that mice programmed to develop brain cells tend to live longer than control mice when the tumors were programmed for normal IDH1. The study also showed that the IDH1 mutation had made the glioma cells less aggressive. When implanted in the brain of mice, it was very likely that cell division increased tumor growth at lower rates. IDH1 mutations as well as mutations of the TP53 and ATRX genes lead to the resistance of the tumor to ionizing radiation. This treatment often damages the DNA by killing the cells. Subsequent studies have shown that IDH1 alters activity due to a pathogenic mutation. For this reason, several chemical reactions that alter the genes of the cancerous cells begin in a way that increases the production of a protein that can repair the damaged DNA. Dr. Maria G. Castro, professor of neurosurgery at Michigan Medicine and principal author of the study, said, “Our team’s mission is to find life-saving treatments for these patients. The results from this study could be a blueprint for extending, if not saving, the lives of many patients.” Dr. Jane Fountain, a presenter at the National Institute of Neurological Diseases and Stroke at NIH, said: “These findings have the potential to impact many younger glioma patients with low-grade tumors by either ‘curing’ them or extending their lives, the preclinical model Dr. Castro’s team developed will be extremely valuable to cancer researchers. It closely mirrors the human disease.” In this study, researchers formulated and experimented with a new combination therapy. They found that mice exposed to mutated IDH1 tumors with radiation and injected with cancer drugs to prevent DNA repair can prolong life. In contrast, mice showed no side effects when treated or radiated individually. Similar results were observed in human gliomas grown in a Petri dish.

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FDA Approved a Combo Drug (Lonsurf) for Gastric Cancer

The report on Lonsurf  was published on the official website of U.S Food and Drug Administration. Gastric adenocarcinoma is a type of stomach cancer and is considered the second most common cancer in the world. According to reports, the combined drug Lonsurf  can cure those patients who are suffering from gastric adenocarcinoma. Gastric cancer is the fifth most common cancer in the world and the third leading cause of cancer deaths (after lung and liver cancer) with about 723,000 deaths a year. In recent years, the result in gastric cancer has improved dramatically, and survival has increased dramatically over the last 10 years. With the advancement of cancer, but can limit many drug-usable complications and rule out intensive chemotherapy. The extension of survival and alleviate the symptoms of advanced treatment of metastatic gastric cancer are problems for which it is considered important to increase the possibilities of new therapeutic drugs. At present recommended for metastatic gastric cancer in Japan nivolumab and irinotecan as standard treatment of the third line. The new drug is a combination of trifluridine, Tipiracil, a nucleoside metabolic inhibitor, and a thymidine phosphorylase inhibitor. This dose will benefit the patients who have gastric cancer and can no longer be treated with other therapies. Lonsurf consists of a nucleoside analogue that is based on thymidine, and the trifluridine thyridine phosphorylase inhibitor Tipiracil. After taking in tumor cells trifluridine is incorporated into the DNA, interfering with DNA synthesis and inhibiting cell proliferation. In addition to the indication for metastatic gastric cancer Lonsurf is also indicated for the treatment of adult patients with metastatic colorectal cancer previously treated with fluoropyrimidine-based chemotherapy, oxaliplatin and irinotecan, an anti-cancer therapy. Biological VEGF, anti-EGFR treatment. The research was conducted on 507 patients with unresectable metastatic adenocarcinoma in the stomach. The research included two different groups, the trifluridine / tipiracyl group and the placebo group. David Cunningham, a consultant oncologist, says: “We have nothing else we can offer those patients, and this study shows that we can extend life expectancy and improve disease control rates up to a very significant level.” According to the researchers, this new treatment would meet the needs of patients. How Lonsurf  Work? Its dual mechanism of action is designed to maintain clinical activity and differs from conventional fluoropyrimidines. The trifluridine (FTD) is an antineoplastic nucleoside analog that is embedded directly into the DNA and therefore interferes with the function of DNA. The blood concentration of FTD is maintained by tipiracil (TPI), an inhibitor of the FTD thymidine phosphorylase degradation enzyme. Dosage The scientists recommended an oral dose of Lonsurf of about 35 mg / m2 / dose twice a day. The drug should be taken during the 28-day cycle from day 1 to day 5 and from day 8 to day 12. In Japan, Taiho Pharmaceutical has been marketing Lonsurf for the treatment of advanced or recurrent advanced colorectal cancer. In the United States, Taiho Oncology, Inc., a US subsidiary of Taiho Pharmaceutical, began the pharmacological treatment of patients with mCRC previously treated with fluoropyrimidine-based chemotherapy as of 2015. Oxaliplatin and irinotecan, an anti-VEGF biological therapy and in wild-type RAS an anti-EGFR therapy. In 2015, Taiho Pharmaceutical and Servier entered into an exclusive licensing agreement for the joint development and marketing of LONSURF in Europe and other countries compared to the United States, Canada, Mexico and Asia. TTY Biopharm, a commercial partner of Taiho Pharmaceutical, launched LONSURF in July 2018 in parts of Asia outside of Japan in Taiwan. Jeil Pharmaceutical is preparing to commercialize the drug in South Korea.

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Evion 400 (Vitamin E): Uses, Side Effects, Dosage

The active ingredient present in Evion 400 Capsule is Vitamin E. Vitamin E is a powerful lipid-soluble antioxidant that protects cell membranes from free radical damage and prevents the oxidation of LDL cholesterol. Vitamin E is an important nutrient for the vision, reproduction, and health of blood, brain, and skin. Vitamin E helps keep skin and eyes healthy and strengthens the body’s defenses against diseases and infections (the immune system). Vitamin E is naturally present in some foods, is added to others, and is available as a dietary supplement. “Vitamin E” is the collective name for a group of lipid-soluble compounds with pronounced antioxidant activity. Scientists are investigating whether vitamin E can help prevent or delay chronic free radical disease by limiting the production of free radicals and possibly other mechanisms. Evion 400 is manufactured and distributed by Merck Consumer Healthcare Ltd in India. Vitamin E deficiency Vitamin E deficiency is extremely rare in humans because it is unlikely to be caused by a diet low in vitamin E. Symptoms of a vitamin E deficiency include Chronic diarrhea An inability to secrete bile Greasy stools, and Premature low birth weight infants with a weight less than 1500 grams. Natural sources It is naturally found in Vegetable oils like sunflower, wheat germ, and safflower oils are among the best sources of vitamin E. Green vegetables like spinach & broccoli, provide some vitamin E. You can also get some vitamin E from nuts like peanuts, hazelnuts, and almonds. and it’s also found in seeds such as sunflower seeds. Evion 400 Uses Evion 400 Capsule can be used for the treatment and prevention of various medical conditions such as: Vitamin E deficiency, Nocturnal muscle cramps, Liver disease, Painful mensuration, Dyspraxia Parkinson’s disease and more, Tardive dyskinesia, Reduction of risk of coronary artery disease, Cystic fibrosis, Dementia Painful menstruation Kidney problems A genetic disorder like G6PD Nerve damage due to chemotherapy Blood disease Laser eye surgery Nitrate tolerance Bladder cancer Nonalcoholic steatohepatitis Granuloma annulare Prevent hair loss Improve scalp circulation Huntington’s disease Balance oil production Support a healthy scalp Add shine Mechanism Vitamin E in Evion 400 is a fat-soluble vitamin that reacts with free radicals that oxidatively damage the cell membrane without forming another free radical. Evion 400 slows down processes that damage cells. Evion 400 Side effects Common side-effects of Evion 400 are: Diarrhea Nausea Stomach ache Drowsiness Rashes Blurred vision Headache Weakness Some other serious but very rare side effects like allergic reactions, including: Itching Rashes Trouble breathing Swelling Severe dizziness Risk Warnings Read the label carefully before use. Keep out of the reach and sight of children Store in a cool dry place away from direct sunlight. Use under medical supervision. Used with caution and consult your doctor in case of the following diseases. Hypertension, Myopathy, Thrombophlebitis, Fatigue, Weakness, Nausea, Headache, Dizziness, Blurred vision, Flatulence, Diarrhea, Abdominal pain, Contact dermatitis. Precautions Before using Evion 400 Capsule, tell your doctor about Medications, over-the-counter products (vitamins, herbal supplements, etc.), Allergies, If you are pregnant, planning to get pregnant or breastfeeding If you have Diabetes If you Have a history of heart attack, stroke If you have a Bleeding disorder Liver disease Eye disorder Kidney disease Vitamin K deficiency If you are a Patients suffering from or with a history of head and neck cancer Patients allergic to its ingredients Interaction Evion 400 Interactions with different medicines Heparin Warfarin Aspirin Clopidogrel Ferrous fumarate Colesevelam Carbonyl iron Tipranavir This is not a complete list of drug interactions. Evion 400 Dosage The dose of the Evion 400 capsule depends on the advice of the expert doctor. You must not pick things up to change the dose of 400 Evion and stop taking it abruptly. The recommended daily allowance of vitamin E for teens and adult is 15mg per day. The usual recommended dose To improve male fertility, vitamin E 200-600 IU is needed regularly. The usual recommended dose To treat Huntington’s disease at the earliest stage, 3000 IU is needed. The usual recommended dose To get rid of menstrual problems, essentially 200 to 500 IU of Vit E are required. The dosage is usually one Evion 400 capsule per day or as prescribed by the doctor. This depends on the treatment and the degree of reaction of the patient. Dosage changes are not recommended as this may cause side effects. According to a study published at Harvard University that the dose of Vitamin E above 400 mg a day may be harmful. Frequently asked questions  1. Is Evion 400 safe with alcohol? The interactions with alcohol are unknown. It is advisable to consult your doctor before eating. 2. Is Evion 400 a habit-forming drug? No habit has been reported. 3. Is the use of Evion 400 safe during pregnancy? For pregnant women, the use of Evion 400 is only recommended if the need is clearly identified and if the potential benefits outweigh the risks associated with its use. Ask your doctor before use. 4. Is it safe to use Evion 400 during breastfeeding? When feeding mothers, Evion 400 is only recommended if the need is clearly identified and if the potential benefits outweigh the risks associated with its use. Ask your doctor before use. 5. Can Evion 400 be used to treat menstrual problems? Yes, it can be used for menstrual problems. Evion contains tocopherol acetate, which helps reduce the synthesis of prostaglandins (a chemical agent that causes pain in cells), reducing the duration and intensity of pain. 6. Is Evion 400 an antioxidant? It is a vitamin supplement and has several antioxidant properties. The capsule of Evion 400 contains tocopheryl acetate (vitamin E), a natural chemical compound, and full of antioxidants. It helps protect the body from damage caused by substances called free radicals. 7. Can I use Evion 400 for hair loss? Yes, it can be used for hair loss. It has tocopherol acetate, which helps repair, reduces inflammation and damage to the hair follicles. 8. What to do if you overdose on Evion 400?

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Dart Tablet: Uses, Side Effects, Dosage & 10 FAQs

Dart Tablet is the brand name of an analgesic and antipyretic medicine prescribed for the treatment of headache, pain and fever. This tablet is manufactured and distributed by Juggat laboratories limited. Dart tablet is actually a combination of antipyretic, analgesic and anti-inflammatory medicines. It is used to relax muscles and treat headache, fever, cold, muscle pain, toothache, flu etc. You will need to take take the Dart tablet as prescribed by your healthcare provider. It is recommended to take it with food to avoid stomach upset. Talk to your doctor if you are already taking other medications or if you have any other medical conditions. Also, talk to your healthcare provider if you are pregnant or breastfeeding before using this medicine. Paracetamol Paracetamol, or Acetaminophen, is a commonly used analgesic and antipyretic medication. It effectively relieves various types of pain, including back pain, headaches, and toothaches, while also reducing fever. Widely available over the counter, it is crucial to follow recommended dosage guidelines to avoid potential liver damage, especially in individuals with pre-existing liver conditions. Caffeine There is a small amount of caffeine in this medicine that prevents drowsiness caused by the effect of the other two components. It is a central nervous system stimulant and is most commonly found in coffee beans, tea leaves, and kola nuts. It is one of the most commonly used psychoactive drugs. [1] Propyphenazone Propylphenazone works quickly and effectively for shorter periods of time. It is a derivative of phenazone, an anti-inflammatory analgesic and non-steroidal (NSAID). In addition to analgesic and antipyretic properties, it also has anti-inflammatory properties. Dart Tablet Uses Dart Tablet is a widely used analgesic (pain reliever) and antipyretic (fever reducer) medication. Its primary function is to alleviate pain and reduce fever. This tablet can be used for the treatment and prevention of the following conditions and symptoms: Pain of any origin Migraine Headache Cold Mild to moderate pain Menstrual pain Sore throat Cerebral palsy Drowsiness Ache Cephalalgia Fever Fatigue Bronchopulmonary dysplasia in premature infants. Note: This may not be a complete list of Dart tablet uses. Your doctor may prescribe it for other conditions or in combination with other drugs. Side effects While Dart Tablet can be effective, it may cause certain side effects. It’s essential to be aware of these potential reactions and seek medical attention if they persist or worsen. Here is a list of some very common side effects; Nausea Diarrhea Acidity Gastrointestinal problems like upset stomach, IBS May affect Liver at higher doses Anxiety Nervousness Sleeplessness Skin Rashes Itching Serious side effects Some serious side effects which may be very rare but If you notice such side effects consult your doctor immediately. Breathing problems like Asthma, Dyspnea Anaphylaxis – Swelling of face Blood loss – Decrease in the number of blood cells may happen Contraindications Dart Tablet is contraindicated  for use in the following conditions If you are hypersensitive to any of the ingredients in this tablet. Chronic active alcoholism, Increased sensitivity to paracetamol, In the patients suffering Porphyria disorder. Marked disturbances of liver function and kidney disease, Anaemia, Pregnancy. Consult your doctor for proper guidance in such cases Dart Tablet Precautions Avoid Dart Tablet; If you have an allergic disorder like asthma or any other allergic symptoms. If you are pregnant and breastfeeding women If You have a history of heart disease, depression, low blood pressure. If you are suffering stomach ulcer, any inflammatory bowel disorder like ulcerative colitis or Crohn’s disease If you are allergic to any other medicines (Like as aspirin, naproxen, and ibuprofen), or to any other NSAIDs. Avoid in High blood pressure suffering patients. Caution should be taken in Patients suffering from heart problems or any blood vessels related problems, or blood clotting problems If your kidney or liver-related problems. You are taking any other medication. Interactions Dart Tablet may interact with the following medicines and products: Oral birth control pills Phenytoin Warfarin Cimetidine Ephedrine Mexiletine Disulfiram Fluoroquinolones This is not a complete list of drug interactions and conditions that might interfere with the Dart Tablet. Before taking this drug, inform your GP about all your present medications. How does it work? Dart is an analgesic-antipyretic. It has an analgesic, antipyretic and weak anti-inflammatory effect. The mechanism of action is related to the inhibition of prostaglandin synthesis, the predominant influence on the thermoregulatory centre in the hypothalamus, and improves heat transfer. However, it is believed that Acetaminophen acts primarily in the central nervous system and increases the pain threshold by inhibiting any isoform of cyclooxygenase, COX-1, COX-2 and COX-3 enzymes involved in prostaglandin synthesis (PG), Propyphenazone is an NSAID derived from pyrazolone and related to phenazone. It has antipyretic and analgesic properties. Three main mechanisms of caffeine action on the central nervous system have been described. The mobilization of intracellular calcium and the inhibition of specific phosphodiesterases occur only at high non-physiological concentrations of caffeine. The only likely mechanism of action of methylxanthine is antagonism at the adenosine receptor level. Caffeine increases the energy metabolism in the entire brain, but at the same time reduces the cerebral blood flow and leads to relative cerebral hypoperfusion. Caffeine activates norepinephrine neurons and appears to affect the local release of dopamine. Dart Tablet stimulates the central nervous system; antagonizing adenosine receptors; Blocking the action of cyclooxygenase in the body. Dart Tablet Dosage The appropriate dosage of Dart Tablet is crucial for its effectiveness and to minimize the risk of adverse effects. It’s important to follow the recommendations provided by healthcare professionals or as indicated on the medication packaging. Here are general guidelines for the dosage of Dart Tablet: For Adults: The typical prescription for adults is often two tablets per day. It is advisable to take the tablets during meals or immediately afterward to mitigate the risk of stomach upset. For Children and Elderly Patients: Dart Tablet is not recommended for use in children and elderly patients without specific guidance from a healthcare provider. Dosage adjustments may be necessary based on individual health conditions

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30 Best Stethoscopes for Accurate Heart & Lung Auscultation

Since its invention in 1816 by René Laennec, the stethoscope has been an indispensable tool for medical professionals. Today, with advancements in technology and a wide variety of options available, choosing the right stethoscope can be a daunting task. This comprehensive guide aims to help doctors, nurses, medical students, and other healthcare professionals make an informed decision when selecting the best stethoscope for their needs. First, let’s talk about a stethoscope and who needs one. What is a stethoscope? A stethoscope is a device that transmits low sounds, such as a heartbeat, intestines, lungs, or fetus, to the listener’s ear. A stethoscope has become one of the hallmarks of the medical profession. Stethoscopes are a very convenient tool but essential for accurate monitoring simultaneously. Unfortunately, many stethoscopes are currently available that cannot confirm which is best for you. But the real question is, which is the best stethoscope? In my opinion, this depends on your daily needs and budget. The 3M Littmann Core Digital is incredible if you can afford it. Other than this, all of the below are the best-selling stethoscopes on Amazon. You can check the full review below. If you are in a hurry, read our quick list of the best stethoscopes available in each category. 3M Littmann Core Digital—Best Digital Stethoscope 3M Littman Classic III—Best Overall Conventional Stethoscope ADC Digital Stethoscope Navy—Best Runner-Up Digital Stethoscope 3M Littmann Master Cardiology—Best Stethoscope For Cardiologists 3M Littmann Classic II Pediatric—Best Stethoscope For Pediatricians. Omron Sprague Rappaport—Best Price Healthcanal.com encourages explicitly professionals to use high-quality equipment like top-rated scopes when performing their jobs. Best Stethoscopes For Doctors And Nurses Let’s dig deep into some of the world’s best-rated and commonly used stethoscopes. 1. 3M Littmann CORE Digital Stethoscope Best Digital The most advanced stethoscope yet, with up to 40x amplification (at peak frequency) and other powerful new features designed to help give you a clearer picture of your patient’s health. The FDA-cleared 3M Littmann CORE Stethoscope is now available for sure. The 3M Littmann CORE Stethoscope is a tunable diaphragm technology that lets you hear different frequency sounds by adjusting the pressure on your chest piece. Hold with light or press more to hear higher-pitched tones for optimal comfort and excellent sound occlusion, which are important when taking vital signs. The stethoscope also features soft-sealing ear tips, so they stay in place no matter what activity you’re doing at any given moment – whether running an errand around town or giving birth without interruptions from nurses nearby. We Like; This digital stethoscope comes with Eko software on iOS and Android devices. This device has 40x sound amplification. It is FDA-cleared and paired with a HIPPA-compliant cellular program. A rechargeable battery that lasts 9 hours of constant use Don’t Like; It is expensive and may be outside the range of many common people. 3M Littmann Core is a heavy and bulky device. You will need to charge its battery daily, making it uncomfortable.   2. 3M Littmann Classic III (Editor Choice) 3M Littmann Classic II Stethoscope is no doubt one of the best stethoscopes in the world. It includes tunable diaphragms, making it a fantastic selection for pediatric and adult patients. These features make it one of the best stethoscopes for nursing students or doctors who need quality sound in a durable, affordable package. The stethoscope comes with a flexible two-sided chest piece alongside tunable diaphragms. It is excellent for performing various functions, such as listening to the heart, lungs, and other body sounds. In comparison with other best stethoscopes, this one includes more robust tubing. It may withstand skin, alcohol, and oils, making it less likely to burn quickly. It is not expected to pick up stains, either. This device had got 4.8/5 star ratings when the total review was more than 41,000. This means that most people love this medical gadget. The original price of this stethoscope on Amazon is $130, but it is now on sale, and you can save up to 27%. You will need to pay $98 for this fantastic medical device. Isn’t it great? We Like; 3M Littmann Classic III comes in 10 colors, and you can choose according to your personality. The sound of this stethoscope is excellent. The product can resist skin oil and alcohol. It is comfortable in the ears The open bell stays clear from dirt and debris by wrapping it with the small diaphragm. Don’t Like; This stethoscope is heavier than the others. The length is short. Lastly, the device is costly, and you must pay about $100. Please keep in mind that the actual price is $130     3. 3M Littmann Lightweight II S.E. The 3M Littmann Lightweight II S.E. Stethoscope is also the best for blood pressure monitoring. It features a tunable diaphragm capable of capturing both low and high-frequency sounds. It helps to ensure that you listen to sounds as correctly as possible. In addition, it’s a teardrop shape, which makes it effortless to fit under your blood pressure cuff. Another notable thing about this stethoscope is the fact that it’s a non-chill rim. Thus, it is fantastic for keeping patients comfortable through examinations. This one is cheaper than the above one, and its original price is around $63.22, but you can get it for $54.23 if you purchase it from Amazon. The customer feedback on this product is fantastic, and most people have praised it. This stethoscope had a 4.7/5 star rating when the total reviews were more than 7000. We Like; The diaphragm is also tunable and can help you hear high and low-intensity voices. The earbuds in this scope are angled, which may be comfortable for ears. The device is easy to clean and sanitize. 3M Littmann is lightweight and doesn’t feel bulky. The total weight is 118 grams, which makes it easy for the caregiver to transport it everywhere. The device is patient-friendly and easily fits inside the B.P. cuffs and around bandages with a teardrop chest piece shape. Most importantly,

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Does Gammora Really Kills 99% Of HIV/Aids Virus?

A new drug from Zion Medical named—Gammora claims to kill 99 % of the HIV virus during the first human trial. The therapy was made to kill HIV-infected cells without damaging uninfected ones. Compared to current antiretroviral medications that only suppress the spread of this virus, Gammora provides hope that a real cure may one day be discovered. According to the company, The drug was proven to eliminate around 99 % of HIV in four months of therapy. Gammora is a complex remedy composed of a synthetic peptide compound derived from the HIV-derived integrase. Taking advantage of the procedure, Gammora arouses the integration of numerous HIV DNA fragments to the host cell’s genomic DNA. But the question is, does it really kill 99% of HIV? First, let’s find out how does it work? How does Gammora work? Zion Medical describes the mode of activity as follows. Gammora is a synthetic peptide compound derived from the HIV enzyme integrase, responsible for integrating the virus’s genetic material into the infected cell’s DNA. Gammora arouses the integration of multiple HIV DNA fragments to the host cell’s genomic DNA, which activates the self-destruction of the infected cell, known as apoptosis. The drug seems to be a broad-spectrum disrupter of viral replication (such as ribavirin, a drug previously utilized in hepatitis C therapy ). It may restrict viral proliferation in established diseases and the disease of cells that are further (as other antiretroviral medications do). “These initial clinical outcomes were beyond our expectations and assure confidence in finding a cure for a disease that has been detected within 35 years,” said in a statement Dr. Esmira Naftali, head of growth in Zion Medical. “Given the restricted nature of the study, we’re eager to show the efficacy of our medication in Phase 2b using a larger number of participants within a longer period.” If this stage proves equally effective, its consequences will be life-altering. Now, present commercially available HIV retroviral treatments work by curbing the spread of this virus but don’t provide any treatment for the disease. Therefore, HIV patients may only hope for a better lifespan, not an actual respite. Nevertheless, Zion Medical’s peptide can destroy all cells carrying the HIV virus genome, offering a true cure for contaminated patients. Zion Medical’s Stage 1/2a Gammora human clinical trial found that many patients revealed a substantial decrease in the viral burden of around 90 percent in the baseline through the initial four months. In Part II of this analysis, Gammora was further combined with added retroviral remedies, resulting in patients showing around a 99 percent decrease in viral load from baseline in four months. Additionally, during the whole process of evaluations, Gammora has been proven to be secure and well-tolerable. In reality, no side effects at all have been reported. What’s more, Gammora was discovered to boost individual CD4 cell count — around 97 percent in the baseline. CD4 cells also called some T cells or T cells, are the cells that HIV kills. They’re white blood cells that play an integral part in the human immune system, the body’s natural defense mechanisms against germs, diseases, and disorders. “Zion Medical’s Gammora is a synthetic peptide compound derived from the HIV enzyme integrase, which helps insert genetic material into cells. This process stimulates apoptosis in infected tissues and triggers their self-destruction.” The drug appears to have anti-viral properties. It might work by limiting the amount of virus in an existing infection and preventing it from spreading further (like other antiretrovirals). However, no evidence suggests this particular medication can clear out latently infected cells that already contain integrated HIV DNA; if we were curing patients, they would need something entirely different for their treatment plan since all current drugs target actively recruiting cell surfaces. Since HIV infections advancement, CD4 cells have considerably decreased. Someone will be diagnosed with AIDS if their numbers fall below 200 and subsequently be considered at high risk of developing serious illnesses. A healthy person’s typical range for CD4 cells is roughly 500-1,500. The favorable news caused quite a few frenzies directing Zion Medical to describe the company still has a long way before a remedy could be ensured, but it has gotten a measure nearer. The business also disclosed that its peer-reviewed research ought to be accessible in 2019. An Israeli-based pharmaceutical firm, Zion Medical, which recently broke the news of an adequate initial clinical trial because of what they predicted as a possible HIV remedy, has issued a further statement on Twitter which makes it crystal clear that more trials will be required, and also their official outcomes need to get peer-reviewed and published. Since the organization was announced on 31 October, there’s been a tide of enthusiasm on social websites, particularly with people clamoring to learn more about this”possible cure.” Zion Medical is a relatively new firm based in 2014. According to the business site, it manufactures AIDS and Cancer treating products on peptides derived from HIV and targeted lentivirus (LV) particles. The FDA has recently approved Dovato— a combination of two antiretroviral drugs like dolutegravir and lamivudine for the treatment of HIV. You can also read more information related to medicine and supplements on DrugsBank. Read more trending topics. Focus Factor Review: Does It Works? Zyrexin Review: Uses, Dosage, Side Effects, Customer Reviews 15 Best Vein Finders Available On The Market Tebo Massage Chair: Everything From A-Z

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Anastrozole (Arimidex): Uses, Side Effects, Dosage

Anastrozole (Brand name: Arimidex) belongs to a group of drugs called aromatase inhibitors. Anastrozole reduces estrogen levels in postmenopausal women, which might impede the development of specific kinds of breast tumors that need estrogen to grow in the human body. It is a type of hormone treatment (also called hormone treatment) and belongs to a group of medications known as aromatase inhibitors. Anastrozole (Arimidex) is the generic (non-branded) name of this medication. All brands include exactly the exact same dose of this medication. Consequently, the quantity of estrogen that the tumor is exposed to is reduced, limiting the development of the tumor. Men with breast cancer might also be given anastrozole, though tamoxifen is much more commonly utilized. Arimidex Uses Anastrozole is used in the treatment of the following conditions For adjuvant treatment of hormone receptor-positive breast cancer, Hormonal treatment of breast cancer in postmenopausal women. Used to treat pubertal gynecomastia. McCune-Albright syndrome. Arimidex Mechanism of Action Anastrozole is a nonsteroidal aromatase inhibitor. It works by blocking aromatase, an enzyme that causes increased levels of estrogen in postmenopausal women. Consequently, estrogen levels in the body are diminished, as well as the increase of cancer cells that rely on estrogen can be stopped or slowed. Aromatase inhibition Contributes to a decrease in tumor and serum concentration of estrogen, resulting in a decreased tumor mass or delayed progression of tumor growth in certain women Arimidex Side effects Like most hormonal treatment drugs, anastrozole may cause unwanted side effects. A number of Arimidex side effects may be serious so it’s important to see the comprehensive information below. How hormonal treatment impacts individuals changes from person to person. Your physician or nurse can speak with you about this and provide you suggestions for the best way best to handle Arimidex side effects. Arimidex side effects are different in different people. Following are some of the side effects related to this drug. Some common Arimidex Side effects are; Pain, Arthritis, Hot flashes, Headache, Depression, Nausea, Vomiting, Bone pain, Sleeplessness, and Rash Serious Arimidex side effects are: Low red blood cell count Weak or broken bones Blood clots Stroke, heart attack Cancer of the lining of the uterus Low white blood cell count Increased blood pressure Stevens-Johnson syndrome Liver inflammation Cataracts. Anastrozole in Pregnancy & Breastfeeding Anastrozole isn’t advisable for pregnant moms under any conditions. Anastrozole can cause fetal damage and terminate maternity. It Shouldn’t Be administered to nursing moms to avoid any injury to the newborn. Precautions In case you haven’t gone through menopause you shouldn’t take anastrozole. Avoid if you’ve got osteoporosis (a condition that causes your bones to become thinner and weaker than normal) Avoid if you have issues with your kidneys or liver. If you are currently taking any other medicines, including medicines you may buy without a prescription, like herbal and complementary medicines Interaction with other medications Anastrozole (Arimidex) shouldn’t be used with tamoxifen since tamoxifen can decrease anastrozole amounts within the body and lessen its curative outcomes. Estrogens reduce the impact of anastrozole by raising estrogen levels in the human body. Foods To Avoid When Taking Anastrozole While taking Anastrozole, most individuals can maintain a regular diet. However, if you experience diarrhea, it’s advisable to avoid raw fruits, vegetables, whole-grain foods, cereals, and seeds. Instead, opt for soluble fiber-rich foods to alleviate diarrhea. Additionally, consider reducing your intake of spicy foods, caffeine, alcohol, and refrain from smoking for overall well-being during Anastrozole treatment. Always consult your healthcare provider for personalized dietary guidance. Arimidex Dosage Anastrozole is generally taken once every day. Follow all instructions on your prescription label. Don’t take this medication in smaller or larger quantities or for longer than advised. The suggested Arimidex dosage for adults such as the elderly is just one 1 mg tablet once each day. For postmenopausal women using hormone receptor-positive early invasive breast cancer, the recommended length of adjuvant hormone therapy is 5 years. You might take anastrozole with or without meals. You might want to continue taking this medicine for as many as five decades. Follow your physician’s directions. But if it’s almost time for the next dose, skip the missed dose and return to your regular dosing schedule. Don’t double doses. Store at room temperature away from heat and moisture. Related article: More Medicine Brands

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Crocin Tablet: Uses, Side Effects, Precautions, Dosage

Crocin Tablet contains paracetamol as an active ingredient and belongs to a medicine group known as an analgesic (Pain killer). It is used to treat fever, pain like headache, Toothache, Bodyache, Menstrual Pain, Joint Pain, and Muscle pain. Crocin Tablet is also used after surgery to reduce pain. This tablet may use alone or in combination with drugs. You will need to take it daily and with food to avoid stomach upset. It’s important to know that exceeding the dose will increase the chances of side effects. So strictly follow your doctor’s instructions and ask your pharmacist for dose adjustment. GlaxoSmithKline Pharmaceuticals manufactures Crocin Tablet and other dosage forms. It comes in various form and strengths like Crocin Suspension-A cold syrup for Children (Paracetamol 120MG) Crocin Tablets (Paracetamol 500MG) Crocin Tablets (Paracetamol 1000MG) Crocin Advance (Paracetamol 500MG) Crocin Drops (Paracetamol 240MG/5ML). It contains paracetamol, which inhibits the effects of cyclooxygenase (COX) enzymes. These enzymes (COX) are naturally present in our body and help produce certain chemicals (known as prostaglandins) that cause pain and swelling, and redness at the injury site. Therefore, with the inhibition of COX enzymes’ effects, the production of prostaglandins is inhibited, which in turn relieves pain and increases blood flow through the skin, heat loss, and sweating. [1] It is used in the treatment of the following medical conditions: Fever Joint Pain Neck Pain Headache Arthritis Muscle Pain Menstrual Cramps Post Immunization Pyrexia Cold Flu. It is contraindicated in the following conditions. If you have kidney disease If you are allergic to paracetamol or any other ingredients present in these formulations. If you have liver disease If you normally consume 3 or more alcoholic beverages per day. Crocin Tablet is not safe for children. If you are already taking warfarin, talk to your doctor as it may cause liver damage. It is generally well-tolerated, but it can cause some side effects along with its beneficial effects. Following are some side effects associated with the use of this medication. Severe Liver damage in High doses Allergic reactions like swelling of your face, lips, throat, or tongue, hives, difficulty breathing or swallowing, severe itching, peeling, or blistering skin. Nausea and vomiting Low blood pressure and Flushing. Anemia Thrombocytopenia (low number of platelet cells) Leukopenia (low number of white blood cells). Feeling sickness Stevens-Johnson Syndrome. Fatigue. Note: It may also cause other side effects not listed here. Crocin Advance tablet may interact with other medicines. This might increase the risk of side effects. Talk to your doctor or pharmacist before taking this medicine with other drugs. Other products containing paracetamol. carbamazepine colestyramine imatinib and busulfan ketoconazole lixisenatide metoclopramide phenobarbital, phenytoin, and primidone warfarin. Yes, its active ingredient is paracetamol, which is the same as paracetamol. It can be taken during pregnancy. Paracetamol is safe to use during pregnancy. However, it is recommended that you always consult your doctor before using any medication during pregnancy. For adults, 500 mg tablet is the general dose for fever and pain of 325-650 mg tablets once every 4 to 6 hours or 1000 mg tablets once every 6 to 8 hours. The forgotten dose should be taken as soon as possible. It would help if you did not take the missed dose when the next scheduled dose comes. Contact your doctor if you suspect an overdose of this medication. Frequently Asked Questions (FAQS) What is the Crocin tablet used for? The Crocin have paracetamol, which is an analgesic and antipyretic. It can be used in pain and fever. Is Crocin a paracetamol? Yes, already discussed above, these tablets contain Paracetamol, which is an analgesic and antipyretic agent. Is Crocin good for fever? Yes, it is good for fever. Is Crocin Safe in Pregnancy? Yes, Paracetamol is the safest drug in pregnancy, but it’s always recommended to follow your doctor’s instructions. Excess of anything can be dangerous, especially in pregnant women. Can I take Crocin for a long time? It is safe for the long term but don’t take more than the recommended dose. How does Crocin work? It works by blocking the chemical cyclooxygenase (COX)-mediated production of prostaglandins. It also reduces fever by affecting the chemical messengers in the brain that controls body temperature.

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