Isotretinoin (Zenatane): Uses, Side Effects, Dosage

Isotretinoin (Zenatane) is an effective systemic medication used in the treatment of severe inflammatory acne. Isotretinoin is categorized as a retinoid created from a synthetic form of vitamin A.

This medication can have severe side effects, but it has to be treated and supervised by a healthcare provider.

Isotretinoin is a medicine used for treating severe acne. It’s occasionally utilized in the avoidance of certain skin cancers.

Isotretinoin is an oral medication used for the prevention and treatment of acute acne. Acne results from inflammation of the skin.

The we Food and Drugs Administration approved Isotretinoin in May 1982.

Precautions (Zenatane)

  • Before taking isotretinoin, tell your Physician if you or Anybody in your family has any of the conditions like Diabetes, asthma, liver disease, heart disorder and depression.
  • You should also tell your doctor if you are allergic to any medications, particularly parabens (compounds used in cosmetics, moisturizers, and isotretinoin).
  • Do not take isotretinoin if you have hypervitaminosis A.
  • Be sure to tell your doctor if you are taking any other medicines, even over-the-counter medicines.
  • Do not take isotretinoin if you have severe liver disease.
  • Do not take isotretinoin if you have very high-fat levels (cholesterol, triglycerides) in your blood.


Isotretinoin (Zenatane) reduces the size and activity of the sebaceous glands within the skin, which lowers the total amount of sebum that’s generated. This prevents the glands from getting obstructed, and germs are not as likely to flourish. Additionally, it lessens the redness of the skin.

Side effects

Serious side effects are rare and occur in less than 1 in 1,000 individuals.

Stop taking isotretinoin Zenatane capsules and inform a doctor straight away in the Event That You get:

  • Stress,
  • Suicidal ideas – these may be indications of mental health issues
  • Acute pain in your stomach without diarrhea,
  • Violence and aggression,
  • Feeling ill, and
  • Nausea
  • Trouble moving your arms or thighs, and painful, swollen or bruised parts of the body.
  • A Severe skin rash that soothes or has blisters
  • Even darkened urine
  • Yellowish eyes or skin,
  • Difficulty swallowing or feeling quite tired
  • A lousy headache which does not go off and cause you to feel sick or vomit
  • Abrupt changes in vision
  • It is infrequent; however, isotretinoin capsules can occasionally result in sadness or make it worse and also make people feel dizzy.
  • In rare situations, it is likely to have a severe allergic reaction to isotretinoin capsules.

Zenatane in Pregnancy

  • Isotretinoin is damaging to the fetus and so shouldn’t be used through pregnancy. Women of childbearing age should have two negative pregnancy evaluation results before treatment is initiated, and a pregnancy test must be run during every month of treatment. Two powerful kinds of birth control have to be utilized throughout treatment. Pregnancy ought to be avoided a month prior to, during, and at least one month after stopping isotretinoin.
  • It’s not known whether isotretinoin is secreted in breast milk, but because of its potentially serious side effects, it Shouldn’t Be utilized by breastfeeding moms.

Isotretinoin Interactions

Inform your doctor of all of the medications you are taking.

  • This also has over-the-counter and prescription drugs, vitamins and other nutritional supplements (nutritional shakes, protein powders, etc.), herbal remedies and some other recreational and illegal drugs.
  • Speak with Your doctor about the risks and benefits of taking isotretinoin (Zenatane) if you are using Phenytoin, carbamazepine, Corticosteroids, such as prednisone, prednisolone, or triamcinolone and herbal treatments.
  • Do not take isotretinoin (Zenatane) if you are taking tetracycline antibiotics, such as demeclocycline, doxycycline or vitamin A.
  • You need to limit or avoid drinking while taking isotretinoin.

Dose for isotretinoin

  • The suggested dose of isotretinoin (Zenatane) is 0.5 to 2 mg per kg of body weight every day.
  • The daily dose generally is administered in 2 divided doses for 15-20 weeks.
  • Isotretinoin should be taken with meals so as to increase its absorption.

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