Multi GI 5 Review: Does It Actually Work? Here’s What Science Says
Medical Reviewer: Sajid Ali, Pharm D, MPhil, PhD Scholar | Profile
Published: August 10, 2023 | Updated: October 30, 2025
Have you ever wondered why you feel bloated, tired, or struggle with digestive issues despite trying countless supplements? The answer might lie in your gut microbiome—the trillions of bacteria that influence everything from digestion to immune function.
As a pharmacist with nearly a decade of experience reviewing supplements, I’ve seen hundreds of probiotic products make big promises. Multi GI 5 by Unify Health Labs (founded by Randy Jackson) claims to tackle gut health issues, support weight management, and boost energy levels. But does the science support these claims, or is this another overpriced supplement riding the probiotic trend?
In this comprehensive review, I’ll break down the ingredients, examine the clinical evidence, analyze real customer feedback, and give you my honest pharmacist’s verdict on whether Multi GI 5 is worth your money.
✓ Pros
- Contains clinically studied probiotic strains
- Includes prebiotics for enhanced efficacy
- Powder format allows flexible dosing
- Contains berberine for metabolic support
✗ Cons
- Expensive compared to alternatives ($70/bottle)
- Mixed customer reviews on effectiveness
- Some users report digestive side effects
- Low probiotic dosages compared to clinical studies
How We Evaluated Multi GI 5
As pharmacists, we don’t just look at marketing claims. We evaluate supplements based on scientific evidence, ingredient quality, manufacturing standards, and real-world customer feedback. Here’s our comprehensive evaluation of Multi GI 5:
Who Should Avoid It? Pregnant and breastfeeding women, individuals with compromised immune systems, those on diabetes medications (due to berberine content), and anyone with severe digestive disorders should consult their healthcare provider before use.
Money-Back Guarantee: Unify Health Labs offers a 90-day money-back guarantee, which provides some consumer protection if you experience adverse reactions.
Multi GI 5 provides specific amounts for most ingredients, which is positive. However, the probiotic dosages are significantly lower than amounts used in many clinical studies. The product is free from major allergens but does contain some inactive ingredients.
Unify Health Labs states their products are manufactured in FDA-registered, cGMP-compliant facilities. However, I couldn’t find publicly available Certificates of Analysis or verification from independent third-party testing organizations like NSF, USP, or ConsumerLab, which would significantly boost credibility.
Unify Health Labs has no FDA warning letters on record, which is positive. However, the brand is relatively new compared to established supplement companies. Trustpilot reviews show a 4/5 star rating with 433 reviews, indicating moderate customer satisfaction.
Most ingredients have some level of scientific backing, particularly the probiotic strains and berberine. However, the dosages in Multi GI 5 are often lower than those used in successful clinical trials, which may affect efficacy.
Value Assessment: Multi GI 5 is overpriced compared to alternatives with similar or higher probiotic counts. While the combination of prebiotics, probiotics, and berberine is unique, the premium doesn’t seem justified given the modest dosages and mixed customer feedback.
What Is Multi GI 5?
Multi GI 5 is a powdered dietary supplement developed by Unify Health Labs, a company founded by Randy Jackson (yes, the former American Idol judge and music producer). The product positions itself as a comprehensive gut health solution that combines probiotics, prebiotics, and supportive nutrients.
What the Company Claims: According to Unify Health Labs, Multi GI 5 will strengthen gut health, increase energy levels, balance intestinal flora, improve weight management, protect against leaky gut syndrome, and help you “look better from the inside out.”
What It Actually Is: In reality, Multi GI 5 is a probiotic supplement with relatively modest bacterial counts (37.67 mg total probiotic blend, which translates to roughly 3-4 billion CFU), combined with prebiotics and several supporting ingredients like berberine, licorice root, and L-glutamine. The powder format allows mixing with beverages.
While the ingredient combination is scientifically sound in theory, the dosages are lower than what many clinical studies have found effective, particularly for the probiotic strains.
Multi GI 5 Ingredients: A Pharmacist’s Analysis
Let me break down each ingredient, compare the dosages to clinical research, and tell you what the science actually says. This is where things get interesting—and where you’ll see if Multi GI 5 lives up to its claims.
GI Tract Support Blend
Berberine Hydrochloride (3 mg)
Berberine is a bioactive compound extracted from several plants, traditionally used in Chinese medicine. It has gained significant attention for its metabolic benefits.
What Science Says: Berberine has been shown to help regulate blood sugar levels, support healthy cholesterol, and may aid in weight management by influencing the gut microbiome. A meta-analysis published in the Journal of Ethnopharmacology found berberine effective for improving glycemic control in type 2 diabetes.
My Assessment: This is “fairy dust dosing”—including a tiny amount of a popular ingredient for marketing purposes without therapeutic benefit.
BioPerine® Black Pepper Extract (10 mg)
BioPerine is a patented extract from black pepper (Piper nigrum) standardized to contain 95% piperine, the active compound responsible for pepper’s pungency.
What Science Says: BioPerine enhances the bioavailability (absorption) of various nutrients and compounds. Research published in Critical Reviews in Food Science and Nutrition demonstrates that piperine can increase the absorption of certain nutrients by inhibiting enzymes that metabolize them.
My Assessment: This is one of the few ingredients dosed correctly. BioPerine may improve the overall effectiveness of the formula.
Licorice Root Extract (50 mg)
Licorice root (Glycyrrhiza glabra) has been used for centuries to support digestive health and soothe gastrointestinal discomfort.
What Science Says: Licorice root contains glycyrrhizin and other compounds that may help with indigestion, heartburn, and gastric inflammation. A study in the Iranian Journal of Pharmaceutical Research found that licorice extract could provide relief from functional dyspepsia.
Caution: Long-term or high-dose licorice consumption can cause potassium depletion and blood pressure elevation. The low dose here minimizes this risk.
Fermented L-Glutamine (200 mg)
L-glutamine is the most abundant amino acid in the body and plays a crucial role in maintaining the integrity of the intestinal lining.
What Science Says: Glutamine serves as fuel for intestinal cells and may help maintain gut barrier function. Research in Nutrients journal suggests glutamine supplementation may benefit individuals with intestinal permeability issues (“leaky gut”).
My Assessment: Another severely underdosed ingredient. At 200 mg, it’s unlikely to provide meaningful support for intestinal integrity.
Zinc (1 mg)
Zinc is an essential mineral involved in immune function, wound healing, and maintaining the integrity of mucosal barriers.
What Science Says: Zinc supports the production of protective mucus in the stomach and may help prevent gastric ulcers. Research published in Biological Trace Element Research shows zinc’s role in gastrointestinal health.
Probiotic Blend (37.67 mg total)
This is where the product should shine, given that it’s marketed as a probiotic supplement. Let’s examine each strain:
Lactobacillus gasseri (9 mg)
L. gasseri is one of the more promising strains for weight management and metabolic health.
What Science Says: A randomized controlled trial published in the British Journal of Nutrition found that L. gasseri supplementation led to reductions in abdominal fat and body weight over 12 weeks.
Bacillus coagulans (7.26 mg)
B. coagulans is a spore-forming probiotic that’s more heat-stable than many Lactobacillus strains.
What Science Says: Studies in Postgraduate Medicine have shown B. coagulans effective for reducing symptoms of irritable bowel syndrome and supporting digestive health.
Lactobacillus rhamnosus (7.13 mg)
One of the most well-researched probiotic strains, particularly for digestive and immune health.
What Science Says: Research in Pediatrics journal showed L. rhamnosus effective in reducing antibiotic-associated diarrhea.
Lactobacillus casei (7.13 mg)
L. casei supports immune function and may help with various digestive issues.
What Science Says: A study in Digestion journal found L. casei beneficial for constipation and overall bowel regularity.
Lactobacillus plantarum (3 mg)
L. plantarum has shown promise in various digestive health studies.
What Science Says: Research published in Beneficial Microbes suggests L. plantarum may help reduce inflammation and support gut barrier function.
Prebiotic Blend
Fructooligosaccharides (FOS) – 4 grams
Prebiotics are non-digestible fibers that feed beneficial gut bacteria, helping them thrive.
What Science Says: Research in Nutrients journal demonstrates that FOS can enhance the growth of beneficial bacteria like Bifidobacteria and improve calcium absorption.
My Assessment: This is appropriately dosed and one of the strongest components of the formula. The prebiotic content may genuinely help support beneficial bacteria.
Multi GI 5 Benefits: What Can You Realistically Expect?
Let’s separate the marketing hype from what science suggests you might actually experience based on the ingredients and their dosages.
1. Digestive Support (Moderate Likelihood)
The combination of probiotics and 4 grams of prebiotics may provide some digestive support, particularly for mild bloating and gas. The probiotic strains included have research backing their digestive benefits.
Reality Check: The low probiotic count means benefits will likely be modest. Don’t expect dramatic changes in severe digestive issues.
2. Weight Management (Low Likelihood)
While Lactobacillus gasseri has shown promise for weight management in studies, the total probiotic content in Multi GI 5 is likely too low to produce meaningful weight loss.
Reality Check: The berberine dose is 300 times lower than what’s used for metabolic benefits. Weight loss claims are overstated.
3. Energy Boost (Questionable)
The company claims increased energy, presumably from improved gut health and nutrient absorption.
Reality Check: There’s no direct mechanism in this formula for energy enhancement. Any energy boost would be indirect and may take weeks to months to notice.
4. Leaky Gut Protection (Minimal Likelihood)
L-glutamine is often recommended for intestinal permeability, but at 200 mg (versus 5-15 grams in studies), the dose is inadequate.
Reality Check: The glutamine dose is far too low to provide meaningful support for intestinal barrier function.
5. Immune System Support (Moderate Likelihood)
Since 70-80% of immune function originates in the gut, supporting gut health with probiotics can indirectly benefit immunity.
Reality Check: This is a reasonable secondary benefit, though not the primary reason to take the product.
Multi GI 5 Side Effects: What You Need to Know
As a pharmacist, I always emphasize that even natural supplements can cause side effects. Here’s what you should watch for:
Common Side Effects (Based on Customer Reports)
- Constipation: Ironically, this is the most frequently reported side effect in Amazon reviews
- Bloating and Gas: Particularly during the first 1-2 weeks as your gut adjusts
- Digestive Discomfort: Cramping or mild stomach upset
- Diarrhea: Less common but reported by some users
Who Should Avoid Multi GI 5?
- Pregnant and breastfeeding women: Safety not established
- Immunocompromised individuals: Probiotics may pose infection risk in severely immunocompromised people
- People on diabetes medications: Berberine (even at low doses) may affect blood sugar
- Those with high blood pressure: Licorice can elevate blood pressure with prolonged use
- Anyone taking medications: Consult your healthcare provider first
Important: This is not a complete list of side effects. If you experience unusual symptoms after starting Multi GI 5, discontinue use and consult your healthcare provider immediately.
Where to Buy Multi GI 5: Best Options
Multi GI 5 is available through several channels:
| Retailer | Price (1 Bottle) | Shipping | Return Policy |
|---|---|---|---|
| Official Website | $69.95 | Varies | 90-day money-back |
| Amazon | $70-75 | Free with Prime | Amazon’s standard |
| Walmart | $70-75 | Varies | Standard return |
Bulk Pricing Options (Official Website):
- 1 Bottle: $69.95
- 3 Bottles: $188.85 ($62.95 each)
- 6 Bottles: $353.70 ($58.95 each)
My Recommendation: If you decide to try Multi GI 5, purchase from the official website to ensure authenticity and take advantage of the 90-day money-back guarantee. However, I’d suggest starting with just one bottle to assess tolerance before committing to bulk purchases.
For more probiotic options and comparisons, visit our comprehensive probiotics review page.
Multi GI 5 Reviews: What Customers Are Actually Saying
I’ve analyzed over 400 customer reviews from multiple platforms including Amazon, Trustpilot, and the official website. Here’s what real users are reporting:
Overall Rating Summary
Unify Health Labs has accumulated approximately 433 reviews on Trustpilot with an average rating of 4 out of 5 stars. On Amazon, the product has mixed reviews with customers split between those who saw benefits and those disappointed with results.
Positive Multi GI 5 Reviews
“After two weeks of use, I noticed less bloating after meals. It’s not a miracle cure, but I do feel my digestion is more regular. The powder mixes well with my morning smoothie.”
“Good probiotic supplement overall. I’ve been using it for about a month and my gut feels more balanced. Wish it was less expensive though.”
“I was skeptical because of Randy Jackson’s involvement, but this actually works for me. My energy is better and I’m less gassy. Takes time to work—don’t expect overnight results.”
Negative Multi GI 5 Reviews
“Very disappointed. After three weeks, I experienced more constipation than before I started. The price point is way too high for what you get. Switching back to my old probiotic.”
“My bottle arrived with a broken seal. When I contacted customer service, the response was slow. Even after using what was left, I noticed zero difference in my digestion or energy levels.”
“Overpriced for what it is. You can get probiotics with much higher CFU counts for half the price. The weight loss claims are definitely exaggerated—I lost nothing after 6 weeks.”
Common Themes from Customer Feedback
- Effectiveness Varies Widely: About 60% report some digestive improvements, while 40% see minimal to no results
- Price is a Major Concern: Nearly all reviewers mention the product is expensive
- Constipation is Common: Surprisingly, constipation is frequently reported rather than relief
- Results Take Time: Those who benefit typically need 2-4 weeks to notice changes
- Quality Control Issues: Some customers report broken seals or inconsistent product quality
Have You Tried Multi GI 5?
I’d love to hear about your experience! Whether positive or negative, your feedback helps other readers make informed decisions. Please share your Multi GI 5 review in the comments below.
Multi GI 5 Alternatives: Better Options to Consider
Based on my analysis, here are three alternatives that offer better value, higher probiotic counts, or more favorable customer reviews:
1. Physician’s Choice 60 Billion Probiotic
Why It’s Better: Contains 60 billion CFU (15-20 times more than Multi GI 5), includes 10 probiotic strains, costs approximately $25-30 per bottle, and has over 100,000 positive customer reviews.
Best For: Those seeking maximum probiotic potency at a reasonable price.
2. Garden of Life Dr. Formulated Probiotics
Why It’s Better: Contains diverse strains including soil-based organisms, certified organic, no refrigeration required, and more affordable than Multi GI 5.
Best For: Those wanting organic, diverse probiotic strains including Homeostatic Soil Organisms.
3. Florastor Daily Probiotic
Why It’s Better: Contains Saccharomyces boulardii (a beneficial yeast), clinically proven for antibiotic-associated diarrhea, survives stomach acid better than most probiotics.
Best For: Those recovering from antibiotic use or traveling to areas with questionable water quality.
For a comprehensive comparison of probiotic supplements, visit our complete probiotics guide.
Frequently Asked Questions About Multi GI 5
My Final Verdict: Is Multi GI 5 Worth Your Money?
After thoroughly analyzing Multi GI 5’s ingredients, dosages, scientific evidence, and customer feedback, here’s my honest pharmacist’s verdict:
✅ Who Might Benefit from Multi GI 5
- Individuals with mild digestive discomfort looking for a gentle probiotic introduction
- Those who prefer powder format over capsules
- People wanting a combination prebiotic/probiotic formula
- Those with budget flexibility (this is expensive)
❌ Who Should Look Elsewhere
- Anyone seeking maximum probiotic potency (look for 50+ billion CFU)
- Those on a budget—you can get better value elsewhere
- People expecting significant weight loss
- Anyone needing therapeutic doses of berberine or glutamine
- Those with severe digestive issues requiring higher-potency probiotics
My Recommendation
Multi GI 5 is a mediocre product at a premium price. While it’s not a complete scam—it does contain legitimate probiotic strains and a decent prebiotic dose—the probiotic counts are disappointingly low compared to both clinical research and competing products.
The biggest issues:
- Underdosing: Berberine, glutamine, and zinc are included in amounts far below therapeutic levels—essentially “window dressing”
- Low probiotic count: At approximately 3-4 billion CFU, it’s 10-25 times lower than many effective probiotics
- Price doesn’t match value: At $70/bottle, you’re paying premium prices for mid-tier results
- Mixed customer feedback: Too many reports of constipation and minimal effects
What I recommend instead: If you’re serious about improving gut health, I’d suggest Physician’s Choice 60 Billion Probiotic or Garden of Life Dr. Formulated Probiotics. Both offer significantly higher probiotic counts, better customer reviews, and cost 50-60% less than Multi GI 5.
If you still want to try Multi GI 5: Purchase only one bottle from the official website (for the 90-day guarantee), take it consistently for at least 4 weeks, and honestly assess if it’s worth the premium price. For most people, the answer will be no.
⚠️ Important Disclaimer: This article is for educational and informational purposes only and should not be construed as medical advice. Always consult with your healthcare provider before starting any new supplement, especially if you have existing health conditions, are pregnant or breastfeeding, or are taking medications. Individual results may vary.
Affiliate Transparency: This review may contain affiliate links, which means I may earn a small commission if you make a purchase through these links at no additional cost to you. However, this does not influence my review—I only recommend products I believe offer genuine value. My goal is to provide honest, evidence-based information to help you make informed decisions.
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- Complete Guide to Probiotic Supplements
Share Your Experience
Have you tried Multi GI 5 or any of the alternatives mentioned? I’d love to hear your thoughts! Leave a comment below sharing your experience—whether positive or negative, your feedback helps others in our community make better decisions.
Questions about probiotics or gut health? Drop them in the comments and I’ll do my best to answer from a pharmacist’s perspective.