Zerodol SP

Zerodol SP: Uses, Side Effects, Mechanism, Dosage

Zerodol SP prepared by IPCA Laboratories is  the combination of three drugs, such as Aceclofenac, acetaminophen and serrathiopeptidase.

Acetaminophen, known as paracetamol, is used to treat pain and fever. It is usually used to relieve mild to moderate pain.

Aceclofenac (brand name: Airtal) belongs to a group of drugs, steroidal anti-inflammatory drugs (NSAIDs) and to treat pain and inflammation associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is also used in fever, toothache headache, postoperative pain.

Serratopeptidase is a proteolytic enzyme obtained from silkworm. It is used to reduce pain and inflammation associated with symptoms such as back pain, arthritis, tension headaches and migraines.


Mechanism of action

Aceclofenac blocks the effect of cyclooxygenase enzymes. These enzymes help with the production of other chemicals in the body called prostaglandins. Prostaglandins are produced in damaged or injured areas and cause pain and swelling. The effect of cyclooxygenase enzymes to block the production of prostaglandins is reduced, thus relieving pain and inflammation.

Serratopeptidase helps the body break down proteins.

Paracetamol increases the pain threshold and increases blood flow through the skin, heat loss and sweating.

Zerodol SP Uses

Zerodol SP Tablet is usually used to treat fever, muscle pain, but there are some other conditions where it can be considered such as:

  • Bones and joints pain
  • Toothache
  • Muscles pain
  • Bloating
  • Ear pain
  • Headache
  • Periods pain
  • Migraine
  • Pain caused by nonaticular rheutism
  • Rheumatoid arthritis
  • Osteoarthritis
  • Ankylosing spondylitis
  • Sore throat
  • Ear infections
  • Blood clots
  • Swelling
  • Fever
  • Cold & Flu
  • Lumbago
  • Ischiadynia.

Side Effects

Zerodol SP can cause side effects. Although they do not occur in most cases, some effects can be serious. This is especially true if you take more than the recommended dose. These are some of the expected side effects associated with the use of Zerodol SP tablets:

  • Allergic Reaction due to paracetamol or any other ingredients.
  • Nausea
  • Vomiting
  • Gas, Flatulence
  • Abdominal Pain
  • Dizziness
  • Constipation
  • Diarrhea
  • Indigestion
  • Heartburn

Note: This is not a complete list of possible side-effects.Consult Your Doctor in case of Serious side effects.


Before using Zerodol SP Tablet, please consult a doctor and avoid using Zerodol SP if You are/have:

  • Allergic to paracetamol
  • Severe cardiac impairment
  • Driving and operate dangerous machinery
  • Have Bleeding disorders
  • With Alcohol
  • Gastro-intestinal disorders
  • History of gastroulceration
  • Patients recovering after a surgery.


Zerodol SP is Contraindicated in patients with Following conditions:

  • Hypersensitivity
  • Gastrointestinal bleeding, and
  • Severe ulcer.

Zerodol SP In Pregnancy:

Zerodol SP is not safe to take if you are pregnant or are planning to be pregnant. Consult Your Doctor.

Zerodol SP In Breast Feeding:

Zerodol SP Can Pass to Breast Milk and is not safe to take if you are breastfeeding or are planning for breast feeding.Always Consult With Your Doctor Before Using This Medicine.

Zerodol SP interactions

If you are taking other medicines or complementary products at the same time, the effects of Zerodol Tablet may will change. This may increase the risk of side effects or your medication may not work properly. Tell your GP about all the medications, vitamins and herbal supplements you use, so your doctor can help you prevent or control drug interactions. It may interact with the following medications and products:

Note: This is not a complete list of drug interactions associated with the use of this medicine.

Zerodol SP Dosage

The usual Recommended dose for adult is 1-2 Tablets Per day with Foods.


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