Zerodol SP: Uses, Side Effects, Mechanism, Dosage

Zerodol SP prepared by IPCA Laboratories is  the combination of three drugs, such as Aceclofenac, acetaminophen and serrathiopeptidase.

Acetaminophen, known as paracetamol, is used to treat pain and fever. It is usually used to relieve mild to moderate pain.

Aceclofenac (brand name: Airtal) belongs to a group of drugs, steroidal anti-inflammatory drugs (NSAIDs) and to treat pain and inflammation associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is also used in fever, toothache headache, postoperative pain.

Serratopeptidase is a proteolytic enzyme obtained from silkworm. It is used to reduce pain and inflammation associated with symptoms such as back pain, arthritis, tension headaches and migraines.


  • Aceclofenac 100 mg
  • Serratopeptidase 15 mg
  • Paracetamol 325 mg.

Mechanism of action

Aceclofenac blocks the effect of cyclooxygenase enzymes. These enzymes help with the production of other chemicals in the body called prostaglandins. Prostaglandins are produced in damaged or injured areas and cause pain and swelling. The effect of cyclooxygenase enzymes to block the production of prostaglandins is reduced, thus relieving pain and inflammation.

Serratopeptidase helps the body break down proteins.

Paracetamol increases the pain threshold and increases blood flow through the skin, heat loss and sweating.

Zerodol SP Uses

Zerodol SP Tablet is usually used to treat fever, muscle pain, but there are some other conditions where it can be considered such as:

  • Bones and joints pain
  • Toothache
  • Muscles pain
  • Bloating
  • Ear pain
  • Headache
  • Periods pain
  • Migraine
  • Pain caused by nonaticular rheutism
  • Rheumatoid arthritis
  • Osteoarthritis
  • Ankylosing spondylitis
  • Sore throat
  • Ear infections
  • Blood clots
  • Swelling
  • Fever
  • Cold & Flu
  • Lumbago
  • Ischiadynia.

Also, Read

Side Effects

Zerodol SP can cause side effects. Although they do not occur in most cases, some effects can be serious. This is especially true if you take more than the recommended dose. These are some of the expected side effects associated with the use of Zerodol SP tablets:

  • Allergic Reaction due to paracetamol or any other ingredients.
  • Nausea
  • Vomiting
  • Gas,
  • Flatulence
  • Abdominal Pain
  • Dizziness
  • Constipation
  • Diarrhea
  • Indigestion
  • Heartburn

Note: This is not a complete list of possible side-effects.Consult Your Doctor in case of Serious side effects.


Before using Zerodol SP Tablet, please consult a doctor and avoid using Zerodol SP if You are/have:

  • Allergic to paracetamol
  • Severe cardiac impairment
  • Driving and operate dangerous machinery
  • Have Bleeding disorders
  • With Alcohol
  • Gastro-intestinal disorders
  • History of gastroulceration
  • Patients recovering after a surgery.


Zerodol SP is Contraindicated in patients with Following conditions:

  • Hypersensitivity
  • Gastrointestinal bleeding, and
  • Severe ulcer.

Zerodol SP In Pregnancy:

Zerodol SP is not safe to take if you are pregnant or are planning to be pregnant. Consult Your Doctor.

Zerodol SP In Breast Feeding:

Zerodol SP Can Pass to Breast Milk and is not safe to take if you are breastfeeding or are planning for breast feeding. Always Consult With Your Doctor Before Using This Medicine.

Zerodol SP interactions

If you are taking other medicines or complementary products at the same time, the effects of Zerodol Tablet may will change. This may increase the risk of side effects or your medication may not work properly. Tell your GP about all the medications, vitamins and herbal supplements you use, so your doctor can help you prevent or control drug interactions. It may interact with the following medications and products:

Note: This is not a complete list of drug interactions associated with the use of this medicine.

Zerodol SP Dosage

The usual Recommended dose for adult is 1-2 Tablets Per day with Foods.

Frequently Asked Questions

Q. 1 Is it safe to use during Pregnancy?

Zerodol SP Tablet may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Q.2 Is it safe to use while breast feeding?

Zerodol SP Can Pass to Breast Milk and is not safe to take if you are breastfeeding or are planning for breast feeding. Always Consult With Your Doctor Before Using This Medicine. Zerodol Sp Contain Aceclofenac Which is not recommended for use in Breastfeeding. It’s better you ask your pharmacist or consult your doctor.

Q. 3 Can Zerodol SP Tablet be used for bones and joints pain and toothache?

Yes you can use this drug for toothache, joint and bones pain. Aceclofenac is used for tootache while paracetamol and serrathiopeptidase both are use for pain, fever and inflammation.

Q. 4 What is Zerodol used to treat?

Zerodol Sp is used for the treatment and prevention of conditions like Bones and joints pain, Toothache, Muscles pain, Bloating, Ear pain, Headache, Periods pain, Migraine and many other. Check above.

Q. 5 What are the side effects of Zerodol tablets?

The most common side effects are nausea, vomiting, gas, flatulence, heartburn etc. This is not a complete list of side effects you can check it above.

Q. 6 Is Zerodol Sp a painkiller?

Zerodol is the combination of three active ingredients thet can be used for the relieving of certain types of Pain.

Q. 7 Can I take Zerodol SP Tablet with alcohol?                             

No, you can’t take Zerodol SP with alcohol as it may increase the risk of side effects.

Q. 8 Is it habit forming?

No, Zerodol Sp is not a habit forming medicine.
Q. 9 Should I use Zerodol SP Tablet empty stomach, before food or after food?
This can be taken on an empty stomach; however doctors generally prescribe Zerodol to be taken with food.

Q. 10 How Zerodol SP Works?

Zerodol SP reduces pain and inflammation by blocking the release of certain chemicals in the brain that produce pain and inflammation signals in the nervous system.

  • Paracetamol is an antipyretic that prevents the brain from raising body temperature or causing fever.
  • Aceclofenac is a non-steroidal anti-inflammatory drug that blocks pain and inflammation.
  • Serratiopeptidase is an enzyme that breaks down the abnormal proteins at the site of inflammation and allows healing at the site of inflammation.

Q. 11 How to store Zerodol Sp?

Store the medicine in a cool and dry place away from sunlight. Don’t freeze the medicine. Keep it away from the reach of the children. Don’t flush the tablet unless instructed to avoid contamination of the environment.Keep it away from pets.

Q. 12 Is it safe to drive after the intake of Zerodol SP Tablet?

If you feel  dizziness, drowsiness,hypotension, headache as side effects of the tablet, then it is advisable to discontinue Zerodol SP.

Q. 13 What to do if i  missed a dose of Zerodol Sp? 

If you miss a dose of Zerodol Sp, take it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and take your usual dose as planned. Do not take a double dose.

Q. 14 What should I do in an emergency or overdose of Zerodol Sp?

In case of an emergency or overdose, consult your local ambulance or go to the nearest emergency room.

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3 thoughts on “Zerodol SP: Uses, Side Effects, Mechanism, Dosage”

  1. Dr Mahadi Hasan

    Very much useful. Can I have the updated informatio daily from this side

  2. Jitendra Singh

    Could I give it 7 year old

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