Hyoscyamine: Uses, Side Effects, Dosage etc

Hyoscyamine belongs to a group of prescription drugs known as anticholinergic drugs.

It is used in the treatment of gastrointestinal disorders including  irritable bowel syndrome, cramp, and peptic ulcers; It is also used for rigidity, excess saliva in parkinsonism, tremors, and used as a drying agent in acute rhinitis.

Hyoscyamine Uses

Hyoscyamine is used to treat and prevent many different conditions. some of the uses of Hyoscyamine are;

  • It can be used to treat stomach/intestinal issues like cramps and irritable bowel syndrome.
  • Hyoscyamine can also be used for cramping pain brought on by kidney stones and Infection.
  • This drug can also be used for treatment of bladder spasms,
  • Peptic ulcer disease,
  • Diverticulitis,
  • Colic,
  • Irritable bowel syndrome,
  • Cystitis, and
  • Pancreatitis.
  • Also used to treat certain heart conditions,
  • To control the symptoms of Parkinson’s disease and rhinitis.

Mechanism of action

Hyoscyamine competes favorably with acetylcholine for the binding of muscarinic receptors in the saliva, bronchial and forearm of the gastrointestinal tract.

This drug works by reducing the production of acid in the stomach, slowing down normal bowel movements and relaxing the muscles of many organs (such as the intestines, intestines, kidneys, liver and kidneys). Intestine).

The activities of hyoscyamine result in a decrease in the secretions of sweat,  bronchi, gastric and sweat glands, mydriasis, cycloplegia, heart rate change, regeneration of the bladder detrusor muscle and gastrointestinal musculature, and reduced gastrointestinal motility.

Hyoscyamine further reduces the amount of specific body fluids (eg, saliva, sweating).

Side Effects of Hyoscyamine

The following is a list of possible side effects that may occur with medicines containing iosciamin sulfate. This is not a complete list. These side effects are possible but do not always occur. Some side effects can be rare but serious. Ask your doctor if you notice any of the following symptoms, especially if they do not disappear.

Frequent side effects of hyoscyamine include the following:

  • Dizziness or lightheadedness
  • headache
  • Infection
  • blurry vision
  • dry mouth
  • constipation
  • flushing (feeling of warmth)
  • difficulty urinating
  • abdominal cramps
  • increased sensitivity to light
  • drowsiness
  • choking

This isn’t a comprehensive list of all hyoscyamine side effects. Consult your physician or pharmacist to learn more.


Before taking hyoscyamine, tell your doctor or pharmacist

  • if you are allergic to it or if you have other allergies.
  • Limit alcoholic beverages while taking this medication.
  • This medication can increase the risk of heat stroke as it reduces sweating. Avoid overheating in hot weather, in saunas, in sporting activities or in other exhausting activities.
  • This medication can cause dizziness or drowsiness or cause blurred vision. Do not drive, operate machinery or perform activities that require attention or clear vision until you are sure you can perform these activities safely.
  • Older people may be more sensitive to the side effects of this medication, including confusion, drowsiness, unusual agitation, constipation and difficulty in urination. Confusion and drowsiness can increase the risk of falling.
  • If you have some diseases, such as prostate enlargement, urinary tract disorders, some gastrointestinal problems (slow, constipation, ulcerative colitis, infections), glaucoma (narrow angle type, untreated open angle type),
  • Children may be more sensitive to the effects of this medicine.
  • If you have heart problems with severe bleeding.
  • Before using this medication, tell your doctor or pharmacist your medical history, including: hyperthyroidism, other heart problems (eg, coronary heart disease, heart failure, rapid heart rate, irregular heartbeat), hypertension, disease kidney, pyrosis (acid reflux, hiatal hernia)), problems of the nervous system (autonomic neuropathy), myasthenia gravis.
  • You should only use iosciamin if it is clearly necessary during pregnancy. Discuss the risks and benefits with your doctor.
  • This medicine passes into breast milk. Ask your doctor before breast-feeding.

Pregnancy & Breast feeding

Hyoscyamine could damage an unborn baby. You need to tell your doctor if you’re pregnant or intend to become pregnant. You need to speak with your physician before breastfeeding while taking the medication.


Antacids can inhibit absorption. Additive anticholinergic effects with other anticholinergics, type I antiarrhythmics, antihistamines, phenothiazines, tricyclics, MAOIs.

It interact with the following drugs and products:


The dose depends on the medical conditions and the response to treatment. You should not increase the dose or take more than prescribed without first talking to your doctor.

Adults and children 12 years of age and older should not take more than 1.5 milligrams (mg) of hyoscyamine daily. Children aged 2 to 12 years should not take more than 0.75 mg per day.

You should take this medication orally, usually 30 to 60 minutes before a meal, and drink plenty of fluids while you take it.

  • Usual recommended Adult dose is  1-2 tabs sublingually, swallowed, or chewed each four hrs or as desired; maximum 12 tabs/day.
  • Usual recommended Childrens dose for  more than 2 years  1/2 -1 tabs sublingually, swallowed, or chewed every 4 hrs or as required; maximum 6 tabs/day. For Children age  less than 2 years it is not recommended.

Frequently Asked Questions (FAQS)

Why Hyoscyamine is Prescribed?

It can be used to treat irritable bowel syndrome (IBS), diverticulosis and / or bladder cramps.

Is hyoscyamine sulfate safe to use during pregnancy?

You should only use iosciamin if it is clearly necessary during pregnancy. Discuss the risks and benefits with your doctor.

Is Hyoscyaminsulfate safe while breastfeeding?

No, this drug can cause unexpected side effects for the fetus. It can also cross the breast milk, thats why its contraindicated in breastfeeding.

How do you take hyoscyamine?

This drug should be taken between 30 and 60 minutes before eating. It should never be taken with antacids (such as Tums or Rolaids), since these drugs can reduce the absorption of levsin in the body. Wait at least an hour after taking levsin to take antacids.

Is it safe to drive or handle heavy machinery when using this product?

They can become dizzy or drowsy or cause blurred vision. Do not drive, operate machinery or perform activities that require attention or clear vision until you are sure you can perform these activities safely.

What to do if you miss a dose?

If you miss a dose, take it as soon as you remember. If the next dose should be taken quickly, just take that dose. Do not double or take more than one dose at a time.

What happens with an overdose?

Symptoms of overdose include: headache, dizziness, dry mouth, difficulty swallowing, nausea, vomiting, blurred vision, dry skin, agitation or nervousness. Consult a doctor or call the gift hotline.

What should i avoid while taking Hyoscyamine?

Avoid antacids simultaneously with hyoscyamine. Antacids can make it difficult for your body to consume hyoscyamine. If you are taking an antacid, take it after taking hyoscyamine and eat a meal.

Is it safe to drive or operate heavy machinery when using Hyoscyamine?

Hyoscyamine can change your thinking or reactions. Be careful when driving or doing something that requires alertness.

Does this drug or product lead to addiction or addiction?

No, but always ask your doctor or pharmacist.

Is hyoscyamine safe for children?

Some doctors prescribe it, but it can cause side effects.  Always ask your doctor before using it on children.

Is Hyoscyamine used for pain relief?

Hyoscyamine is used to treat conditions of the gastrointestinal tract, including convulsions, irritable bowel syndrome and gastric ulcer; for rigidity, tremor, excessive saliva in Parkinsonism; as a desiccant in acute rhinitis.

How do you store hyoscymanine?

Store your medicines at room temperature, away from heat and direct light. Do not freeze medicines unless otherwise stated in the package leaflet. Keep medicines away from children and pets.
Do not rinse the medicine in the toilet and do not dispose of it in the sewer unless instructed to do so. Medicines can contaminate the environment in this way.

I can take expired Hyoscyamin?

It is unlikely that taking a single dose of expired hyoscyamine  will result in an adverse event. However, contact your doctor or pharmacist for advice or if you feel unwell. The expired drug may become ineffective in the treatment of the prescribed conditions. To be sure, it is important not to use the expired medications.

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