The active ingredient present in Dolo 650 mg is Paracetamol/Acetaminophen.Acetaminophen belong to a class of drug called Analgesic (pain reliever) and Antipyretics (fever reducer).It is used to treat different medical conditions such as headache, muscle aches, arthritis, backache, toothaches, colds,menstrual periods and fevers.The FDA approved acetaminophen in 1951.
Dolo 650 mg is manufactured and marketed by Micro Labs Ltd.
Dolo 650 Mg Tablet Uses
- Joint pain
- Muscle aches
- Ear pain
- Periods/menstrual pain
Avoid Dolo 650 mg Tablet If
- You are allergic to Paracetamol or any other ingredient present in Dolo 650 MG Tablet
- You are suffering from a serious liver disorder.
- Do not take paracetamol if you consume alcoholic beverages every day.
It is contraindicated in the patients with the following medical conditions
- Liver Disease
- Kidney Disease
- Chronic alcoholism
- Allergy to any of the components present in the formulation.
Mechanism of Action
Its precise mechanism of action continues to be poorly understood.However Acetaminophen is assumed to act primarily within the central nervous system, increasing the pain threshold by inhibiting each isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
Studies additionally report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that’s completely different from the known variants cox-1 and Cox-2. This enzyme is currently stated as COX-3.
The antipyretic properties of paracetamol are possible as a result of direct effects on the heat-regulating centres of the hypothalamus leading to peripheral dilatation, sweating and thus temperature reduction.
Dolo 650 mg is generally well tolerated but like any other drugs this medicine may cause some side effects.Please consult your doctor if you experience any side effect to the drug.
Common and moderate side effects include
- Allergic reactions
- Gastric Ulcer
- Mouth ulcer
While rare and less common side effects include
- Stevens-Johnson Syndrome
- Liver Damage (On high doses)
- Shortness of Breath.
Use in Pregnancy & Breast Feeding
Paracetamol (Dolo 650 Mg) has been used routinely during all stages of pregnancy to reduce a high temperature and for pain relief. There is no clear evidence that it has any harmful effects on an unborn baby.It can also be used in Breast feeding.
Dolo 650 mg may interact with other OTC drugs, Herbal medicine, or supplement .This may increase your risk for adverse-effects or cause your drug not to work properly. Following are some drugs product which interact with Dolo 650 mg Tablets. Consult your GP Before using any other medicine along with this drug.
Major interactions occur with the following drugs
- Sodium nitrite
While Moderate interactions Occur with
This drug may also interact with other medicine not listed here so it’s better consult your doctor.
The dosage of this medication may vary depending on the weight, size, age, health status and symptoms of each patient. The doctor should be notified immediately if symptoms persist or worsen after taking this medicine, and if there is an adverse effect.
- Dolo 650 MG Tablet is usually administered orally or rectally, and is also available for intravenous administration.
- According to FDA guidelines, the maximum dose of paracetamol is 4000 mg daily in divided doses.
- Swallow the tablet immediately and do not chew it. Use the dose recommended by a doctor.
- The usual recommended dose of acetaminophen for pain and fever is 325 mg to 1 g every 4 to 6 hours. Take the Dolo 650 mg tablet as directed by your doctor.
- In case of overdose or side effect, a doctor or health professional such as a nurse or pharmacist should be notified immediately so that the patient receives first aid before he or she can be transported to the hospital.