Generic Drugs

Amiodarone: Uses, Side effects, Dosage

Amiodarone prolonged the refractory period of the heart with out causing of the blockade of the sodium. It can be given orally and parenterally.it is absorbed from the intestine, widely distributed and mainly deposited in the adipose tissue is metabolized in the liver and excreted in the bile and faeces. when given for a prolonged period, its plasma half life is about 54 days due to its slow elimination from the body. Amiodarone treats and prevents abnormal heartbeats by working inside cells to control muscle contractions in the heart. This helps your heart beat normally. Clinical uses: Amiodarone is a powerful antiarrhythmic drug which is used for the treatment of ventricular arrhythmias. It may be used for the prevention of ventricular response in cases of atrial fibrillation and atrial flutter. It may restore sinus rhythm in cases of atrial fibrillation and flutter.also it may be used for the maintenance of sinus rhythm in cases of atrial fibrillation and flutter after cardioversion. It may be effective for the arrhythmias of wolf-Parkinson-white syndrome. Adverse effects: Most common side effects includes Nausea,Vomiting,constipation,tremors,fatigue,lack of cordination,headache,stomach pain,sleep disturbances etc Bradycardia and heart block can occur. Ventricular arrhythmia can occur with amiodarone. Microdeposits can occur on the cornea that can cause photophobia and visual halos, but these are reversible when treatment with amiodarone is stopped. Both hypo and hyperthyroidism can occur with it.Thus thyroid function tests should be done both before and after treatment with amiodarone. Rarely, hepatitis and pulmonary fibrosis can occur with it. Drug interaction It increases the effects of digoxin and warfarin. It increases the depressant effects of beta blockers and calcium channel blockers on the sinoatrial node and AV node.  

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Methyldopa: Uses, Side effects, Dosage

Methyldopa produces its antihypertensive effect by acting on the alpha adrenoceptors in the vasomotor center of the brain.though it is sympathomimetic drug they can cause decreased activity of the sympathetic nervous system to the cardiovascular system by acting as an agonist on the alpha-adrenoceptors, leading to falling in blood pressure. Methyldopa when given orally or parenterally, passes into the brain by an active process.it is converted in the brain into alpha methyldopa>>>alpha methyldopamine>>>alpha methyl noradrenaline.Alpha methyl noradrenaline then acts on alpha adrenoceptors in the vasomotor center of the brain and inhibit the sympathetic outflow to the peripheral tissues, especially CVS.Methyldopa produces its antihypertensive effects by causing reduction of peripheral vascular resistance. It is one of the safest antihypertensive drug in Pregnancy. Its maximum antihypertensive effect occurs in 4-6hoirs and then persist for about 24hours. Pharmacokinetics: Absorption of methyldopa after oral administration is incomplete and its bioavailability after oral administration is about 25%.Most of the drug is excreted unchanged in the urine i.e about two third and the remaining is metabolized in the liver.its dosage should be reduced in renal and hepatic failure. Methyldopa Adverse effects: The Most common side effects related tothis drug are the following; Sedation, Dizziness, Dry mouth and postural hypotension. Other less common adverse effects include anxiety, blurred vision, sleep disturbances, parkinsonism, and impotence. More serious but rare adverse effects are hemolytic anemia, hepatitis, thrombocytopenia, leukopenia, and a lupus erythematosus-like syndrome.Hepatitis with methyldopa is usually reversible when the drug is stopped .it usually occurs during the initial two months of therapy, but sometimes it can occur after a prolonged therapy with the drug. Doses: A dose of 500-2000mg daily in a single or 2-3 divided doses orally .injection of methyldopa is available as 5 ml ampoules containing 50mg/ml. A dose of 250-500mg by IV infusion and can be repeated after every six hours.

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Pentazocine: Uses, Side effects, Dosage

Pentazocine is a synthetic opioid that has agonist activity at kappa and weak antagonist activity at Mu receptors. Pentazocine is used to relieve moderate to severe pain. Its analgesic activity is almost equal to that of morphine. It has a short duration of action i.e 3-4 hours. Pentazocine is Available in Combination with Naloxone To Avoid its misuse various Available in various dosage forms like Tablet and Injection. 50mg of pentazocine orally is almost equal to 60mg of oral codeine in analgesic activity. Nausea and vomiting are common with pentazocine. Dependence and tolerance can occur but is less as compared to that of morphine. Pentazocine can produce mental confusion, tachycardia, dysphoria, Hypertension, and Palpitations. Also, Causes Trouble passing urine or change in the amount of urine. Should be used with cautions in the following conditions; cardiac arrhythmias, Phaeochromocytoma, Pancreatitis, Arterial or pulmonary hypertension, And acute myocardial infarction.   This drug can enter the foetal circulation and has the potential to cause opioid effects including central depression, can cause respiratory depression and withdrawal symptoms in the neonates if used during delivery. There is very less data on the secretion of pentazocine in breast milk, so it is recommended that infants of nursing mothers who are receiving high doses of pentazocine, be appropriately monitored Less Likely To Cause constipation. It is contraindicated in acute respiratory depression and in patients dependent on opioids, heart failure secondary to chronic lung disease, acute porphyria. Pentazocine may interact with the following medicines Like antihistamines,alcohol,atropine,anxiolytics or sleep,Medications,oxybutynin, tolterodine,certain medicines for depression like amitriptyline, fluoxetine, sertraline,certain medicines for stomach problems like dicyclomine, hyoscyamine,certain medicines for seizures like phenobarbital, primidone,certain medicines for travel sickness like scopolamine,certain medicines for Parkinson’s disease like benztropine, trihexyphenidyl,general anesthetics like halothane, isoflurane, methoxyflurane, propofol,ipratropium,MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate,medicines that relax muscles for surgery,local anesthetics like lidocaine, pramoxine, tetracaine,other narcotic medicines for pain or cough,phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine. Dosage Dosage for Adults: The usual initial dosage is 50mg every 3-4 hours after meals followed by 50-100mg every three to four hours.The maximum dose is 600 mg daily. Dose For Children under 12 years: It is recommended that another dosage form ie tablets, be used as appropriate for this age group.

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Metformin: Uses, Side Effects, Dosage

Metformin is an oral antidiabetic drug, especially used in Noninsulin dependent Diabetes Mellitus Patients who are obese because it doesn’t cause an increase in body weight. On the other hand, body weight may be increased with insulin and sulphonylureas. It is excreted unchanged in the urine, and its plasma half-life is 1.30 to 3 hours. Clinical Uses: It is the drug of choice in non-insulin-dependentnoninsulin diabetes mellitus patients. It is also used along with sulphonylureas when blood glucose is not fully controlled with sulphonylureas alone. It is also used in polycystic ovary syndrome (Unlicensed use) Dose Of Metformin: The usual recommended dose is 0.5 -2.55g daily in two to three divided doses after meals. Metformin in Pregnancy: It can be used in pregnancy for both pre-existing and gestational diabetes. Mechanism Of Action Its exact mechanism of action is unknown, but it seems to inhibit the formation of glucose in the liver (gluconeogenesis). Another possible mechanism of action may decrease glucose absorption from the GIT and increase its uptake by the skeletal muscle. Adverse Effects: Anorexia, nausea, abdominal pain, vomiting, and diarrhea are the most common adverse effects associated with metformin. These can be reduced by starting the drug with a small dose after meals and then gradually increasing the dose. Cold Feeling in your arms and legs. Chronic administration of metformin may decrease the absorption of vitamin B12 from the intestine. Hence, serum vitamin B12 Should be monitored during chronic administration of biguanides, and if a deficiency occurs, then vitamin B12 should be given by injection. Lactic acidosis is a serious adverse effect that is more liable to occur in patients with renal failure, cardiorespiratory insufficiency, alcoholism, and elderly people. Trouble breathing. Related Article: Important information about Gaviscon

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Clonidine: Uses, Side Effects, Dosage

Clonidine is a prescription medication. It’s available as a patch, an oral tablet, and an oral extended-release tablet. The form you use may depend on your condition. Facts: Clonidine is a centrally-acting α2-adrenergic agonist. It crosses the blood-brain barrier. Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.Also used to treat attention deficit hyperactivity disorder(ADHD). Mechanism Of Action: Clonidine stimulates alpha-adrenergic receptors in the brain stem. This action results in reduced sympathetic outflow from the central nervous system and decreases in peripheral resistance, renal vascular resistance, heart rate, and blood pressure. Clonidine Side Effects: A very slow heart rate (fewer than 60 beats per minute); Fast or pounding heartbeats, tremors; Feeling short of breath, even with mild exertion; Confusion, hallucinations; Swelling, rapid weight gain; Feeling like you might pass out. Flu symptoms; Urination problems; or Other common side effects may include: Cold symptoms such as runny or stuffy nose, sneezing, cough, sore throat; Feeling tired or irritable; Drowsiness, dizziness; A headache, ear pain; Mood changes; Sleep problems (insomnia), nightmares; Feeling hot; Mild fever; Loss of interest in sex, impotence, difficulty having an orgasm. Constipation, diarrhea, pain in your upper stomach; Dry mouth increased thirst; Clonidine Dosage The usual oral adult dose is 0.1–0.3 mg twice daily. The Usual Adult Dose For Hypertension is 0.2-0.6mg orally per day in a divided doses. The Usual Adult Dose for Pain Is 30mcg/hr As a continuous infusion. The Usual Pediatric Dose for attention deficit disorder (For age 6 year and more ) is 0.1 mg orally at bedtime and Increase in 0.1 mg/day increments every 7 days until desired response; doses should be administered twice daily . The maximum oral dose is 2.4 mg daily. Topical patches should be applied to an area of hairless skin on the upper arm or torso, once every 7 days. When applying a new topical patch, a different area of skin should be used.

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Hydrochlorothiazide

Hydrochlorothiazide belongs to a group of drugs called diuretics. It works by causing the kidneys to get rid of excess water and salt from the body into the urine. Facts: Hydrochlorothiazide is used alone or in combination with other drugs to treat Hypertension (high blood pressure). Hydrochlorothiazide is used to treat edema Or Swelling caused by various medical problems, including liver disease, heart, And kidney diseases and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide may also be used to treat patients with diabetes insipidus and to prevent kidney stones in patients with high levels of calcium in their blood. It is a prescription drug. It comes as a capsule, tablet or solution that you take by mouth. Mechanism Of Action : Hydrochlorothiazide, a thiazide water pill, inhibits water reabsorption within the nephron by inhibiting the sodium-chloride symporter in the distal convoluted tubule, that is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining the distal convoluted tube-shaped structure. The energy for this can be provided by a sodium gradient established by sodium-potassium ATPases on the basolateral membrane. Once sodium has entered the cell, it’s transported out into the basolateral interstitium via the sodium-potassium ATPase, causing a rise in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. By obstruction the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the tubule. Hydrochlorothiazide In Pregnancy: Many studies including a big data of almost 7000 neonates exposed to diuretics during pregnancy did not find an increased risk of adverse effects, such as fetal growth restriction birth defects, thrombocytopenia, or diabetes, among neonates exposed to diuretics in utero.The drug should be used if it is clearly needed. If you are diabetic, or allergic to sulfa medications, you should not use Hydrochlorothiazide. Forms And Strength : Available in Oral Tablet as both Generic (Hydrochlorothiazide) And Brand (Microzide): Strengths: 12.5 mg, 25 mg, and 50 mg Dosage: The usual adult dose for treating edema is 25-100 mg once daily or in divided doses. The usual adult dose for hypertension is 12.5 to 50 mg once daily. Hydrochlorothiazide Side effects Side effects include Low blood pressure, Nausea Weakness, Light sensitivity (rash caused by sunlight), Impotence, and Abdominal pain. More serious side effects include pancreatitis, jaundice, electrolyte disturbances, and anaphylaxis (a life-threatening allergic reaction).

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Naproxen: Uses, Side Effects, Dosage etc

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that is widely used to treat a variety of painful conditions, including arthritis, menstrual cramps, headache, and fever. It is available over-the-counter or by prescription, depending on the strength and dosage form. Naproxen has been used in the United States since 1980. It is available generically and under many brand names. Naproxen was approved by the FDA in December 1991. In this article, we will provide an overview of naproxen, including its uses, side effects, precautions, mechanism, dosage, and frequently asked questions. Uses of Naproxen Naproxen is commonly used to treat the following conditions: Arthritis – Naproxen can help relieve pain and inflammation associated with various types of arthritis, such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Menstrual cramps – Naproxen is effective in reducing menstrual pain and cramps. Headache – Naproxen is used to treat migraine headaches, tension headaches, and other types of headaches. Fever – Naproxen can be used to lower fever. Other pain – Naproxen is also used to treat other types of pain, such as back pain, toothache, and musculoskeletal pain. Mechanism of Naproxen Naproxen works by inhibiting the production of prostaglandins, which are substances in the body that cause inflammation and pain. Naproxen blocks the activity of the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. By reducing the production of prostaglandins, naproxen can help reduce inflammation, pain, and fever. These enzymes help to make other chemicals in the body, called prostaglandins, Blocking of these enzymes resulting in lower concentrations of prostaglandins. These enzymes (COX) are responsible for pain, fever, and inflammation. As a Result Of low concentration of these enzymes inflammation, pain and fever are reduced. Dosage of Naproxen The dosage of naproxen depends on the condition being treated, the strength of the medication, and the age and weight of the patient. The recommended dose for adults with mild to moderate pain is 250-500 mg twice daily. For arthritis, the recommended dose is 250-500 mg twice daily, up to a maximum of 1,500 mg per day. Children should not take naproxen unless directed by a doctor. Dose for Osteoarthritis Controlled Release: 750 mg to 1000 mg orally once a day Delayed Release: 375 mg to 500 mg orally twice a day Immediate Release Tablets and Suspension: 250 mg to 500 mg (naproxen) or 275 mg to 550 mg (naproxen sodium) orally twice a day Dysmenorrhea Initial dose of 500 mg Orally, then 250 mg PO  after every 6-8hr or 500 mg Orally After every  12hr , not to exceed 1250 mg/day on the first day; subsequent doses should not exceed 1000 mg/day naproxen base In Acute Gout Initial Dose of 750 mg Orally, followed by 250 mg After every 8hr until attack subsides Extended release: 1000-1500 mg  Once A Day, followed by 1000 mg  Once A Day until attack subsides Side Effects of Naproxen Like all medications, naproxen can cause side effects. Common side effects of naproxen include: Nausea and vomiting Diarrhea or constipation Headache Dizziness or lightheadedness Stomach pain or cramps Heartburn or indigestion Bloating or gas Rash or itching More serious side effects may occur, such as: Chest pain Shortness of breath or difficulty breathing Swelling of the face, tongue, or throat Severe skin rash or blisters Unusual bleeding or bruising Jaundice (yellowing of the skin or eyes) Kidney problems If you experience any of these serious side effects, seek medical attention immediately. Precautions for Naproxen Before taking naproxen, inform your doctor if you have any of the following conditions: Allergies to aspirin or other NSAIDs Heart disease or high blood pressure Liver or kidney disease Asthma or other breathing problems Stomach ulcers or bleeding Pregnancy or breastfeeding Naproxen may interact with other medications or supplements, so inform your doctor if you are taking any other medications or supplements. Read below. Naproxen and Pregnancy Naproxen may cause harm to a developing fetus, and should not be used in the later stages of pregnancy. There’s some evidence that it can cause problems for developing babies and increase the risk for maternal bleeding during delivery. Interactions It can interact with the following drugs: Aspirin Certain blood pressure medications such as angiotensin-converting enzyme inhibitors Certain drugs to treat cholesterol such as cholestyramine Diuretic also called water pills Methotrexate, which is used for rheumatoid arthritis and some kinds of cancer The bipolar disorder drug lithium Blood thinners such as warfarin Certain drugs for depression such as selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs) Certain antacid drugs such as h2 blockers and sucralfate Frequently Asked Questions About Naproxen Can I take naproxen with other pain relievers? A: It is not recommended to take naproxen with other pain relievers, such as aspirin or acetaminophen, without consulting your doctor first. Combining multiple pain relievers can increase the risk of side effects and complications. Can I drink alcohol while taking naproxen? A: Drinking alcohol while taking naproxen can increase the risk of stomach bleeding and other complications. It is best to avoid alcohol while taking naproxen. Can naproxen be taken during pregnancy or breastfeeding? A: Naproxen should not be taken during the third trimester of pregnancy as it can harm the unborn baby. It should also be avoided during breastfeeding as it can pass into breast milk and harm the nursing baby. Can naproxen cause addiction or dependence? A: Naproxen is not addictive and does not cause dependence. However, it should be taken as directed by your doctor and should not be taken for a prolonged period without medical supervision. How long does it take for naproxen to start working? A: Naproxen typically takes 30-60 minutes to start working and can provide relief for up to 12 hours. Conclusion Naproxen is a commonly used NSAID that can effectively treat pain, inflammation, and fever. It works by inhibiting the production of prostaglandins, which are involved in inflammation and pain. However, like all medications, it can cause side effects and should be taken as directed by your doctor. If you

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Simvastatin: Uses, Side effects, Dosage

Facts: • Belong To A group of drugs called “Statins” And Is Used to reduce bad cholesterol like LDL And Triglyceride Level In the Blood.While Increasing level of good cholesterol. • It Is also used to prevent Angina ,heart attack and stroke and decrease the risk of Heart diseases. • It is being tested for secondary progressive multiple sclerosis in a phase 3 clinical trials .This trial will take six years to complete and results are expected in 2023. • It is a prescription-only medicine. However the 10mg tablets can be bought without a prescription to lower the risk of having a heart attack in people with a moderate risk of heart disease. • One Of the top Prescribing Drug In United States With Over 94 million Prescriptions. • Take simvastatin even if you feel well, as you will still be getting the benefits. Most people with high cholesterol don’t have any symptoms. Mechanism Of Action: There are two types of cholesterol; One is ‘bad’ type known as low-density lipoprotein (LDL) and the other is ‘good’ type known as high-density lipoprotein (HDL). LDL is deposited in the arteries and increases the risk of heart disease like atherosclerosis.In this, the arteries become clogged and narrow while HDL actually protects the arteries against this. Simvastatin works by reducing the production of LDL cholesterol by the liver. This has a knock-on effect of making the liver cells take up LDL cholesterol from the blood. Simvastatin also causes a small decrease in the production of other ‘bad fats’ in the blood called triglycerides and a small increase in the level of HDL cholesterol. The overall result is lowered levels of ‘bad fats’ and raised levels of ‘good fats’ in the blood. Simvastatin Doses: • For Cardiovascular prevention, The usual dose of simvastatin is 20 to 40 mg/day orally once a day in the evening. • Patient With Coronary heart disease:10 to 20 mg orally once a day in the evening • For Homozygous Familial Hypercholesterolemia: Usual dose of 40 mg orally once a day in the evening • It is not recommended for children age less than 10 years.And for age 10 or more in familial hypercholesterolemia, the initial dose should be 10 mg/day orally in the evening and then a maintenance dose of 40 mg/day orally. Simvastatin Side effects: Simvastatin is one of the safest medicine, it’s unusual to have side effects but still if You feel any of the following Side Effects below immediately call your doctor Pain or burning when you urinate Swelling, weight gain, little or no urinating Memory problems , Confusion, Fever, unusual tiredness, and dark colored urine Unexplained muscle pain, tenderness, or weakness Upper stomach pain, Nausea, itching, loss of appetite, clay-colored stools, dark urine, And jaundice.  Increased urination, Increased thirst, hunger, weight loss, dry mouth, drowsiness, dry skin, fruity breath odor, blurred vision. Less serious side effects may include: Mild skin rash; Headache; Constipation, stomach pain or indigestion, mild nausea; Joint pain, Mild muscle pain; Sleep problems (insomnia); or Cold symptoms such as stuffy nose, sneezing, sore throat.

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Warfarin: Everything You need to Know

Therapeutic Uses : Warfarin is a prescription anticoagulant drug used to treat blood clots and to lower the chance of blood clots forming in your body. Warfarin is indicated for prophylaxis after the insertion of prosthetic heart valves. Warfarin is indicated for transient cerebral ischaemic attacks. Warfarin is indicated for the prophylaxis of systemic embolization in patients with rheumatic heart disease and atrial fibrillation. Warfarin is indicated for the prophylaxis and treatment of venous thrombosis and pulmonary embolism. Side effects of warfarin Bleeding is the main side effect associated with warfarin. Women who are taking warfarin in their Periods may have heavy or increased bleeding from their vagina. have bleeding gums pass black feces pass blood in your urine or feces have severe bruising have long nosebleeds – lasting more than 10 minutes cough up blood or have blood in your vomit experience unusual headaches Dosage Warfarin is used to thin your blood to prevent clotting that can lead to strokes or heart complications. The dose varies and is adjusted by monitoring you with blood work. A blood test called an “INR” (International Normalized Ratio) measures blood clotting speed. Your doctor will determine your dose of warfarin based on your INR and likely check your blood a few days later, and possibly adjust your dose.  A typical INR range for a patient on warfarin is between 1.5-2.5 (but doctors might desire a higher number for some patients). Most patients take between 1-10mg per day depending on patient INR. Dose for Prevention of Thromboembolism in Atrial Fibrillation: Initial dose of 2 to 5 mg orally once a day Then Maintenance dose of 2 to 10 mg orally once a day Dose for Prophylaxis of Thromboembolic Stroke: The Initial dose should be 2 to 5 mg orally once a day And then a Maintenance dose of 2 to 10 mg orally once a day Dose for Myocardial Infarction: The Initial dose should be 2 to 5 mg orally once a day And then a Maintenance dose of 2 to 10 mg orally once a day for at least 3 months after myocardial infarction. Dose for the Prophylaxis of Deep Vein Thrombosis: Initial dose of 2 to 5 mg orally once a day and then a maintenance dose of 2 to 10 mg orally once a day Dose for Pulmonary Embolism: Initial dose of  2 to 5 mg orally once a day and then a Maintenance dose of 2 to 10 mg orally once a day Dose for Prosthetic Heart Valves – Tissue Valves: Initial dose of 2 to 5 mg orally once a day and then a maintenance dose of 2 to 10 mg orally once a day.

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Ranitidine: Uses, Side effects, Dosage

Facts Ranitidine belongs to a group of drugs called H2 Receptors Antagonists Or H2 Blockers; they reduce the amount of acid produced by the cells in the lining of the stomach.This helps heal and prevent ulcers and improves symptoms such as heartburn and stomach pain. This medication is used to treat and prevent certain stomach and throat (esophagus) problems caused by too much stomach acid (e.g., Zollinger-Ellison syndrome, erosive esophagitis) or a backward flow of stomach acid into the esophagus (gastroesophageal reflux disease-GERD). Ranitidine is also used to treat ulcers of the stomach and intestines and prevent them from returning after treatment. This medication is also available without a prescription. Mechanism Of Action: The H2 blockers are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: Histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked. Ranitidine Side effects : Diarrhea, constipation Headache. Pain, redness, burning or stinging at the site of injection. A very serious allergic reaction to this drug is rare Many people using this medication do not have serious side effects But Tell your doctor immediately if any of these unlikely but serious side effects occur: blurred vision, mental/mood changes (e.g agitation, confusion, depression, hallucinations). Mental/mood changes (e.g., agitation, confusion, depression, hallucinations). Very Rare And Serious Side effects Like  severe tiredness, fast/slow/irregular heartbeat, enlarged breasts, signs of infection (e.g., fever, persistent sore throat, cough) ,easy bleeding/bruising, severe stomach/abdominal pain, dark urine, yellowing skin/eyes Ranitidine Dosage ADULTS Treatment of reflux oesophagitis: Take one 150mg tablet twice a day OR one 300mg tablet at bedtime In severe oesophagitis, take one 150mg tablet four times a day for a maximum of 12 weeks. Treatment of stomach or duodenal ulcers: Take one 150mg tablet twice a day, one in the morning and one in the evening OR one 300mg tablet at bedtime. For maintenance, the usual dose is 150mg at bedtime. Zollinger-Ellison syndrome: Take one 150mg tablet three times a day. This may be increased as necessary. Elderly In patients with normal renal function, the doses of Ranitidine Tablets arc the same as for younger adults. How To Take It: For Adults and children 16 years and older:150mg of  One tablet should be taken when symptoms appear, day or night. If symptoms persist for more than 1 hour or return after 1 hour, a second tablet may be taken. For prevention of symptoms brought on by consuming food or beverages, 1 tablet should be taken 30 to 60 minutes before eating a meal or consuming beverages expected to cause symptoms. The maximum daily dose of ranitidine is 300 mg  (24 hours) .

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