Naproxen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to treat painful conditions such as arthritis, gout pain, sprains and strains, period (menstrual) pain, and backache.
- Naproxen blocks the enzyme called cyclooxygenase, These enzymes help to make other chemicals in the body, called prostaglandins, Blocking of these enzymes resulting in lower concentrations of prostaglandins. These enzymes are responsible for pain, fever, and inflammation. As a Result Of low concentration of these enzymes inflammation, pain and fever are reduced.
- Naproxen has been used in the United States since 1980. It is available generically and under many brand names.
- Naproxen was approved by the FDA in December 1991.
The most common side effects from naproxen are:
- ringing in the ears,
- shortness of breath
- drowsiness, abdominal pain, nausea,
- fluid retention, and
Other important side effects include:
- blood clots,
- fluid retention,
- heart attacks,
- heart failure and
Naproxen and Pregnancy
Naproxen may cause harm to a developing fetus, and should not be used in the later stages of pregnancy.
There’s some evidence that it can cause problems for developing babies and increase the risk for maternal bleeding during delivery.
It can interact with the following drugs:
- Certain blood pressure medications such as angiotensin-converting enzyme inhibitors
- Certain drugs to treat cholesterol such as cholestyramine
- Diuretic also called water pills
- Methotrexate, which is used for rheumatoid arthritis and some kinds of cancer
- The bipolar disorder drug lithium
- Blood thinners such as warfarin
- Certain drugs for depression such as selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs)
- Certain antacid drugs such as h2 blockers and sucralfate
Dose for Osteoarthritis
750 mg to 1000 mg orally once a day
375 mg to 500 mg orally twice a day
Immediate Release Tablets and Suspension:
250 mg to 500 mg (naproxen) or 275 mg to 550 mg (naproxen sodium) orally twice a day
Initial dose of 500 mg Orally, then 250 mg PO after every 6-8hr or 500 mg Orally After every 12hr , not to exceed 1250 mg/day on the first day; subsequent doses should not exceed 1000 mg/day naproxen base
In Acute Gout
Initial Dose of 750 mg Orally, followed by 250 mg After every 8hr until attack subsides
Extended release: 1000-1500 mg Once A Day, followed by 1000 mg Once A Day until attack subsides