The H2 blockers are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: Histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.
Treatment of reflux oesophagitis:
Take one 150mg tablet twice a day OR one 300mg tablet at bedtime
In severe oesophagitis, take one 150mg tablet four times a day for a maximum of 12 weeks.
Treatment of stomach or duodenal ulcers:
Take one 150mg tablet twice a day, one in the morning and one in the evening OR one 300mg tablet at bedtime. For maintenance, the usual dose is 150mg at bedtime.
Take one 150mg tablet three times a day. This may be increased as necessary.
In patients with normal renal function, the doses of Ranitidine Tablets arc the same as for younger adults.
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