Manzoor (Pharm-D)

Prebiotics are non-digestible food ingredients that are used selectively in the colon to multiply healthy bacteria. They promote digestion and stimulate the production of valuable vitamins. They also promote the growth of beneficial bacteria (lactobacilli and bifidobacteria) to feed without the “bad” types. Good bacteria play an important role in regulating your immune system, inhibiting the growth of pathogens (disease-causing bacteria) and digesting food. Galactooligosaccharides (GOS) are the most advanced form of prebiotics They were first identified by Marcel Roberfroid in 1995. Prebiotic fiber passes undigested to the small intestine and ferment when they reach the colon. Researchers have found that probiotics are useful for increasing the beneficial bacteria already found in the intestine, which reduces the risk of disease and improves overall well-being. Prebiotic fiber are not as vulnerable as probiotic bacteria, since they are not affected by heat, gastric or time. The fermentation process also does not differ depending on the person. Prebiotic supplements are different from probiotic supplements, as they are very stable and reach the intestine intact. In addition, all prebiotics are not the same and some are more selective for good bacteria than others and offer them for the unique characteristics. Originally prebiotics were not classified as fiber connections, but recent research has shown that these compounds behave like other fiber forms. These days, prebiotic carbohydrates that have been studied in people, mostly fructans or galactans, both of which are fermented by anaerobic bacteria in the colon. “A prebiotic is a selectively fermented ingredient that allows specific changes, both in the composition and in the activity in the gastrointestinal microbiota that benefits the welfare and health of the host.” Probiotics Probiotics are live bacteria. This bacteria is found in certain foods or supplements such as Yogurt etc. They can be killed by heat, stomach acid, or simply die with time. Examples: Bifidobacteria and lactobacilli. Prebiotics: These are Non-living & Non-digestible fiber. They occur naturally in fruits and vegetables  such as garlic, asparagus, onion. They are resistant to stomach acid or other enzyme. They acts as a fertilizer for the good bacteria in your gut. Indigestion, Higher levels of inflammation, Lower immune function, Higher likelihood of weight gain and A raised risk for various chronic diseases. Prebiotic work naturally in your gut to feed existing good bacteria, helping them to grow and multiply. Important benefits can include the following: Prebiotics help “improve stool quality (frequency and consistency) Reduces the risk of gastroenteritis and infections. Improving the barrier function of the gut. It prevent cancer, Strengthening the immune system Lower inflammation and autoimmune reactions. Boosting overall digestive health. Help Lower Inflammation. Lowering some risk factors for cardiovascular disease. Enhancing your body’s nutrition by allowing better mineral and nutrient uptake. Contributing positively to your mental health. Minimising the risk of developing diarrhoea. Increasing absorption of calcium to improve bone density. Prebiotics Also Protect Bones Improved Moods. Regulate glucose. The Major Source of Prebiotics is dietary fibre.Following are some of the best source of prebiotocs Oatmeal Apple With Skin Onion and Garlic Wheat Bread Chicory Root Leeks Asparagus Barely Dandelion Greens Under-ripe bananas Acacia gum Jerusalem artichoke It Is generally well tolerated But Some Time It Cause Certain Side Effects Because Of Interaction With Normal Flora Of The Gut That’s Why Some People may find it difficult to use as it takes a few days for their system to adjust.Natural Prebiotics are as important and safe as your food but some prebiotics product may cause some side effects such as: Tummy gurgling Excess of gas in the intestine Abdominal bloating and Discomfort.

ITALY – Anatolia Vertadella, a 100-year-old woman, has given birth to a baby after a successful transplant. The controversial transplantation is often criticized by medical professionals because of their advanced age. The illegal and controversial surgical operation was carried out in a private clinic in Turkey, where the European law on ovarian transplantation does not apply, admits the one-hundred-year-old mother who refuses to disclose the name of the clinic where the operation was performed. Although the husband of Miss Vertadella has died since 1998, the widow of the centenarians has found a sperm donor to make the birth possible. “I still love my deceased husband and desire to stay a widow until I leave this earth, but I needed the seed of this young fervent Catholic to fulfill God’s will,” she concluded. This 100-year-old Italian has given birth to a 9-pound baby after a controversial transplantation of ovaries criticized by doctors for their old age, Rivista Napoli reports. I am so grateful to have given birth to my 17th child. This is a true blessing and a testament to the power of the creator” she told local journalists. “I could not reproduce since I was diagnosed with ovarian cancer.” For a long time I believed that God punished me, but God is real and he hears our prayers, has given me fertility at an age that is nothing short of a miracle. , recognizes the fervent centenarian Catholic. The operation was completely legal in Turkey and was carried out by a handful of medical specialists. According to medical reports, the woman is in good health at her age and has many good years to share with her child.

A research, published in the British Journal of Pharmacology, showed that both proteins significantly reduced the growth of almost all cancers and blocked the work of specific receptors on the surface of cells that led to division. Biologists found that the number of cancer cells decreased by 40-70% after one day compared to the tumor control samples. Molecular biologists from the Moscow State University and the Russian Academy of Sciences have discovered proteins that can suppress the growth of cancerous tumors. The genomes of humans and other multicellular organisms contain multiple groups of genes with special “instructions” that prompt their cells to self-destruct when certain conditions are met. As a rule, these reactions are not triggered by internal cellular processes, but by the contact of cell membranes with molecules emitting specific signals. As a result, the immune system can kill “rebellious” cells that threaten to cause cancerous tumors and purify the organism of old and weak cells. Dr. Mikhail Shulepko the Institute of Biochemistry of the Russian Academy of Sciences, co-author of a new study on the subject stated that special proteins in skin cells of mammals have a similar toxins of the structure snakes and other reptiles. Unlike their toxic “cousins”, which work to block the transmission of nerve impulses, mammalian proteins called SLURP do not act in the nervous system, but in all cells in general and accelerate or slow their growth The discovery of the scientists prompted them to consider whether such proteins could be used to fight cancer as a kind of “stop sign” against the proliferation of cancer cells. They tested this idea by cultivating skin, breast, lung and rectal cells in a laboratory and treating them with large amounts of the SLURP-1 and SLURP-2 type of  proteins. Injecting large amounts of SLURP-1 and SLURP-2 proteins into the cell broth also caused the cancer cells to produce even more of these same molecules, causing a chain reaction and destroying the cancer cells themselves. “We will continue to investigate how SLURP  works in other models of cancer, including cell cultures of primary tumors and human tumors implanted in the bodies of laboratory animals. If these effects are confirmed, it will be possible to view clinical trials for our protein, “he said. Shulepko. According to biologists, more work is needed to determine how exactly these proteins cause cancer cells to self-destruct and what role they play in the body’s work.