Ampiclox: Uses, Side Effects, Mechanism, Dosage & 8 FAQs

Ampiclox is the combination of two active ingredients, such as Ampicillin and Cloxacillin.

Ampiclox belongs to a group of drugs known as Penicillin antibiotics and is used to treat various bacterial infections.

SmithKline Beecham Pharmaceutical manufactures it.

Ampiclox is a combination of penicillin antibiotics, commonly prescribed to provide a broader spectrum of activity, especially against penicillin-resistant infections.

It is available in oral tablets and capsules, injectable, syrup, and neonatal drops.

  • Ampiclox 500 (capsules)
  • Ampiclox 500 I (injection)
  • Ampiclox S (syrup)
  • Ampiclox D (neonatal drops)
  • Ampiclox 75 I (neonatal injection)

Ampiclox uses

It is used in the treatment of a wide range of bacterial infections caused by susceptible organisms, including:

  • Upper and lower respiratory tract infections,
  • Urinary tract infection
  • Middle ear infections,
  • Gastrointestinal infections
  • Bone and joint infection
  • It can be used in skin and soft-tissue infections such as boils or infections due to spider bites.
  • Endocarditis – Inflammation of the lining of the heart and its valves.
  • Impetigo – a bacterial skin infection characterized by small pus-filled blisters.

How Ampiclox Work?

Ampicillin exerts its effect by inhibiting the synthesis of the bacterial cell wall.

Cloxacillin inhibits the third and final stage of bacterial cell wall synthesis. Cell lysis is then mediated by the bacterial cell wall’s autolytic enzymes, such as autolysins; Cloxacillin may interfere with an autolysin inhibitor.

Ampiclox Side Effects

Common side effects include,

  • Minor stomach upsets.
  • Blotchy skin rash.
  • Nausea.
  • Inflammation of blood vessels.
  • Pink or dark urine.
  • Gastrointestinal discomfort.
  • Vomiting.
  • Diarrhea.
  • Allergic reaction.
  • Hypersensitivity reactions.
  • Anemia.
  • Thrombocytopenia
  • Gas.
  • Blood in stool.
  • Swelling of the mouth and tongue,
  • Itching.
  • Breathing difficulties.
  • Joint pain.
  • Enlargement of the lymph nodes.
  • Hives and itchiness in private parts.


  • Avoid taking this drug if you are allergic to Penicillin or any other component of this medicine.
  • Ampiclox is not suitable for infants.
  • Should not use Ampiclox for a prolonged time.
  • Avoid taking this medication. If you have Kidney or Liver ailments, this medicine dosage should be lower.
  • Contraindicated in glandular fever
  • Not suitable if you have leukemia
  • Do not take If you are on Sodium restrictive diet.
  • Avoid taking this medication in case of diabetes, arthritis, psoriasis, and cancer patients.
  • Use with caution If you have Gout and taking allopurinol and probenecid.

Ampiclox in Pregnancy:

It is FDA category B drugs. No risk in other studies. Please consult with your doctor for case-specific recommendations.



  • The usual dose for adults for susceptible infections one capsule four times a day.
  • For severe infections, the dose can be increased up to 12 capsules per day.
  • The usual childhood dose for susceptible infection is one dose four times a day. The upper dose contains 125 mg of ampicillin and 125 mg of cloxacillin.
  • The usual dose in adults for skin and soft tissue infections Osteomyelitis and other bone infections. In acute osteomyelitis, parenteral therapy for the first three weeks for another three weeks in chronic osteomyelitis, parenteral therapy for one or two months, followed by oral therapy in the episode.


  • The usual dose for adults for septicemia, meningitis, endocarditis caused by sensitive organisms 500mg (ampicillin 250 mg and cloxacillin 250 mg) in ten ml or 1 g (ampicillin 500 mg and 500 mg) cloxacillin in 20 ml of water for injections. Given slowly for three or four minutes, repeated every six hours.
  • Doses of more than 500 mg should be administered in two different locations of no more than 500 mg in 3 ml.
  • The doctor can suggest the dose depending on your medical history and other medical conditions, physical health, and current medications. The dosage also depends on the patient’s response.

Also, Read

Frequently Asked Questions (FAQs)

1. What Ampiclox is used for?

Ampiclox is the combination of two active ingredients, such as Ampicillin and Cloxacillin. It is used in different bacterial infections such as upper and lower respiratory infections, urinary tract infections, ear infections, skin, soft tissue infections, etc. Check above for more.

2. What are the side effects of Ampiclox?

Common side effects include,

  • Minor stomach upsets.
  • Nausea.
  • Vomiting.
  • Diarrhea.
  • Blotchy skin rash.
  • Inflammation of blood vessels.
  • Pink or dark urine.
  • Gastrointestinal discomfort.

This is not a complete list of side effects. Check above for more.

3. Can Ampiclox treat urinary tract infection?

One of the reported indications of this medicine is urinary tract infection. However, It’s advised to consult your physician before using this drug.

4. How to Take It?

It is used 1 hour before food. The oral absorption of Ampiclox may get decreased due to the presence of food in the stomach. Use Ampiclox Capsule as per the instructions provided by your doctor.

5Can Ampiclox be used during pregnancy or breastfeeding?

Ampiclox contains Ampicillin and cloxacillin. Both of these drugs are classified as category B drugs By FDA. This mean’s that there are no controlled data on human pregnancies. It should only be given during pregnancy when the need has been established.

6. What happens if I overdose on Ampiclox?

If you believe that you have taken more than the prescribed amount of this drug, talk to a doctor immediately. Taking more than the prescribed amount can cause serious side effects.

7. what happens if I take expired Ampiclox?

Taking a single dose of expired, this drug is unlikely to cause any side effects. However, talk to your doctor or pharmacist if you are not feeling well or ill. An expired drug may become ineffective in the treatment of your prescribed conditions. For safety reasons, it is essential not to use an expired drug. You are much safer if you always stock up on unexpired medicines.

8. How to store Ampiclox?

Store this medicine at a temperature not exceeding 25 ° C (77 ° F). The suspension must be used within seven days of delivery. Oral drops for neonates should be stored in the refrigerator, not frozen, and protected within five days of delivery and protected from moisture. Keep this medicine away from children.

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3 thoughts on “Ampiclox: Uses, Side Effects, Mechanism, Dosage & 8 FAQs”


    Thnkx for educating me.. Am already know that the cloxazilin inhibit the third and final stage of bacteria cell wall synthesisi.. please help m to know what the role of ampicillin in ampicloxin

  2. Gloria bakare

    Can u take amplico without food?

  3. Faith adeyanju

    Can I treat P I D with ampiclox

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