Antianginal drugs

Angina Pectoris 

Angina pectoris is a disease that often occurs due to deposition of lipids material inside the coronary arteries. This causes narrowing of the coronary arteries and the patient feels Throbbing pain in the chest during exertion because narrowed arteries cannot cope with Increased demand of blood supply by the heart during physical exertion or mental stress.

There are three main type of angina ;

1. Angina Of Effort

This type of angina in which chest pain occurs during physical or mental stress is known as angina of effort.

2. Variant Angina

Another less common type of angina occurs at rest due to spasm of the coronary arteries.This is known as variant angina or prinzmetal angina.

3. Unstable angina.

A third Type of angina in is known as unstable angina in this type the disease is severe and patient feel pain in the chest even with a slight degree of exertion.This is s serious condition and if not treated can lead to myocardial infarction.Thus angina pectoris can be of the following three type;

 

Classification Of Drugs

Drugs Used in treatment and prevention  Of angina can be classified into three main groups;

  1. Organic Nitrates and Nitrites
  • Nitroglycerin
  • Isosorbide Dinitrate
  • Isosorbide mononitrate
  • Amyl nitrite.

     2. Calcium Channel Blockers

These can be further  divided into two groups;

  1. Dihydropyridines
  • Amlodipine
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrendipine

    2. Miscellaneous Drugs

  • Verapamil
  • Diltiazem
  • Bepridil

   3. Beta-Adrenoceptor Blockers

These can be further subdivided into two groups;

  1. Beta 1 and Beta2 Antagonist
  • Propranolol
  • Penbutolol
  • Pindolol
  • Satolo
  • Timolol
  1. Beta 1 Selective Blockers
  • Metoprolol
  • Atenolol
  • Esmolol
  • Acebutolol
  • Betaxolol

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1 comment

  1. May I please know more about their pharmacodynamics , pharmacodynamics,contraindications, mode of action, and side effects
    Thanks

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