Classification Of Antianginal Drugs

Angina Pectoris 

Angina pectoris is a disease that often occurs due to deposition of lipids material inside the coronary arteries. This causes narrowing of the coronary arteries and the patient feels Throbbing pain in the chest during exertion because narrowed arteries cannot cope with Increased demand of blood supply by the heart during physical exertion or mental stress.

There are three main type of angina ;

1. Angina Of Effort

This type of angina in which chest pain occurs during physical or mental stress is known as angina of effort.

2. Variant Angina

Another less common type of angina occurs at rest due to spasm of the coronary arteries.This is known as variant angina or prinzmetal angina.

3. Unstable angina.

A third Type of angina in is known as unstable angina in this type the disease is severe and patient feel pain in the chest even with a slight degree of exertion.This is s serious condition and if not treated can lead to myocardial infarction.Thus angina pectoris can be of the following three type;

Classification Of Drugs

Drugs Used in treatment and prevention  Of angina can be classified into three main groups;

1. Organic Nitrates and Nitrites

• Nitroglycerin
• Isosorbide Dinitrate
• Isosorbide mononitrate
• Amyl nitrite.

     2. Calcium Channel Blockers

These can be further  divided into two groups;

1. Dihydropyridines

• Amlodipine
• Nicardipine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrendipine

    2. Miscellaneous Drugs

• Verapamil
• Diltiazem
• Bepridil

   3. Beta-Adrenoceptor Blockers

These can be further subdivided into two groups;

1. Beta 1 and Beta2 Antagonist

• Propranolol
• Penbutolol
• Pindolol
• Satolo
• Timolol

2. Beta 1 Selective Blockers

• Metoprolol
• Atenolol
• Esmolol
• Acebutolol
• Betaxolol

In case you’ve got stable angina (the most frequent kind ), you’re going to be given medication to consider when you experience an angina attack.

You might even use glyceryl trinitrate  (GTN) to prevent an assault prior to doing something such as exercise. You could have a headache, itching or flushing soon after using it.

Glyceryl trinitrate pills usually expire about 8 weeks following the package is started, at which point you will want to substitute them. GTN spray lasts considerably longer, so can be more suitable.

To help avert more strikes, you will also must take at least 1 other medication daily for the rest of your life. Some people will need to take two or more medications.

If you can not have either of these medications, you could be given another medication like ivabradine, nicorandil or ranolazine.

Angina is a warning sign that you are in a greater risk of severe problems such as heart attacks or strokes.

You might also have to take additional medicines to decrease this threat.

These include:low-dose aspirin to stop blood clots and statins to Lower Your cholesterol (blood glucose ) amount while ACE inhibitors to Lower Your blood pressure
Surgery

Surgery may be recommended when medications are not helping control your angina.

Both these operations are likewise powerful. The very best one for you depends upon your own circumstances. If surgery is recommended, speak with your physician or doctor about your alternatives.

You are probably going to have to keep on taking some medications after operation.

In case you’ve got unstable angina (where symptoms grow unpredictably), then you will need medicines to reduce blood clots and lower your chance of experiencing a heart attack or stroke.

Surgery (either CABG or PCI) might be recommended if you’ve got a high risk of getting a different angina attack, or else you are at a higher risk of experiencing a heart attack or stroke.