Plexaderm Review: Does It Work In 2024? [Pharmacist’s Guide]

In this buyer’s, we’ll take a closer look at this serum to see;

  • What’s unique about this product?
  • What are its pros and cons?
  • What are Plexaderm ingredients?
  • Is It safe to use—Plexaderm side effects?
  • What do other people think about it—Plexaderm reviews? and
  • Whether it’s worth buying or not?

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Updated: 23/4/2024


Out Of 100

We score different supplements based on objective testing data. Our scoring factors are weighted based on the effectiveness. transparency of the ingredients, formulation, customer satisfaction, convenience and Value for money. Here is how we test each supplement we review.

Overall Score

Effectiveness 75%
Transparency Ingredients 85%
Formulation 78%
Customer Satisfiction 71%
Convenient 78%
Value For Money 69%

Efficacy (75%): Our tester, Amanda, found Plexaderm effective in reducing under-eye bags and wrinkles. However, it requires practice for optimal application and might not be a perfect solution for everyone.

Transparency of Ingredients (85%): Plexaderm gets a high score for clearly listing all ingredients on the label. This allows users to make informed choices based on their sensitivities.

Formulation (78%): While the formula works, it might not be the most ground-breaking. Other products offer similar results with potentially more effective ingredients at lower costs.

Customer Satisfaction (71%): With a 3.8/5 star rating on Amazon (over 19,000 reviews), Plexaderm receives positive feedback from many users. However, it falls short of an exceptional rating.

Convenience (78%): The application process seems easy and convenient, making it a user-friendly product.

Value for Money (69%): Here’s where things get debatable. At $60 per month’s supply, Plexaderm sits on the expensive side. While customer feedback suggests it might be worth the price for some, others might find comparable products at a lower cost.


Looking to diminish the appearance of wrinkles, crow’s feet, and dark circles? Plexaderm Rapid Reduction serum promises to be your one-stop solution for a youthful eye area. This anti-aging formula boasts quick results, but is it too good to be true?

In this in-depth Plexaderm review, we leave no stone unturned. We meticulously examine the product’s claims, explore its ingredients and application process, and, most importantly, whether it delivers on its promises. We’ll also uncover the current pricing structure, including their “2+1” offer, to help you decide if it aligns with your budget.

So, buckle up as we unveil the truth behind Plexaderm. By the end of this review, you’ll be armed with the knowledge to decide if it’s a worthy addition to your skincare routine.

Plexaderm Review (Quick)

Product Name: Plexaderm Rapid Reduction Eye serum

Plexaderm where to buy?: Official Website & Amazon

Plexaderm cost: $59.95 per bottle

Amazon Rating

6000+ reviews (May change with time)

Our Rating: 6/10


What is Plexaderm Rapid Reduction Serum?

Plexaderm is a topical formula designed to target visible signs of aging around the eyes. It aims to reduce the appearance of wrinkles, crow’s feet, and under-eye bags. While the company claims it can also be used on laugh lines, it’s best to focus on the areas it’s specifically designed for.

After applying a thin layer, you’ll need to keep your face still for 10 minutes while it dries. This allows the formula to work effectively. Makeup can be applied on top, but for best results, let the serum dry completely for another 10 minutes. Remember, the results are temporary and will wash off with water.

Plexaderm is made by True Earth Health, a company offering various skincare and supplement options. While they emphasize natural ingredients, independent verification is recommended. Sheer Science is a US-based company that distributes Plexaderm.

The Better Business Bureau (BBB) can be a helpful resource to assess a company’s reputation. As of April 23, 2024, Plexaderm had 10 complaints filed that were resolved. It’s wise to check the BBB page for more recent information.

Plexaderm’s Claims: Our Thoughts

Let’s look at Plexaderm’s promises and see if they hold water.

Reduced Wrinkles? While Plexaderm claims to diminish wrinkles, it likely offers a temporary tightening effect. This “mask” may conceal wrinkles for a few hours but won’t permanently reduce their appearance. Consider it a short-term fix, similar to makeup, rather than a long-term solution.

Under-Eye Bags? Like the wrinkle claim, Plexaderm might offer temporary relief from under-eye bags. However, its effects are likely superficial and won’t address deeper skin concerns.

Clinically Proven? Transparency is key. Plexaderm links to a clinical study on its website, but independent verification of its effectiveness is crucial. Look for studies published in reputable scientific journals for a more objective assessment.

Money-Back Guarantee: A Safety Net? Plexaderm offers a 100% money-back guarantee, but remember, you’ll shoulder return shipping costs. This can be helpful for trying the product, but consider the potential cost before purchasing.

Our Take: Plexaderm might offer temporary visual improvements, but its long-term effectiveness for wrinkle reduction and under-eye bags remains to be seen. Independent verification of claims and a closer look at the ingredients are recommended before deciding if they align with your skincare goals.

Pros & Cons Of Plexaderm

What do i like about It?

  • The cream can be used on all types of skins. It’s safe and doesn’t cause any major side effects.

  • The ingredients can fill up the wrinkles and disappear lines for several hours.

  • The product works very fast—You will need to apply it before 10 minutes, and it is easy to apply.

  • They also offer a money-back guarantee. You can return all their products within 30 days and get a full refund.

  • Only one ingredient could cause some minor side effects.


What I don't like about It?

  • It is not a permanent solution, and the effects wear offs after some time (effects are temporary).

  • It can’t be used with a moisturizer at the same time.

  • Plexaderm can sometimes irritate your skin and cause allergies.

Plexaderm Ingredients

Plexaderm formulation is completely different from Miami MD cream, and the main ingredients in this formulation are sodium silicate and magnesium-aluminum silicate, derived from shale clay. Plexaderm ingredients are listed below,

  • Magnesium aluminum silicate (purified clay)— It helps absorb oil from oily skin and is also used as a thickening agent. [1]
  • Titanium Dioxide— This is another excellent ingredient in this formulation, and the purpose of this ingredient is to block harmful UV rays.
  • Sodium silicate— Help balance the PH of the product. According to the cosmetics ingredients review (CIR) panel, it is safe to use in cosmetic and other skin-related products.
  • Hydrolyzed Rice protein— It is one of the most commonly used ingredients in skincare products. It works as an absorbing agent, bulking agent, and binder.
  • Acetyl hexapeptide-8—It is a synthetically derived peptide used in a wide range of skincare products and has water-binding properties. It is supposed to have anti-aging effects.
  • Ethylhexylglycerin— It is included in this formulation as a preservative and conditioning agent.
  • Phenoxyethanol— is a preservative and helps fight bacteria.
  • Cellulose gum— This functions as a viscosity agent in Plexaderm. It is also a safe ingredient for cosmetic products, per CIR’s recommendation. [2]

Other ingredients include

  • Yellow 5 (CI 19140),
  • Red 40 (CI 16035).
  • Water (aqua).

Bottom Line: For me, this is not a revolutionary supplement—rather it is a mixture of some commonly used skincare ingredients. Some of the constituents of this product can cause side effects like skin irritation. They should have added some proven ingredients like hyaluronic acid, kojic acid, niacinamide, and Hydroquinone. All of these ingredients are present in Musely cream.

Plexaderm Benefits

Based on the ingredients and some supporting clinical backings, we learn that It can be helpful for the following conditions. 

  • Plexaderm decreases the appearance of under-eye bags.
  • It can also be used for wrinkles around the eyes.
  • You can use it for dark circles.
  • Reduces the appearance of Laugh Lines
  • It can improve the look of fine lines.
  • It can also be used for crow’s feet and forehead lines.

How Does Plexaderm Work?

This product stands out due to its unique blend of ingredients. Each ingredient plays a crucial role in pulling, tightening, and filling in the skin, resulting in a youthful look and a reduction in wrinkles and under-eye bags.

The two main ingredients in this product are sodium silicate and magnesium aluminum silicate.

  • Sodium silicate, one of the key ingredients, acts as an adhesive on your skin. It starts as a liquid or gel, gliding smoothly onto your skin. Once it dries, it forms a thin layer that causes a slight shrinkage or pulling of the skin. This can create a temporary stretching effect when applied to wrinkles and under the eyes, making the skin appear tighter. It’s also believed to lift the skin once it’s scorched.The magnesium aluminum silicate works as a filler, filling the wrinkles and helping them look plumped up and even. Together, they reduce under-eye bags and fix wrinkles and lines. 

It’s important to note that the effects of these ingredients, while impressive, are temporary. They work to draw, tighten, and firm the skin, giving it a more attractive, youthful appearance for a limited time.

What are the side effects of Plexaderm?

It is generally very well tolerated and does not cause serious side effects, although it may lead to less severe side effects.

The silicate in this product is considered safe, and the FDA recognizes it as a safe constituent. Other ingredients like magnesium and aluminum silicate are also safe and effective.

However, as we all know, every skin product has the potential to cause skin-related problems. That’s this cream can also cause the following side effects;

  • It can cause skin irritation because it contains alkaline silicate compounds.
  • One customer complained that the cream leaves a white residue on the skin.
  • Plexaderm rapid reduction cream can also cause redness, skin irritation, and swelling.
  • It may also cause a burning sensation if your skin is allergic.
  • Plexaderm may hurt the eyes, so avoid touching your eyes while using it.

What Other People Think About Plexaderm?

The customer reviews on were impressive, and people were happy with the results.

About 94% of reviewers recommend it for wrinkles on under-eye bags. This product has 4.69 ratings out of 5. The total number of reviews was 1158 at the time of writing this review. (This may change with time.)

The trust score of this product on Trustpilot was terrible, and it only got 1.7/5 stars based on 164 reviews. Many people think it’s complete garbage and a waste of money.

The customer Plexaderm reviews on Amazon are pretty decent. About 55% of people have added a 5-star review. The number of reviews on Amazon when writing this guide was around 1800, and the product has received a 3.4/5 stars rating.

Positive Plexaderm Reviews

  • For some people, it is an excellent product with instant results.
  • For others, it worked well, but the pump was faulty.
  • Some customers think this stuff works great for under-eye bags.
Plexaderm reviews
Plexaderm Reviews (Amazon)

Negative Plexaderm Reviews

Some of the customers were not happy with this skincare product on Amazon.

Although it’s a best seller in eye treatment, 44% of the customers on Amazon don’t recommend it because they think the product doesn’t work as advertised.

  • For some people, it didn’t work as advertised.
  • The product has caused some allergic reactions.
  • For others, the price of this product is very high.

Plexaderm reviews

Only 38% of 5-star reviews have been given to Plexaderm Rapid Reduction Serum. The total number of reviews on Amazon at the time of writing this review was around 912. (This number may change with time.)

So, the Plexaderm rapid reduction reviews from customers are mixed. Amazon’s rating is average or on the good side. Still, if you look at the testimonials on Trustpilot or Better Business Bureau (BBB), you will see more negative feedback. However, every product has negative reviews from customers. But this shouldn’t be considered a negative thing. You must use the product personally to know what works and what doesn’t.

Does Plexaderm Work?

If you look at the customer Plexaderm reviews on Amazon, you will see many unsatisfied customers. However, some people have reported positive results like the smoothness of under-eye bags, which may also soften and enhance your skin.

So, is Plexaderm worth it, and does it work?

As a pharmacist, I think it’s only a temporary solution. The effects are modest and will disappear after some time.

So, the short answer is no.

Let me explain why.

#1→The product is expensive and doesn’t provide long-lasting results. (The results are temporary).

#2→The ingredients present in Plexaderm are not very bad, but there is room for better and proven ingredients like hyaluronic acid, retinol, alpha hydroxy acids (AHAs), and vitamin C.

So, if you have decided to buy a product that can reverse your aging signs, why not go for a full product that can improve your HGH levels, skin tone, and overall health and well-being?

Yes, I am talking about GenF20 Plus. You can read our honest and full review here.

How To Apply Plexaderm?

First, wash your face to remove dirt, makeup, and oils. Then, dry your face before applying Plexaderm rapid reduction cream. This will allow Plexaderm to maximize its efficacy.

After that, you’re now ready to spread the cream. Apply the cream using downward and upward strokes. Applying your fingers to spread the cream on delicate lines, bags of under-eyes, and wrinkles is easy. Avoid direct contact to avoid irritation.

Spread the cream evenly across the area you wish to apply the cream. If you apply it excessively, you’ll see a white residue on the skin. To get rid of this problem, you need to use a moist cloth and gradually remove the accumulated cream.

Then, it would help if you waited between 10 and 15 minutes to observe the outcomes. Don’t let your facial muscles move around as far as you can. Muscle movements may cause delayed results.

If you don’t notice any improvement within 10 to 15 minutes, applying Plexaderm to the same Spot is possible. Make sure to do this only when you need to. In excess, the product could cause your skin to look odd.

Other Products From This Company

Sheer Science is known for many other dermal and cosmetic products, but the Plexaderm Serum is the most popular in this range. Rapid Reduction Serum is their most well-known product, as the introduction mentions. However, this company also manufactures and markets other products. Below are brief descriptions of the brand’s different products.

  • Plex Perfect Daily Moisturizer—This is combined with rapid reduction cream to hydrate and tighten the skin. 
  • Reset and Replenish Pads—These pads clean the facial skin before applying the Plexaderm cream. 
  • Vitamin C Serum—The Triple Action Vitamin C Serum is another product anyone can apply daily. Its main benefit is improving your skin’s smoothness and glow. It is a vitamin C mix and hyaluronic acid. This combination leads to more healthy skin and improves skin elasticity.
  • Dark Spot Fade—This product is not a helping product for the rapid reduction cream but is used alone to reduce dark spots, skin discoloration, and hyperpigmentation. 
  • Hyaluronic Acid Moisturizer—The company also manufactures hyaluronic acid, which retains moisture on your skin. This product is also used in combination with the Plexaderm rapid reduction cream. 
  • Night Collagen Serum—We know that collagen levels diminish with age, resulting in less elasticity for the skin. If so, you should incorporate Night-Time Collagen Serum into your skincare routine. The product will reduce wrinkles and fine lines the appearance of wrinkles, making appearances appear years younger. 

Plexaderm Alternatives 

While Plexaderm might offer temporary benefits, you may be considering other long-term solutions. Here’s a quick comparison of some Plexaderm alternatives based on brand and price:

Murad Renewing Eye Cream$89/pack
Agelyss Restorative Eye Cream$89/pack

Frequently Asked Questions (FAQs)

Plexaderm reviews

  1. Does Plexaderm really work on wrinkles?

After reading the ingredients list, it is clear that this cream will work on wrinkles, but remember that Plexaderm rapid reduction serum only temporarily alleviates wrinkles and skin aging.

  1. How long does Plexaderm last?

It is recommended that you apply this serum to dry and clean skin and leave it for at least 10 minutes to dry. Once you apply the Plexaderm cream, it will last for at least 8-10 hours on your skin. But the question is, how many hours does Plexaderm last?

After applying this cream, you can enjoy a bright, youthful, and wrinkle-free face for over 10 hours. It is most effective when applied to dry, clean skin. It should take at least 8 to 10 minutes for Plexaderm to dry before using any other product over it.

  1. Where To Buy Plexaderm?

The best places to buy this cream are the official site and Amazon. However, it is also available at Walmart and other such online stores.

  • Official website ($59.95/ 1 bottle and $119.90/ 3 bottles)
  • ($64.95/ 1 bottle)

This topical serum is not available at Walmart, Walgreens, and CVS. We always recommend purchasing it on Amazon and the Official site.

The official site also offers a 30-day money-back guarantee, but this offer may only be available for some Amazon users.

  1. What Does Plexaderm Cost? (Plexaderm price)

A one-month supply of this product will cost you 59.95$, while if you want to buy a three-month supply, you will pay 119.90$. (Buy 2, get one Free).

  • Keep in mind that this product doesn’t offer an auto-ship subscription program.
  • They also offer a hassle-free 30-day guarantee. This means you can return your purchase for any reason during this time frame for a full refund, minus the shipping fee.
  • Plexaderm Walmart’s price may differ from that of Amazon and the official website.
  1. How often can you use Plexaderm?

You can use Plexaderm skincare daily or if you are going to a party. Usually, one bottle of Plexaderm will last about four weeks.

  1. What have we learned from this Plexaderm Review?
  • The product is excellent for short-term effects.
  • Mixed customer reviews, but most consumers still need to be satisfied.
  • The product is safe except for skin irritation but has not been clinically proven.
  • It comes with a semi-length return policy of 30 days.

Verdict—Plexaderm Review

If you are looking for a temporary solution, this may reduce your wrinkles and under-eye bags for a short period. (You can say for several hours).

However, if you want a permanent solution, we recommend changing your lifestyle, such as avoiding smoking, stress, and anxiety, which can significantly reduce your skin wrinkles and laugh lines. 

This supplement will help boost your pituitary gland’s release of more human growth hormone, also known as the fountain of youth.

GenF20 Plus suits both men and women who want to enjoy a youthful appearance, lose weight, and reverse other aging effects.

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Plexaderm Rapid Reduction

Plexaderm Rapid Reduction Cream Plus is an advanced antiaging formula specially designed to reduce wrinkles, dark circles, crow's feet, and eye bags around your eyes.

Product Brand: Plexaderm

Product Currency: USD

Product Price: 59.95

Product In-Stock: InStock

Editor's Rating: