Mefenamic Acid: Important Information

Mefenamic Acid Uses

Mefenamic acid (Ponstan) is a Fenamic acid derivatives and is employed in the treatment of pain and inflammation in rheumatoid arthritis and osteoarthritis.Mild to moderate pain,Postoperative pain, menorrhagia (Abnormally heavy periods) and dysmenorrhoea (Painful periods),Pain following surgery, And Pain following childbirth.

It has less anti-inflammatory and more harmful effects as compare to aspirin and that is why it mustn’t be used for more than one week at a time.It is contraindicated in children and disease like inflammatory bowel disease.It is available in Tablets of 250 and 500 mg.

Mechanism Of Action

Ponstan contain the active ingredient Mefenamic acid-Which is a type of drugs known as a non-steroidal anti-inflammatory drug (NSAID). NSAIDs are used to relieve pain and inflammation.Mefenamic acid binds the prostaglandin synthetase receptors Cox-1 and Cox-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a significant mediator of inflammation and/or a job for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.

Side Effects

The most common side effects that occur with Mefenamic acid include: nausea, vomiting, constipation, rash, ringing in your ear (tinnitus), abdomen pain, heartburn, diarrhea, dizziness whereas Serious side effects and their symptoms will include; heart attack or stroke, heart failure, stomach issues, like ulcers or hurt,liver issues, skin reactions, allergic reactions.

Mefenamic Acid in Pregnancy

This drugs isn’t counseled to be used in pregnancy unless considered essential by your doctor. this can be significantly important within the 1st and third trimesters. If taken in the third trimester it should delay labour, increase the length of labour and cause complications in the newborn. Some proof suggests that NSAIDs should even be avoided by women making an attempt to conceive, as they’ll temporarily reduce female fertility throughout treatment and will also increase the danger of miscarriage or malformations. ask for medical recommendation from your doctor.

Dosage Information 

  • Usual Adult Dose for Pain and Dysmenorrhea: starting dose should be 500 mg once daily Then followed by 250 mg 4 times each day or after every six hours.Duration of therapy is typically 7 days for pain and 2-3 days for Dysmenorrhea.
  • Usual pediatric (Age fourteen years or older) dose for Pain and Dysmenorrhea Starting dose should be 500 mg once daily Then followed by 250 mg 4 times each day or after every six hours.Duration of therapy is typically seven days for pain and 2-3 days for Dysmenorrhea.

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