Ondansetron: Important Information

Ondansetron is in a category of medicines known as serotonin 5-HT3 receptor antagonists. Ondansetron is employed to stop nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery.

Chemotherapy, radiation therapy, and surgery will cause a substance known as serotonin (5HT) to be released into the body. This 5HT stimulates the 5HT3 receptors that are found within the brain and gut and causes nerve messages to be sent to the emesis center – a section of the brain that makes you feel sick and controls emesis.It works by obstruction the action of 5-hydroxytryptamine, a natural substance that will cause nausea and vomiting.

The more common side effects of ondansetron will include diarrhea, dizziness, headache, constipation, drowsiness while Serious side effects and their symptoms will include the following: serotonin syndrome. Symptoms will include: hallucinations, sweating, muscle rigidity (stiffness), nausea, diarrhea, agitation, fast heartbeat, feeling hot, tremor, vomiting, coma.


Before you start taking ondansetron it’s vital that your doctor knows: If you have got any issues with the way your liver works, If you’re taking the other medicines. This includes any medicines you are taking that are accessible to buy without a prescription, as well as herbal and complementary medicines If you’re pregnant or breastfeeding If you have got ever had a hypersensitive reaction to drugs If you have been told you have got an irregular heartbeat.

You may need extra doses up to 3 times on a daily basis throughout treatment or for a few days after treatment of cancer.For radiotherapy, a typical adult dose of Zofran is 24 mg daily.For chemotherapy, a typical adult dose of Zofran will vary from 16 to 24 mg daily.For prevention of nausea and emesis after surgery, a typical adult dose of Zofran is 16 mg before surgery.

Ondansetron was never approved to treat nausea and emesis from morning sickness in pregnant ladies. because of No information Available; Avoid pregnancy unless potential advantages outweigh the risk.

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