Dexamethasone, a corticosteroid, is analogous to a natural hormone produced by your adrenal glands. It usually is employed to replace this chemical once your body doesn’t make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is employed to treat certain types of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma attack.dexamethasone is also used to treat certain types of cancer.
Side effects of Dexamethasone:
- The more common side effects that may occur with dexamethasone oral tablets include: emesis, nausea,swelling (edema),dizziness,trouble falling asleep,low potassium levels (causing symptoms like tiredness),high blood pressure, indigestion, headache, mood changes, like depression, mood swings, or personality changes, anxiety, high blood sugar
- Whereas Serious side effects and their symptoms will include the following:Unusual lightheadedness,Unusual tiredness,Blood in your stool, or black stools,uncommon bleeding or bruising,Infection,Severe hypersensitive reaction,more frequent infections (can occur with long-term use),congestive heart failure, uncommon digestive upset, Blood in your pee, uncommon swelling throughout your body, or bloating in your abdomen (stomach area), Changes in mood or thoughts, or mood disorders like depression, Adrenal insufficiency, stomach ulcers, osteoporosis (thinning of the bones)
Mechanism of action of Dexamethasone
- Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to deoxyribonucleic acid elements (glucocorticoid response elements) which ends in a modification of transcription and, hence, protein synthesis so as to attain inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in oedema or scar tissue. The antiinflammatory actions of Dexamethasone Intensol are thought to involve phospholipase A2 inhibitory proteins, lipocortins, that control the synthesis of potent mediators of inflammation like prostaglandins and leukotrienes.
Dexamethasone In Pregnancy
- If taken for long periods or repeatedly throughout pregnancy, corticosteroids have the potential to slow growth within the developing baby. short-run use isn’t associated with this. Steroid medicines taken by the mother might also cause the baby to create less of its own steroid hormones once birth, though this sometimes resolves on its own and barely causes any issues. If your doctor thinks you would like to take dexamethasone throughout your pregnancy, it’s because any risks related to taking the medication are less than the risks of not treating your condition. If you are worried then you ought to discuss this with your doctor, midwife or druggist.The benefits of using dexamethasone during pregnancy will sometimes outweigh any risks.
- The prescribed dose depends on the medical condition.For children: 0.02 to 0.3 mg per kg (2.2 pounds) of body weight each day, spread out throughout the day.For adults: 0.75 to 9 mg each day, adjusted as required.The dose for intravenous and intramuscular injections ranges from 0.5 to 9 mg daily, however can be higher or lower.