Glipizide: Uses, Side effects, Dosage

Glipizide is an oral anti diabetic medicine that helps management blood glucose levels. This medication helps your pancreas manufacture insulin. It is employed along with diet and exercise to treat type 2 diabetes.

Contraindications

  • It is Contraindications In Hypersensitivity to glipizide, alternative sulfonylureas or sulfonamides, Insulin-dependent DM, diabetic ketoacidosis, diabetic coma, Severe renal or hepatic insufficiency, Patients treated with miconazole.Glipizide is an Food and Drug Administration pregnancy class C drug, which suggests damage to an unborn baby is possible.

Glipizide Mechanism 

  • Sulfonylureas possible bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and inflicting depolarisation of the membrane. depolarisation stimulates calcium ion inflow through voltage-sensitive calcium channels, raising intracellular concentrations of Ca+ ions, that induces the secretion, or exocytosis, of insulin.

 

  • It lowers blood glucose by inflicting the pancreas to supply insulin (a natural substance that’s required to break down sugar within the body) and helping the body use insulin efficiently. This medication can only facilitate lower blood glucose in individuals whose bodies manufacture insulin naturally. Glipizide isn’t used to treat type 1 diabetes or diabetic ketoacidosis (a serious condition that may occur if high glucose isn’t treated).

Glipizide Side effects

  • Common side effects could include: diarrhoea, constipation; mild nausea,dizziness, drowsiness; or rash, redness, or itching. Call your doctor directly if you are feeling tired or in need of breath,easy bruising or bleeding (nosebleeds, bleeding gums), fast heart rate; upper stomach pain, itching, loss of craving, dark urine, clay-colored stools,severe nausea and emesis, jaundice;pale skin, fever, confusion; or throbbing headache,fast or pounding heartbeats, feeling such as you may pass out, sweating or thirst.

Glipizide Dose

  • The usual beginning dose once using immediate-release tablets is 5 mg daily administered half-hour before a meal. The maximum dose is 40 mg daily. Doses above 15 mg per day ought to be divided and given in divided doses daily. The beginning dose once using extended-release tablets is 5 mg daily up to a maximum dose of 20 mg daily.
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