Benazepril (Brand Name: Lotensin) is in a class of medicines referred to as angiotensin-converting enzyme (ACE) inhibitors. it’s a prodrug, converted into benazepril at that is the active type of the drug.It works by decreasing certain chemicals that tighten the blood vessels, thus blood flows more smoothly.Benazepril is employed alone or together with different medications to treat high blood pressure, congestive heart failure, and chronic renal failure.
- Benazeprilat, the active metabolite of Benazepril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE leads to reduced plasma angiotensin II. As angiotensin II may be a vasoconstrictive and a negative-feedback mediator for renin activity, lower concentrations lead to a decrease in pressure and stimulation of baroreceptor reflex mechanisms, that results in decreased vasopressor activity and to reduced aldosterone secretion. Benazeprilat may additionally act on kininase II, an enzyme similar to ACE that degrades the vasodilative bradykinin.
Benazepril Side effects
- Some of the more common side effects which will occur with use of this drug include a headache, sleepiness, cough, lightheadedness that happens once changing positions whereas Serious side effects and their symptoms will include the following: Angioedema, skin rash (Stevens-Johnson syndrome), Infection. Such as a pharyngitis, fever, mental health problems. like trouble sleeping, anxiety. Nausea and emesis that happens with pain within the abdomen (stomach area), erectile dysfunction (impotence), Lower sexual desire (sex drive) than normal.
Benazepril in pregnancy
- It Is Food and Drug Administration category “D” Drug and will not be given to Pregnant Women’s. If Your healthcare provider justifies the advantages of the drug against the potential damages he/she should assess them and consult the reference material and previous studies.
- The usual starting dose of benazepril is 10 mg daily. If patients are taking a diuretic drug (water pill) the beginning dose is 5 mg daily. Doses could also be raised to 20-40 mg once daily or divided and administered twice daily.