Glimepiride:Uses, Side Effects, Dosage

Glimepiride is an oral diabetes medication that helps to control blood sugar levels. This medication helps your body to respond better to the insulin of your pancreas.


Glimepiride is used in conjunction with diet and exercise for the treatment of type 2 diabetes, insulin or other diabetes medications are sometimes used in combination with glimepiride when needed.

Mechanism of action

Glimepiride helps to reduce the amount of glucose in the blood by stimulating the release of insulin from the pancreas into the blood and promoting the use of sugar in the blood by the cells that need it.

Side effects

The most common side effects with glimepiride include:

  • Low blood sugar (hypoglycemia).
  • a headache
  • Nausea
  • Dizziness
  • Weakness
  • Unexplained weight gain

Serious side effects may include:

  • Severe hypoglycemia (less than 35-40 mg / dl).
  • Hypersensitivity reactions (allergic). This medicine can cause various types of allergic reactions,
  • Liver damage.
  • a low number of blood cells or platelets.
  • low sodium levels (hyponatremia) and inappropriate syndrome of secretion of the antidiuretic hormone (SIADH). In SIADH, your body can not get rid of excess water by urinating. This leads to sodium concentrations in the blood (hyponatremia) that are dangerous.

Glimepiride during pregnancy:

Glimepiride is in category C. There are no well-controlled studies in pregnant women. It should be used during pregnancy only if the potential benefit outweighs the potential risk to the unborn child. Tell your doctor if you are pregnant or planning to become pregnant.

Dosage for Glimepiride

As with other medicines used to treat diabetes, the dose of glimepiride is individualized using periodic blood glucose measurements to determine the best dose. The usual starting dose is 1 or 2 mg orally once a day with breakfast or the first main meal of the day. The dose may be increased from 1 to 2 mg in 1 to 2 weeks, up to a maximum of 8 mg, depending on the glycemic response and once daily.

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