Gemfibrozil: Important Information

Gemfibrozil is a lipid regulating drug And was approved in Sept 1993.It helps cut back cholesterol and triglycerides (fatty acids) in the blood. High levels of those kinds of fat in the blood are related to an exaggerated risk of atherosclerosis (clogged arteries).It lowers very high levels of “bad cholesterol” (low-density lipoprotein, or LDL) and fatty acids (triglycerides) in the blood.It is employed to treat very high cholesterol and triglyceride levels in individuals with pancreatitis.Gemfibrozil is additionally used to lower the chance of stroke, heart attack, or different heart complications in individuals with high cholesterol and triglycerides who haven’t been helped by different treatment strategies.

  • It will increase the activity of lipoprotein lipase enzyme, causing a raised formation of free fatty acids and glycerine from the triglycerides of VLDL, thus, decreasing the concentration of VLDL in the blood. It probably also decreases the formation of VLDL in the liver.
  • The more common side effects that may occur with use of gemfibrozil include stomach pain, nausea, constipation, dizziness, changes in the way things taste, indigestion, diarrhea, vomiting, rash, headache, muscle pain while Serious side effects and their symptoms will include; Gallstones, Rhabdomyolysis (muscle toxicity).
  • Avoid gemfibrozil if you’re allergic to that if you have: severe renal disorder, severe liver disease, gallbladder disease; or if you’re additionally taking repaglinide or simvastatin (Zocor, Vytorin, Juvisync, Simcor).Also Avoid intense foods that are high in fat or cholesterol whereas taking gemfibrozil, or the medication won’t be as effective at lowering cholesterol.
  • The result of this drug in pregnant women has not been well-studied. gemfibrozil ought to be used during pregnancy only if the potential profit justifies the unknown but potential risk to the fetus.It is not best-known whether or not gemfibrozil is excreted in human milk.
  • The suggested dose for adults is 1200 mg administered in 2 divided doses half-hour before the morning and evening meal.

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