Quetiapine: Important Information

Quetiapine belongs to a class of drugs known as atypical antipsychotics.It is a cheap drug Indicated for the treatment of the schizophrenic disorder and bipolar disorder also called manic-depression.The Food and Drug Administration (FDA) approved quetiapine in 1997.

Mechanism of action

  • Quetiapine’s antipsychotic activity is likely as a result of a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal area. Antagonism at D2 receptors relieves positive symptoms whereas antagonism at 5HT2A receptors relieves negative symptoms of the schizophrenic disorder.

Side Effects 

  • The more common side effects will include: dry mouth, pain in the abdomen (stomach area)
    dizziness, nausea, constipation, vomiting, weight gain, raised appetite, A pharyngitis, fast heartbeat, weakness, increased appetence, tiredness, stuffy nose, trouble moving while Serious side effects and their symptoms will include the following: self-destructive thoughts or actions, neuroleptic malignant syndrome, hyperglycaemia (high blood sugar), inflated cholesterol and triglycerides (high-fat levels in your blood), Weight gain, tardive dyskinesia, postural hypotension (decreased blood pressure once rising too quickly when sitting or lying down), Low white blood cell count, Cataracts, Abnormal thyroid levels (shown in tests your doctor can do), will increase in blood prolactin levels, Risk of death from stroke in seniors with dementia.


  • It is a Food and Drug Administration class “C” medicine this means that there’s restricted human information available whereas animal information suggests Risk.Extrapyramidal side effects and withdrawal syndrome are reported occasionally within the neonate once taken throughout the third trimester of pregnancy.Use on condition that Potential benefit Outweighs risk.


  • The usual recommended adult dose for schizophrenic disorder might vary from 150 to 750 milligrams (mg) every day.A typical adult dose for bipolar disorder might vary from 400 to 800 mg every day.Usual Dose In Geriatric For The treatment of Schizophrenia is 150 to 750 mg orally per day in divided doses And For bipolar disorder is 400 to 800 mg orally per day in divided doses.While Usual Geriatric dose for depression is 150 mg to 300 mg orally once every day.

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