Clopidogrel (Plavix): Uses, Side Effects, Dosage

Clopidogrel is an antiplatelet drug.(Brand name is Plavix Generic is Clopidogrel).

Uses of Plavix:

  • It reduces your risk of getting blood clots by affecting cells in your blood known as platelets.

It is used to stop heart attacks, prevent strokes,

  • Also Used after a heart treatment to protect the arteries.
  • Additionally used to lower the number of heart attacks in patients who have unstable angina or mild heart attacks.

Flavix (Clopidogrel) Side Effects 

  • The more common side effects which will occur with clopidogrel include:
  • Bleeding and itchy skin
  • whereas Serious side effects and their symptoms can include the following: Serious, severe bleeding.
  • In Urine, Red Or Black stools,
  • Coughing Up Blood Or Blood Clots,
  • Vomiting Blood and Unexplained bleeding that lasts a long time And Blood-clotting problem referred to as thrombotic thrombocytopenic purpura (TTP).

Do not stop taking clopidogrel without calling the doctor who Prescribed it for you.Be careful and avoid injury.You may bleed more easily.Use a soft toothbrush and an electric razor.Very dangerous and typically deadly bleeding problems have happened with this drugs.

  • Don’t Take Plavix If you have had a hypersensitivity to any medication before, Have a stomach ulceration, or have had stomach ulcers in the past,have had bleeding on your brain (brain haemorrhage),have haemophilia or another bleeding disorder, have a liver or kidney downside, And are pregnant or breastfeeding.

Mechanism Of Action Of Plavix

  • The active substance of clopidogrel prevents binding of adenosine diphosphate (ADP) to its blood platelet receptor, impairing the ADP-mediated activation of the conjugated protein GPIIb/IIIa complex. it’s proposed that the inhibition involves a defect within the mobilization from the storage sites of the blood platelet granules to the outer membrane. The drug specifically and irreversibly inhibits the P2Y12 subtype of ADP receptor, that is vital in aggregation of platelets and cross-linking by the protein fibrin. No direct interference happens with the GPIIb/IIIa receptor. because the conjugated protein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to blood platelets and inhibits platelet aggregation. By block, the amplification of blood platelet activation by discharged ADP, blood platelet aggregation evoked by agonists apart from ADP is additionally inhibited by the active matter of clopidogrel.

Plavix Dosage 

  • The suggested dose for treating unstable angina or heart failure is 300 mg at first followed by 75 mg daily together with 75-325 mg of aspirin. Peripheral arterial illness or recent stroke and is treated with 75 mg daily.Clopidogrel (Plavix) typically is taken once daily. It is taken with or without food. Clopidogrel is activated by enzymes in the liver to its active type. people who have reduced activity of liver enzymes that activate clopidogrel due to liver disease may not adequately respond to clopidogrel. various treatments ought to be used for these patients.

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