Combiflam Tablet is a combination of two pain killer ingredients, such as Ibuprofen and Paracetamol (Acetaminophen).
- Ibuprofen belongs to a group of drugs known as a nonsteroidal anti-inflammatory drug (NSAID).
- Acetaminophen or Paracetamol belongs to analgesics (pain relievers) and antipyretics (fever reducers).
They both work together to reduce your pain, inflammation, and fever. It may be used for headache, fever, muscle pain, and menstrual cramps.
TO reduce the side effects you will need to take it with food and the dose of this medicine depends on the severity of the condition. Your doctor and pharmacist will adjust the dose.
Combiflam Tablet should be used with caution in people with liver diseases and it may cause bleeding so use it with caution.
Combiflam Tablet Composition
It is composed of the following active ingredients (salts)
These two ingredients work together to stop hormones that are responsible for pain and inflammation. That’s why this tablet is mostly prescribed for pain associated with arthritis, headache, back pain, and menstrual pain. Read more below.
A study confirmed that these two drugs combination don’t cause any serious adverse effects and are safe and effective in treating pain and fever in children.
Please keep in mind that this medicine is not an over-the-counter medication, and you will need a doctor’s prescription. Also, it is worth noting that it is contraindicated in children age less than 6 months.
The usual recommended dose is 1 tablet three times a day or as prescribed by your GP.
Combiflam Tablet Uses
This tablet is beneficial for pain, which requires stronger analgesia than ibuprofen or paracetamol alone.
Combiflam is used for the treatment and prevention of the following diseases, conditions, and symptoms:
- Ear pain
- Pain in teeth
- Back pain
- Joints pain
- Muscles pain
- Pain in nerves
- Pain in body
- Menstruation pain
- Joint pain
Ibuprofen and Paracetamol are the active ingredients present in Combiflam tablets.
⇒ Ibuprofen is a nonselective inhibitor of an enzyme called cyclooxygenase (COX), which is required to synthesize prostaglandins via the arachidonic acid pathway. COX is needed to convert arachidonic acid into prostaglandin H2 (PGH2) in the body. This PGH2 is then converted to prostaglandins. The inhibition of COX by ibuprofen, therefore, reduces the number of prostaglandins produced by the body.
⇒ Paracetamol selectively inhibits COX activity in the brain, contributing to its ability to treat fever and pain. This activity does not seem to be a direct inhibition when an active site is blocked, but it reduces COX that needs to be oxidized to function.
The combination of ibuprofen and paracetamol blocks the production of these chemicals in the body, causing pain, fever, swelling, and inflammation.
Consult your doctor before using this drug if:
- You are allergic to ibuprofen or paracetamol, or any other medication.
- You have a stomach ulcer
- You have asthma
- You have a bleeding disorder
- you are taking blood-thinning medication
- you are taking other medication.
This medication is contraindicated in the following conditions:
- Gastrointestinal bleeding
- Active peptic ulcer
- Hepatic impairment
Combiflam in Pregnancy & Breast Feeding
Combiflam Tablet may be unsafe during pregnancy. Studies in animals have shown adverse effects on the fetus, but there are limited human studies. The benefits of using it in pregnant women may be acceptable despite the risk. Please consult your doctor.
Combiflam is safe to use in breastfeeding. However, you should discuss the use with your doctor.
Interaction with Other drugs
Combiflam Tablet may interact with the following drugs and products. Consult your GP before using Combiflam with the following drugs.
- Blood pressure-lowering medicine
- Warfarin (Risk of Bleeding)
- Reduced effect of asthma medications.
- Interfere with certain laboratory tests
- Juxtapid mipomersen
- Concurrent administration with digoxin may increase the risk of heart failure.
- Lithium drugs
- Other NSAIDs
Note: This is not a complete list of interactions.
Combiflam Tablet Side Effects
The following list contains possible side effects that you may experience when using Combiflam Tablet. This is not a complete list. These side effects are possible but do not always occur. Some of the side effects can be rare but serious. Consult your doctor if you notice any of the following, especially if they do not disappear.
In addition to the necessary effects, some unwanted effects can be caused by paracetamol. If any of these side effects occur, they may need medical help.
⇒ Common side effects
- Heart Burn
- Abdominal pain
According to a study published in The British Pharmacological Society, Paracetamol’s long-term use can increase the risk of gastrointestinal bleeding and a small (~4 mmHg) increase in systolic blood pressure.
⇒ Rare side effects
- Bloody or black, tarry stools
- Bloody or cloudy urine
- Fever with or without chills
- Pain in the lower back
- Red spots on the skin
- Skin rash, hives, or itching sore throat
- Sores, ulcers, or white spots on the lips or in the mouth
- A sudden decrease in the amount of urine
- Unusual bleeding or bruising
- Unusual tiredness or weakness
- Yellow eyes or skin
Combiflam Tablet Dosage
The dose of Combiflam depends on the severity of the disease and the patient’s medical history. When the condition is severe, the prescribed dosage is usually high. It is also advisable never to exceed the dosage without medical advice, as this can be very dangerous.
If you miss a dose of Combiflam, you should take medicine as soon as you remember. However, if the missed dose time overlaps with the next dose; It is advisable to skip the missed dose and continue with the usual program. If an overdose occurs, consult a doctor as soon as possible.
- Combiflam is usually used every 6 to 8 hours, as needed, for pain or as directed by your doctor.
- Take the drug with a meal or snack to prevent an upset stomach.
- It is recommended to take it as prescribed by your doctor. Don’t crush the tablet and swallow it with water.
Apart from Tablet, it comes in three other forms as well;
- Combiflam Tablet (Ibuprofen 400 mg and Paracetamol 325 mg)
- Combiflam Suspension (Ibuprofen 100 mg + Paracetamol 162.5 mg)
- Combiflam gel and spray (Diclofenac based topical pain reliever)
- Combiflam Plus (Paracetamol 650 mg + Caffeine 50 mg)
Frequently Asked Questions
1. Is it safe to use Combiflam Tablet in Pregnancy?
This medicine may be unsafe during pregnancy. Studies in animals have shown adverse effects on the fetus, but there are limited human studies. The benefits of using it in pregnant women may be acceptable despite the risk. Please consult your doctor
2. Is Combiflam Tablet safe While breastfeeding?
It is safe for use. However, you should discuss the use with your doctor.
3. Should I take Combiflam before breakfast or after meals?
It should be used daily as directed by your doctor. It is usually used after meals to prevent stomach upset.
4. Can I stop using Combiflam immediately, or should I stop using it?
Some medications can not be stopped immediately due to rebound effects. It contains paracetamol and ibuprofen, which can be stopped immediately. Ask your doctor for recommendations about your body, your health, and other medications.
5. Is it an addictive habit forming?
No, it is not addictive.
6. What happens if you overdose on Combiflam?
It should not be administered at more than the prescribed dose. Taking a larger dose will not improve your symptoms sooner. Instead, it can cause serious side effects like liver cirrhosis. In case of overdose, consult your doctor immediately.
7. What happens if I have been using Expired Combiflam?
Always check the expiration of medications and never use them. The medication may not work as well as it can affect its effectiveness. Please inform your doctor.
8. What happens if I miss a dose of Combiflam?
The missed dose should be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for the next dose.
9. How to store Combiflam?
The tablet must be kept away from light and heat. The recommended storage temperature is 25 °C.
10. Is Combiflam a painkiller?
It contains two active ingredients like Paracetamol and Ibuprofen. Paracetamol is an analgesic, while ibuprofen is a nonsteroidal anti-inflammatory drug. This drug can be used for pain like headaches, menstrual cramps, and fever.
11. Can we use Combiflam for the headache?
Yes, This drug can be used for headaches.
12. What are the side effects of Combiflam?
Common side effects include Heart Burn, Indigestion, Nausea, Constipation, Abdominal pain, and Gas. Check above for more.
Q. 13 Does Combiflam reduce pain?
One of the ingredients is Ibuprofen, which is used to reduce muscle pain, headache, etc.
Q. 14 Is it safe to use with alcohol?
The concurrent use of this medicine with alcohol is strictly prohibited because of the increased risk of serious adverse effects such as severe gastrointestinal (GI) bleeding, fatigue, weakness, dizziness, rashes, nausea, fever, joint pain, etc.
- Ibuprofen [Internet]. [Cited January 2019]. Available from: https://www.drugs.com/ibuprofen.html
- Long-term adverse effects of paracetamol – a review. [Internet]. [Cited January 2019]. Available From: https://www.ncbi.nlm.nih.gov/pubmed/29863746