Combiflam: Uses, Side Effects, Mechanism,Dosage

Combiflam Tablet is the combination of two active ingredients such as Ibuprofen and Paracetamol.

  • Ibuprofen belongs to a group of drugs known as a nonsteroidal anti-inflammatory drug (NSAID).
  • Acetaminophen or Paracetamol belongs to a class of drugs called analgesics (pain relievers) and antipyretics (fever reducers).

It may be used for headache, fever, muscle pain, and menstrual cramps.

Combiflam Tablet is manufactured by Sanofi Aventis.
Combiflam Tablet is composed of the following active ingredients (salts)

Combiflam Tablet Uses

Combiflam Tablet is especially suitable for pain which requires stronger analgesia than ibuprofen or paracetamol alone.

Combiflam is used for the treatment and prevention, of the following diseases, conditions, and symptoms:

  • Headache
  • Febrility
  • Cold
  • Flu
  • Fever
  • Ear pain
  • Cephalalgia
  • Pain in teeth
  • Analgesic
  • Back pain
  • Joints pain
  • Muscles pain
  • Pain in nerves
  • Pain in body
  • Menstruation pain
  • Periods pain
  • Toothache
  • Joint pain

Combiflam Mechanism

Combiflam is the combination of two active ingredients such as ibuprofen and paracetamol.

Ibuprofen is a nonselective inhibitor of an enzyme called cyclooxygenase (COX), which is required for the synthesis of prostaglandins via the arachidonic acid pathway. COX is needed to convert arachidonic acid into prostaglandin H2 (PGH2) in the body. This PGH2 is then converted to prostaglandins. The inhibition of COX by ibuprofen, therefore, reduces the number of prostaglandins produced by the body.

Paracetamol selectively inhibits COX activity in the brain, which may contribute to its ability to treat fever and pain. This activity does not seem to be a direct inhibition when an active site is blocked, but it reduces COX that needs to be oxidized to function. ,

The combination of ibuprofen and paracetamol blocks the production of these chemicals in the body that causes pain, fever, swelling, and inflammation.


Consult your doctor before using this drug if:

  • You are allergic to ibuprofen or paracetamol or any other medication.
  • You have a stomach ulcer
  • You have asthma
  • You have a bleeding disorder
  • you are taking blood-thinning medication
  • you are taking other medication.


This medication is contraindicated in the following conditions:

  • Hypersensitivity
  • Gastrointestinal bleeding
  • Active peptic ulcer
  • Hepatic impairment

Combiflam in Pregnancy:

Combiflam Tablet may be unsafe during pregnancy. Studies in animals have shown adverse effects on the fetus, but there are limited human studies. The benefits of using it in pregnant women may be acceptable despite the risk. Please consult your doctor


Combiflam is safe for use. However, you should discuss the use with your doctor.

Interaction with Other drugs

Combiflam Tablet may interact with the following drugs and products.consult your GP before Using Combiflam with the following drugs.

  • Blood pressure-lowering medicine
  • Alcohol
  • Aspirin
  • Warfarin (Risk of Bleeding)
  • Corticosteroids
  • Cyclosporin
  • Reduced effect of asthma medications.
  • Interfere with certain laboratory tests
  • Juxtapid mipomersen
  • Ketoconazole
  • Concurrent administration with digoxin may increase the risk of heart failure.
  • Leflunomide
  • Lithium drugs
  • Methotrexate
  • Isoniazid
  • Diuretics
  • Other NSAIDs

Note: This is not a complete list of interactions.

Combiflam Side Effects

The following list contains possible side effects that you may experience when using Combiflam Tablet. This is not a complete list. These side effects are possible but not always occur. Some of the side effects can be rare but serious. Consult your doctor if you notice any of the following, especially if they do not disappear.

In addition to the necessary effects, some unwanted effects can be caused by paracetamol. If any of these side effects occur, they may need medical help.

Common side effects

  • Heart Burn
  • Indigestion
  • Nausea
  • Constipation
  • Abdominal pain
  • Gas

According to a study published in The British Pharmacological Society, The long term use of Paracetamol can cause an increased risk of gastrointestinal bleeding and a small (~4 mmHg) increase in systolic blood pressure.

Rare side effects

  • Bloody or black, tarry stools
  • Bloody or cloudy urine
  • Fever with or without chills
  • Pain in the lower back
  • Red spots on the skin
  • Skin rash, hives, or itching sore throat
  • Sores, ulcers, or white spots on the lips or in the mouth
  • A sudden decrease in the amount of urine
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Yellow eyes or skin


The dose of Combiflam depends on the severity of the disease and on the patient’s medical history. When the condition is severe, the prescribed dosage is usually high. In addition, it is advisable never to exceed the dosage without medical advice, as this can be very dangerous. If you miss a dose of Combiflam you should take the medicine as soon as you remember. However, if the missed dose time overlaps with the next dose; It is advisable to skip the missed dose and continue with the usual program. If overdose, consult a doctor as soon as possible.

  • Combiflam is usually given to be used every 6 to 8 hours, as needed, for pain or as directed by your doctor.
  • Take the drug with a meal or snack to prevent an upset stomach.

Apart from Tablet, it comes in three other forms as well;

  • Syrup
  • Gel
  • Pain relief spray.

Frequently Asked Questions

1. Is it safe to use Combiflam Tablet in Pregnancy?

This medicine may be unsafe during pregnancy. Studies in animals have shown adverse effects on the fetus, but there are limited human studies. The benefits of using it in pregnant women may be acceptable despite the risk. Please consult your doctor

2. Is Combiflam Tablet safe While breastfeeding?

It is safe for use. However, you should discuss the use with your doctor.

3. Should I take Combiflam before breakfast or after meals?

It should be used daily as directed by your doctor. It is usually used after meals to prevent stomach upset.

4. Can I stop using Combiflam immediately or should I stop using it?

Some medications can not be stopped immediately due to rebound effects. It contains paracetamol and ibuprofen which can be stopped immediately. Ask your doctor for recommendations about your body, your health, and other medications.

5. Is it addictive habit forming?

No, it is not addictive.

6. What happens if you overdose on Combiflam?

It should not be administered at more than the prescribed dose. Taking a larger dose will not improve your symptoms sooner. instead, it can cause serious side effects like liver cirrhosis. In case of overdose, consult your doctor immediately.

7. What happens if I have been using Expired Combiflam?

Always check the expiration of medications and never use them. The medication may not work as well as it can affect its effectiveness. Please inform your doctor.

8. What happens if I miss a dose of Combiflam? 

The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for the next dose.
9. How to store Combiflam?

The tablet must be kept away from light and heat. The recommended storage temperature is 25 °C.

10. Is Combiflam a painkiller?

It contains two active ingredients like Paracetamol and Ibuprofen. Paracetamol is an analgesic while ibuprofen is a nonsteroidal anti-inflammatory drug. This drug can be used for pain like headaches, menstrual cramps, and fever.

11. Can we use Combiflam for the headache?

Yes,  This drug can be used for headaches.

12. What are the side effects of Combiflam? 

Common side effects include Heart Burn, Indigestion, Nausea, Constipation, Abdominal pain, and Gas. Check above for more.

Q. 13 Does Combiflam reduce pain?

Yes, one of the ingredients is Ibuprofen which is used in reducing muscle pain, headache, etc.


Read More

Leave a Comment