Combiflam Tablet: Uses, Side Effects, Mechanism, Dosage

Combiflam is a brand name for the combination of two pain killer ingredients, such as Ibuprofen and Paracetamol (Acetaminophen). It is mostly used to treat and prevent many different conditions like headache, muscle pain, reduced fever, period pain, toothache, and joint pain.

  • Ibuprofen belongs to a group of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Acetaminophen or Paracetamol belongs to analgesics (pain relievers) and antipyretics (fever reducers).

They both work together to reduce your pain, inflammation, and fever. It may be used for headaches, fever, muscle pain, and menstrual cramps.

Combiflam is a popular brand from Sanofi India and it also comes in gel/spray, suspension, and extra tablet dosage forms.

To reduce the side effects, you will need to take it with food, and the dose of this medicine depends on the severity of the condition. Your doctor and pharmacist will adjust the dose.

Combiflam Tablet should be used with caution in people with liver or kidney diseases, allergies, history of ulcers because it may cause bleeding, so use it with caution. It is also contraindicated in the third trimester of pregnancy, or in children under 12 years of age.

Combiflam Tablet Composition

It is composed of the following active ingredients (salts)

These two ingredients work together to stop hormones that are responsible for pain and inflammation. That’s why this tablet is mostly prescribed for pain associated with arthritis, headache, back pain, and menstrual pain. Read more below.

study confirmed that these two drugs’ combinations don’t cause any serious adverse effects and are safe and effective in treating pain and fever in children.

Please keep in mind that Combiflam is not an over-the-counter medication, and you will need a doctor’s prescription. Also, it is worth noting that it is contraindicated in children aged less than 6 months.

The usual recommended dose of Combiflam is 1 tablet three times a day or as prescribed by your GP.

Combiflam Tablet

  • Product Name: Combiflam Tablet
  • Composition: Ibuprofen 400mg+ Paracetamol 325mg
  • Specially Designed: To reduce pain and fever of any cause.
  • Dosage: After food and 2-3 times a day.
  • Manufactured By: Sanofi India
  • Storage: At room temprature

Combiflam Tablet Uses

This tablet is beneficial for pain, which requires stronger analgesia than Ibuprofen or Paracetamol alone.

Combiflam is used for the treatment and prevention of the following diseases, conditions, and symptoms:

  • Headache
  • Febrility
  • Cold
  • Flu
  • Fever
  • Ear pain
  • Cephalalgia
  • Pain in teeth
  • Analgesic
  • Back pain
  • Joints pain
  • Muscles pain
  • Pain in nerves
  • Pain in body
  • Menstruation pain
  • Toothache
  • Joint pain

Combiflam Mechanism

Ibuprofen and Paracetamol are the active ingredients present in Combiflam tablets.

Our body naturally produces an enzyme called cyclo-oxygenase (COX) that further helps in the production of certain chemicals called prostaglandins which act as a body defense mechanism when there is an injury. Prostaglandin actually causes pain, inflammation, redness, and swelling. So, here is how they both work in combination.

⇒ Ibuprofen is a nonselective inhibitor of an enzyme called cyclooxygenase (COX), which is required to synthesize prostaglandins via the arachidonic acid pathway. COX is needed to convert arachidonic acid into prostaglandin H2 (PGH2) in the body. This PGH2 is then converted to prostaglandins. The inhibition of COX by Ibuprofen, therefore, reduces the number of prostaglandins produced by the body.

⇒ Paracetamol selectively inhibits COX activity in the brain, contributing to its ability to treat fever and pain. This activity does not seem to be a direct inhibition when an active site is blocked, but it reduces COX that must be oxidized to function.

The combination of Ibuprofen and Paracetamol blocks the production of these chemicals in the body—which ultimately reduces the pain, fever, swelling, and inflammation.


As we have already discussed in the above one sentence but here is a look at some of the precautions associated with the use of Combiflam; 

  • You are allergic to Ibuprofen or Paracetamol, or any other medication.
  • You have a stomach ulcer
  • You have asthma
  • You have a bleeding disorder
  • you are taking blood-thinning medication
  • you are taking other medicines.

Please consult your doctor or medical expert before using this drug or any other such medicine. 


This medication is contraindicated in the following conditions:

  • Hypersensitivity
  • Gastrointestinal bleeding
  • Active peptic ulcer
  • Hepatic impairment

Combiflam in Pregnancy & Breast Feeding

Combiflam Tablet may be unsafe during pregnancy. Studies in animals have shown adverse effects on the fetus, but there are limited human studies. The benefits of using it in pregnant women may be acceptable despite the risk. Please consult your doctor.

Combiflam is safe to use in breastfeeding. However, you should discuss its use with your healthcare provider or doctor.

Interaction with Other drugs

Combiflam Tablet may interact with the following drugs and products. Consult your GP before using Combiflam with the following medicines.

  • Blood pressure-lowering medicine
  • Alcohol
  • Aspirin
  • Warfarin (Risk of Bleeding)
  • Corticosteroids
  • Cyclosporin
  • Reduced effect of asthma medications.
  • Interfere with certain laboratory tests
  • Juxtapid mipomersen
  • Ketoconazole
  • Concurrent administration with digoxin may increase the risk of heart failure.
  • Leflunomide
  • Lithium drugs
  • Methotrexate
  • Isoniazid
  • Diuretics
  • Other NSAIDs

Note: This is not a complete list of interactions. It may also interact with other drugs that you are already taking. Please ask your pharmacist if you are already taking any other medicine concurrently. 

Combiflam Tablet Side Effects

The following list contains possible side effects that you may experience when using Combiflam Tablet. These side effects are possible but do not always occur. Some of the side effects can be rare but serious. Consult your doctor if you notice any of the following, especially if they do not disappear.

In addition to the necessary effects, some unwanted effects can be caused by Paracetamol. If any of these side effects occur, they may need medical help.

⇒ Common side effects

  • Heart Burn
  • Indigestion
  • Nausea
  • Constipation
  • Abdominal pain
  • Gas

According to a study published in The British Pharmacological Society, Paracetamol’s long-term use can increase the risk of gastrointestinal bleeding and a small (~4 mmHg) increase in systolic blood pressure.

⇒ Rare side effects

  • Bloody or black, tarry stools
  • Bloody or cloudy urine
  • Fever with or without chills
  • Pain in the lower back
  • Red spots on the skin
  • Skin rash, hives, or itching sore throat
  • Sores, ulcers, or white spots on the lips or in the mouth
  • A sudden decrease in the amount of urine
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Yellow eyes or skin

Combiflam Tablet Dosage

The dose of Combiflam depends on the severity of the disease and the patient’s medical history. When the condition is severe, the prescribed dosage is usually high. It is also advisable never to exceed the dosage without medical advice, as this can be very dangerous.

If you miss a dose of Combiflam, you should take medicine as soon as you remember. However, if the missed dose time overlaps with the next dose, skip the missed dose and continue with the usual program. If an overdose occurs, consult a doctor as soon as possible.

  • Combiflam is usually used every 6 to 8 hours, as needed, for pain, or as directed by your doctor.
  • The manufacturer-recommended dose of Combiflam tablet is 1 tablet three times a day or as directed by your healthcare provider. Your doctor can increase the dose based on your health condition.
  • You will need to take the drug with a meal or snack to prevent an upset stomach.
  • It is recommended to take it as prescribed by your doctor. Don’t crush the tablet and swallow it with water.
  • Please note that this drug is only for a short time because long-term use can cause side effects such as GI problems, including intestinal bleeding.
  • Ask your doctor if you need to use this medicine for more than 3 days in case of fever or pain.

Apart from Tablet, it comes in three other forms as well;

  • Combiflam Tablet (Ibuprofen 400 mg and Paracetamol 325 mg)
  • Combiflam Suspension (Ibuprofen 100 mg + Paracetamol 162.5 mg)
  • Combiflam gel and spray (Diclofenac based topical pain reliever)
  • Combiflam Plus (Paracetamol 650 mg + Caffeine 50 mg)

Frequently Asked Questions

1. Is it safe to use Combiflam Tablet in Pregnancy?

This medicine may be unsafe during pregnancy. Studies in animals have shown adverse effects on the fetus, but there are limited human studies. The benefits of using it in pregnant women may be acceptable despite the risk. Please consult your doctor

2. Is Combiflam tablet safe While breastfeeding?

The manufacturer doesn’t recommend using it in lactating women because it is a combination medicine. One of the ingredients is Ibuprofen, which causes premature closing of a baby’s ductus arteriosus. However, you should discuss the use with your doctor.

3. Should I take Combiflam before breakfast or after meals?

It should be used daily as directed by your doctor. It is usually used after meals to prevent stomach upset.

4. Can I stop using Combiflam immediately, or should I stop using it?

Some medications can not be stopped immediately due to rebound effects. It contains Paracetamol and Ibuprofen, which can be stopped immediately. Ask your doctor for recommendations about your body, your health, and other medications.

5. Is it an addictive habit forming?

No, it is not addictive.

6. What happens if you overdose on Combiflam?

It should not be administered at more than the prescribed dose. Taking a larger dose will not improve your symptoms sooner. Instead, it can cause serious side effects like liver cirrhosis. In case of overdose, consult your doctor immediately.

7. What happens if I have been using Expired Combiflam?

Always check the expiration of medications and never use them. The drug may not work as well as it can affect its effectiveness. Please inform your doctor. In most cases, the expired medicines don’t cause any adverse effects, but they may not work the way they should work.

8. What happens if I miss a dose of Combiflam?

The missed dose should be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for the next dose.

9. How to store Combiflam?

The tablet must be kept away from light and heat. The recommended storage temperature is 25 °C.

10. Is Combiflam a painkiller?

It contains two active ingredients like Paracetamol and Ibuprofen. Paracetamol is an analgesic, while ibuprofen is a nonsteroidal anti-inflammatory drug. This drug can be used for pain like headaches, menstrual cramps, and fever.

11. Can we use Combiflam for headaches?

Yes, This drug can be used for headaches.

12. What are the side effects of Combiflam?

Common side effects include Heart Burn, Indigestion, Nausea, Constipation, Abdominal pain, and Gas. Check above for more.

13 Does Combiflam reduce pain?

One of the ingredients is Ibuprofen, which is used to reduce muscle pain, headache, etc.

14 Is it safe to use with alcohol?

The concurrent use of this medicine with alcohol is strictly prohibited because of the increased risk of serious adverse effects such as severe gastrointestinal (GI) bleeding, fatigue, weakness, dizziness, rashes, nausea, fever, joint pain, etc.

15 Where to buy Combiflam?

This is a popular brand in India, and it is available in most of the well-known pharmacies and drug stores. However, please note that this is a prescription medicine, and you will need a doctor’s prescription to get it from any pharmacy.


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