Ciprofloxacin (Ciproxin): Uses, Side Effects, Dosage
Ciprofloxacin (Brand Name: Ciproxin)belongs to a group of broad-spectrum antimicrobial drugs known as fluoroquinolones.
It is the most active second generation fluoroquinolone against a wide range of bacteria that are susceptible to Gram-negative aerobic rods, especially the Enterobacteriaceae Neisseria.
Ciprofloxacin is effective against Staphylococcus aureus and Staphylococcus epidermidis.It is active against susceptible strains of Staphylococcus aureus and is not effective against Methicillin-Resistant Staphylococcus aureus.
Ciprofloxacin (Ciproxin) has a very good activity against gram-negative bacteria, but enterococci, Streptococcus group A, B, D and streptococcal viridans with moderate susceptibility to ciprofloxacin.
It is also very effective against Mycobacterium tuberculosis and M.Kansasii M.Fortuitum.If used alone is not effective against M. avium infections caused by M. avium infection. They must be combined with other tuberculosis drugs rifampicin and ethambutol.
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Uses of Ciprofloxacin
Ciprofloxacin (Ciproxin) works against a variety of infections, some of which are difficult to treat. Due to its broad spectrum, its oral effectiveness and its good tolerability, it is often used to treat infections, but should not be used for minor infections. or anaerobes are mainly causative. in severe cases, treatment by intravenous infusion may be initiated, then continue with the oral. Ciproxin is used to treat bacterial infections, for example:
Urinary tract infections (UTIs) caused by certain bacteria such as E. coli.
Cervical and urethral gonorrhea due to Neisseria gonorrhoeae
Uncomplicated acute cystitis
Chronic bacterial prostatitis
Pulmonary or respiratory tract infections, for example, tuberculosis, lower respiratory tract infections, and chronic bronchitis) Pneumonia and sepsis caused by Yersinia pestis (Y. pestis).
Infectious diarrhea caused by E. coli, Campylobacter jejuni, and Shigella.
Prophylaxis of infections in neutropenic / cancer patients and other sensitive patients.
Patients with anthrax with fever and low white blood cell count as well as intra-abdominal infections.
It is rapidly absorbed orally, but the diet delays the intake and first-pass metabolism occur. The key feature of ciprofloxacin is high tissue penetration. The concentration in the lungs, sputum, muscles, bones, prostate, and phagocytes exceeds that of the plasma. It is excreted mainly in the urine, both glomerular filtration and tubular secretion. Urinary and biliary concentrations are 10 to 50 times higher than those of plasma.
Mechanism of action Of Ciprofloxacin (Ciproxin)
Ciprofloxacin ( Ciproxin ) inhibits the synthesis of DNA in microorganisms by inhibiting the bacterial topoisomerase enzyme DNA (DNA gyrase). This prevents relaxation of the supercoiled DNA and thus prevents normal transcription and replication in the body.
When we give the patient Ciprofloxacin (Ciproxin). Ciprofloxacin enter into Bacteria by passive diffusion and approached Topoisomerases enzyme and they bind to DNA gyrase domain of the enzyme and block or inhibit it so the other domain (nuclease) keep on cutting the overtwisted DNA but the Ligase point Can’t reseal it because of Ciprofloxacin (Ciproxin) and in the end all the bacteria divided into fragments and bacterial death occur.
Side effects Of Ciprofloxacin (Ciproxin)
Ciprofloxacin ( Ciproxin ) has a good safety profile and side effects are present in only 10% of cases, but they are generally mild. Here are some of the side effects associated with the use of Ciproxin.
Nausea, vomiting, and diarrhea may occur.
Ciprofloxacin may affect the clearance of theophylline and cause an increase in serum concentration.
Headaches, insomnia, dizziness, liver problems and rashes can sometimes occur.
Ciprofloxacin can cause tendonitis, which is a serious complication in adults and can cause tendon rupture. Although tendonitis occurs rarely (some cases have been reported), but is more common in elderly failure, renal failure, and renal failure in people with corticosteroids.
Skin / Hypersensitivity are rashes, itching, photosensitivity, swelling of the lips, urination, and swelling of the lips. Serious skin reactions are rare.
The use of ciprofloxacin for long periods can lead to oral candidiasis or a new yeast infection such as white spots in the mouth, a change in vaginal discharge.
Ciprofloxacin during Pregnancy
Ciproxin is contraindicated in pregnancy because ciprofloxacin has caused arthropathy in animal studies. However, to prevent a secondary case of meningococcal meningitis, a single dose of ciprofloxacin may be used.
Some medicines may affect the action of ciprofloxacin, and ciprofloxacin may affect other medicines you ingest.
Many antacids, vitamins, and supplements containing magnesium, calcium, aluminum, iron or zinc can interfere with ciprofloxacin.
Other over-the-counter medicines, which include painkillers and fever medicines such as ibuprofen, naproxen, may also interact with ciprofloxacin.
Ciprofloxacin can increase the effects of caffeine.
If you are taking caffeine-containing drinks or over-the-counter medications that contain caffeine while you are taking ciprofloxacin, you may have some side effects of caffeine, such as nervousness, insomnia, or anxiety.
You may not be able to take Ciprofloxacin if you also take the drug Theophylline for the treatment of asthma and wheezing.
Severe reactions such as heart attack decreased the ability to breathe and seizures have occurred when people have taken these drugs together.
The usual recommended dose for urinary tract infections in adults is 200 to 400 mg IV every 8 to 12 hours for 7 to 14 days, while the oral dose once 250 to 500 mg orally every 12 hours for 7 to 14 days.
The usual adult dose for a soft tissue infection or skin is 400 mg IV every 8 to 12 hours, and orally 500 to 750 mg orally every 12 hours for 7 to 14 days.
The usual adult dose for infectious diarrhea is 500 mg orally every 12 hours for 5-7 days.
The usual adult dose for pneumonia is 400 mg iv every 8 to 12 hours and the oral dose of 500 to 750 mg orally every 12 hours for 7 to 14 days.
The usual adult dose for joint infection is 400 mg iv every 8 to 12 hours and an oral dose of 500 to 750 mg orally every 12 hours for 4 to 8 weeks.
The usual adult dose for sinusitis is 400 mg IV every 12 hours and an oral dose of 500 mg orally every 12 hours for 10 days.
The usual adult dose for typhoid fever is 500 mg orally every 12 hours for 10 days.
The common adult dose for gonococcal infection – uncomplicated is 250 mg orally once.
The usual adult dose for Chancroid is 500 mg orally, twice daily for 3 days.
The usual preoperative dose for surgical prophylaxis is 400 mg intravenously, starting within 120 minutes of the surgical incision.