Cefuroxime: Uses, Side Effects, Dosage

Cefuroxime belongs to a group of drugs known as cephalosporin antibiotic.Cefuroxime oral pill is a prescription medication that is available as the brand-name medication Ceftin among other. Additionally, it is available in generic form.

Cefuroxime was initially approved by the Food and Drug Administration (FDA) under the brand name Ceftin, made by GlaxoSmithKline, in 1987.

Cefuroxime axetil Uses

Cefuroxime is a broad-spectrum antibiotic used to treat many different infection like include pharyngitis, otitis media, sinusitis, and bronchitis.

  • Acute Bacterial Otitis Media
  • Pharyngitis/Tonsilitis
  • Skin Care Illness
  • Sinusitis
  • Lyme disease
  • Bronchitis
  • Cystitis
  • Gonococcal Infection
  • Pyelonephritis

Mechanism

Cefuroxime, is a beta-lactam antibiotic.it inhibits both the third and final stage of bacterial cell wall synthesis. By binding to particular penicillin-binding proteins (PBPs) located inside the bacterial cell wall.

Precautions

You Shouldn’t take cefuroxime for those who:

  • Are allergic to cefuroxime or some of the other components in the medication
  • Are allergic to penicillin
  • Are allergic to additional antibiotics like ceflacor, cefdinir, Keflex (cephalexin), or antibiotics at the cephalosporin course
  • Have liver or kidney problems
  • Have Infection
  • Have Bad eating habits or suffer from malnutrition
  • Have recently had an possibly disease or inflammation of your intestines while or after taking antibiotics

Contraindications

Cefuroxime is contraindicated in the following conditions

  • History of hypersensitivity (e.g. anaphylactic reaction) to some other kind of betalactam antibacterial agent (penicillins, monobactams and carbapenems).

Side effects

Common side effects of injectable and oral cefuroxime comprise the following:

  • Upset stomach
  • Allergic reactions
  • Vomiting
  • Yeast infection
  • Diarrhea
  • Stomach pain

Serious unwanted effects of cefuroxime contain but are not Limited to:

  • Life-threatening allergic response known as anaphylaxis in Which You Might have difficulty breathing, your throat closes up, along with your skin breaks out into hives
  • Intense and potentially life-threatening skin-reactions such as Steven-Johnsons syndrome or toxic epidermal necrolysis (TENs)
  • Swelling of the face, such as lips, eyes, tongue, mouth, and throat
  • Blood ailments including low platelet count or reduced levels of blood cells
    elevated levels of white blood cells
    Seizures
  • A serious form of nausea noticed by loose, watery feces along with a foul odor that Is Significantly worse than ordinary

Cefuroxome at Pregnancy & Lactation

Cefuroxime falls into class B. There aren’t any proper studies which were performed in human with cefuroxime. In animal research, pregnant animals were given this medicine, and the infants didn’t demonstrate any healthcare problems associated with this drug.

Cefuroxime was detected in breast milk. Due to the potential for adverse reactions in nursing infants from cefuroxime, an option ought to be made whether to discontinue nursing or to prevent use of the medicine.

Interactions

Your healthcare professionals may already know about any potential medication interactions and might be monitoring you for it. Don’t start, stop, or change the dosage of any medicine before checking with them first. Before with this medicine, tell your doctor or pharmacist of all prescription and nonprescription/herbal products that you can use, especially

  • Blood thinners” (e.g., warfarin),
  • Live vaccines.
  • Concomitant use of probenecid is not recommended.
  • Although many antibiotics likely don’t influence hormonal birth control like tablets, patch, or ring, some antibiotics can diminish their efficacy.
  • Make Sure You ask your doctor or pharmacist if you should use additional reliable birth control procedures Whilst using this antibiotic

Cefuroxime Dosage 

Cefuroxime is generally taken twice per day, with or after meals.

If you forget to take a dose of cefuroxime, take it as soon as you remember, unless it is almost time for the next dose. Don’t take a double dose to make up for the missed dose.

Like all antibiotics it’s very important to complete the prescribed course of cefuroxime, even in the event that you are feeling better or the disease appears to have cleared up.

Adult dose

  • For acute otitis media 500 mg twice per day
  • For cystitis 250 mg twice per day
  • For Pyelonephritis 250 mg twice per day
  • For Lyme disease 500 mg twice per day.

Dose for childrens weight less than 40 kg

  • For Acute tonsillitis and pharyngitis, acute bacterial sinusitis 10 mg/kg twice per day to a max of 125 mg twice per day.
  • For acute otitis media 15 mg/kg twice per day to a maximum of 250 mg twice per day.
  • For cystitis 15 mg/kg twice per day to a maximum of 250 mg twice per day
  • For Pyelonephritis 15 mg/kg twice per day to a maximum of 250 mg twice per day for 10 to 14 days
  • For Uncomplicated skin and soft tissue infections 15 mg/kg twice every day to a maximum of 250 milligrams
  • For Lyme disease 15 mg/kg twice per day to a maximum of 250 mg twice per day for 14 days (10 to 21 days).
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