HGH Supplements

GF-9 Review: Does Growth Factor 9 Really Work in 2025? GF-9 Review: Does Growth Factor 9 Really Work in 2025? An Evidence-Based Analysis Written by Manzoor Khan, Pharm.D. Pharmacist with 9+ years of experience in supplements & health writing Author Profile Facebook Twitter LinkedIn Medically Reviewed by: Sajid Ali, Pharm.D., MPhil, PhD Scholar Published: January 2025 | Last Updated: January 2025 Are you noticing stubborn belly fat, decreased energy, slower recovery after workouts, and visible signs of aging that seem impossible to reverse? Could declining human growth hormone (HGH) levels be the hidden culprit behind your aging concerns? As we age, our body’s natural production of human growth hormone declines by approximately 14% per decade after age 30. This hormonal shift can lead to increased body fat, reduced muscle mass, diminished stamina, poor sleep quality, and accelerated aging signs like wrinkles and sagging skin. While synthetic HGH injections have been used to combat these effects, they come with significant risks, high costs, and are banned in competitive sports by the World Anti-Doping Agency. This has led many individuals to seek safer, natural alternatives to support healthy HGH levels. Enter GF-9 (Growth Factor 9) by Novex Biotech—a dietary supplement claiming to boost HGH levels by an impressive 682% using a proprietary blend of amino acids and herbal ingredients. But does this supplement actually deliver on its bold promises, or is it another overhyped product in a crowded market? As a licensed pharmacist with over 9 years of experience analyzing supplements, I’ve conducted a comprehensive, evidence-based evaluation of GF-9. This review examines the clinical research, ingredient efficacy, real customer experiences, potential side effects, and whether this premium-priced supplement justifies its cost. GF-9 Quick Overview Reduced lean muscle mass and increased body fat Decreased energy levels and stamina Slower post-workout recovery Poor sleep quality Diminished libido and sexual function Visible aging signs (wrinkles, sagging skin, under-eye bags) Weakened bone density and joint health The supplement is positioned as a safer, more convenient alternative to synthetic HGH injections, which require prescriptions, are expensive, and carry significant health risks. GF-9 is available over-the-counter and sold through various channels including Amazon, Walmart, CVS, and the official Novex Biotech website. About Novex Biotech: The Company Behind GF-9 Founded in 2005, Novex Biotech is a United States-based supplement company specializing in men’s health and performance products. The company’s mission centers on helping men optimize their hormonal health, physical performance, and overall vitality through scientifically-formulated supplements. Novex Biotech’s product portfolio includes several well-known brands in the sports nutrition and men’s health space, including TestroVax (testosterone support), Oxydrene (thermogenic fat burner), and Pre7 (pre-workout formula). GF-9 remains one of their flagship products, with the company claiming over 3.5 million bottles sold since its launch in 2012. The company operates with GMP (Good Manufacturing Practice) certified facilities and positions itself as a quality-focused brand. However, it’s worth noting that the clinical study supporting GF-9’s claims was funded by Sierra Research Group, which shares the same registered business address as Novex Biotech—a connection that raises questions about potential bias in the research findings. GF-9 Ingredients: A Deep Dive into the Formulation GF-9 contains a proprietary blend totaling 2.9 grams per serving, which is one of the most controversial aspects of this supplement. While the manufacturer lists the ingredients, they do not disclose the individual amounts of each component—a practice that limits transparency and prevents consumers from verifying whether the doses align with clinical research. Here’s a comprehensive analysis of each ingredient based on available scientific evidence: L-Lysine Hydrochloride Undisclosed Amount* What It Is: L-lysine is an essential amino acid that the body cannot produce on its own, making dietary intake necessary. It plays crucial roles in protein synthesis, calcium absorption, and immune function. Clinical Evidence for HGH: Research suggests that L-lysine, particularly when combined with L-arginine, may stimulate growth hormone release. A study published in the Journal of Clinical Endocrinology found that the combination of lysine and arginine increased GH levels significantly more than either amino acid alone. Standard Effective Dose: Clinical studies typically use 1,200-3,000 mg of L-lysine for HGH support. Additional benefits have been observed at doses of 1,000-3,000 mg daily for: Reducing anxiety in males (published in Biomedical Research) Managing stress response in women (Nutritional Neuroscience journal) Supporting healthy blood sugar levels after 2 months supplementation Accelerating healing of cold sores and herpes outbreaks GF-9 Concern: Without disclosed amounts, we cannot verify if GF-9 contains therapeutic doses. The entire proprietary blend is only 2,900 mg, which must be divided among six ingredients. 📚 Study: Lysine-Arginine for GH Release (PubMed) 📚 Study: Lysine for Anxiety Reduction L-Arginine Hydrochloride Undisclosed Amount* What It Is: L-arginine is a semi-essential amino acid that serves as a precursor to nitric oxide (NO), a molecule crucial for blood vessel dilation and cardiovascular health. It’s one of the most researched amino acids for HGH stimulation. Clinical Evidence for HGH: Multiple studies confirm L-arginine’s ability to increase growth hormone levels. Research published in the Journal of Applied Physiology demonstrated that arginine supplementation caused approximately a 100% increase in GH levels at rest. However, the same study found that during exercise, arginine supplementation actually decreased GH levels compared to placebo—an important consideration for athletes. Additional Benefits: Erectile Function: By increasing nitric oxide production, arginine helps relax blood vessels and improve blood flow, which is essential for erectile function Cardiovascular Health: May help lower blood pressure and improve blood flow in individuals with heart disease Athletic Performance: Some evidence suggests improved exercise tolerance and reduced fatigue Wound Healing: Supports protein synthesis and tissue repair Standard Effective Dose: Clinical studies typically use 5,000-9,000 mg daily for HGH effects. For erectile function, studies use 2,500-5,000 mg daily. Lower doses (1,000-2,000 mg) show minimal effects. GF-9 Concern: If the entire 2,900 mg blend contained only arginine, it would still be below the clinically effective dose range for significant HGH increase. 📚 Study: Arginine & Growth Hormone (PubMed) 📚 Study: Arginine for Erectile Function 📚 Review: Arginine Supplementation Effects Oxo-Proline (Pyroglutamic Acid)