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Clonazepam (Rivotril): Uses, Side Effects,Mechanism & Dosage

Clonazepam (Brand name Rivotril) belongs to a group of drugs known as Benzodiazepine.Other members of This group are diazepam, alprazolam, Lorazepam, and Flurazepam.Generally, these drugs are used as a sedative, or to decrease anxiety and Seizures. Clonazepam is available as Rivotril Injection 1 mg/mL Rivotril Tablets include; Rivotril 0.5 mg Rivotril 2 mg  (Rivotril 2 mg tablet is used is a very effective medicine for the treatment of seizures of different types. It is also used to treat panic attacks and sleep disorders.) Klonopin Tablets. Rivotril Uses Rivotril (Clonazepam) is used primarily as an anticonvulsant in the treatment of; Absence seizures, Petit mal variant seizures (Lennox-Gastaut syndrome), Akinetic and myoclonic seizures, and Nocturnal myoclonus. It can also be used for the treatment of panic disorders. Pharmacokinetics Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is approximately 90%. C max, oral administration = 1-4 hours. The biotransformation occurs mainly by reduction of the 7-nitro group to the 4-amino derivative. This derivative can be acetylated, hydroxylated and glucuronide. 85% bound to plasma proteins. and the half-life of clonazepam is 30 to 40 hours. It is highly metabolized, with less than 2% unchanged Clonazepam excreted in the urine. Clonazepam metabolites are excreted by the kidneys. Clonazepam is also acetylated via NAT2. Rivotril Mechanism Of Action Benzodiazepines act on specific receptors in the CNS. These are located on a complex glycoprotein molecule that surrounds a chloride channel.This Glycoprotein act as a GABA Receptor.This GABA receptor is made up of five subunits, a pentameric structure.These Five Subunits are selected from eight types if polypeptides, alpha, beta, gamma, delta, epsilon, Pi, Rho, and Theta.There are six different types of alpha, four types of beta and three types of gamma subunits.Alpha, Beta and Gamma subunits are the major polypeptide of the GABA receptors and their presence is essential for normal function of the receptor.They are distributed in various combinations in different parts of the CNS.Clonazepam enhances the activity of gamma-aminobutyric acid (GABA), which is a major inhibitory neurotransmitter in the central nervous system.Binding of GABA on these receptors causes the opening of chloride channels.This causes passage of chloride ions into neuron increasing negative ions inside the neurons.This result in hyperpolarization of neurons and these are difficult to be depolarised. Rivotril Side Effects The more common side effects of clonazepam oral tablet can include: Dizziness A headache Weakness Drowsiness Amnesia Confusion Depression Problems with walking and coordination Problems with memory Fatigue While Serious side effects include the following: Depressed mood or thoughts of suicide (harming yourself) Seizures Respiratory Depression Low Blood Pressure Increased Heart Rate. Don’t Use Rivotril If  You Have acute narrow or closed angle glaucoma You Are allergic to clonazepam or any ingredients of the medication You Have had an allergic reaction to any other medicine of benzodiazepine group.s You have myasthenia gravis You have sleep apnea You have severe breathing problems You have a severe liver disease. Rivotril In Pregnancy If you take Clonazepam during pregnancy, your baby is at risk of serious birth defects. These defects can occur in the first month of pregnancy, even before you know that you are pregnant. Congenital malformations may even occur in children born to women who are not on medication and have no other risk factors. This medicine should be used during pregnancy only in severe cases where it is necessary to treat a dangerous condition in the mother. Clonazepam Dosage  Rivotril injection, Clonazepam 1 mg /ml in Solvent for dilution with 1 ml water for injections immediately before injection. The dose of Klonopin Tablets and Rivotril Tablet (Containing Clonazepam) is tailored to the patient’s needs. For adult convulsions, the starting dose is 1.5 mg daily in 3 divided doses.The dosage may be increased from 0.5 to 1 mg per day every 3 days until seizures are controlled or side effects prevent further dose increase. The maximum dose is 20 mg per day. The starting dose for panic disorder is 0.25 mg twice daily. The dose may be increased to the target dose of 1 mg daily after 3 days. Related Article: Pharmacology Of Benzodiazepines

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Flixotide (Fluticasone): Uses, Side Effects, Dosage

Flixotide is a brand name for fluticasone – a drug also known as corticosteroids prevents the release of substances in the body that cause inflammation. It is a prescription-only medicine. Flixotide the respiratory system protects against overstimulation. This medication reduces hypersensitivity reactions in the lungs and reduces inflammation. Flixotide is taken by inhalation and is available in two types of inhalers: Flixotide Evohaler and Flixotide Accuhaler Inhaler. Flixotide Accuhaler is available in three strengths: Flixotide Junior Accuhaler 100 micrograms fluticasone propionate in a blister pack Flixotide Accuhaler 250 micrograms fluticasone propionate in a blister pack Flixotide Accuhaler 500 micrograms fluticasone propionate in a blister pack The Flixotide formulation contains the active substance fluticasone and lactose powder as an inactive ingredient (containing milk proteins). Flixotide uses Inhaled fluticasone propionate provides prophylactic treatment for asthma. Mild or Light Asthma (Adults): Patients who regularly need symptomatic intermittent bronchodilator treatment for asthma. Moderate asthma (adults): patients with unstable asthma or deteriorates despite prophylaxis or bronchodilator alone. Severe asthma (adults): Patients with severe chronic asthma and patients who depend on systemic corticosteroids to control symptoms adequately. With the introduction of inhaled fluticasone propionate, many of these patients can significantly reduce or eliminate their need for oral corticosteroids. Is Flixotide a Preventor? Fluticasone, which is taken by inhalation, is known as “Preventer”. This is because it is taken regularly every day to reduce inflammation in the lungs and prevent asthma attacks. Symptoms usually improve four to seven days after the start of treatment. However, it is important to use this medication regularly even after an improvement in the symptoms of asthma to prevent a recurrence. How does Flixotide work? (Mechanism Of Action) Flixotide contains the active substance fluticasone propionate, a type of medication known as a corticosteroid. When fluticasone is inhaled into the lungs, it is absorbed into the cells of the lungs and respiratory tract. Here, it prevents the release of certain chemicals from the cells. These chemicals are important for the immune system and are normally involved in the production of immune and allergic reactions that lead to inflammation. By reducing the release of these chemicals into the lungs and airways, inflammation is reduced. In asthma, the airways shrink due to inflammation and can also be blocked by mucus. This makes it difficult to get in and out of the lungs. By preventing inflammation and excessive mucus formation, fluticasone helps prevent asthma attacks. It is not used to treat an asthma attack. Side Effects of Fluticasone (Flixotide) This medication may cause side effects, including: Nausea Vomit Indigestion (Very Rare) A headache, Painful tongue Unpleasant taste in the mouth. Husky voice; A sore throat Raised blood sugar level (Very Rare) Hypersensitivity reactions such as rash, itching, swelling of the face, and anaphylaxis may occur. High doses and rarely normal doses can suppress the adrenal glands and affect their ability to produce natural cortisone. Avoid using This drug and consult your doctor if you are allergic to fluticasone or any other ingredient in this medicine; or if you have a viral infection and if you have tuberculosis. Flixotide during pregnancy It should not be used by pregnant or breastfeeding women without consulting a doctor. Flixotide Dose (Fluticasone) For adult patients with mild asthma, a typical starting dose is 100 micrograms twice daily. In moderate and more severe asthma, starting doses may need to be 250 to 500 micrograms twice daily. Where the additional clinical benefit is expected, doses of up to 1000 micrograms twice daily may be used. The initiation of such doses should be prescribed only by a specialist in the management of asthma (such as a consultant physician or general practitioner with appropriate experience). The dose should be titrated down to the lowest dose at which effective control of asthma is maintained. For Children, over 4 years of age the typical doses will be 50 to 100 micrograms twice daily. Many children’s asthma will be well controlled using the 50 to 100 microgram twice-daily dosing regimen. For those patients whose asthma is not sufficiently controlled, additional benefit may be obtained by increasing the dose up to 200 micrograms twice daily. The maximum recommended dose in children is 200 micrograms twice daily. Related Article: Salbutamol: Uses, Side Effects, Dosage

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Ciprofloxacin (Ciproxin): Uses, Side Effects, Dosage

Ciprofloxacin  (Brand Name: Ciproxin) belongs to a group of broad-spectrum antimicrobial drugs known as fluoroquinolones. It is the most active second-generation fluoroquinolone against a wide range of bacteria susceptible to Gram-negative aerobic rods, especially the Enterobacteriaceae Neisseria. [1] Ciprofloxacin is effective against Staphylococcus aureus and Staphylococcus epidermidis. It is active against susceptible strains of Staphylococcus aureus and is not effective against Methicillin-Resistant Staphylococcus aureus. Ciprofloxacin (Ciproxin) has excellent activity against gram-negative bacteria, but enterococci, Streptococcus group A, B, D and streptococcal viridans with moderate susceptibility to ciprofloxacin. It is also very effective against Mycobacterium tuberculosis and M.Kansasii M.Fortuitum.If used alone is not effective against M. avium infections caused by M. avium infection. They must be combined with other tuberculosis drugs, rifampicin and ethambutol. Ciprofloxacin (Ciproxin Tablet) Other Brands: Novidat Manufactured By Sami Pharmaceutical Pvt Limited. Novidat is available in Dry Powder For Suspension. 125mg/5ml. Novidat Tablet 500mg. Novidat Injection 200 mg 1 Vialx100 mg. Mercip 500mg tablet manufactured By Merck. Ciprofloxacin (Ciproxin) works against a variety of infections, some of which are difficult to treat. It’s broad-spectrum, its oral effectiveness, and its good tolerability is often used to treat infections. Still, it should not be used for minor infections. or anaerobes are mainly causative. In severe cases, treatment by intravenous infusion may be initiated, then continue with the oral. Ciproxin is used to treat bacterial infections, for example: Urinary tract infections (UTIs) caused by certain bacteria such as E. coli. Cervical and urethral gonorrhoea due to Neisseria gonorrhoeae Typhoid Skin infections Bone infections Joint infections Uncomplicated acute cystitis Chronic bacterial prostatitis Meningitis Pulmonary or respiratory tract infections, for example, tuberculosis, lower respiratory tract infections, and chronic bronchitis) Pneumonia and sepsis caused by Yersinia pestis (Y. pestis). Infectious diarrhoea caused by E. coli, Campylobacter jejuni, and Shigella. Prophylaxis of Infections in neutropenic / cancer patients and other sensitive patients. Patients with anthrax with fever and low white blood cell count as well as intra-abdominal infections. Ciprofloxacin ( Ciproxin ) inhibits DNA synthesis in microorganisms by inhibiting the bacterial topoisomerase enzyme DNA (DNA gyrase). This prevents relaxation of the supercoiled DNA and thus prevents normal transcription and replication in the body. When we give the patient Ciprofloxacin (Ciproxin), ciprofloxacin enters into Bacteria through passive diffusion and approaches Topoisomerase enzyme. They bind to the enzyme’s DNA gyrase domain and block or inhibit it, so the other domain (nuclease) keeps on cutting the overtwisted DNA. Still, the Ligase point Can’t reseal it because of Ciprofloxacin (Ciproxin), and in the end, all the bacteria divided into fragments and bacterial death occur. Ciprofloxacin ( Ciproxin ) has a good safety profile, and side effects are present in only 10% of cases, but they are generally mild. Here are some of the side effects associated with the use of Ciproxin. Nausea, vomiting, and diarrhoea may occur. Ciprofloxacin may affect the clearance of theophylline and cause an increase in serum concentration. Headaches, insomnia, dizziness, liver problems and rashes can sometimes occur. Ciprofloxacin can cause tendonitis, which is a serious complication in adults and can cause tendon rupture. Although tendonitis rarely occurs (some cases have been reported), but is more common in elderly failure, renal failure, and renal failure in people with corticosteroids. Skin / Hypersensitivity are rashes, itching, photosensitivity, swelling of the lips, urination, and swelling. Serious skin reactions are rare. Ciprofloxacin use for long periods can lead to oral candidiasis or a new yeast infection such as white spots in the mouth, a change in vaginal discharge. It can destroy your beneficial bacteria, so you need to take probiotics to flourish your gut flora. One such product is synbiotic 365. Some medicines may affect the action of ciprofloxacin, and ciprofloxacin may affect other medicines you ingest. Many antacids, vitamins, and supplements containing magnesium, calcium, aluminium, iron or zinc can interfere with ciprofloxacin. Other over-the-counter medicines, including painkillers and fever medicines such as ibuprofen and naproxen, may also interact with ciprofloxacin. Ciprofloxacin can increase the effects of caffeine. If you are taking caffeine-containing drinks or over-the-counter medications that contain caffeine while you are taking ciprofloxacin, you may have some side effects of caffeine, such as nervousness, insomnia, or anxiety. You may not be able to take Ciprofloxacin if you also take the drug Theophylline to treat asthma and wheezing. Severe reactions such as heart attack decreased the ability to breathe, and seizures have occurred when people have taken these drugs together. Other drugs that interact with ciprofloxacin are: Anticoagulants like warfarin. Anticonvulsant drugs, including phenytoin. Certain antidepressants and drugs for the treatment of mental illnesses, such as clozapine. Caffeine-containing drugs The immunosuppressant cyclosporine. The muscle relaxant tizanidine Diuretics (water pills) Certain medications for an irregular heartbeat, such as amiodarone, disopyramide, and procainamide. The drug for arthritis methotrexate. A drug used to treat nausea, vomiting, heartburn, and reflux called metoclopramide. Type 2 diabetes drug Glyburide. Some nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen. Ciprofloxacin during Pregnancy Ciprofloxacin Nursing Mothers This antibiotic is excreted in milk, and therefore it is best to avoid it while breastfeeding or consult your doctor before using this medicine if you are a nursing mother. Ciproxin in Pediatrics population Although it is effective in paediatrics still it is not a drug of choice because of adverse effects caused by this medicine.  Always consult your doctor before using any medicine. Ciprofloxacin Contraindications This drug is contraindicated in people with hypersensitivity to Ciprofloxacin or any other similar drugs in this group. Concomitant use of this drug with Tizanidine is contraindicated. The usual recommended dose for urinary tract infections in adults is 200 to 400 mg IV every 8 to 12 hours for 7 to 14 days, while the oral dose once 250 to 500 mg orally every 12 hours for 7 to 14 days. The usual adult dose for a soft tissue infection or skin is 400 mg IV every 8 to 12 hours, and orally 500 to 750 mg orally every 12 hours for 7 to 14 days. The usual adult dose for

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Chlorphenamine (Piriton): Uses, Side Effects, Dosage

Chlorpheniramine (Piriton) belongs to a group of drugs known as sedating antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can cause symptoms such as sneezing, itching, watery eyes, and runny nose. Chlorpheniramine (Piriton) Uses: Chlorpheniramine (Piriton) is used for the symptomatic relief of allergies such as Hay fever, Urticaria, Food Allergy, Drug Reactions, A runny nose, Sneezing, itching, Watery eyes caused by allergies, Colds or flu, Emergency Treatment Of Anaphylactic Reactions. Chlorpheniramine (Piriton) Mechanism Of Action Piriton products contain the active ingredient chlorphenamine maleate, a type of medicine called the calming antihistamine. It works by avoiding the effects of histamine, a substance that is produced by the body when it reacts to a foreign substance such as pollen or the coat of pets (an allergen). Histamine causes a chain reaction that causes allergic symptoms. In allergies such as hay fever and pet allergies, histamine causes inflammation of the nose, eyes, or respiratory tract, resulting in itchy eyes, watery nose, stuffy nose, and sneezing. In allergic skin reactions, histamine causes dermatitis, rashes, and itching. Chlorphenamine blocks the histamine receptors and therefore stops the chain reaction that causes the symptoms of the allergy. It usually begins to relieve symptoms within half an hour to an hour after taking a dose. Chlorphenamine is referred to as a sedative antihistamine because it enters the brain in significant amounts and causes drowsiness. The antihistamine action and the fact that it causes drowsiness makes chlorpheniramine also useful in relieving the itching caused by chickenpox. It can be especially useful for itching, which gets worse at night. This is often the case in children who notice less itching during the day when they are active, but it bothers them at night when they are quiet and have nothing left to concentrate on. Piriton Side effects Chlorphenamine (Piriton) Can cause Some Side effects along with their useful effects which are: Drowsiness, Dizziness, A headache, Constipation, Upset stomach, Blurred vision, Decreased coordination or dry mouth/nose/throat may occur. These effects may decrease as your body adapts to the medication. If any of these effects persist or worsen, contact your doctor or pharmacist immediately. Piriton In Pregnancy: Most manufacturers advise avoiding the use of Piriiton In Pregnancy, However, There is no evidence of teratogenicity. But Using Piriton in the Third Trimester of Pregnancy may cause adverse effects in neonates such as irritability, tremor, and paradoxical excitability. Dosage: Adults and children over 12 years: 1 tablet for 4 to 6 hours. Maximum daily dose: 6 tablets (24 mg) in 24 hours Elderly: Older people have more frequent neurological anticholinergic effects. The use of a lower daily dose (eg maximum of 12 mg in 24 hours) should be considered. Children from 6 to 12 years: ½ tablet from 4 to 6 hours. Maximum daily dose: 3 tablets (12 mg) in 24 hours Not recommended for children under 6 years. Related Article: Terbutaline: Uses, Side Effects, Dosage

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Clopidogrel (Plavix): Uses, Side Effects, Dosage

Clopidogrel is an antiplatelet drug.(Brand name is Plavix Generic is Clopidogrel). Uses of Plavix: It reduces your risk of getting blood clots by affecting cells in your blood known as platelets. It is used to stop heart attacks, prevent strokes, Also Used after a heart treatment to protect the arteries. Additionally used to lower the number of heart attacks in patients who have unstable angina or mild heart attacks. Flavix (Clopidogrel) Side Effects  The more common side effects which will occur with clopidogrel include: Bleeding and itchy skin whereas Serious side effects and their symptoms can include the following: Serious, severe bleeding. In Urine, Red Or Black stools, Coughing Up Blood Or Blood Clots, Vomiting Blood and Unexplained bleeding that lasts a long time And Blood-clotting problem referred to as thrombotic thrombocytopenic purpura (TTP). Do not stop taking clopidogrel without calling the doctor who Prescribed it for you.Be careful and avoid injury.You may bleed more easily.Use a soft toothbrush and an electric razor.Very dangerous and typically deadly bleeding problems have happened with this drugs. Don’t Take Plavix If you have had a hypersensitivity to any medication before, Have a stomach ulceration, or have had stomach ulcers in the past,have had bleeding on your brain (brain haemorrhage),have haemophilia or another bleeding disorder, have a liver or kidney downside, And are pregnant or breastfeeding. Mechanism Of Action Of Plavix The active substance of clopidogrel prevents binding of adenosine diphosphate (ADP) to its blood platelet receptor, impairing the ADP-mediated activation of the conjugated protein GPIIb/IIIa complex. it’s proposed that the inhibition involves a defect within the mobilization from the storage sites of the blood platelet granules to the outer membrane. The drug specifically and irreversibly inhibits the P2Y12 subtype of ADP receptor, that is vital in aggregation of platelets and cross-linking by the protein fibrin. No direct interference happens with the GPIIb/IIIa receptor. because the conjugated protein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to blood platelets and inhibits platelet aggregation. By block, the amplification of blood platelet activation by discharged ADP, blood platelet aggregation evoked by agonists apart from ADP is additionally inhibited by the active matter of clopidogrel. Plavix Dosage  The suggested dose for treating unstable angina or heart failure is 300 mg at first followed by 75 mg daily together with 75-325 mg of aspirin. Peripheral arterial illness or recent stroke and is treated with 75 mg daily.Clopidogrel (Plavix) typically is taken once daily. It is taken with or without food. Clopidogrel is activated by enzymes in the liver to its active type. people who have reduced activity of liver enzymes that activate clopidogrel due to liver disease may not adequately respond to clopidogrel. various treatments ought to be used for these patients.

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Ibuprofen (Nurofen): Best Pain Killer

Ibuprofen (Brand: Nurofen)  is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Nirofen is available in various dosage forms Nurofen Pain Relief 256mg Tablets Nurofen For Children )Ibuprofen 100mg/5ml) Nurofen for children Chewable Capsule. Nurofen Uses Nurofen is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury. Also Used In Pain Caused By Common Cold And Flu. For symptomatic treatment of Juvenile Rheumatoid Arthritis. Nurofen Mechanism Of Action: The exact mechanism of action of ibuprofen is unknown. ibuprofen is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacologic effects are believed to be due to inhibition cyclooxygenase-2 (COX-2) that decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects is also due to action on the hypothalamus, resulting in an exaggerated peripheral blood flow, dilation, and resulting temperature reduction. Inhibition of cox-1 is assumed to cause a number of the side effects of ibuprofen including GI ulceration. ibuprofen is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer. Side effects of Nurofen Ibuprofen can cause a number of side effects. You should take the lowest possible dose for the shortest possible time needed to control your symptoms. See the patient information leaflet that comes with your medicine for a full list of side effects.   Common side effects of ibuprofen (Nurofen)  include:   Constipation or diarrhoea Nausea or vomiting Indigestion (dyspepsia) or abdominal pain Heartburn Stomach Ulcers Headache Dizziness Salt and fluid retention High blood pressure Flatulence Loss of appetite Stomach cramps Less common side effects include: Raised blood pressure Headache or dizziness Inflammation of the stomach (gastritis) Bloating (fluid retention) Black stools and blood in your vomit – this can indicate bleeding in your stomach Allergic reactions – such as a rash A stomach ulcer Worsening of asthma symptoms by causing narrowing of the airways (bronchospasm) Kidney failure Nurofen in Pregnancy  It is best not to take Ibuprofen as a normal pain reliever during pregnancy. The reason for your caution is that taking ibuprofen regularly may harm your baby. Taking ibuprofen often in the first trimester may increase the likelihood of miscarriage. Your baby may also develop a heart defect or other anomalies, such as cleft palate or abdominal wall defects. Its best to consult your doctor before using Nurofen in Pregnancy. Nurofen Contraindications Nurofen is contraindicated in Hypersensitivity to ibuprofen or to any of the excipients present in Nurofen. It is also contraindicated in Active or a history of recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding). Nurofen is contraindicated in People with a History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy. It is Also contraindicated in Severe hepatic failure, renal failure or heart failure. Ibuprofen dosing information Usual Adult Dose for Fever: Oral: 200 to 400 mg orally every 4 to 6 hours as needed. IV: (Patients should be well hydrated before IV ibuprofen administration): Fever: Initial: 400 mg intravenously over 30 minutes Maintenance: 400 mg every 4 to 6 hours or 100 to 200 mg every 4 hours as needed. Usual Adult Dose for Osteoarthritis: Initial dose: 400 to 800 mg orally every 6 to 8 hours. Maintenance dose: May be increased to a maximum daily dose of 3200 mg based on patient response and tolerance. Usual Adult Dose for Rheumatoid Arthritis: Initial dose: 400 to 800 mg orally every 6 to 8 hours. Maintenance dose: May be increased to a maximum daily dose of 3200 mg based on patient response and tolerance. Usual Adult Dose for Dysmenorrhea: 200 to 400 mg orally every 4 to 6 hours as needed. Usual Adult Dose for Headache: Study (n=34) – Prevention of Electroconvulsive therapy (ECT)-induced headache: 600 mg orally 90 minutes prior to the initial ECT session Usual Adult Dose for Pain: Oral: Mild to moderate pain: 200 to 400 mg orally every 4 to 6 hours as needed. Doses greater than 400 mg have not been proven to provide greater efficacy. IV: (Patients should be well hydrated before IV ibuprofen administration): Pain: 400 to 800 mg intravenously over 30 minutes every 6 hours as needed. Usual Pediatric Dose for Fever: Greater than 6 months to 12 years: 5 mg/kg/dose for temperature less than 102.5 degrees F (39.2 degrees C) orally every 6 to 8 hours as needed. 10 mg/kg/dose for temperature greater than or equal to 102.5 degrees F (39.2 degrees C) orally every 6 to 8 hours as needed. The recommended maximum daily dose is 40 mg/kg. OTC pediatric labeling (analgesic, antipyretic): 6 months to 11 years: 7.5 mg/kg/dose every 6 to 8 hours; Maximum daily dose: 30 mg/kg Usual Pediatric Dose for Rheumatoid Arthritis: 6 months to 12 years: Usual: 30 to 40 mg/kg/day in 3 to 4 divided doses; start at lower end of dosing range and titrate; patients with milder disease may be treated with 20 mg/kg/day; doses greater than 40 mg/kg/day may increase risk of serious adverse effects; doses greater than 50 mg/kg/day have not been studied and are not recommended. Maximum dose: 2.4 g/day. Relate Article : Important Information About Diclofenac

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