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Antibiotics Resistance: Important Facts You Need To Know

Why is Antibiotic Resistance so Important? Antibiotic resistance will result in a severe bacterial infection and Is the Biggest Threat To World Health. One reason bacterium have become resistant is as a result of antibiotics are typically not suitably used for a health problem caused by a virus. an antibiotic cannot cure a virus infection. Examples of diseases that are caused by a virus include most:coughs,sore throats,colds and runny noses,sinusitis,bronchitis, the flu. According to the Center for Disease Control and Prevention, about half of the antibiotic prescriptions handed to patients don’t seem to be optimal: they will be prescribed once no antibiotic is needed, there is an incorrect dose, or the length of treatment is wrong. Talk to your doctor concerning your health problem, discuss whether or not it’s a bacterial or viral illness, and ask if you actually need an antibiotic. Antibiotics are typically linked with side effects — like rash or diarrhoea — you would possibly prefer to avoid, if possible. you can treat most viral diseases with simple treatments to ease your symptoms, and, like most viral diseases, be better in a very few days to a week.   How Do Bacteria Become immune to Antibiotics? The mechanism of bacterial resistance could happen in many ways: Bacteria is also able to “pump” the antibiotic out of the cell Bacteria can neutralize the antibiotic before it’s an effect Bacteria might change the site of action (or receptor) wherever the antibiotic commonly works Bacteria can change and transfer genetic material to other bacteria. Common antibiotic-resistant bacterium include staph aureus (serious skin infections) and mycobacterium tuberculosis(tuberculosis of the lungs). Resistant bacteria will spread from human-to-human in healthcare facilities and throughout the community. In addition, stock and crops will contribute to the speading of microorganism resistance. Animals get antibiotics and might develop drug-resistant bacteria. These same resistant bacterium will transfer to crops via animal fecal matter contaminated fertilizer or water, that the human then consumes. The resistant bacteria keep within the human gut and might be spread within the community. salmonella and Campylobacter are the first organisms changing into resistant in animals which will transfer to humans. Antibiotics Resistance What You Can Do? Only Use Antibiotics When Prescribed By A Certified Health Practitioner. Always Take The Full Dose Even If You Feel Better. Never Use Left Over Antibiotics Never Share Antibiotics With Others Prevent Infection By Regularly Washing Your Hands,Avoiding Contact With Sick People And Keeping Your Vaccinations Up to Date.  

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what your urine says about your health

• Some foods and medicines will change the colour of your pee. For example, beets will make it blood-red or dark brown, asparagus will make it green, and carrots will flip it orange. certain antacids will turn your pee a shade of blue, and a few chemotherapy medicines will make it orange. typically an uncommon color are often a signal of a pathological state. talk to your doctor if your pee suddenly changes color and you’re unsure why. • If you see blood in your pee. It could be caused by something fairly harmless, like exhausting exercise or medication. Or it should be a signal of something more serious like renal disorder, an enlarged prostate, bladder cancer, or sickle cell anemia. • Foods, vitamins, and drugs will all change the way your pee smells. for example, asparagus causes an ammonia-like odor for some individuals. Your pee additionally might smell stronger if you don’t drink enough water otherwise you take vitamin B-6 supplements. however some health conditions will do it, too. Diabetes, bladder infections, kidney infections, and liver failure will all change the approach your pee smells. seek advice from your doctor if there’s a sharp change and it doesn’t depart. • If your pee is extremely dark, something could be occurring with one of these organs. an excessive amount of of certain medicine, like Panadol (Tylenol), will cause problems. And cancer, a stone blocking the way to your gallbladder, viruses like hepatitis C, and different illness will, too. These problems will cause your body to form a yellow fluid known as bilirubin that turns your pee terribly dark. And it will leak of your liver and into your blood and create your skin and eyes turn yellow (this is named jaundice). Blood and pee tests will measure your level of bilirubin. • If you have got one of these, your pee could also be red or dark-brown or have spots of red in it. Or it would be green or cloudy and have a powerful smell. UTIs typically happen as a result of bacteria has gotten into your bladder or your urethra, the tube that carries pee out of your body. Your doctor will take a look at a sample of your pee to search out out if you have got one. If you do, it can be treated with antibiotics. • If your pee appearance dark and you’re not going as often as usual, that would mean you don’t have enough water in your body. you also may feel tired, nauseated, or groggy. Your doctor might take a look at a sample of your pee to see what proportion water is in it. • A chemical strip from a pharmacy pregnancy kit will take a look at a woman’s urine for a hormone that may only be there if she’s pregnant (it’s known as human chorionic gonadotropic hormone or hCG). The results are possibly to be accurate 5 to 10 days after a missed period. • Hyperglycemia occurs once you have an excessive amount of sugar (glucose) in your blood. High levels of glucose can also show up in your pee. you cannot tell by looking at it, however your doctor will check by testing a sample. It are often a signal of diabetes and might result in heart condition, stroke, kidney disease, blindness, and other issues. • Foamy pee will mean you have got a lot of protein in your pee than normal. this is often the earliest sign of this disease, that is the leading cause of kidney failure. It damages your kidneys’ little blood vessels. That leads your body to carry on to more salt, water, and waste in your blood than it should. Your doctor will take a look at your pee for a protein known as albumin to seek out out if you have got it. • If you can’t go otherwise you feel like you have to go typically however don’t pee much when you do, that may mean something is keeping it from coming out. you’ll additionally see blood in your urine, or it would look cloudy. A blockage are often caused by an enlarged prostate, kidney stones, bladder cancer, or blood clots, among different conditions.  

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Top 10 Early Signs Of Alzheimer’s Disease You Simply Can’t Ignore

A person with Alzheimer’s disease could start to remove themselves from hobbies, social activities, work projects or sports. they will have trouble maintaining with a favourite sports team or remembering the way to complete a favourite hobby. they will additionally avoid being social as a result of the changes they have experienced. One of the foremost common signs of Alzheimer’s disease is amnesia, particularly forgetting recently learned data. Others include forgetting vital dates or events; requesting the same info over and over; increasingly eager to accept memory aids (e.g., reminder notes or electronic devices) or members of the family for things they wont to handle on their own. People with Alzheimer’s disease usually realize it exhausting to complete daily tasks. Sometimes, individuals may have trouble driving to a well-recognized location, managing a budget at work or remembering the principles of a favourite game. Some individuals could experience changes in their ability to develop and follow an idea or work with numbers. they will have trouble following a well-recognized instruction or keeping track of monthly bills. they will have a problem concentrating and take for much longer to do things than they did before. People with Alzheimer’s disease will lose track of dates, seasons and therefore the passage of time. they will have hassle understanding something if it’s not happening instantly. sometimes they will forget wherever they’re or how they got there. The mood and personalities of individuals with Alzheimer’s disease can change. they’ll become confused, suspicious, depressed, fearful or anxious. they will be simply upset at home, at work, with friends or in places wherever they’re out of their comfort zone. People with Alzheimer’s could have trouble following or joining an oral communication. they will stop in the middle of a speech and have no plan how to continue or they will repeat themselves. they will struggle with vocabulary, have issues finding the correct word or decision things by the incorrect name. For some individuals, having vision issues may be a sign of Alzheimer’s disease. they may have problem reading, judgment distance and determining color or distinction, which can cause problems with driving. People with Alzheimer’s disease could experience changes in judgment or decision-making. for instance, they will use poor judgment when handling cash, giving massive amounts to telemarketers. they will pay less attention to grooming or keeping themselves clean. A person with Alzheimer’s disease could place things in unusual places. they will lose things and be unable to travel back over their steps to seek out them again. Sometimes, they will accuse others of stealing. this could occur more often over time.  

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Methyldopa: Uses, Side effects, Dosage

Methyldopa produces its antihypertensive effect by acting on the alpha adrenoceptors in the vasomotor center of the brain.though it is sympathomimetic drug they can cause decreased activity of the sympathetic nervous system to the cardiovascular system by acting as an agonist on the alpha-adrenoceptors, leading to falling in blood pressure. Methyldopa when given orally or parenterally, passes into the brain by an active process.it is converted in the brain into alpha methyldopa>>>alpha methyldopamine>>>alpha methyl noradrenaline.Alpha methyl noradrenaline then acts on alpha adrenoceptors in the vasomotor center of the brain and inhibit the sympathetic outflow to the peripheral tissues, especially CVS.Methyldopa produces its antihypertensive effects by causing reduction of peripheral vascular resistance. It is one of the safest antihypertensive drug in Pregnancy. Its maximum antihypertensive effect occurs in 4-6hoirs and then persist for about 24hours. Pharmacokinetics: Absorption of methyldopa after oral administration is incomplete and its bioavailability after oral administration is about 25%.Most of the drug is excreted unchanged in the urine i.e about two third and the remaining is metabolized in the liver.its dosage should be reduced in renal and hepatic failure. Methyldopa Adverse effects: The Most common side effects related tothis drug are the following; Sedation, Dizziness, Dry mouth and postural hypotension. Other less common adverse effects include anxiety, blurred vision, sleep disturbances, parkinsonism, and impotence. More serious but rare adverse effects are hemolytic anemia, hepatitis, thrombocytopenia, leukopenia, and a lupus erythematosus-like syndrome.Hepatitis with methyldopa is usually reversible when the drug is stopped .it usually occurs during the initial two months of therapy, but sometimes it can occur after a prolonged therapy with the drug. Doses: A dose of 500-2000mg daily in a single or 2-3 divided doses orally .injection of methyldopa is available as 5 ml ampoules containing 50mg/ml. A dose of 250-500mg by IV infusion and can be repeated after every six hours.

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Pentazocine: Uses, Side effects, Dosage

Pentazocine is a synthetic opioid that has agonist activity at kappa and weak antagonist activity at Mu receptors. Pentazocine is used to relieve moderate to severe pain. Its analgesic activity is almost equal to that of morphine. It has a short duration of action i.e 3-4 hours. Pentazocine is Available in Combination with Naloxone To Avoid its misuse various Available in various dosage forms like Tablet and Injection. 50mg of pentazocine orally is almost equal to 60mg of oral codeine in analgesic activity. Nausea and vomiting are common with pentazocine. Dependence and tolerance can occur but is less as compared to that of morphine. Pentazocine can produce mental confusion, tachycardia, dysphoria, Hypertension, and Palpitations. Also, Causes Trouble passing urine or change in the amount of urine. Should be used with cautions in the following conditions; cardiac arrhythmias, Phaeochromocytoma, Pancreatitis, Arterial or pulmonary hypertension, And acute myocardial infarction.   This drug can enter the foetal circulation and has the potential to cause opioid effects including central depression, can cause respiratory depression and withdrawal symptoms in the neonates if used during delivery. There is very less data on the secretion of pentazocine in breast milk, so it is recommended that infants of nursing mothers who are receiving high doses of pentazocine, be appropriately monitored Less Likely To Cause constipation. It is contraindicated in acute respiratory depression and in patients dependent on opioids, heart failure secondary to chronic lung disease, acute porphyria. Pentazocine may interact with the following medicines Like antihistamines,alcohol,atropine,anxiolytics or sleep,Medications,oxybutynin, tolterodine,certain medicines for depression like amitriptyline, fluoxetine, sertraline,certain medicines for stomach problems like dicyclomine, hyoscyamine,certain medicines for seizures like phenobarbital, primidone,certain medicines for travel sickness like scopolamine,certain medicines for Parkinson’s disease like benztropine, trihexyphenidyl,general anesthetics like halothane, isoflurane, methoxyflurane, propofol,ipratropium,MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate,medicines that relax muscles for surgery,local anesthetics like lidocaine, pramoxine, tetracaine,other narcotic medicines for pain or cough,phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine. Dosage Dosage for Adults: The usual initial dosage is 50mg every 3-4 hours after meals followed by 50-100mg every three to four hours.The maximum dose is 600 mg daily. Dose For Children under 12 years: It is recommended that another dosage form ie tablets, be used as appropriate for this age group.

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Antacids: Mechanism, Uses, Side effects

These are alkaline drugs which neutralize the gastric acid to form salts.Sodium, magnesium, and aluminum compounds are commonly used as antacids. Sodium Bicarbonate acts quickly but has a significant absorption from GIt.Thus It can Cause alkalosis with its prolonged use especially in patients with renal failure.Magnesium compounds such magnesium oxide and magnesium hydroxide act quickly to neutralize the acid, but they tend to cause diarrhea.Aluminium hydroxide is an effective antacid but it causes constipation.Thus, in antacid mixtures, magnesium and aluminum compounds are used in combination to prevent diarrhea or constipation. Common types of antacids: Sodium bicarbonate Magnesium carbonate Magnesium trisilicate Magnesium hydroxide Aluminium hydroxide Calcium carbonate Mechanism Of Action: Antacids work by counteracting (neutralizing) the acid on your stomach. They do this because the chemical compounds in antacids are bases (alkalis) that are the opposite of acids. A reaction among an acid and base is referred to as neutralization. This neutralization makes the stomach contents much less corrosive. This can assist to alleviate the pain related to ulcers and the burning sensation in acid reflux disease. Side effects: Though Side effects associated with antacid are very low, sometimes they can cause: flatulence diarrhea or constipation feeling sick or vomiting stomach cramps Uses: Antacids can be used to prevent ulcer symptoms, Thus they are used initially to relieve the discomfort of the patient. It can also be used in Peptic ulcer disease if given in sufficient amount for a sufficient period of time It Can Also be used to neutralize stomach acid and used in Dyspepsia. Also used to reduce symptoms of Gastro Esophageal reflux disease (GERD)

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Metformin: Uses, Side Effects, Dosage

Metformin is an oral antidiabetic drug, especially used in Noninsulin dependent Diabetes Mellitus Patients who are obese because it doesn’t cause an increase in body weight. On the other hand, body weight may be increased with insulin and sulphonylureas. It is excreted unchanged in the urine, and its plasma half-life is 1.30 to 3 hours. Clinical Uses: It is the drug of choice in non-insulin-dependentnoninsulin diabetes mellitus patients. It is also used along with sulphonylureas when blood glucose is not fully controlled with sulphonylureas alone. It is also used in polycystic ovary syndrome (Unlicensed use) Dose Of Metformin: The usual recommended dose is 0.5 -2.55g daily in two to three divided doses after meals. Metformin in Pregnancy: It can be used in pregnancy for both pre-existing and gestational diabetes. Mechanism Of Action Its exact mechanism of action is unknown, but it seems to inhibit the formation of glucose in the liver (gluconeogenesis). Another possible mechanism of action may decrease glucose absorption from the GIT and increase its uptake by the skeletal muscle. Adverse Effects: Anorexia, nausea, abdominal pain, vomiting, and diarrhea are the most common adverse effects associated with metformin. These can be reduced by starting the drug with a small dose after meals and then gradually increasing the dose. Cold Feeling in your arms and legs. Chronic administration of metformin may decrease the absorption of vitamin B12 from the intestine. Hence, serum vitamin B12 Should be monitored during chronic administration of biguanides, and if a deficiency occurs, then vitamin B12 should be given by injection. Lactic acidosis is a serious adverse effect that is more liable to occur in patients with renal failure, cardiorespiratory insufficiency, alcoholism, and elderly people. Trouble breathing. Related Article: Important information about Gaviscon

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Top 100 Extremely Important Pharmacology Mnemonics

Pharmacology mnemonics are various techniques that facilitate students to recall larger pieces of clinical information, particularly in the form of lists like characteristics, classification, side effects, benefits, stages, steps, parts, phases, etc. Pharmacology is the study of how drugs effects the body. It is the study of pharmacokinetics and pharmacodynamics. There are many types of mnemonics that work better like name mnemonics, model mnemonics, expression or word mnemonics, image mnemonics, etc. Pharmacology is a very vast subject, That’s why it’s very difficult to cover the whole subject but we have compiled a list of some very important Pharmacology Mnemonics in this article. Pharmacology Mnemonics helping students performs better in exams. In this article, we will highlight top 100 of the most important pharmacology mnemonics. Pharmacology Mnemonics Sulfonamides: common characteristics SULFA: S-Steven-Johnson syndrome U-Urine precipitation/ Useful for UTI L-Large spectrum F-Folic acids synthesis blocker A-Analog of PABA Diuretics: groups “Leak Over The CAN“: L-Loop diuretics O-Osmotics T-Thiazides C-Carbonic anhydrase inhibitors A-Aldosterone inhibitors N-Na (sodium) channel blockers Tuberculosis: treatment If you forget your TB drugs, you’ll die and might need a PRIEST“: P-Pyrazinamide R-Rifampin I-Isoniazid (INH) E-Ethambutol St-Streptomycin Aminoglycosides: common characteristics AMINO: A- Active Against Aerobic gram-negative M-echanism of resistance are Modifying enzymes I– Inhibit protein synthesis by binding to 30S subunit N- Nephrotoxic O- Ototoxic Femara (Letrozole)  Side Effects  Just Remember “FEMARA”  F–Fracture (Bone), Flushes (Hot)  E–Edema (Peripheral)  M–Memory impairment  A–Anxiety (Less Common)  R–Raised Sweating  A–Arterial thrombosis(very rare        6. Thalidomide: effect on cancer cells “Thalidomide Makes the blood vessels hide“: Use thalidomide to stop cancer cells from growing new blood vessels.        7. Carbamazepine (CBZ): use CBZ:         C-Cranial Nerve V (trigeminal) neuralgia         B-Bipolar disorder         Z-Zeisures        8. Warfarin: interactions              ACADEMIC QACS:          A-Amiodarone          C-Cimetidine          A-Aspirin          D-Dapsone          E-Erythromycin          M-Metronidazole          I-Indomethacin          C-Clofibrates          Q-Quinidine          A-Azapropazone          C-Ciprofloxacin          S-Statins       9. Morphine: side-effects MORPHINE:          M-Myosis          O-Out of it (sedation)          R-Respiratory depression          P-Pneumonia (aspiration)          H-Hypotension          I-Infrequency (constipation, urinary)          N-Nausea          E-Emesis      10. Tricyclic antidepressants (TCA):                side effects TCA’S:          T-Thrombocytopenia          C-Cardiac (arrhythmia, MI, stroke)          A-Anticholinergic (tachycardia, etc)          S-Seizures Corticosteroids: adverse side effects CUSHINGS BAD MD: C-Cataracts U-Up all night (sleep disturbances) S-Suppression of HPA axis H-Hypertension/ Buffalo Hump I-Infections N-Necrosis (avascular) G-Gain weight S-Striae B-Bone loss (osteoporosis) A-Acne D-Diabetes M-Myopathy, moon faces D-Depression and emotional changes Microtubules: drugs that act on microtubules. “The  MicroTubule Growth Voiding Chemicals”: T-Thiabendazole M-Mebendazole T-Taxol G-Griseofulvin V-Vincristine/ Vinblastine C-Colchicine BromoCRYPTine is a DOPamine agonist. Beta-blockers: members “The NEPAL Prime M-Minister”: T-Timolol N-Nadolol E-Esmolol P-Pindolol A-Atenolol L-Labetalol P-Propranolol M-Metoprolol Insulin: mixing regular insulin and NPH “Not Ready, Ready Now”: Air into NPH Air into Regular Draw up Regular Draw up NPH Parasympathetic vs. sympathetic neurotransmitters “No sympathy for a Pair of Aces”: Norepinephrine is secreted in by the Sympathetic nervous system while Acetylcholine is secreted in the Parasympathetic nervous system. Benzodiazepines: 3 members that undergo extrahepatic metabolism “Outside The Liver”: O-Oxazepam T-Temazepam L-Lorazepam These undergo extrahepatic metabolism and do not form active metabolites. Guanethidine: mechanism GuaNEthidine prevents NE (norepinephrine) release. Opioids: mu receptor effects “MD CARES“: M-Miosis D-Dependency C-Constipation A-Analgesics R-Respiratory depression E-Euphoria S-Sedation Adrenoceptors: the vasomotor function of alpha vs. beta ABCD: Alpha = Constrict. Beta = Dilate. Beta 1 selective blockers “BEAM ONE up, Scotty”: Beta 1 blockers: E-Esmolol A-Atenolol M-Metoprolol Atropine use: tachycardia or bradycardia “A goes with B“: Atropine used clinically to treat Bradycardia. Cancer drugs: time of action between DNA->mRNA ABCDEF: A-Alkylating agents B-Bleomycin C-Cisplatin D-Dactinomycin/ Doxorubicin E-Etoposide F-Flutamide and other steroids or their antagonists (eg tamoxifen, leuprolide) Busulfan: features ABCDEF: A-Alkylating agent B-Bone marrow suppression s/e C-CML indication D-Dark skin (hyperpigmentation) s/e E-Endocrine insufficiency (adrenal) s/e F-Fibrosis (pulmonary) s/e Tricyclic antidepressants: members worth knowing “I have to hide, the CIA is after me”: C-Clomipramine I-Imipramine A-Amitriptyline Torsades de Pointes: drugs causing APACHE: A-Amiodarone P-Procainamide A-Arsenium C-Cisapride H-Haloperidol E-Erythromycin Asthma drugs: leukotriene inhibitor action zAfirlukast: Antagonist of lipoxygenase zileuton: Inhibitor of LT receptor Propranolol and related ‘-olol’ drugs: usage “olol” is just two backward lower case b’s. Backward b’s stand for “beta-blocker”. · Beta-blockers include acebutolol, betaxolol, bisoprolol, oxprenolol, propranolol. Beta-blockers: B1 selective vs. B1-B2 non-selective A through N: B1 selective: Acebutolol, Atenolol, Esmolol, Metoprolol. O through Z: B1, B2 non-selective: Pindolol, Propanolol, Timolol. Antirheumatic agents (disease-modifying): members CHAMP: C-Cyclophosphamide H-Hydroxychloroquine and chloroquine A-Auranofin and other gold compounds M-Methotrexate P-Penicillamine HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactions HMG–CoA: · Side effects: H-Hepatotoxicity M-Myositis [aka rhabdomyolysis] · Contraindications: G-Girl during pregnancy/ Growing children · Interactions: C-Coumarin/ Cyclosporine Serotonin syndrome: components Causes HARM: H-Hyperthermia A-Autonomic instability (delirium) R-Rigidity M-Myoclonus Therapeutic index: formula TILE: TI = LD50 / ED50 Antiarrhythmics: class III members BIAS: B-Bretylium I-Ibutilide A-Amiodarone S-Sotalol Read, More Pharmacology Mnemonics 33-66 MAOIs: indications MAOI‘S: M-Melancholic [classic name for atypical depression] A-Anxiety O-Obesity disorders [anorexia, bulemia] I-Imagined illnesses [hypochondria] S-Social phobias K+ increasing agents K-BANK: K-K-sparing diuretic B-Beta blocker A-ACEI N-NSAID K-K supplement Ribavirin: indications RIBAvirin: R-RSV I-Influenza B A-Arenaviruses (Lassa, Bolivian, etc.) SIADH-inducing drugs ABCD: A-Analgesics: opioids, NSAIDs B-Barbiturates C-Cyclophosphamide/ Chlorpromazine/ Carbamazepine D-Diuretic (thiazide) Diuretics: thiazides: indications “CHIC to use thiazides”: C-CHF H-Hypertension I-Insipidous C-Calcium calculi Parkinsonism: drugs SALAD: S-Selegiline A-Anticholinenergics (trihexyphenidyl, benzhexol, orphenadrine) L-L-Dopa + peripheral decarboxylase inhibitor (carbidopa, benserazide) A-Amantadine D-Dopamine postsynaptic receptor agonists (bromocriptine, lisuride, pergolide) Thrombolytic agents USA: U-Urokinase S-Streptokinase A-Alteplase (tPA) Morphine: effects at mu receptor PEAR: P-Physical dependence E-Euphoria A-Analgesia R-Respiratory depression Morphine: effects MORPHINE: M-Miosis O-Orthostatic hypotension R-Respiratory depression P-Pain suppression H-Histamine release/ Hormonal alterations I-Increased ICT N-Nausea E-Euphoria S-Sedation Anticholinergic side effects “Know the ABCD’S of anticholinergic side effects”: A-Anorexia B-Blurry vision D-Constipation/ Confusion D-Dry Mouth D-Sedation/ Stasis of urine Antiarrhythmics: classification I to IV MBA College · In order of class I to IV: M-Membrane stabilizers (class I) B-Beta blockers A-Action potential widening agents C-Calcium channel blockers Teratogenic drugs “W/ TERATOgenic”: W-Warfarin T-Thalidomide E-Epileptic drugs: phenytoin, valproate, carbamazepine R-Retinoid A-ACE inhibitor T-Third element: lithium O-OCP and other hormones (eg danazol) Epilepsy types, drugs of choice “Military General Attacked Weary Fighters Pronouncing ‘Veni Vedi Veci’ After Crushing Enemies”: ·Epilepsy types: M-Myoclonic G-Grand

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Clonidine: Uses, Side Effects, Dosage

Clonidine is a prescription medication. It’s available as a patch, an oral tablet, and an oral extended-release tablet. The form you use may depend on your condition. Facts: Clonidine is a centrally-acting α2-adrenergic agonist. It crosses the blood-brain barrier. Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.Also used to treat attention deficit hyperactivity disorder(ADHD). Mechanism Of Action: Clonidine stimulates alpha-adrenergic receptors in the brain stem. This action results in reduced sympathetic outflow from the central nervous system and decreases in peripheral resistance, renal vascular resistance, heart rate, and blood pressure. Clonidine Side Effects: A very slow heart rate (fewer than 60 beats per minute); Fast or pounding heartbeats, tremors; Feeling short of breath, even with mild exertion; Confusion, hallucinations; Swelling, rapid weight gain; Feeling like you might pass out. Flu symptoms; Urination problems; or Other common side effects may include: Cold symptoms such as runny or stuffy nose, sneezing, cough, sore throat; Feeling tired or irritable; Drowsiness, dizziness; A headache, ear pain; Mood changes; Sleep problems (insomnia), nightmares; Feeling hot; Mild fever; Loss of interest in sex, impotence, difficulty having an orgasm. Constipation, diarrhea, pain in your upper stomach; Dry mouth increased thirst; Clonidine Dosage The usual oral adult dose is 0.1–0.3 mg twice daily. The Usual Adult Dose For Hypertension is 0.2-0.6mg orally per day in a divided doses. The Usual Adult Dose for Pain Is 30mcg/hr As a continuous infusion. The Usual Pediatric Dose for attention deficit disorder (For age 6 year and more ) is 0.1 mg orally at bedtime and Increase in 0.1 mg/day increments every 7 days until desired response; doses should be administered twice daily . The maximum oral dose is 2.4 mg daily. Topical patches should be applied to an area of hairless skin on the upper arm or torso, once every 7 days. When applying a new topical patch, a different area of skin should be used.

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Important information about Nitroglycerin

Nitroglycerin is in a class of Prescription medications called vasodilators. It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen. Nitroglycerin are used to treat and prevent episodes of angina in indiviuals who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring. This drug works by relaxing the smooth muscle and blood vessels in your body. This increases the amount of blood and oxygen that reaches your heart. In turn, your heart works less hard. This reduces chest pain. This drug may lower your blood presure and orthostatic hypotension. Nitroglycerin sublingual tablet is available as both a generic and brand-name drug. Brand names: Nitrostat,Nitromist,Nitroquick,Nitrolingual,Nitro-Dur,Minitran,Nitro-Bid etc It was granted FDA approval in 1938. Side effects  Common side effects include: lightneadedness headache Other side effects include: Sweating a lot Nausea Vomiting Blurred vision Fainting Dry mouth Fast or slow heart beat Serious side effects: Low Blood pressure Flushing of the head and neck can occur. Pregnancy and Nitroglycerin: Nitroglycerin falls into category C. No animal studies have been conducted with nitroglycerin transdermal patches. No well-controlled studies have been conducted in pregnant women. Nitroglycerin should only be given to a pregnant woman if clearly needed.   Dosage For angina pectoris prophylaxis: SUBLINGUAL TABLET: 0.3 to 0.6 mg sublingually or in the buccal pouch 5 to 10 minutes prior to engaging in activities that might precipitate an acute attack . For Myocardial Infarction 5 mcg/min continuous IV infusion via non-absorptive tubing; increase by 5 mcg/min every 3 to 5 minutes as needed up to 20 mcg/min, then by 10 or 20 mcg/min if needed

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