Bromhexin (Bisolvon): Uses, Side Effects, Dosage

Bromhexine (Brand name Bisolvon) belongs to a group of medications known as expectorant / mucolytic agents. It is a phenylmethylamine compound.

Bisolvon comes in tablet, liquid and aerosol form.

  • Bisolvon 4mg / 5ml
  • Bisolvon Chesty Forte 8 mg.
  • Bisolvon Tish Spray.


Bromhexine hydrochloride is prescribed for
Cough that works by dissolving the hard mucus.

  • In general, bisolvon is given to patients with respiratory problems who have difficulty expectorating it; breaking it makes it smaller and easier to handle, which means that they can breathe without blocking the airways and at the same time relieve coughing.
  • It is used in conditions where breathing is difficult, since there are many secretions (also called mucus) in the airways. Like respiratory tract infections, flu and cold.
  • Bromhexine works after approximately five hours. This medicine can be used for cough, caused by influenza, bronchitis, chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF).

Mechanism of action

Bromhexine hydrochloride acts as a mucokinetic and mucolytic agent. Reduces the viscosity of the mucus by changing its structure. It depolymerizes mucopolysaccharides directly and releases lysosomal enzymes and the network of resistant sputum fibers breaks down. It Induces a broad and wide bronchial secretion.


Bromhexine (Bisolvon) should be avoided in patients allergic to this medicine. The symptoms of an allergy are:

  • Swelling of the face,
  • Itching,
  • The difficulty to breathe.
  • Swelling of the tongue

Tell your doctor if you have any of the above symptoms.

Do not use bisolvon cough syrup if you are allergic to any of the ingredients of bisolvon. Cough syrup should not be given to children under two years of age. Tablets should only be used in children over the age of five. Expectorant cough medicine should not be combined with cough medicine.

Side effects

Bisolvon is generally well tolerated, but as you know, any medication has some negative effects with good effects. Here is a list of some rare and common side effects associated with the use of Bisolvon.
Side effects of Bromhexine include

  • Runny nose
  • Lacrimation
  • Allergic reactions
  • Stomach irritation (flatulence),
  • Diarrhea,
  • Dizziness,
  • Headache,
  • Indigestion,
  • Nausea

There are some rare side effects that can occur and occur

  • Immune system disorders
  • Diseases of the skin and
  • Respiratory disorders.
  • In some rare cases, skin lesions have been associated with the medication.
    Other side effects included
  • Pruritus
  • Tightness of the chest

Bisolvon in pregnancy and lactation:

It is recommended that you do not use the medication during pregnancy, especially during the first three months, or if you are breast-feeding. As animal studies have shown, bromhexine inhalers, syrups and tablets have side effects in the fetus.
It is also recommended not to use it when breastfeeding when it passes into breast milk. Avoid breast-feeding while taking this medication.


You need to check all the probable interactions with your health care provider prior to beginning any medication.

Another drugs or over the counter products should you choose in precisely the exact same period, the consequence of Bromhexine drug can change. And can increase odds of unwanted effects or create your medication to not operate correctly. Inform your doctor about all of your health history, therefore simple to handle or protect against drug interactions.

At any time you choose more than 1 medication, or mix it with specific foods or drinks, you are in danger of a medication interaction.

Some herbal medications and Suplements can interact with Bisolvon thus avoid concomitant use.


Dosage for Bisovlon 4 mg / 5ml

  • The usual dose for adults begins in 10 ml three times a day. Your doctor can increase it up to 15 ml 4 times a day.
  • The usual dose for children aged 2 to 5 years is 5 ml 2-3 times a day.
  • The usual pediatric dose for 5-12 years is 5 ml 4 times a day.

Dosage for Bisolvon tablets

  • The usual dose for adults and children over 12 years is 1 tablet three times a day, if necessary. This dose can be increased to 2 tablets three times a day for the first 7 days.
  • The usual dose for children aged 6 to 11 years is 1 tablet three times a day if necessary.

Related Article: Important Information About Clobetasol (Clovate) 

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