Adfolic Tablet Uses, Side Effects, Dosage: A Comprehensive Guide

What is Adfolic Tablet?

In the pharmaceutical world, numerous drugs cater to various medical conditions. One such medication that has gained recognition is Adfolic. Adfolic is a brand of folic acid made by PharmEvo, with its main active component being Quatrefolic. This article aims to provide a detailed overview of Adfolic tablet uses, its dosage, side effects, contraindications, and more.

Folic acid is a crucial nutrient in the B-vitamin group, commonly known as vitamin B9. It plays a key role in various bodily functions, including the production of red blood cells, DNA synthesis, and cell division. Adfolic comes in two variants, Adfolic 300mg and Adfolic OD 600mg, each with its distinct usage and indications.

Quick Facts

  • Product Name: Adfolic and Adfolic OD
  • Active Ingredient: Quatrefolic
  • Manufacturer: PharmEvo
  • Adfolic Tablet Uses: Help maintain pregnancy,  prevent neural defects and abortion.


Adfolic Tablet Uses
Adfolic Tablet Uses

Adfolic Tablet Uses

  • Pregnancy and Lactation: Folic acid is essential during pregnancy and lactation. Quatrefolic helps prevent neural tube defects in babies and supports the healthy development of the fetus.
  • Dietary Supplement for Adults and Older People: Adfolic is a dietary supplement for adults, especially older individuals who may have difficulty absorbing folate.
  • Prevention of Spontaneous Abortions: Occasionally, recurrent spontaneous abortions may occur due to folate deficiency. Adfolic can be used to address this deficiency and reduce the risk of miscarriages.
  • Hyperhomocysteinemia: increased levels of homocysteine in the blood, known as hyperhomocysteinemia, can lead to various health issues. Adfolic helps in managing this condition.
  • Folate Deficiency Caused by Medications: Certain medications, such as phenytoin, phenobarbital, and primidone, can lead to folate deficiency. Adfolic can be prescribed to counteract this deficiency.
  • Folate Deficiency Caused by Health Conditions: Long-term damage to red blood cells or kidney dialysis can result in folate deficiency. Adfolic is used to address this deficiency in such cases.
  • Neurological Conditions: Some research suggests that folic acid supplementation might benefit conditions like depression, cognitive impairment, dementia, and Alzheimer’s. However, it is important to consult a healthcare professional before using Adfolic.

Adfolic Tablet Dosage and Administration:

The recommended dosage of Adfolic is similar to that of regular folic acid, expressed based on the “Recommended Dietary Allowances for Folate in Children and Adults.” The dosage may vary depending on the specific condition being treated and individual health factors.

For pregnant women, a daily dose of 600 mcg of folic acid is commonly prescribed to prevent neural tube defects in the baby. For other indications, healthcare professionals may adjust the dosage accordingly.

Adfolic Tablet Side Effects:

Like any medication, Adfolic may cause side effects in some individuals. Common side effects of folic acid supplementation include:

  • Anorexia
  • Nausea
  • Abdominal Distension
  • Flatulence
  • Allergic Reactions (erythema, rash, pruritus, urticaria, dyspnea, anaphylactic reactions, including shock)

It is crucial to be aware of these potential side effects (adverse events) and seek medical attention if any adverse reactions occur.


Certain conditions and scenarios warrant caution or avoidance when using Adfolic:

  • Long-term folate therapy is contraindicated in individuals with untreated cobalamin deficiency, such as pernicious anemia or other causes of cobalamin deficiency, including lifelong vegetarians. An absorption test for cobalamin should be performed before starting long-term folate therapy, especially in elderly patients.
  • Folic acid should not be administered alone in treating Addisonian, pernicious anemia, or other vitamin B12 deficiency states, as it may trigger sub-acute combined spinal cord degeneration.
  • Folic acid should be used with caution in patients with folate-dependent tumors.
  • Pregnant or breastfeeding women should consult healthcare professionals before using Adfolic.
  • Individuals with seizure disorders should be cautious with folic acid supplementation, especially in high doses, as it might worsen seizures.


Adfolic OD 600mg Tablet Uses
Adfolic OD 600mg Tablet

Drug Interactions:

Adfolic may interact with other medications, affecting their effectiveness. Some notable drug interactions include:

  • Fosphenytoin: Adfolic might decrease the effectiveness of fosphenytoin in preventing seizures.
  • Methotrexate: Adfolic might decrease the effectiveness of methotrexate.
  • Phenobarbital and Phenytoin: Adfolic can decrease the effectiveness of these drugs in preventing seizures and increase the risk of seizures.
  • Primidone: Adfolic might reduce the efficacy of primidone in preventing seizures.
  • Pyrimethamine: Adfolic might decrease the effectiveness of pyrimethamine in treating parasite infections.
  • Sulfasalazine: Sulfasalazine can reduce the absorption of folic acid.

Use in Special Populations:

  • Pregnancy: Folic acid is considered safe during pregnancy when taken appropriately. A daily dose of 600 mcg is commonly recommended to prevent congenital disabilities and neural tube defects in babies.
  • Nursing Mothers: Folic acid is excreted into human milk, but no adverse effects have been associated with its use during lactation.

Mechanism of Action of Quatrefolic:

The mechanism of action of Quatrefolic, the active component of Adfolic, is related to its 5-methyltetrahydrofolate content. This derivative of tetrahydrofolic acid plays a crucial role as a coenzyme in various metabolic reactions, including the biosynthesis of nucleotide purines and pyrimidines, as well as the metabolism of critical amino acids. Quatrefolic aids in converting homocysteine to methionine when combined with vitamin B12, preventing potential pathologies and diseases associated with its deficiency.


Adfolic tablets, containing Quatrefolic as the main active component, are valuable supplements for various health conditions. From preventing neural tube defects in pregnant women to managing hyperhomocysteinemia, Adfolic is essential in promoting overall health. However, as with any medication, it is crucial to use Adfolic under the guidance of a healthcare professional to ensure safe and effective results.

In conclusion, Adfolic’s efficacy lies in its potent combination of folic acid and Quatrefolic, making it a reliable and beneficial medication for individuals requiring folate supplementation. Always consult your pharmacist or doctor before starting any new medicines, including Adfolic, to ensure their suitability for your specific health needs.

By providing detailed information about Adfolic’s uses, dosage, side effects, contraindications, and mechanism of action, this article aims to empower readers with essential knowledge about this medication and its potential benefits for various health conditions.

So, whether you are a healthcare professional looking for insights into Adfolic or an individual seeking answers about this medication, the information provided here will assist you in making informed decisions about its usage. Remember, knowledge is power; with proper guidance, you can lead a healthier and happier life.

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