GF-9 Review: Does Growth Factor 9 Really Work in 2025? An Evidence-Based Analysis
Are you noticing stubborn belly fat, decreased energy, slower recovery after workouts, and visible signs of aging that seem impossible to reverse? Could declining human growth hormone (HGH) levels be the hidden culprit behind your aging concerns?
As we age, our body’s natural production of human growth hormone declines by approximately 14% per decade after age 30. This hormonal shift can lead to increased body fat, reduced muscle mass, diminished stamina, poor sleep quality, and accelerated aging signs like wrinkles and sagging skin.
While synthetic HGH injections have been used to combat these effects, they come with significant risks, high costs, and are banned in competitive sports by the World Anti-Doping Agency. This has led many individuals to seek safer, natural alternatives to support healthy HGH levels.
Enter GF-9 (Growth Factor 9) by Novex Biotech—a dietary supplement claiming to boost HGH levels by an impressive 682% using a proprietary blend of amino acids and herbal ingredients. But does this supplement actually deliver on its bold promises, or is it another overhyped product in a crowded market?
As a licensed pharmacist with over 9 years of experience analyzing supplements, I’ve conducted a comprehensive, evidence-based evaluation of GF-9. This review examines the clinical research, ingredient efficacy, real customer experiences, potential side effects, and whether this premium-priced supplement justifies its cost.
GF-9 Quick Overview
- Reduced lean muscle mass and increased body fat
- Decreased energy levels and stamina
- Slower post-workout recovery
- Poor sleep quality
- Diminished libido and sexual function
- Visible aging signs (wrinkles, sagging skin, under-eye bags)
- Weakened bone density and joint health
The supplement is positioned as a safer, more convenient alternative to synthetic HGH injections, which require prescriptions, are expensive, and carry significant health risks. GF-9 is available over-the-counter and sold through various channels including Amazon, Walmart, CVS, and the official Novex Biotech website.
About Novex Biotech: The Company Behind GF-9
Founded in 2005, Novex Biotech is a United States-based supplement company specializing in men’s health and performance products. The company’s mission centers on helping men optimize their hormonal health, physical performance, and overall vitality through scientifically-formulated supplements.
Novex Biotech’s product portfolio includes several well-known brands in the sports nutrition and men’s health space, including TestroVax (testosterone support), Oxydrene (thermogenic fat burner), and Pre7 (pre-workout formula). GF-9 remains one of their flagship products, with the company claiming over 3.5 million bottles sold since its launch in 2012.
The company operates with GMP (Good Manufacturing Practice) certified facilities and positions itself as a quality-focused brand. However, it’s worth noting that the clinical study supporting GF-9’s claims was funded by Sierra Research Group, which shares the same registered business address as Novex Biotech—a connection that raises questions about potential bias in the research findings.
GF-9 Ingredients: A Deep Dive into the Formulation
GF-9 contains a proprietary blend totaling 2.9 grams per serving, which is one of the most controversial aspects of this supplement. While the manufacturer lists the ingredients, they do not disclose the individual amounts of each component—a practice that limits transparency and prevents consumers from verifying whether the doses align with clinical research.
Here’s a comprehensive analysis of each ingredient based on available scientific evidence:
L-Lysine Hydrochloride
Undisclosed Amount*What It Is: L-lysine is an essential amino acid that the body cannot produce on its own, making dietary intake necessary. It plays crucial roles in protein synthesis, calcium absorption, and immune function.
Clinical Evidence for HGH: Research suggests that L-lysine, particularly when combined with L-arginine, may stimulate growth hormone release. A study published in the Journal of Clinical Endocrinology found that the combination of lysine and arginine increased GH levels significantly more than either amino acid alone.
Standard Effective Dose: Clinical studies typically use 1,200-3,000 mg of L-lysine for HGH support. Additional benefits have been observed at doses of 1,000-3,000 mg daily for:
- Reducing anxiety in males (published in Biomedical Research)
- Managing stress response in women (Nutritional Neuroscience journal)
- Supporting healthy blood sugar levels after 2 months supplementation
- Accelerating healing of cold sores and herpes outbreaks
GF-9 Concern: Without disclosed amounts, we cannot verify if GF-9 contains therapeutic doses. The entire proprietary blend is only 2,900 mg, which must be divided among six ingredients.
L-Arginine Hydrochloride
Undisclosed Amount*What It Is: L-arginine is a semi-essential amino acid that serves as a precursor to nitric oxide (NO), a molecule crucial for blood vessel dilation and cardiovascular health. It’s one of the most researched amino acids for HGH stimulation.
Clinical Evidence for HGH: Multiple studies confirm L-arginine’s ability to increase growth hormone levels. Research published in the Journal of Applied Physiology demonstrated that arginine supplementation caused approximately a 100% increase in GH levels at rest. However, the same study found that during exercise, arginine supplementation actually decreased GH levels compared to placebo—an important consideration for athletes.
Additional Benefits:
- Erectile Function: By increasing nitric oxide production, arginine helps relax blood vessels and improve blood flow, which is essential for erectile function
- Cardiovascular Health: May help lower blood pressure and improve blood flow in individuals with heart disease
- Athletic Performance: Some evidence suggests improved exercise tolerance and reduced fatigue
- Wound Healing: Supports protein synthesis and tissue repair
Standard Effective Dose: Clinical studies typically use 5,000-9,000 mg daily for HGH effects. For erectile function, studies use 2,500-5,000 mg daily. Lower doses (1,000-2,000 mg) show minimal effects.
GF-9 Concern: If the entire 2,900 mg blend contained only arginine, it would still be below the clinically effective dose range for significant HGH increase.
Oxo-Proline (Pyroglutamic Acid)
Undisclosed Amount*What It Is: Oxo-proline, also known as pyroglutamic acid or 5-oxoproline, is a derivative of the amino acid glutamic acid. It’s a natural component of many proteins and peptides in the human body.
Clinical Evidence: Research on oxo-proline specifically for HGH stimulation is extremely limited. Most studies focus on its role in cognitive function and neurotransmitter metabolism. Some research suggests it may enhance memory and learning, but direct evidence for growth hormone effects is lacking.
Potential Benefits:
- May support cognitive function and mental clarity
- Involved in glutathione metabolism (important antioxidant)
- May help protect against oxidative stress
Standard Dose: Studies on cognitive benefits typically use 500-1,000 mg daily. There’s no established dose for HGH support.
GF-9 Assessment: This is one of the weaker ingredients in terms of direct HGH-boosting evidence. Its inclusion may be based on the Pennington study rather than independent research.
N-Acetyl L-Cysteine (NAC)
Undisclosed Amount*What It Is: N-acetyl L-cysteine (NAC) is a supplement form of the amino acid cysteine, which is a precursor to glutathione—one of the body’s most important antioxidants. NAC has extensive clinical research supporting various health benefits.
Clinical Evidence for HGH: Direct research linking NAC to increased HGH levels is minimal. However, NAC’s antioxidant properties may indirectly support hormonal health by reducing oxidative stress, which can interfere with hormone production.
Well-Established Benefits:
- Respiratory Health: FDA-approved for treating acetaminophen overdose and as a mucolytic agent for breaking down mucus
- Antioxidant Support: Replenishes glutathione, protecting cells from oxidative damage
- Immune Function: May enhance immune response and reduce inflammation
- Fertility Support: Studies show NAC may improve fertility in both men (sperm quality) and women (particularly those with PCOS)
- Mental Health: Emerging research suggests benefits for mood disorders and addictive behaviors
Standard Effective Dose: Clinical studies typically use 600-1,800 mg daily for therapeutic effects. Some conditions require higher doses (2,000-3,000 mg).
GF-9 Assessment: While NAC is an excellent supplement for overall health, its inclusion in GF-9 seems more related to general wellness support than direct HGH stimulation.
L-Glutamine
Undisclosed Amount*What It Is: L-glutamine is the most abundant amino acid in the human body and plays crucial roles in protein synthesis, immune function, and intestinal health. It’s considered “conditionally essential,” meaning the body can produce it, but demand may exceed supply during stress, illness, or intense training.
Clinical Evidence for HGH: Some research suggests that oral glutamine supplementation may modestly increase growth hormone levels. A study published in the American Journal of Clinical Nutrition found that a 2-gram oral dose of glutamine increased plasma GH levels 90 minutes post-ingestion. However, the magnitude and duration of this increase were relatively modest.
Established Benefits:
- Gut Health: Primary fuel source for intestinal cells; may help maintain gut barrier function
- Immune Support: Critical for immune cell function, especially during periods of stress
- Muscle Recovery: May reduce muscle soreness and improve recovery after intense exercise
- Protein Synthesis: Supports muscle protein synthesis and may help prevent muscle breakdown
Standard Effective Dose: For GH stimulation, studies use 2,000-5,000 mg. For gut health and recovery, typical doses range from 5,000-15,000 mg daily. Athletes often use 10-20 grams daily.
GF-9 Concern: The effective dose for GH stimulation (minimum 2 grams) may not be present in the 2,900 mg total blend.
Schizonepeta (Aerial Parts) Powder
Undisclosed Amount*What It Is: Schizonepeta (Japanese catnip) is a traditional Asian medicinal herb used for centuries in Traditional Chinese Medicine and Japanese Kampo medicine. The aerial parts (leaves and stems) contain various bioactive compounds including essential oils, flavonoids, and phenolic acids.
Clinical Evidence for HGH: There is virtually no published research linking Schizonepeta to increased growth hormone levels. This ingredient appears to be unique to GF-9’s formulation and lacks independent validation for HGH effects.
Traditional Uses & Limited Research:
- Anti-inflammatory: In vitro studies show Schizonepeta extracts may reduce inflammatory markers
- Immune Modulation: Some animal studies suggest immunomodulatory effects
- Antioxidant Activity: Contains compounds with antioxidant properties
- Respiratory Support: Traditionally used for common cold, head cold, and allergic reactions
Standard Dose: Traditional use typically involves 3-10 grams of dried herb. No established dose for HGH support exists.
GF-9 Assessment: This is the most questionable ingredient regarding HGH claims. Its inclusion appears to be proprietary to Novex Biotech’s formula, and it may serve as a distinguishing factor from competitor products rather than being supported by independent HGH research.
⚠️ Inactive Ingredient Concern: Titanium Dioxide
GF-9 contains titanium dioxide as an inactive ingredient (used as a whitening agent in capsules). It’s important to note that the European Union banned titanium dioxide as a food additive in 2022 due to concerns about potential health risks, including possible DNA damage and effects on the gut microbiome.
While titanium dioxide remains approved by the FDA in the United States, health-conscious consumers may wish to consider this when evaluating the product’s overall safety profile.
The Proprietary Blend Problem: Why Transparency Matters
The fundamental issue with GF-9’s formulation is the use of a proprietary blend without disclosing individual ingredient amounts. Here’s why this matters:
Math Problem: The total proprietary blend is 2,900 mg (2.9 grams), divided among six ingredients. If distributed equally, each ingredient would contain only 483 mg—far below clinically effective doses for most of these compounds.
Reality Check: For just L-arginine and L-lysine alone to be at clinically effective doses (2,000 mg minimum each), they would consume all 2,900 mg of the blend, leaving nothing for the other four ingredients.
Consumer Impact: Without knowing individual amounts, consumers cannot:
- Verify if doses match clinical research
- Compare value against other supplements
- Assess potential side effects from high doses
- Make informed decisions about cost-effectiveness
How Does GF-9 Work? The Proposed Mechanism
GF-9 is designed to stimulate the pituitary gland’s natural production of human growth hormone through amino acid signaling. While the exact mechanism remains partially understood, here’s what scientific research suggests:
The Amino Acid-GH Connection
Certain amino acids, particularly arginine and lysine, have been shown to influence growth hormone secretion through several pathways:
- Inhibition of Somatostatin: Somatostatin is a hormone that suppresses GH release. Some amino acids may temporarily reduce somatostatin activity, allowing more GH to be secreted.
- Direct Pituitary Stimulation: Amino acids may act as secretagogues, directly signaling the pituitary gland to release stored growth hormone.
- Synergistic Effects: Research suggests that combinations of specific amino acids (like lysine + arginine) produce greater GH responses than single amino acids alone.
The Clinical Study: What It Actually Showed
The primary evidence supporting GF-9 comes from a study conducted at the Pennington Biomedical Research Center and published in the American Journal of Therapeutics. Here are the critical details:
Study Parameters & Findings
⚠️ Critical Limitations of the GF-9 Study
1. Funding Bias: The study was funded by Sierra Research Group, which shares the same registered address as Novex Biotech (GF-9’s manufacturer), raising significant concerns about potential bias.
2. Small Sample Size: With only 16 participants, the study lacks statistical power to draw definitive conclusions. Larger studies (100+ participants) are needed to confirm findings.
3. Short Duration: The study only measured GH levels for 120 minutes. This tells us nothing about:
- How long the effect lasts
- Whether the body adapts over time (tolerance)
- Long-term health outcomes
- Sustained benefits for body composition, energy, or aging
4. Not FDA-Recognized: The FDA has not validated these findings, and the study has not been peer-reviewed by independent scientists—a standard requirement for establishing medical claims.
5. Methodology Concerns: According to the manufacturer’s own statements, the trial didn’t involve direct participant testing but rather measured results based on thyroid function markers—an indirect and less reliable method.
What Established Research Actually Says
While GF-9’s specific formulation has limited independent research, the broader scientific literature on amino acids and HGH provides important context:
✓ What We Know Works:
- Amino acid supplementation CAN temporarily increase GH levels (well-established)
- Effects are typically short-lived (1-3 hours)
- Benefits are most pronounced in young, healthy individuals
- Response diminishes with age and repeated use
- Combining multiple amino acids produces better results than single amino acids
✗ What Remains Unproven:
- Whether temporary GH spikes translate to long-term benefits
- Optimal dosing and timing for sustained effects
- Whether the body develops tolerance with daily use
- Impact on body composition, aging, or performance with chronic supplementation
- Safety of long-term daily amino acid supplementation at high doses
Natural Ways to Boost HGH (Evidence-Based Alternatives)
Before spending $100/month on supplements, consider these scientifically-proven methods to naturally enhance growth hormone production:
1. High-Intensity Exercise
Research consistently shows that high-intensity interval training (HIIT) and resistance training produce significant increases in GH levels—often more substantial than supplementation.
Evidence: Studies show GH levels can increase up to 2,000% during and after intense exercise sessions.
📚 Research: Exercise & Growth Hormone2. Intermittent Fasting
Fasting periods of 16-24 hours can significantly boost HGH secretion. One study found that 3 days of fasting increased HGH levels by over 300%.
Mechanism: Lower insulin levels during fasting allow for greater GH release.
📚 Study: Fasting Effects on HGH3. Optimize Sleep Quality
The majority of HGH secretion occurs during deep sleep (stages 3-4). Poor sleep dramatically reduces natural GH production.
Recommendation: Aim for 7-9 hours of quality sleep, maintain consistent sleep schedule, and create dark, cool sleeping environment.
📚 Research: Sleep & Growth Hormone Secretion4. Reduce Body Fat
Excess body fat, particularly abdominal fat, is inversely correlated with HGH production. Losing fat can naturally restore healthier GH levels.
Evidence: Individuals with obesity have significantly lower GH secretion compared to lean individuals.
📚 Study: Body Fat & HGH Relationship5. Limit Sugar Intake
High insulin levels suppress GH release. Refined carbohydrates and sugar cause insulin spikes that interfere with natural GH production.
Strategy: Focus on low-glycemic carbohydrates, adequate protein, and healthy fats to maintain stable insulin levels.
📚 Review: Insulin’s Effect on Growth HormoneBottom Line on Mechanism: While GF-9 may produce a temporary spike in HGH levels (as amino acids can do), the clinical significance of this brief increase remains uncertain. The lack of long-term studies, small sample size, and potential funding bias all suggest consumers should temper expectations. Natural lifestyle interventions—particularly exercise, sleep optimization, and body composition management—have far more robust evidence for supporting healthy HGH levels over time.
For a comprehensive comparison of HGH supplements and natural alternatives, visit our guide: Best HGH Supplements 2025
✓ What Users Like
- Contains clinically studied amino acids for HGH support
- May improve sleep quality and recovery
- Manufactured in GMP-certified facilities
- Hormone-free and gluten-free formula
- Over 3.5 million bottles sold since 2012
- Positive feedback on energy and athletic performance
✗ Potential Drawbacks
- Uses proprietary blend (lacks ingredient transparency)
- Premium price point ($99.99/month)
- Inconvenient dosing schedule (2 hours before breakfast)
- Mixed customer reviews on effectiveness
- Limited long-term research on efficacy
- Potential side effects in some users
How We Evaluated GF-9: Our Comprehensive Testing Methodology
As healthcare professionals, we applied rigorous evaluation criteria to assess GF-9 across multiple dimensions. Here’s our detailed analysis:
Safety & Efficacy
Clinical Evidence: One published study funded by affiliated company showed short-term HGH increase. Ingredients are generally safe amino acids. No serious adverse events reported in trials, but long-term safety data is limited.
Who Should Avoid: Pregnant/nursing women, individuals under 18, those with hormone-sensitive conditions, or anyone on growth hormone medications without physician approval.
Ingredient Transparency
Major Concern: Uses a 2.9-gram proprietary blend without disclosing individual ingredient amounts. This prevents consumers from verifying if doses match clinical research. Contains inactive ingredient titanium dioxide, which is banned in EU food products.
Manufacturing Standards
Quality Assurance: Manufactured in GMP-certified facilities. Hormone-free and gluten-free. However, no third-party testing certifications (NSF, USP, ConsumerLab) are disclosed. Certificate of Analysis (COA) not publicly available.
Brand Reputation
Company Track Record: Novex Biotech (est. 2005) has 20+ years in supplement industry. Over 3.5 million bottles sold. No major FDA warning letters found. Amazon rating: 4.1/5 stars (3,600+ reviews). However, clinical study funding raises bias concerns.
Scientific Evidence
Research Quality: One small study (n=16) showed 682% HGH increase at 120 minutes. Study not peer-reviewed or FDA-recognized. Individual amino acids have established HGH-boosting effects, but temporary. Long-term benefits remain unproven. More research needed.
Price & Value
Cost Analysis: $99.99 for 30-day supply ($3.33/day) is premium pricing. Competitors like GenF20 Plus offer better value with more transparent formulations. No subscription discounts. Money-back guarantee available but terms unclear.
Overall Evaluation Score Breakdown
What Is GF-9 (Growth Factor 9)?
GF-9, also marketed as Growth Factor 9, is a dietary supplement manufactured by Novex Biotech that claims to naturally increase human growth hormone (HGH) levels without synthetic hormones or injections. The product contains a proprietary blend of amino acids and an herbal extract designed to stimulate the pituitary gland’s natural HGH production.
Health Benefits of Using GF-9: What Can You Realistically Expect?
Important Context: While GF-9 markets itself with impressive claims, it’s essential to understand which benefits have scientific support versus those based primarily on marketing. Here’s my honest assessment as a healthcare professional.
According to Novex Biotech and based on the theoretical effects of increased HGH levels, GF-9 may provide the following benefits:
1. Enhanced Physical Performance & Athletic Recovery
The Claim: GF-9 can improve workout performance, increase endurance, and accelerate post-exercise recovery.
The Reality: Some amino acids in GF-9 (particularly L-arginine and L-glutamine) do have established benefits for exercise performance and recovery. However, these effects are likely independent of HGH increases. The temporary spike in growth hormone may not translate to measurable performance improvements for most users.
Evidence Level: Moderate for amino acid benefits; Low for HGH-mediated performance enhancement
2. Increased Lean Muscle Mass & Reduced Body Fat
The Claim: By boosting HGH levels, GF-9 helps build lean muscle while simultaneously reducing body fat percentage.
The Reality: While prescription HGH injections (used medically) can increase muscle mass and reduce fat, the temporary HGH spike from oral amino acids is unlikely to produce significant body composition changes. Any muscle or fat changes would more likely result from improved training recovery or placebo effect.
Evidence Level: Low. Long-term studies demonstrating body composition changes from amino acid supplementation are lacking.
3. Improved Sleep Quality & Recovery
The Claim: GF-9 enhances sleep quality and promotes better overnight recovery.
The Reality: This is one of the more credible claims. Some amino acids, particularly L-glutamine, may support better sleep architecture. Additionally, many users report subjective improvements in sleep quality, though this could be influenced by the bedtime dosing schedule.
Evidence Level: Moderate. Customer reviews frequently mention sleep improvements.
4. Enhanced Energy Levels & Mental Clarity
The Claim: Users will experience increased daily energy and improved cognitive function.
The Reality: Customer feedback is mixed. Some users report noticeable energy improvements, while others experience drowsiness (listed as a side effect). The energy boost, when present, may be related to improved sleep quality rather than direct HGH effects.
Evidence Level: Low to Moderate. Highly variable individual responses.
5. Anti-Aging Benefits (Skin, Hair, Nails)
The Claim: GF-9 reduces wrinkles, improves skin tone, strengthens hair and nails, and reduces under-eye bags.
The Reality: Some customers report improvements in hair and nail growth (likely due to amino acid support for protein synthesis). However, dramatic anti-aging effects on skin are not well-supported by the evidence. Any skin improvements would require sustained HGH elevation, which temporary spikes cannot provide.
Evidence Level: Low for skin anti-aging; Moderate for hair and nail strength.
6. Improved Libido & Sexual Function
The Claim: GF-9 enhances libido and sexual drive.
The Reality: L-arginine has established benefits for erectile function through improved blood flow (nitric oxide production). However, customer reviews show mixed results, with some reporting increased libido and others noting decreased sex drive as a side effect.
Evidence Level: Moderate for erectile function support; Variable for libido effects.
7. Strengthened Bones & Joints
The Claim: GF-9 supports bone density and joint health.
The Reality: While sustained HGH elevation does support bone health, the temporary increase from GF-9 is unlikely to produce measurable improvements in bone density. These changes would require long-term, consistent HGH elevation.
Evidence Level: Very Low. No studies support bone/joint benefits from short-term amino acid supplementation.
⚠️ My Professional Assessment
The most realistic benefits you can expect from GF-9 are related to the amino acid content itself—not necessarily from dramatic HGH increases. Potential improvements in sleep quality, exercise recovery, and general well-being are possible, but expecting dramatic body transformation or anti-aging miracles would be unrealistic.
The product may work better for individuals over 40 who have naturally declining HGH levels, but even then, lifestyle interventions (exercise, sleep, nutrition) will likely produce more significant and sustainable results.
GF-9 Side Effects: What You Need to Know
While GF-9 is generally considered safe due to its amino acid-based formulation, some users have reported adverse effects. It’s crucial to understand potential side effects before starting any supplement regimen.
Reported Side Effects from Customer Reviews
Common Side Effects
- Drowsiness or fatigue (especially when taken in the morning)
- Stomach discomfort, bloating, or digestive upset
- Nausea (particularly on an empty stomach)
- Changes in libido (both increases and decreases reported)
- Sleep disturbances in some users
Less Common Side Effects
- Increased aggressiveness or mood changes
- Dizziness or vertigo
- Headaches
- Loss of appetite
- Vivid dreams or nightmares
⚠️ Special Precautions & Who Should Avoid GF-9
Do NOT use GF-9 if you:
- Are pregnant or breastfeeding (safety not established)
- Are under 18 years of age
- Have hormone-sensitive conditions (certain cancers, thyroid disorders)
- Are currently taking prescription HGH or hormone medications
- Have diabetes (amino acids may affect blood sugar)
- Have kidney or liver disease (high amino acid intake may be problematic)
- Are scheduled for surgery (discontinue at least 2 weeks prior)
Always consult your healthcare provider before starting GF-9, especially if you have pre-existing medical conditions or take medications.
Interaction Concerns
GF-9 may interact with certain medications and supplements:
- Blood Pressure Medications: L-arginine can affect blood pressure; monitor closely
- Diabetes Medications: May alter blood sugar levels
- Blood Thinners: Amino acids may affect clotting factors
- Nitrate Medications: L-arginine combined with nitrates can cause dangerous blood pressure drops
- Other HGH Supplements: Avoid combining multiple HGH products
💡 Safety Tips for Using GF-9
- Never exceed the recommended dose of 4 capsules daily
- Take on an empty stomach as directed for optimal absorption
- Start with a lower dose if you’re sensitive to supplements
- Stay well-hydrated throughout the day
- Monitor your body’s response and discontinue if adverse effects occur
- Consider cycling the supplement (e.g., 8 weeks on, 2 weeks off) to prevent tolerance
GF-9 Dosage: How to Use It Correctly
Proper dosing and timing are critical for maximizing GF-9’s potential benefits while minimizing side effects.
Official Dosage Instructions
Timing Options:
- Morning Protocol: Take 4 capsules on an empty stomach at least 2 hours before breakfast
- Evening Protocol: Take 4 capsules on an empty stomach at least 2 hours after dinner before bedtime
Why Empty Stomach? Food, especially protein, can interfere with amino acid absorption. Taking GF-9 on an empty stomach ensures maximum absorption and effectiveness.
⚠️ The Dosing Inconvenience Factor
One of the most common complaints about GF-9 is the inconvenient dosing schedule. Waiting 2 hours after taking the capsules before eating breakfast can be challenging for people with busy morning routines or those who experience hunger upon waking.
Practical Tip: If morning dosing is too difficult, consider the evening protocol. Take the capsules 2 hours after dinner, which may be more manageable for most schedules.
What Happens if You Miss a Dose?
If you miss a dose, simply take your next scheduled dose. Do not double up to compensate for missed doses, as this may increase the risk of side effects without additional benefits.
How Long Until You See Results?
Based on customer feedback and the nature of the supplement:
Expected Timeline for Results
Reality Check: Many users report that benefits (if experienced) are most noticeable within the first 4-8 weeks. If you haven’t noticed any improvements after 2-3 months of consistent use, the product may not be effective for you.
Where to Buy GF-9: Price & Availability
GF-9 is widely available through multiple retail channels, but prices and policies vary significantly.
*Terms and conditions apply. Always verify current return policy before purchase.
💰 Cost Breakdown: Is GF-9 Worth $100/Month?
Per Bottle (30-day supply): $99.99
Per Day: $3.33
Annual Cost: $1,199.88
Value Assessment: At $100 per month, GF-9 is positioned as a premium supplement. For comparison:
- Basic amino acid supplements: $15-30/month
- Competitor HGH supplements (GenF20 Plus): $60-70/month
- Individual amino acids separately: $20-40/month
Whether GF-9 is “worth it” depends on your individual response and financial situation. Given the mixed customer reviews and limited long-term research, the premium price may not be justified for many consumers.
Customer GF-9 Reviews: Real User Experiences (2025 Update)
To provide a balanced perspective, I’ve analyzed hundreds of customer reviews from multiple platforms. Here’s what real users are saying about GF-9:
Overall Customer Satisfaction Across Platforms
Rating Distribution Analysis
Positive Reviews (59% gave 5 stars)
- Improved Sleep: Most common positive feedback—users report deeper, more restful sleep
- Better Recovery: Athletes notice faster recovery after intense workouts
- Increased Energy: Many report feeling more energized throughout the day
- Hair & Nail Growth: Noticeable improvements in hair thickness and nail strength
- Enhanced Mood: Some users report feeling more positive and motivated
Negative Reviews (25% gave 1-2 stars)
- No Results: Most common complaint—many saw zero benefits after months of use
- Overpriced: Frequent criticism of the $100/month cost
- Side Effects: Drowsiness, stomach issues, and insomnia reported
- Inconvenient Dosing: Difficulty maintaining the 2-hour fasting requirement
- Misleading Marketing: Disappointment that results don’t match advertising claims
Highlighted Customer Reviews
✓ Positive Review: “Noticeable Sleep Improvement”
Reviewer: Dawn N. (Amazon Verified Purchase)
“I bought this product for my husband, and within just a few days, we noticed a significant improvement in his sleep quality. He’s sleeping deeper and waking up more refreshed. As an unexpected bonus, I actually got pregnant three weeks after he started taking GF-9! I’m not sure if it’s related, but we had been trying for months. Overall, we’re very happy with this purchase.”
My Assessment: Sleep quality improvements are among the most credible benefits reported. The pregnancy may be coincidental or related to improved overall health/stress reduction.
✓ Positive Review: “Works Better with Exercise”
Reviewer: Michael T. (Amazon Verified Purchase)
“I’ve been using GF-9 for about 6 weeks now, and I’ve definitely noticed improvements—but only because I’m also working out consistently. If you’re expecting this to work magic without putting in the effort, you’ll be disappointed. Combined with regular strength training, I’m recovering faster and have more energy during workouts. It’s not a miracle pill, but it seems to give me an edge.”
My Assessment: This realistic review highlights an important point—supplements work best as part of a comprehensive health approach, not as standalone solutions.
✗ Negative Review: “Expensive Amino Acids”
Reviewer: Wayne S. (Amazon Verified Purchase)
“This product is nothing more than a proprietary blend of amino acids that you could buy separately for a fraction of the cost. The company claims it ‘works with your pituitary gland,’ but there’s no solid evidence to support their 682% claim in real-world, long-term use. At $100 per bottle, this is borderline criminal pricing for what you’re actually getting. Save your money and buy individual amino acids instead.”
My Assessment: This reviewer raises valid concerns about value and transparency. The proprietary blend does make it impossible to compare cost-effectiveness with individual amino acids.
✗ Negative Review: “Made Insomnia Worse”
Reviewer: Dianne B. (Amazon Verified Purchase)
“I started taking GF-9 hoping it would help with energy and sleep, but it had the opposite effect for me. I became more insomniac and anxious. After two weeks, I had to stop taking it because I wasn’t sleeping at all. This was a complete waste of money for me. Everyone’s different, but this product definitely didn’t work for my body chemistry.”
My Assessment: Individual responses vary significantly. Some people experience paradoxical effects from amino acid supplements, highlighting the importance of monitoring your own response.
Our Tester’s Experience: Nathan’s 8-Week Trial
Independent Tester Review
Tester Profile: Nathan, 45-year-old male, moderately active, no significant health conditions
Trial Duration: 8 weeks (2 bottles)
Dosing Protocol: 4 capsules daily, morning dose (2 hours before breakfast)
Week-by-Week Observations:
Weeks 1-2: “The first week was challenging due to the dosing schedule. I had to wake up earlier to take the capsules before my usual breakfast time. I experienced mild stomach discomfort on days 3-5, but this subsided. No noticeable energy or performance changes yet.”
Weeks 3-4: “Starting to notice slightly better sleep quality—I’m waking up feeling more rested. Energy levels during the day seem marginally improved, though this could be placebo effect. No changes in body composition yet.”
Weeks 5-6: “The sleep improvement has continued and is now consistent. I’m falling asleep faster and experiencing fewer middle-of-the-night awakenings. My workout recovery seems faster—less muscle soreness after leg day. Still no visible changes in muscle mass or body fat.”
Weeks 7-8: “Sleep quality remains the most notable benefit. I’ve also noticed my nails are growing faster and seem stronger. Energy levels are stable and perhaps 10-15% better than baseline. However, I haven’t experienced dramatic muscle growth, fat loss, or anti-aging effects that the marketing suggests.”
Final Assessment:
What Worked: Improved sleep quality (significant), slightly better energy levels, faster nail growth, better exercise recovery
What Didn’t Work: No measurable changes in body composition, no reduction in wrinkles or visible anti-aging effects, no significant muscle mass increase
Would He Continue? “At $100/month, probably not. The sleep benefit is real for me, but I could achieve similar results with a $25 magnesium glycinate supplement and basic amino acids. If money wasn’t a concern, I might continue for the recovery benefits, but the cost-to-benefit ratio doesn’t justify long-term use for me personally.”
2025 Update: Nathan continued using GF-9 for an additional year (total 14 months) to assess long-term effects. His conclusion: “The benefits plateaued after 3 months. I’m now getting the same results with a fraction of the cost using individual amino acids and focusing on sleep hygiene.”
High-Quality GF-9 Alternatives Worth Considering
If you’re not convinced that GF-9 offers the best value, or if you want to explore other options with different formulations or pricing, here are three alternatives I recommend based on my professional analysis:
1. GenF20 Plus — My Top Recommendation
Why I Recommend It: GenF20 Plus offers superior value, transparency, and a more comprehensive formula compared to GF-9.
Key Advantages:
- Better Price Point: $60-70/month (nearly 40% less expensive than GF-9)
- Two-Phase System: Includes both capsules AND an oral spray for enhanced absorption
- Alpha GPC Included: Contains growth hormone releasing compounds not found in GF-9
- Enteric Coating: Capsules have enteric coating for better stomach protection and absorption
- Doctor Endorsed: #1 rated doctor-endorsed HGH supplement
- 67-Day Money-Back Guarantee: More than double GF-9’s guarantee period
- Full Transparency: Discloses individual ingredient amounts (no proprietary blend)
Ideal For: Anyone seeking a comprehensive HGH support supplement with better value and more transparent formulation.
2. Serovital HGH — Premium Best Seller
About Serovital: Serovital is actually the original formulation that GF-9 is based on. Both products contain nearly identical amino acid blends, as they were developed by the same research team.
Key Features:
- Clinical Study Support: The famous 682% HGH increase study was originally conducted on Serovital
- Similar Formulation: Contains the same amino acid complex as GF-9
- Female-Focused Marketing: Positioned more toward women’s anti-aging concerns
- Wide Availability: Sold at major retailers including Ulta, Sephora, CVS
- Similar Price Point: $99-120/month depending on retailer
Ideal For: Women specifically seeking anti-aging benefits, or those who prefer the Serovital brand positioning.
3. Nugenix GH Boost — Athletic Performance Focus
About Nugenix GH Boost: This supplement takes a different approach by including GABA (gamma-aminobutyric acid) as a primary ingredient, which has its own research supporting GH release.
Key Features:
- GABA-Based Formula: Contains 3 grams of GABA, which may support GH release and sleep quality
- Additional Amino Acids: Includes L-arginine, L-lysine, L-ornithine, L-glutamine, and glycine
- Alpha-GPC: Contains alpha-glycerylphosphorylcholine for cognitive support
- Performance Oriented: Marketed specifically for athletes and fitness enthusiasts
- Moderate Pricing: $60-80/month
Ideal For: Athletes and active individuals focused on recovery, muscle growth, and performance enhancement.
Quick Comparison: GF-9 vs. Top Alternatives
Frequently Asked Questions (FAQs) About GF-9
Q: How effective is the GF-9 supplement?
A: The effectiveness of GF-9 varies significantly among users. The clinical study showed a 682% increase in HGH levels at 120 minutes, but this was a small study (16 participants) with potential bias concerns. In real-world use, customer reviews are mixed—approximately 59% report positive results (improved sleep, energy, recovery), while 25% report no benefits whatsoever.
The temporary HGH spike demonstrated in the study doesn’t necessarily translate to the long-term benefits advertised (muscle growth, fat loss, anti-aging). Individual amino acids have established benefits independent of HGH effects, which may explain some positive experiences.
My Professional Opinion: GF-9 may provide modest benefits for some individuals, particularly in sleep quality and exercise recovery, but expecting dramatic body transformation or anti-aging results would be unrealistic for most users.
Q: Is GF-9 a steroid?
A: No, GF-9 is definitely not a steroid. It’s a dietary supplement containing amino acids and herbal extracts. Steroids are synthetic versions of hormones (like testosterone or cortisol) that directly introduce hormones into your body.
GF-9 theoretically works by stimulating your body’s natural production of growth hormone through amino acid signaling—it doesn’t contain any synthetic hormones or steroids. This is why it’s legal to purchase without a prescription and is not banned by athletic organizations (though athletes should always verify current regulations).
The supplement is made from natural ingredients and should not cause the same side effects associated with anabolic steroid use.
Q: Is GF-9 legitimate, or is it a scam?
A: GF-9 is a legitimate product manufactured by Novex Biotech, a reputable company established in 2005 with a track record of producing supplements. The company has sold over 3.5 million bottles since 2012, and the product is carried by major retailers like Amazon, Walmart, and CVS—all of which conduct their own vetting processes.
However, “legitimate” doesn’t mean “miracle product.” While GF-9 is a real supplement made by a real company, the marketing claims may overstate the realistic benefits most users will experience. The clinical study supporting the 682% claim has significant limitations (small sample size, short duration, potential funding bias, not peer-reviewed).
Bottom Line: It’s not a scam in the sense of being fake or fraudulent, but consumers should maintain realistic expectations about results. The mixed customer reviews (some love it, others see no benefit) suggest it works for some people but not others—which is typical for many supplements.
Q: How should I take GF-9 for best results?
A: For optimal absorption and effectiveness:
- Dose: Take 4 capsules daily (do not exceed this amount)
- Timing Option 1: Morning—Take on an empty stomach, wait 2 hours before eating breakfast
- Timing Option 2: Evening—Take 2 hours after dinner before bedtime
- With Water: Always take with a full glass of water
- Consistency: Take at the same time daily for best results
- Avoid: Don’t take with protein-rich meals, as protein can interfere with amino acid absorption
Pro Tip: If the morning protocol is too inconvenient, the evening dose may actually be more effective since natural HGH release occurs primarily during sleep. Many users report better results with evening dosing.
When to Avoid: Don’t take GF-9 if you’re under 18, pregnant, nursing, or have hormone-sensitive health conditions without consulting your doctor first.
Q: Where can I buy GF-9, and which retailer is best?
A: GF-9 is available from multiple retailers, each with different advantages:
1. Amazon (Recommended for most buyers)
- Pros: Free Prime shipping, customer reviews, easy returns, competitive pricing
- Cons: Ensure you’re buying from authorized sellers to avoid counterfeits
- Best For: Prime members wanting fast shipping and easy returns
2. Official Novex Biotech Website
- Pros: Guaranteed authentic product, direct from manufacturer
- Cons: Shipping costs may apply, return process may be more complex
- Best For: First-time buyers wanting guaranteed authenticity
3. Walmart
- Pros: In-store and online availability, 90-day return policy
- Cons: May be out of stock at local stores
- Best For: Those who prefer seeing product before buying
4. CVS Pharmacy
- Pros: Pharmacist available for questions, can use rewards
- Cons: May be more expensive than online options
- Best For: Those wanting to consult with a pharmacist before purchase
Price: Regardless of retailer, expect to pay $99.99 for a 120-capsule bottle (30-day supply). Watch for occasional sales or bundle deals that may reduce the per-bottle cost.
Q: What sets GF-9 apart from its competitors?
A: According to Novex Biotech, GF-9’s distinguishing features include:
1. Patented Formula: Protected by 15 patents, meaning the exact formulation cannot be legally replicated by competitors. However, it’s worth noting that similar amino acid combinations are available from other brands.
2. Clinical Study Support: The 682% HGH increase study is frequently cited, though as discussed, this study has significant limitations.
3. Schizonepeta Inclusion: This traditional herb is unique to GF-9’s formula, though its contribution to HGH release is not well-established.
4. GMP-Certified Manufacturing: Produced in facilities following Good Manufacturing Practices, ensuring quality control (though many competitors also use GMP facilities).
5. Market Presence: Over 3.5 million bottles sold since 2012, indicating sustained market acceptance.
My Assessment: While GF-9 has some unique aspects, competitors like GenF20 Plus offer better transparency (full ingredient disclosure), better value ($30/month cheaper), and more comprehensive formulations (two-phase delivery system). The “patented formula” distinction is less meaningful when the efficacy claims remain unproven in long-term studies.
Q: Can women take GF-9?
A: Yes, women can take GF-9, though it’s primarily marketed toward men. The sister product, Serovital, contains an identical formulation but is marketed specifically to women with female-focused advertising.
Considerations for Women:
- The same dosing guidelines apply (4 capsules daily)
- Women may experience different results due to hormonal differences
- Pregnant and nursing women should NOT use GF-9
- Women with hormone-sensitive conditions should consult their doctor first
- Some women report menstrual cycle changes (though this is uncommon)
Alternative: If you prefer female-oriented marketing and packaging, consider Serovital instead—it’s the same formula with different branding.
Q: How long does it take to see results from GF-9?
A: Based on customer feedback and the nature of the supplement, here’s a realistic timeline:
- Sleep Quality: 1-2 weeks (most commonly reported early benefit)
- Energy Levels: 2-4 weeks (variable among users)
- Exercise Recovery: 3-6 weeks (if you’re actively training)
- Hair/Nail Growth: 4-8 weeks (cosmetic changes take time)
- Body Composition: 8-12 weeks minimum (requires consistent use + diet/exercise)
- Anti-Aging Effects: 3-6 months (if they occur at all)
Important Reality Check: Many users report that if they haven’t noticed ANY benefits within 4-6 weeks, they’re unlikely to see improvements even with continued use. The product either works for your individual biochemistry or it doesn’t.
Recommendation: Give GF-9 a 60-day trial before making a final judgment. If you see no improvements after 2 months, it’s probably not worth continuing given the $100/month cost.
Q: Can I take GF-9 with other supplements?
A: Generally, GF-9 can be combined with many supplements, but there are important considerations:
Safe Combinations:
- Multivitamins (take at different times of day)
- Protein powders (separate by at least 2 hours from GF-9)
- Creatine, beta-alanine, or other workout supplements
- Fish oil, vitamin D, and general health supplements
Avoid Combining With:
- Other HGH supplements (risk of excessive dosing)
- Testosterone boosters (hormonal interaction concerns)
- High-dose individual amino acids (redundant and potentially excessive)
- Sleep medications without doctor approval
Special Considerations: If you’re taking prescription medications (especially for blood pressure, diabetes, or hormonal conditions), consult your doctor before adding GF-9 to your regimen.
Final Verdict: Is GF-9 Worth Your Money?
My Professional Assessment as a Pharmacist
After thoroughly analyzing the clinical research, ingredient formulation, customer reviews, and comparing GF-9 to alternatives, here’s my honest verdict:
What GF-9 Gets Right
- Safe Ingredients: The amino acid formulation is generally safe for healthy adults with minimal side effect risk
- Some Clinical Support: While limited, there is at least one study showing temporary HGH increase
- Real Customer Benefits: A significant portion of users (59%) report positive results, particularly for sleep quality
- Established Manufacturer: Novex Biotech has a 20-year track record and produces in GMP-certified facilities
- Wide Availability: Easy to purchase from multiple trusted retailers
Where GF-9 Falls Short
- Proprietary Blend Lack of Transparency: Not disclosing individual ingredient amounts prevents consumers from verifying clinical dosing
- Premium Price Without Premium Value: At $100/month, it’s significantly more expensive than comparable alternatives
- Limited Long-Term Research: The 120-minute HGH spike doesn’t prove sustained benefits
- Study Quality Concerns: Small sample size, potential funding bias, no peer review, no FDA recognition
- Mixed Customer Results: 25% report zero benefits, indicating it doesn’t work for everyone
- Inconvenient Dosing: The 2-hour fasting requirement is challenging for many users
- Titanium Dioxide: Contains an inactive ingredient banned in EU food products
Who Might Benefit from GF-9?
GF-9 may be worth considering if you:
- Are over 40 and experiencing age-related decline in energy and recovery
- Have disposable income and the $100/month cost isn’t a financial burden
- Struggle with sleep quality and haven’t found success with other interventions
- Are already following a solid exercise and nutrition program
- Want to experiment with amino acid supplementation for HGH support
- Prefer purchasing from established brands available at major retailers
Who Should Skip GF-9?
GF-9 is probably not the best choice if you:
- Are on a tight budget ($100/month is a significant expense)
- Value transparency and want to know exact ingredient amounts
- Expect dramatic body transformation results based on marketing claims
- Haven’t first optimized basic lifestyle factors (sleep, diet, exercise)
- Are looking for the most cost-effective amino acid supplement
- Want more robust scientific evidence supporting long-term efficacy
My Recommendation
If you’re determined to try an HGH-boosting supplement, GF9 is not a bad product but I recommend starting with GenF20 Plus instead of GF-9. Here’s why:
- Better Value: $69.95/month saves you $360 annually compared to GF-9
- More Transparent: Full ingredient disclosure allows you to verify clinical dosing
- Comprehensive Formula: Two-phase system (capsules + oral spray) for enhanced effectiveness
- Longer Guarantee: 67-day money-back guarantee vs. 30 days for GF-9
- Doctor Endorsed: #1 rated HGH supplement by healthcare professionals
However, if you prefer to try GF-9 due to brand preference or availability at your local retailer, it’s not a terrible choice—just set realistic expectations and give it a 60-day trial before committing long-term.
The Bottom Line
GF-9 is a legitimate supplement from a reputable manufacturer that may provide modest benefits for some users, particularly regarding sleep quality and exercise recovery. However, the dramatic claims in marketing materials (682% HGH increase, significant anti-aging effects, major body composition changes) are not supported by robust, long-term clinical evidence.
The product’s biggest weaknesses are its proprietary blend (lack of transparency), premium pricing without premium value, and the inconvenient dosing schedule. While the amino acids included have established benefits, you could potentially achieve similar results with individual amino acid supplements at a fraction of the cost.
For most consumers, I recommend exploring alternatives like GenF20 Plus first, which offers better transparency, value, and a more comprehensive formulation. However, if you decide to try GF-9, purchase it from a retailer with a solid return policy (like Amazon or Walmart) so you can get a refund if it doesn’t work for you.
Remember: No supplement—regardless of marketing claims—can replace the fundamental pillars of health: quality sleep, regular exercise, stress management, and proper nutrition. These lifestyle factors have far more robust evidence for supporting healthy HGH levels than any supplement on the market.
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GF 9 (Growth Factor 9)
Growth Factor 9, also called GF-9, is a growth hormone supplement packed with a mixture of different amino acids like L-lysine hydrochloride, L-arginine hydrochloride, oxo-proline N-acetyl L-cysteine, L-glutamine, and schizonepeta (aerial parts) powder.
Product Brand: Novex Biotech
Product Currency: USD
Product Price: 99
Product In-Stock: InStock
4.1
Gf9 is one of the best GH boosting supplements on the market. This one is safe but Abit expensive.