Vivinox (Diphenhydramine): Uses, Side Effects, Dosage

Diphenhydramine (brand: Vivinox) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can cause symptoms such as sneezing, itching, watery eyes and runny nose.

Diphenhydramine (Vivinox) is used to treat

  • Sneezing,
  • Watery eyes,
  • Runny nose,
  • Skin rash,
  • Hives,
  • Itching, and
  • other cold or allergy symptoms.

Diphenhydramine is also used to treat

  • Motion sickness,
  • To induce sleep, and
  • To treat certain symptoms of Parkinson’s disease.

Maximal effect is typically around two hours after a dose, and effects can last for up to seven hours.

Vivinox Mechanism

Diphenhydramine (Vivinox) competes with free histamine for binding to HA receptor sites. This antagonizes the effects of histamine on HA receptors, which leads to a reduction in negative symptoms caused by the binding of the histamine HA receptor.

This drug blocks some natural substance (histamine) that your body forms during an allergic reaction. Its dehydrating effect on symptoms such as watery eyes and nasal discharge is caused by the blockage of another natural substance (acetylcholine).


Side Effects

Following are some of the side effects associated with the use of vivinox

  • Drowsiness,
  • Dizziness,
  • Constipation,
  • Stomach upset,
  • Blurred vision, or
  • Dry mouth/nose/throat may occur.

If any of these effects persist or worsen, tell your doctor or pharmacist promptly.


Vivinox is contraindicated in

  • Hypersensitivity to diphenhydramine or any other ingredients in vivinox.
  • Closure glaucoma,
  • Prostatic hypertrophy,
  • Stenosing peptic ulcer,
  • Stenosis of the bladder neck,
  • Epilepsy
  • Bronchial asthma.

Vivinox In Pregnancy

Diphenhydramine is a category B drug this means that Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.Thats why Should be used with caution in pregnancy.

Dosage and administration

  • Available in Oral, IV, IM, rectal, topical, intranasal, in the conjunctival sac.
  • Usual Oral dose for adults is 30-50 mg 1-3 times / day. The treatment course is 10-15 days.
  • IM in doses of 50-250 mg;
  • IV in drip – 20-50 mg.
  • When oral administered single dose for children under 1 year – 2-5 mg;
  • Usual dose for 2 to 5 years of age- 5-15 mg; of 6 to 12 years – 15-30 mg.
  • Externally applied 1-2 times / day.


Vivinox interactions with Other Drugs

Certain Drugs Increase or decrease the effects of other drugs when use concomitantly.

Diphenhydramine (Vivinox) simultaneous use with Mono Amine Oxidase inhibitors increase the anticholinergic activity of diphenhydramine.

When applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.

The antagonistic interaction observed with a joint appointment with psychostimulants.

Intensifies anticholinergic effects of drugs with anticholinergic activity.

Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning.

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