Rosuvastatin: Uses, Side Effects, Dosage

Rosuvastatin belongs to a group of medicines known as “statins.” It is used to reduce bad cholesterol and increase good cholesterol (HDL), reduce triglycerides, slow the progression of heart disease, prevent heart attacks and prevent strokes.

Use of rosuvastatin

  • Treat high cholesterol
  • Prevent Strokes
  • Slow progression of heart disease
  • Prevent heart attack
  • Used to treat abnormal lipids

Precautions

Tell your doctor or pharmacist if you are allergic to it before taking rosuvastatin; or if you have any other allergies This product may contain inactive ingredients that may cause allergic reactions or other problems. Talk to your pharmacist for more details.

Mechanism of action

Rosuvastatin (Crestor) competitively inhibits HMG coenzyme A reductase, a limiting step in the synthesis of cholesterol. The reduction in cholesterol synthesis results in a compensatory increase in plasma cholesterol absorption mediated by the increase in the number of LDL receptors. Therefore, the level of LDL in the plasma decreases.

Side effects:

The most common side effects that you can experience with rosuvastatin are:

  • Abdominal pain (abdominal area)
  • Headaches
  • Weakness
  • Muscle pain
  • Nausea

Serious side effects include:

  • Heavy muscular problems
  • Liver problems

Rosuvastatin in pregnancy and lactation

Pregnant women should not use statins because of the high risk of fetal harm.There is no information on whether rosuvastatin is excreted in breast milk.

 

Dosage for rosuvastatin

  • The initial dose for most adults is 5 mg once a day. The maximum dose is 40 mg daily and this dose should be reserved for patients who do not respond adequately at a dose of 20 mg.
  • The initial dose for hyperlipidemia in adults is 10 mg to 20 mg orally once a day and then a maintenance dose of 5 mg to 40 mg orally once a day.
  • The initial dose for type III hyperlipoproteinemia (high beta-VLDL + IDL) in adults is 10 mg to 20 mg orally once a day and then a maintenance dose of 5 mg to 40 mg orally once a day. day
  • The initial dose for hypertriglyceridemia is 10 mg to 20 mg orally once a day and a maintenance dose of 5 mg to 40 mg orally once a day.
  • The initial dose for atherosclerosis in adults is 10 mg to 20 mg orally once a day and maintenance dose of 5 mg to 40 mg orally once a day.
  • The initial dose for the prevention of cardiovascular diseases is 10 mg to 20 mg once a day and a maintenance dose of 5 mg to 40 mg once a day

 

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