Pliva 433 Pill: Uses, Side Effects, Dosage and FAQs

Pliva 433 is essentially a footprint on a white pill in a round shape. The tablet contains trazodone hydrochloride as an active ingredient at a dose of 50 mg. Pliva 433 is an antidepressant that belongs to the class of antidepressants called phenylpiperazines. It treats diseases such as depression, insomnia, and fibromyalgia.

It works to balance the chemicals in the brain. The Pliva 433 pills are biconvex on one side, cut in half, and joined on the other.

Pliva 433 Pill
Pliva 433 Pill

Pliva 433 Pill Uses

Trazodone is an antidepressant and is most commonly used in depression. It was approved by FDA in 1981.

  • Depression
  • Anxiety
  • Fibromyalgia
  • Mood disorders
  • Insomnia
  • Sedation

Note: Pliva 433 (Trazodone) may also be used for conditions other than those listed above.

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Side Effects

Common side effects associated with the use of Trazodone Hydrochloride (Pliva 433 Pill) are :

  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Tiredness
  • Blurred vision
  • Changes in your weight
  • Headache
  • Dry mouth
  • Bad taste in the mouth
  • Muscle pains
  • Stuffy nose
  • Constipation
  • Change in sexual desire or/ and ability

Serious side effects can also occur with Pliva 433 Pill. If you have any of these side effects, stop taking them and call your doctor right away:

  • Ringing in the ears
  • Blood in urine
  • Tremors
  • Nightmares
  • Rash
  • Problems urinating
  • Fever
  • Sore throat
  • Stomach or abdominal pain
  • Shortness of breath
  • Fainting
  • Chest pain
  • Widened
  • Irregular heartbeat
  • Trouble breathing
  • Seizures
  • Vision changes
  • Severe dizziness
  • Eye pain or swelling, redness


Before using Pliva 433, Tell your doctor if you have the following conditions

  • If you are allergic to this drug.
  • Low or high blood pressure
  • Heart problems
  • History of substance abuse
  • Cancer
  • Mental health disorders
  • Liver problems
  • Diarrhea or vomiting
  • Kidney problems
  • Bipolar disorder
  • Glaucoma
  • Having a history of suicide
  • The risk of suicide is most significant when starting a treatment or when increasing or decreasing
  • the dose of Trazodone.

Pliva 433 Interaction

Types of drugs that are known to interact with Trazodone include:

  • Drugs used to treat mental illness, including thioridazine; selective serotonin reuptake.
  • Inhibitors (SSRIs), and MAOIs.
  • Blood thinners, including warfarin, aspirin, and ibuprofen
  • Diuretics
  • Cold, cough, and allergy medications, including dexamethasone.
  • Medications are used to treat fungal diseases, such as ketoconazole and itraconazole.
  • Medications used to treat heartburn include cimetidine and cisapride.
  • Medications to treat HIV/AIDS include atazanavir, indinavir, and nelfinavir.
  • Some antibiotics, such as clarithromycin and erythromycin.
  • Some seizure medications such as carbamazepine, ethosuximide, phenobarbital, and Phenytoin.
  • Some heart medications, including sotalol and verapamil


Here are some dosage recommendations

  • The usual recommended dose for depression is 150 mg daily. However, in some cases, Your physician/doctor may start with a lower dose of 100 mg to reduce the risk of side effects.
  • The usual recommended dose for anxiety is 75 mg daily.
  • If your dose is 300 mg daily or less, your doctor will probably tell you to take the single dose at bedtime.
  • Since Trazodone can make you sleepy, it can be helpful during sleep if you have sleep problems.

Frequently Asked Questions (FAQs)

Pliva 433 Pill

1. What is Pliva 433 Pill?

Pliva 433 is an imprint on a tablet of Trazodone hydrochloride. And it is

commonly used in depression.

2. What is Pliva 433 Pill used to treat?

It is used in the treatment, control, and prevention of various medical conditions such as

depression, mood disorders, mental health issues, insomnia, and other conditions.

3. How does Pliva 433 Pill work?

Trazodone binds to the 5-HT2 receptor and acts as a high-dose serotonin agonist and low-dose serotonin antagonist. As with fluoxetine, Trazodone’s antidepressant activity is likely due to the blockade of serotonin reuptake due to inhibition of the serotonin reuptake pump at the presynaptic neuronal membrane.

4. What are the side effects of the Pliva 433 pill (Trazodone Hcl)?

The most common side effects associated with the use of Trazodone are Nausea, Vomiting, Diarrhea, Drowsiness, Dizziness, Tiredness, Blurred vision, Changes in your weight, Headache, Muscle pains, and others. Please check the above.

5. Is PLIVA 433 pill safe during pregnancy?

PLIVA 433 Pill should be used during pregnancy only if the benefits outweigh the risks

to the fetus. Trazodone is classified in the FDA Pregnancy Category C. This means that neonates should monitor withdrawal symptoms if the drug is used until delivery.

6. Is the Pliva 433 pill safe while breastfeeding?

Limited data indicate that the level of Trazodone in milk is low, and no side effects are expected in the breastfed infant, mainly if the infant is older than two months or if

doses of 100 mg or less are administered at bedtime.

7. What happens if you overdose on a pill of Pliva 433?

Overdose is possible with almost all drugs, including Trazodone. An overdose of Trazodone would mean someone accidentally or intentionally ingested more than the prescribed or recommended amount. If you have an overdose on Trazodone, it is crucial to seek help immediately as this can be extremely dangerous.

8. What should you do if you miss a dose of Trazodone HCL?

Take the missed dose as soon as you remember, and when taking the next dose, skip

the previous dose.

9. Is Pliva 433 a habit-forming medicine?

There is no evidence that Trazodone is addictive. However, additional side effects may

occur if you suddenly stop taking it.

10. How do I take it?

It would help if you took Trazodone after meals to reduce the risk of getting sick.

11. Is driving a vehicle or operating machinery safe after taking this medicine?

Trazodone can make you sleepy or less alert. Do not drive, ride a bicycle, or use tools

or machines until you know how this medicine affects you.

12. Can Pliva 433 also be used with alcohol?

You can drink alcohol while taking Trazodone, but it can tire you.

It is best to stop drinking alcohol until you know how you feel about the medicine.

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