Optalidon is the brand name of the combination of two ingredients i.e Caffeine 25mg and Propyphenazone 175mg.
- Caffeine is a central nervous system stimulant of the methylxanthine class.Caffeine is considered the most commonly used psychoactive drug in the world.
- Propyphenazone is Non-steroidal anti-inflammatory drug, NSAID and is used in Analgesic, antipyretic and anti-inflammatory agent.
- Propyphenazone alone is rapidly absorbed. After a single oral dose of 220 mg, peak plasma concentrations of about 1.5-3.5 mg/l are attained at between 0.5 h and 1.2 h with a mean biological half-life of approximately 2.8 ± 0.6 h.
Uses Of Optalidon:
Optalidon is used in:
- Rheumatoid arthritis,
- Juvenile chronic arthritis,
- Ankylosing spondylitis,
- Fever, Acute arthritis,
- Musculoskeletal pain,.
Mechanism of action Of Optalidon
- Caffeine is a central nervous system stimulant that occurs naturally in more than 60 plant species and is used in various foods, drinks and medicines. Caffeine stimulates the medullary, vasomotor and respiratory centers and promotes bradycardia, vasoconstriction and increased respiratory rate. Previously, it was believed that this effect is mainly due to the increase of intracellular cyclic 3 ‘, 5’-adenosine monophosphate (cyclic AMP) after the inhibition of phosphodiesterase, the enzyme that degrades cyclic AMP. Caffeine passes the blood-brain barrier that is supposed to separate the brain from the bloodstream. Once in the brain, caffeine blocks the action of adenosine, which plays an important role in energy transfer and sleep enhancement. Since adenosine acts as an autocoid, it inhibits the release of neurotransmitters from presynaptic sites, but increases the effect of norepinephrine or angiotensin, the antagonism of adenosine receptors promotes the release of neurotransmitters. This explains the stimulating effect of caffeine. The blockade of the adenosine A1 receptor in the heart results in an accelerated and pronounced “heartbeat” of the heart when caffeine is consumed.
- Propyphenazone is an NSAID derived from pyrazolone and related to phenazone. It has antipyretic and analgesic properties.
Side effects of Optalidon
Optalidon (caffeine + propyphenazone) may cause some side effects. Side effects are not common and sometimes very rare, but each medication has some side effects along with beneficial effects:
- Propifenazone may cause myocardial infarction with low atrial rhythm
- Propifenazone may also cause side effects that are not listed here.
- During anxiety disorders, caffeine with bipolar disorder could worsen these conditions. Use carefully.
- There are concerns that caffeine can make bleeding worse.
- Caffeine can lead to irregular heartbeats in sensitive individuals.
- Caffeine, especially when taken in large quantities, can make diarrhea worse.
- People with epilepsy should avoid the use of high-dose caffeine.
- Caffeine intake can increase blood pressure in people with high blood pressure.
- Caffeine, especially when taken in large quantities, can make diarrhea worse and worsen IBS symptoms.
Dosage and administration of Optalidon
- In adults: 1 to 2 tablets 1-3 times daily.
- In children older than 12 years: 1 tablet a day.
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