Miconazole (Miconazol) is an antifungal used topically and by intravenous infusion. This is an antifungal that does not work for bacterial or viral infections. Miconazole was approved by the FDA in 1974.
- Miconazole cream (miconazol) is indicated for topical use in the treatment of fungal and/or skin infections.
- Miconazole is used to treat vaginal infections. Miconazol reduces the burning, itchy, and vaginal discharge that can occur with this condition. This medicine is an azole antifungal. It stops the growth of yeast (fungus), which causes the infection.
- The vaginal product comes in 2 forms (a vaginal cream or a tablet).
- Some products also come with a skin cream that is applied to the area around the outside of the vagina
Mechanism of action of Miconazole (miconazol)
Miconazole (Miconazol) interacts with 14-α-demethylase, a cytochrome P-450 enzyme needed to convert lanosterol to ergosterol. Since ergosterol is an essential component of the fungal cell membrane, the inhibition of its synthesis results in an increase in cell permeability that causes leakage of cellular contents. Miconazole may also endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeast mycelial forms, inhibit the absorption of purines, and interfere with the biosynthesis of triglycerides and/or inhibit phospholipids.
Side effects of Miconazole
Miconazole can cause side effects. If you experience any of the following symptoms, call your doctor immediately:
- Increased burning, itching, or irritation of the skin or vagina
- stomach pain
- Foul-smelling vaginal discharge
Miconazole (Miconazol) in pregnancy
The physician must weigh the potential benefit against potential but unknown risks to the fetus.It is not known whether miconazole is secreted in breast milk in amounts that may affect the baby.
- Miconazole is usually taken once a day at bedtime. 200 mg suppositories (Monistat 3) are used once a night for 3 nights. The suppositories of 100 mg (Monistat-7) and the intravaginal cream are used once a night for 7 nights. The 1200 mg formulation (Monistat 1) is used once a night.
- For fungal infections of the skin, the topical cream is applied as a thin layer to cover the affected skin and the environment usually once or twice daily for 2-4 weeks. Hands should be washed before and after use.
- Store at room temperature not above 30 ° C and in a dry place.