Pantoprazole: Uses, Side effects, Dosage

Pantoprazole is in a class Of drugs called proton pump inhibitors (PPIs), that block the production of acid by the stomach. Pantoprazole blocks the enzyme within the wall of the stomach that produces acid. By obstruction the enzyme, the production of acid is reduced, and this enables the stomach and esophagus to heal.

  • It is used for the treatment of conditions like ulcers,& gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome that are caused by stomach acid.
  • It is not Used for immediate relief of heartburn Symptoms.
  • Pantoprazole is well absorbed. It undergoes very little first-pass metabolism leading to an absolute bioavailability of roughly 77% and its protein binding is 98%.
  • The Food and Drug Administration approved Pantoprazole in February 2000.

Side effects:

Most common side effects

The most common side effects that occur with pantoprazole include:

  • Nausea or vomiting
  • Diarrhea
  • Headache
  • Stomach pain
  • Gas
  • Joint pain
  • Dizziness

Serious side effects

  • Low Mg levels. using this drug for three months or longer will cause low magnesium levels.
    Vitamin B-12 deficiency. using this drug for longer than three years will make it tougher for your body to absorb vitamin B-12.
  • Severe diarrhea. this could be caused by  Clostridium difficile infection in your intestines.
  • Bone fractures
  • Kidney injury.
  • Cutaneous lupus erythematosus (CLE).
  • Systemic lupus erythematosus (SLE).

Pregnancy and breast-feeding

There aren’t any adequate information from the use of pantoprazole in pregnant ladies. Excretion into human milk has been reported. If you’re pregnant or assume you will be pregnant, or if you’re breast-feeding, you must use this medication only if your doctor considers the benefit for you bigger than the potential risk for your unborn child or baby.


The usual dose is one tablet (40mg) on a daily basis For Reflux oesophagitis.

The usual dose For stomach and duodenal ulcer is one tablet (40mg) on a daily basis.

The usual adult dose for For Zollinger-Ellison syndrome is  40 mg twice daily, to a maximum of 240 mg per day.

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