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Clotrimazole: Uses, Side effects, Dosage

Clotrimazole is an antifungal medication an imidazole derivative with a broad spectrum of antimycotic activity. it’s like an antibiotic but is employed to treat yeast (fungal) infections.Oral clotrimazole is employed to treat and stop yeast infections of the mouth and throat(Oral Thrush).

  • Clotrimazole comes in the form of a Topical solution, vaginal pill, vaginal cream, Oromucosal solid And Topical Lotion.

Uses

  • It prevents the expansion of several types of fungi by preventing interfering with the production of the membrane that surrounds fungous cells. it’s used locally on the skin, inserted vaginally or allowed to dissolve within the mouth for local fungal infections.

Mechanism

  • They cause weakness of the fungal cell membrane by preventing the formation of ergosterol by inhibition of enzyme cytochrome P-450.This Will Kill The fungus. Apart From This They also inhibit the human cytochrome P-450 enzyme but to a lesser extent.

Clotrimazole Side effects

  • Clotrimazole might cause side effects like itching, irritation, burning, redness, swelling, fever, foul-smelling discharge if using the vaginal product stomach pain and upset stomach or regurgitation with the lozenges (troches).

Precautions

  • Used With caution if you’re allergic to it; or to different azole antifungals such asĀ econazole,ketoconazole, or miconazole; or if you have got any other allergies. This product might contain inactive ingredients, which might cause hypersensitivity or other issues. talk to your pharmacist for additional details.

Pregnancy

  • Although clotrimazole isn’t best-known to be harmful to Pregnant women or babies, studies in women in their second or third trimesters of pregnancy have demonstrated no ill effects. No information is available in pregnant women throughout their first trimester you should solely use medicines on the advice of a doctor whereas you’re expecting or breast-feeding a baby.

Clotrimazole Dose

  • Recommended Adult Dose for Treatment of Oral Thrush is 10 mg orally 5 times on a daily basis for 14 days and for prophylaxis of Oral Thrush is 10 mg orally 3 times on a daily basis for the period of chemotherapy.
  • Usual recommended pediatric (3 years and older) Dose for Treatment of Oral Thrush is 10 mg orally 5 times on a daily basis for 14 days and for Prophylaxis;10 mg orally 3 times on a daily basis for the period of chemotherapy OR till steroids are reduced to maintenance levels.
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