Ceftriaxone: Uses, Side Effects, Dosage etc

Ceftriaxone is a broad spectrum Cephalosporin antibiotic with a really long half life and is employed to treat or stop bacterial infections such as pelvic inflammatory disease (infection of the female reproductive organs that will cause infertility), gonorrhea (a sexually transmitted disease), meningitis (infection of the membranes that surround the brain and spinal cord), and infections of the lungs, abdomen, ears, skin, urinary tract, blood, bones and joints.

It is conjointly sometimes used to treat endocarditis (infection of the heart lining and valves),sinus infections, ulcer (genital sores caused by bacteria), relapsing fever (an infection that’s transmitted by tick bites that causes recurrent episodes of fever), Lyme disease (an infection that’s transmitted by tick bites that will cause problems with the heart, joints, and nervous system), shigella (an infection that causes severe diarrhea), Whipple’s disease (a rare infection that causes serious issues with digestion, typhoid , and enteric bacteria (an infection that causes severe diarrhea).

Please keep in mind that, This antibiotic will not work for colds, flu, or other viral infections.

  • It Is Contraindicated if you’re allergic to it; or to other antibiotics (such as penicillins, other cephalosporins); or if you have got any other allergies.

Mechanism Of Action Of Ceftriaxone:

It works by inhibiting the mucopeptide synthesis within the bacterial cell wall. The beta-lactam moiety of ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases within the bacterial  cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cellular division. By binding to those enzymes, ceftriaxone leads to the formation of defective cell walls and bacterial cell death occur.

Ceftriaxone Side Effects

The following adverse reactions, which were considered to be related to ceftriaxone for injection therapy or of uncertain etiology, were observed:

  • Rashes, and Pruritus,
  • Bloody, or watery stools,
  • Nausea And Vomiting,
  • Stomach cramps,
  • Fever during treatment,
  • Severe pain in the side and back below the ribs,
  • Swelling in legs and feet,
  • Seizures,
  • Heartburn,
  • Chest pain,
  • Painful urination,
  • Stomach tenderness,pain or bloating,
  • Decreased urination,
  • Urinating more often than usual,
  • Pink, brown, red, cloudy, or bad smelling urine,
  • Peeling, blistering, or shedding skin,
  • A return of fever, sore throat, chills, or other signs of infection,
  • Difficulty swallowing or breathing,
  • Swelling of the throat or tongue.


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1 thought on “Ceftriaxone: Uses, Side Effects, Dosage etc”

  1. PIUS mchewe

    Thank for teaching more details about ceftriaxone

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