Glyburide: Uses, Side effects, Dosage

Glyburide is in a class of medicines known as sulfonylureas is antihyperglycemic drug used to treat type 2 diabetes.

  • Glyburide lowers blood glucose by causing the pancreas to produce insulin (a natural substance that’s needed to break down sugar within the body) and helping the body use insulin efficiently. This medication can only help lower glucose in individuals whose bodies manufacture insulin naturally.
  • Glyburide isn’t used to treat type 1 diabetes (condition in which the body doesn’t manufacture insulin and, therefore, cannot control the amount of sugar within the blood) or diabetic ketoacidosis (a serious condition which will occur if high glucose isn’t treated)
  • Don’t use glyburide for the treatment of type 1 diabetes. glyburide works by increasing the amount of insulin your pancreas produces. In type 1 diabetes, your body no longer produces insulin, therefore glyburide won’t help.

Glyburide Side effects:

Serious side effect such as:

  • Nausea, upper stomach pain, itching, loss of appetite, clay-colored stools,jaundice(yellowing of the skin or eyes).
  • Pale or yellowed skin, dark coloured pee,fever, confusion or weakness; or
    Less serious side effects might include:
  • Headache, mild dizziness; or
  • Sneezing, runny nose,cough or other signs of a cold;
  • Mild nausea or regurgitation ,diarrhea, symptom.
  • Mild dizziness.


  • The recommended starting dose is 2.5 to 5 mg daily of regular tablets or 1.5-3 mg daily of micronized tablets.
  • The maintenance dose is 1.25 to 20 mg of regular tablets and 0.75 to 12 mg of micronized tablets given daily or in divided doses each 12 hours.
  • The maximum dose is 20 mg of standard tablets and 12 mg of micronized tablets daily.
  • Your dose depends on your age, blood sugar levels, and therefore the form of the drug that you’re taking.

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