Dr David Sinclair Supplements List: Top 10 Life-Changing Supplements

Dr. David Sinclair, a world-renowned scientist in the field of aging, recommends a specific supplement regimen to help combat the effects of aging. These supplements are designed to support cellular health and prevent age-related damage.

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Quick Verdict: David Sinclair recommended supplements include nicotinamide mononucleotide (NMN), Resveratrol, metformin, vitamin D3, vitamin K2, and Statin. In addition, low-dose aspirin and alpha lipoic acid (ALA) is also thought to be beneficial, though their exact status is unknown. To get the most benefit from these supplements, Dr. Sinclair recommends taking them in the morning with food. This regimen is designed to support overall health and help reduce the effects of aging. You can read these supplements in more detail below.

David’s focus on tackling aging has led him to develop a regimen of supplements that help him look and feel younger. These supplements help to improve skin health, boost immunity, and protect against cellular damage. In addition, David takes a daily multivitamin and mineral supplement to ensure his body gets all the nutrients it needs. By following this supplementation plan, David can maintain his youthful appearance and enjoy good health into his 50s and beyond. Let’s have a quick look at his daily routine;

David Sinclair Supplements List

Dr. Sinclair is a respected authority on aging and has dedicated his life to researching ways to help people live longer and healthier lives. As such, it’s no surprise that he takes a careful and thoughtful approach to supplements. In interviews and books, he has mentioned several supplements that he takes daily. Please remember that he doesn’t own or promote a specific brand; instead, he takes certain ingredients that help him live a healthy life.

Of course, it’s always important to consult a healthcare provider before beginning any new supplement regimen. But by following Dr. Sinclair’s advice, you can be confident that you’re taking steps in the right direction. Here is Dr. David Sinclair’s supplements list and his daily routine.

Morning Routine;

  • NMN – Every morning, David Sinclair takes 1 gram of NMN pill with a glass of water. He has been doing this for a while now, and it seems to work well for him.
  • Resveratrol – David Sinclair also starts his day with a nutritious breakfast that includes yogurt and 1 gram of Resveratrol. He believes this powerful supplement helps him stay healthy and lively throughout the day.
  • Fisetin – He also takes 500 mg of Fisetin daily with yogurt. This powerful antioxidant has been shown to improve memory and cognitive function.
  • Quercetin – He also takes 500 mg of Quercetin daily with yogurt. Moreover, he ensures that his diet is rich in antioxidants by eating fruits and vegetables. He believes this helps encourage a strong immune system against colds and flu.
  • Spermidine – David also began experimenting with taking 1 mg of spermidine daily. He found that it had some interesting effects on his body and mind.

Evening Routine

  • Metformin-He is also taking Metformin 800mg at night. He takes it every night except for the nights before he exercises. This is because he doesn’t want the medicine to affect his performance.

Some other nutrients he takes:

  • Vitamin D3- Sinclair also said in his podcast that he is also taking Vitamin D3.
  • Vitamin K2-The ideal amount of vitamin K2 per day is between 180 and 360 micrograms. Vitamin K2 is an essential nutrient that helps keep our bones healthy. Getting the right amount of vitamin K2 daily is vital for maintaining bone density and preventing osteoporosis.
  • Omega 3 Fatty Acid: He never discloses how much omega 3 he takes daily. However, If you want to improve your life, consider taking 5,000 mg of Omega 3 fatty acid daily. This natural substance has been shown to provide various benefits, including improved cognitive function and reduced inflammation.
  • Alpha Lipoic Acid- It’s unclear, but you usually should take 600-1800 mg per day orally.
  • Coenzyme Q10-The recommended dose of CoQ10 supplementation is 30 to 200 mg daily. This range is based on an individual’s weight, age, and health condition. For most people, the ideal dose is between 100 and 200 mg per day. Physicians may recommend a higher or lower dose depending on a person’s needs.
  • Aspirin – He also takes 81mg of Aspirin daily, which can help thin your blood and is vital for those who have heart-related problems.
  • Statin – Statin work by reducing the amount of cholesterol your body produces. This lowers your overall cholesterol levels and reduces your risk of heart disease. These prescription drugs are effective in both preventing heart disease and treating it. David Sinclair also used this one from his younger age.

Dr David Sinclair Supplements List

Detail List Of David Sinclair supplements

1. NMN Supplements

Lifespan is a New York Times best-selling book on aging that many people would benefit from reading. On page 304, Sinclair mentions that he takes 1 gram of NMN and Resveratrol every morning, often mixed in with yogurt. Please note that he is not affiliated with any brand and that’s why he didn’t tell what brand of NMN supplements David Sinclair takes.

Nicotinamide mononucleotide, also known as NMN for short, is a molecule your body makes naturally, but some people take it in supplement form. It has been studied by Harvard University professor and longevity expert David Sinclair who found that this protein helps reverse some signs of aging and may help with many areas of health, including diabetes, liver conditions, brain health, heart disease, exercise, training, and sleep, among others.

Without access to NMN, cells can’t function properly. Proteins that help protect and repair our DNA also require this critical molecule for their jobs. We all know that as we grow older, our health starts to decline. Our bodies become more susceptible, and at 50 years old, there is half the amount of NMN in your system than when you were younger. The easiest way to get the benefits of NMN is by taking 250-500 mg daily. This amount will provide you with all that it has in store for your health and longevity. However, some studies have revealed that up to 1000mg is safe and may not cause adverse effects.

Dr. Sinclair believes that NMN is better than NR for extending lifespan, even though the hype claims otherwise on internet forums and websites like Youtube, where people discuss their supplements of choice with each other to reach some conclusion. In his recent Podcast, he said that NMN works better than NR based on his personal experience and observation.

We recommend Liposomal NMN — a product made by a Leading Health Edge company, a company known for producing high-quality products. Liposomal NMN is 100% natural and pharmaceutical-grade, and the best part is they back their product with a 67-day money-back guarantee. To learn more about NMN, its benefits, side effects, and research studies, read our article about NMN supplementation.

2. Resveratrol

Resveratrol is an antioxidant most commonly found in grapes, peanuts, berries, and red wines. David Sinclair, in his book, mentioned that he takes 1 gram of Resveratrol with NMN and Yogurt in the morning.

He believes that Resveratrol and NMN work together to prevent age-related damage to our cells. It has been shown to activate the sirtuin genes responsible for protecting our DNA and cells. However, Resveratrol is challenging to be absorbed by the gut, and the little Resveratrol that ends up in the body is broken down very quickly.

It needs to be clarified if eating resveratrol-rich food provides the same benefits as supplements. Still, some promising animal studies suggest it might be an effective treatment for specific health conditions.

Studies show it can inhibit all stages of cancers, from initiation to promotion as well as progression – meaning there are many potential benefits for those who consume this healthy ingredient! Other studies have also reported bioactive effects, such as anti-inflammatory properties and cardioprotective activity, among others.

In people with diabetes, It has been shown to improve glycemic control for people with type 2 diabetes. However, it’s yet to be determined if this beneficial property of Resveratrol affects insulin sensitivity as well or not.

For now, though, most of our knowledge about this compound comes from tests conducted on animals or test tubes – so let’s hope future human research gives us better answers.

Some of the potential benefits of using Resveratrol are;

  • Resveratrol, a natural polyphenol, has been shown to promote youthful gene expression. This is similar to the benefits seen with a calorie-restricted diet.
  • Resveratrol benefits support a healthy insulin response. Additionally, Resveratrol also helps to improve mitochondrial function.
  • Resveratrol has also been shown to help maintain healthy glucose levels and has an antioxidant effect on the brain area.
  • Resveratrol has many other health benefits, including supporting a healthy inflammatory response. It also helps inhibit oxidation, which can help keep your cells healthy and prevent damage.

David Sinclair usually takes 1000mg of Resveratrol but according to him, taking 500mg each morning, along with yogurt, to improve its absorption.

3. Vitamin D3

It’s no secret that most people get their vitamins from food sources, but some need extra help in the form of supplements. David Sinclair is one such person who takes a few different types for his morning routine.

Vitamin D is a fat-soluble vitamin found in several foods, added to others, and available as dietary supplements. It’s also made by our bodies when we’re exposed to UV rays from the sun. Vitamin D3 has been shown to extend lifespan and reduce risk factors associated with aging-related diseases like cancer or heart disease.

The usual recommended daily dietary intake for males and females aged 14-70 is 15mcg (600IU) daily.

5. Vitamin K

It is important for so many things! It’s great to know that this vitamin also helps with skin health but at the same time, it is crucial for bone health, and vascular and mitochondrial health. If you’re already taking Vitamin D, then it might be best to take Vitamin K2 because the two work together in keeping our bodies healthy and strong.

4. Metformin

Metformin, an old prescription drug known to treat diabetes, has been found in many studies to extend lifespan. However, people taking this medication live longer than healthy non-diabetic people and even those with type 2 diabetes on other anti-diabetic drugs don’t seem to benefit as much from metformin effects on their longevity. It should also be noted that it may have side effects, such as diarrhea or gastrointestinal discomfort, which usually subside after a few weeks.

David Sinclair takes metformin at night, before bedtime. He says this because, during the evening hours, we are already in a fasting state, and he wanted to make sure his body had enough time for insulin sensitivity- increasing benefits that come with sleeping later on throughout each day while also helping him recover from meals better over long periods of usage.

There are a lot of people who live longer than expected and have diseases prevented by taking metformin. However, if you can’t get your hands on the medication or would instead go natural, berberine may be better for helping with diabetes symptoms such as high blood sugar levels and heart health.

A recent podcast from Sinclair revealed that those using this type of medicine appear to suffer fewer complications over time while also being protected against various illnesses. But what if you don’t need to take something with an artificial score? Berberine may be your best bet regarding healthy blood sugar levels or preventing disease. Studies show that this natural compound can help lower cholesterol while also improving heart health, among other things – and no prescription is necessary.

5. Fisetin

Fisetin is another type of nutrient found in plants and may have anti-aging properties. This yellow micronutrient comes from many different kinds of fruits & vegetables like apples (including apple juice), persimmons, grapes, strawberries, kiwi kale, cucumbers onion.

Dr. Sinclair recently said in his tweet that he has been taking Fisetin for over two years. Fisetin is a natural supplement with benefits that continue to grow in discovery. These include “anti-inflammatory, antioxidant and tumorigenic effects for human diseases,” according to a recent study. Sinclair also believes that Fisten is a crucial ingredient in fighting against aging.

6. Quercetin

Quercetin is a powerful antioxidant, a nutrient found in many fruits and vegetables like grapes, apples, broccoli tomatoes, and has been shown to affect slowing down aging. Quercetin reduces signs of aging, such as wrinkles, and destroys cancerous cells. Its benefits extend beyond just looking younger; it can help prevent heart disease, control blood sugar levels, or even reduce swelling.

Quercetin may help protect against degenerative brain disorders such as Alzheimer’s and dementia. Studies also show it can reduce inflammation by neutralizing free radicals; molecules produced when our bodies interact with environmental toxins.

David’s book Lifespan was published in 2019, and at that time, he was only taking Resveratrol with his yogurt in the morning. However, by mid-2021, he had started experimenting with adding Fisetin and Quercetin to his daily routine. By 2022 he was taking 500mg of each senolytic molecule daily, alongside his Resveratrol and yogurt. Both have properties that activate SIRT1, which is known to have anti-aging effects. Senolytic molecules can also kill off senescent cells, which has been shown to help improve lifespan in animal studies.

7. Spermidine

David claims that he is currently taking 1 gram of spermidine each morning.

Spermidine is a polyamine compound produced naturally in our bodies and is also found in blue cheese, shellfish, green peas, chicken liver, soy products, mushrooms, and whole grains. A 2016 study found that spermidine supplementation improved cardiovascular function and turned back the aging clock at the organ level in aged mice. In addition, the treated mice decreased inflammation and increased autophagy (the body’s process of removing damaged cells). These findings suggest that spermidine could potentially treat age-related cardiovascular diseases. However, more research is needed to confirm these results in humans.

8. COQ10

Though it’s unclear why many people who take statins for their cardiovascular health often experience side effects, including muscle pain and weakness. So, if you’re suffering from these symptoms or have been diagnosed with chronic heart disease, in that case, David Sinclair suggests adding Coenzyme Q10 supplements into your routine, as this may help replenish what medications might deplete to promote longer lifespans. This supplement is also crucial in mitochondrial energy production.

Coenzyme Q10 is a nutrient that prevents neurogenerative diseases like Parkinson’s, Alzheimer’s, and Huntington’s disease. It also helps with other forms of dementia to some degree.

9. Trimethylglycine (TMG)

David Sinclair thinks that NMN supplementation can reduce the methyl group; that’s why he is also taking TMG daily to restore the methyl in the body. One way TMG helps protect our cells is by donating a spare methyl group to the cellular DNA and protecting it from damage from aging. This allows it to take part in building new molecules that help keep DNA healthy that are causing cancer or premature aging.

Other David Sinclair Supplements List

10. Alpha Lipoic Acid— a natural antioxidant found in many different foods, including yeast and liver. It’s been shown to help prevent nerve pain for people with diabetes and lower their cholesterol levels when taken regularly at a dose of 50 milligrams or more per day–which most adults need only one tablet each morning.

11. Aspirin—This might look strange because Aspirin is a drug commonly used to treat minor aches, pains, and fevers. However, David Sinclair is using 81mg of this over-this-counter drug daily. However, A recent large study has shown that low doses of aspirin do not reduce cardiovascular disease or improve survival rates.

12. Statin—I’ve heard from many people that Sinclair takes a prescription drug called Statin. He most probably uses this because of a family history of cardiovascular disorders, which can be serious. However, we know that it’s a prescription drug, and you need a doctor’s prescription.

David Sinclair Diet

Dr. David Sinclair knows that nutrition, exercise, and sleep are just as important to extend lifespan as supplements, so he eats only two meals per day instead of three – often drinking lots of green tea while doing this. He also advocates fasting, where you avoid eating all food for some period ( usually 12 hours), but recent research shows the benefits may be even greater if it lasts longer.

Bottom Line

David Sinclair is considered one of those top scientists of all ages, and his number #1 recommended anti-aging supplement is NMN, followed by resveratrol and others discussed above. He is currently testing other supplements and prescription medicine to slow down aging, but he is now satisfied with what he is taking. Here is a quick David Sinclair supplements list;

  • NMN-1 gram
  • Resveratrol-1 gram
  • Spermidine-1 gram
  • Vitamin K2-180-360mcg per day
  • Fisetin-500mg
  • Quercetin-500mg
  • Metformin-800mg
  • Aspirin-81mg
  • Alpha lipoic acid-600-1800 mg
  • TMG-500-1000mg per day. 

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