Mechanism Of Action
Cefixime binds to specific penicillin-binding proteins (PBPs) situated inside the bacterial cell wall, inflicting the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes like autolysins; it’s possible that cefixime interferes with an autolysin inhibitor.
Serious side Effects Include bloody or watery diarrhea, dizziness, pain or trouble passing urine or change in the amount of urine, seizures, unusually weak or tired, allergies like a rash, itch or hives, swelling of the face, lips, or tongue, problem breathing or wheezy, fever, redness, blistering, peeling or loosening of the skin, including within the mouth, uncommon bleeding or bruising, yellowing of the eyes or skin. Less serious side effects that sometimes don’t need medical attention include; nausea, vomiting, headache, diarrhea, abdomen pain, upset, or gas, genital or anal irritation
Use In Pregnancy & Breast-Feeding:
Studies are performed in mice and rats at doses up to 400 times above human dose and result in no proof of impaired fertility or harm to the fetus as a result of cefixime. There are not any adequate and well control studies in pregnant women and nursing mothers available. Cefixime mustn’t be in pregnant women and nursing mothers unless considered essential by the physicians.
The suggested adult dose for otitis media, tonsillitis, pharyngitis, and urinary tract infections is 400 mg once daily or divided and given as 200 mg every 12 hours. pediatric patients (6 months and older) have a suggested dose of 8 mg/kg/day once daily or in 2 doses of 4/mg/kg each 12 hours.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefixime and other antibacterial drugs, Cefixime ought to be used only to treat infections that are tested or strongly suspected to be caused by susceptible bacteria. when culture and susceptibility info is available, they ought to be considered in choosing or modifying antimicrobial therapy. in the absence of such information, local epidemiology and susceptibility patterns might contribute to the empiric choice of therapy.